Review
Endocrinology & Metabolism
Elena Raya-Cano, Rafael Molina-Luque, Manuel Vaquero-Abellan, Guillermo Molina-Recio, Rocio Jimenez-Merida, Manuel Romero-Saldana
Summary: This study conducted a systematic review and meta-analysis to investigate the association between liver enzymes (ALT, AST, GGT) and MetS. The results showed that the concentrations of ALT, AST, and GGT were significantly higher in subjects with MetS compared to the control group.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Psychiatry
Friederike I. Tam, Ilektra Chocholi, Inger Hellerhoff, Malina Kloepfer, Kerstin Weidner, Veit Roessner, Peter Mirtschink, David M. Poitz, Stefan Ehrlich
Summary: This study investigates the involvement of the liver in acute anorexia nervosa (AN) and its relationship with vitamin B12 concentrations. The findings suggest that liver enzymes and vitamin B12 parameters are elevated in acute AN patients, and these alterations persist even after short-term weight restoration.
PSYCHIATRY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
David Petroff, Olaf Baetz, Katrin Jedrysiak, Jan Kramer, Thomas Berg, Johannes Wiegand
Summary: The study found that the normal range of ALT, AST, and GGT is age-dependent, which has important implications for guiding medical diagnoses.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Tamer Selen, Hadim Akoglu, Kemal Agbaht
Summary: This study evaluated the relationship between liver function tests (LFTs) and biochemical cardiovascular risk factors (CRFs) in patients with chronic kidney disease (CKD). The results indicated that the correlation between LFTs and CRFs is influenced by impaired glomerular filtration rate (GFR).
INDIAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Daisuke Miyamori, Marenao Tanaka, Masato Furuhashi, Hirofumi Ohnishi, Masayuki Koyama, Arata Osanami, Yukimura Higashiura, Keita Numata, Takashi Hisasue, Nagisa Hanawa, Norihito Moniwa, Tetsuji Miura
Summary: The combination of high levels of ALT and GGT efficiently predicts the development of diabetes mellitus in male individuals but not significantly in female individuals. The risk of developing diabetes increases with higher levels of ALT and GGT at baseline in both sexes. Adding the combination of high ALT and GGT to traditional risk factors improves the discriminatory capability for predicting the development of diabetes mellitus.
Article
Multidisciplinary Sciences
Sofia Christakoudi, Elio Riboli, Evangelos Evangelou, Konstantinos K. Tsilidis
Summary: This study demonstrates associations between metabolic biomarkers and body shape as measured by waist and hip size, while inflammatory biomarkers were only associated with waist size. This suggests that different mechanistic pathways may contribute to body shape.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Li Liu, Yuhan Shao, Enqiang Feng, Zhugang Shao, Dongming Xing
Summary: This study investigated the independent and combined relationships between alanine aminotransferase (ALT), hemoglobin (Hb), and metabolic syndrome (MetS) in the elderly. The findings showed that increased ALT and Hb levels were associated with higher risks of MetS and its components. The combination of elevated ALT and Hb levels further increased the risks compared to elevated ALT or Hb alone.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Li Liu, Yuhan Shao, Xiaojing Li, Jianping Sun, Dongming Xing
Summary: The study found that alanine aminotransferase (ALT) and serum uric acid (SUA) were associated with metabolic syndrome (MetS), and the combined elevation of ALT and SUA levels increased the risk of developing MetS and its components.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Gastroenterology & Hepatology
Arunkumar Krishnan, Laura Prichett, Xueting Tao, Saleh A. Alqahtani, James P. Hamilton, Esteban Mezey, Alexandra T. Strauss, Ahyoung Kim, James J. Potter, Po-Hung Chen, Tinsay A. Woreta
Summary: Abnormal liver chemistries are common in hospitalized COVID-19 patients and are closely related to disease severity and prognosis. Elevated levels of ALT, AST, ALP, and T-Bil can be used to assess risk and predict the need for advanced therapies in these patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Somaya Albhaisi, Rehan Qayyum
Summary: Elevated levels of serum alanine and aspartate aminotransferase (ALT and AST) were associated with a U-shaped relationship with cancer mortality, while both the lowest and highest levels of these enzymes were linked to increased risk. Higher levels of alkaline phosphatase (ALP) were also associated with higher cancer mortality. Gamma-glutamyltransferase (GGT) levels did not show a consistent relationship with cancer mortality, but an increase after median was associated with higher mortality risk. Further exploration is needed to understand the mechanisms behind these relationships.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Vincent L. Chen, Xiaomeng Du, Yanhua Chen, Annapurna Kuppa, Samuel K. Handelman, Rishel B. Vohnoutka, Patricia A. Peyser, Nicholette D. Palmer, Lawrence F. Bielak, Brian Halligan, Elizabeth K. Speliotes
Summary: The study conducted a meta-analysis on the UK Biobank and BioBank Japan to evaluate the association of three liver enzymes with liver and other metabolic diseases. It identified multiple previously-unreported genome-wide significant associations and provided new insights into the pathophysiology of liver and metabolic diseases.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Na Wu, Mofan Feng, Hanhua Zhao, Nan Tang, Yalan Xiong, Xinyu Shi, Dong Li, Hualing Song, Shengfu You, Jianying Wang, Lei Zhang, Guang Ji, Baocheng Liu
Summary: This study aimed to clarify the female-specific bidirectional relationship between blood alanine aminotransferase and the risk of metabolic syndrome. The study found that the metabolic syndrome score increased with age in females and was positively correlated with serum alanine aminotransferase in females. Genetic testing also revealed that the polymorphism rs295 in the lipoprotein lipase gene was related to the prognosis of metabolic syndrome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoyun Wu, Dongjie Liang, Junfang Sun, Yanyan Lin, Shengjie Wu
Summary: The study found a positive association between serum GGT levels and the incidence of hypertension among Chinese adults without metabolic syndrome, with a stronger association observed in females compared to males.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Chemistry, Medicinal
Fengling Zhou, Wei She, Lin He, Jiuqun Zhu, Lu Gu
Summary: The study did not find any significant changes in liver enzyme levels in metabolic disorder patients who received anthocyanin supplementation. The dose and duration of supplementation may contribute to the heterogeneity in results. Further high-quality studies are needed to confirm these findings.
PHYTOTHERAPY RESEARCH
(2022)
Article
Medicine, General & Internal
Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Yun Soo Hong, Juhee Cho, Geum-Youn Gwak
Summary: Alcohol intake is associated with increased liver-related and all-cause mortality among individuals with elevated ALT levels.
Article
Nutrition & Dietetics
Yu-Jin Kwon, Da Hyun Park, Ja-Eun Choi, Dasom Lee, Kyung-Won Hong, Ji-Won Lee
Summary: A large-scale genome-wide association study in Korean adults found that interactions between specific genetic variants and certain nutrients may influence the risk of obesity and abdominal obesity.
CLINICAL NUTRITION
(2022)
Article
Oncology
Ji Young Kim, Samuel Yoo, Su Jin Yeon, Ji Hee Min, Dong-Il Kim, Ji Won Lee, Jung Woo Han, Chuhl Joo Lyu, Justin Y. Jeon
Summary: The study aimed to explore physical activity levels, exercise preferences, and perceived barriers to physical activity in childhood cancer survivors. Most participants did not meet the physical activity recommendations, but they had positive attitudes towards exercise and intended to participate in it. Exercise and physical activity programs should be tailored to the personal health and preferences of childhood cancer survivors.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Endocrinology & Metabolism
Yu-Jin Kwon, Go Eun Kwon, Hye Sun Lee, Man Ho Choi, Ji-Won Lee
Summary: Orlistat treatment improves oxysterol metabolism in overweight and obese adults and plays a crucial role in the process of atherosclerosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yu-Jin Kwon, Hyangkyu Lee, Su Jung Baik, Hyuk-Jae Chang, Ji-Won Lee
Summary: This study developed a deep neural network model for estimating LDL-C levels and compared its performance with previous estimation equations. The results showed that the developed model had lower bias, root mean-square error, and higher concordance, providing more accurate estimations of LDL levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Jae-Min Park, Ja-Eun Choi, Hye Sun Lee, Soyoung Jeon, Ji-Won Lee, Kyung-Won Hong
Summary: We compared the improvement in components of metabolic syndrome (MS) before and after lifestyle modification, as determined by daily step counts using a wrist-worn Fitbit. The results showed that walking improved MS components more in individuals with metabolic syndrome than those without, suggesting that high-risk MS individuals should be encouraged to walk from a public health perspective.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Yu-Jin Kwon, Hye Sun Lee, Goeun Park, Juyeon Yang, Hyung-Mi Kim, Ji-Won Lee
Summary: This study investigated the association between dietary zinc intake and total deaths, cancer, and cardiovascular disease death. The results showed that dietary zinc intake was inversely associated with all-cause mortality and cardiovascular disease mortality, but not with cancer mortality. These findings suggest that recommending optimal dietary zinc intake is beneficial for human health.
Article
Nutrition & Dietetics
Yu-Jin Kwon, Hye Sun Lee, Goeun Park, Ji-Won Lee
Summary: There is inconclusive evidence regarding the association between dietary sodium, potassium, and the sodium-to-potassium ratio and all-cause and cardiovascular disease mortality. This study found that sodium intake was not associated with all-cause mortality, while potassium intake was inversely associated with all-cause mortality.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Jiin Ryu, Eun-Young Lee, Jihee Min, Sujin Yeon, Ji-Won Lee, Sang Hui Chu, Hyangkyu Lee, Seung Il Kim, Jee Ye Kim, Seho Park, Justin Y. Jeon
Summary: This 12-month randomized controlled trial investigates the effects of tailored home-based exercise programs on short-term and long-term physiological outcomes in patients with breast cancer. The study found that exercise interventions customized to patients' treatment phase, surgery type, and physical function can improve shoulder function, body composition, and insulin resistance. These findings provide guidance for the development of effective exercise programs for patients with breast cancer post-operatively.
Article
Dentistry, Oral Surgery & Medicine
Hyun-Jeong Lee, Ji-Won Lee, Sue Kim, Yu-Jin Kwon
Summary: This study found that TyG, TyG-BMI, TyG-WC, and TyG-WHtR are significantly associated with the risk of periodontitis, and TyG-WHtR has the highest predictive performance.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Behavioral Sciences
Youhyun Song, Dasom Lee, Ja-Eun Choi, Ji Won Lee, Kyung-Won Hong
Summary: In this study, genome-wide association studies revealed genetic loci associated with left-handedness and ambidexterity, which were replicated with previously reported variants. These findings are linked to brain development, neurological processes, and neuropsychiatric diseases, providing intriguing insights for future neurological research.
BRAIN AND BEHAVIOR
(2023)
Article
Primary Health Care
Joon Hyung Lee, Jae Yong Shira, Ji Won Lee
Summary: This study investigated the association between urinary cotinine levels and blood pressure in Korean adults exposed to secondhand smoke. The results showed that in female participants, urinary cotinine levels were positively associated with systolic and diastolic blood pressure. However, there was no association between blood pressure and urinary cotinine levels in male participants.
KOREAN JOURNAL OF FAMILY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sanghoon Kim, Ji-Won Lee, Yaeji Lee, Youhyun Song, John A. Linton
Summary: This study found a correlation between the triglyceride-glucose (TyG) index and mean low-density lipoprotein (LDL) particle size. The results showed that the TyG index cutoff value for sdLDL particle predominance was close to the cutoff value of diabetes risk in Koreans.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Hematology
Dong-Wook Chun, Yae-Ji Lee, Jun-Hyuk Lee, Ji-Won Lee
Summary: This study found that an increasing trajectory of AIP is associated with a higher risk of incident CVD. Monitoring and managing the trajectory of AIP may be a preventive strategy for CVD.
THROMBOSIS JOURNAL
(2023)
Article
Pediatrics
Ehn-Young Kim, Hye-Won Lee, Ji-Won Lee, Yu-Jin Kwon, Nak-Hoon Son
Summary: The study aimed to analyze the trends in serum uric acid (SUA) levels among Korean children and adolescents over a 5-year period, considering factors such as age, sex, obesity, and abdominal obesity. The study utilized nationally representative data from the Korea National Health and Nutritional Examination Survey conducted from 2016 to 2020. The findings showed a significant increase in SUA levels among boys with obesity or abdominal obesity, indicating the need for further research on the health outcomes associated with SUA in this population.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Yea-Chan Lee, Ji-Won Lee, Yu-Jin Kwon
Summary: This study evaluated the relationship between periodontitis and noninsulin-based insulin resistance (IR) indices and compared the predictive values of these indices in the Korean population. The results showed that higher TG/HDL-C ratio, TyG, and METS-IR indices are associated with a higher prevalence of periodontitis. Additionally, the METS-IR index was found to be a more powerful predictor of periodontitis prevalence compared to the TyG index and TG/HDL-C ratio.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)