Review
Cardiac & Cardiovascular Systems
Dimitra Palioura, Antigone Lazou, Konstantinos Drosatos
Summary: KLF5 is a crucial DNA-binding transcription factor that is associated with normal development, cancer, cardiovascular complications, and regulation of metabolic pathways. Research findings suggest that KLF5 plays a significant role in cardiovascular health, and inhibiting KLF5 could be a novel approach for cardiovascular therapeutics.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Oncology
X. Leon, M. Venegas, A. Pujol, C. Bulboa, A. Llansana, M. Casasayas, M. Quer, M. Camacho
Summary: The transcriptional expression of KLF6 is significantly related to local control in HNSCC patients treated with radiotherapy. Patients with high levels of KLF6 expression had a significantly higher risk of local recurrence after treatment.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shu Zhou, Jinjun Li, XiaoNa Zhang, Wen Xiong
Summary: This study investigated the role of miR-124 in AMP-stimulated neuroinflammation and its molecular mechanism. The findings showed that miR-124 can modulate microglia activation via targeting KLF6, accelerating M2 polarization and alleviating neurodegeneration induced by AMP.
Article
Medicine, General & Internal
Qunli Xiong, Zhiwei Zhang, Yang Yang, Yongfeng Xu, Ying Zhou, Su Zhang, Jinlu Liu, Ying Zheng, Qing Zhu
Summary: This study investigates the role of KLF6 in pancreatic cancer (PAAD). The results show that KLF6 is downregulated in pancreatic cancer tissues and is associated with poor survival. Overexpression of KLF6 inhibits proliferation, metastasis, and epithelial-mesenchymal transition (EMT) in pancreatic cancer cells. It is discovered that KLF6 upregulates activating transcription factor 3 (ATF3) in PAAD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Zhongting Huang, Haibin He, Feng Qiu, Hailong Qian
Summary: The study investigated the differential expression and prognostic value of KLF members in CRC, finding potential prognostic indicators and highlighting their involvement in cancer-related biological processes.
JOURNAL OF ONCOLOGY
(2022)
Review
Oncology
Frank A. Simmen, Iad Alhallak, Rosalia C. M. Simmen
Summary: KLF9 and KLF13 are related proteins that play roles as regulators of specific target genes in various tissues and pathophysiological states, including cancer development. They have diverse functions in tumor suppression or promotion, differentiation, inflammatory pathways, oxidative stress, and tumor immune cell infiltration. The study of KLF9 and KLF13 in cancer biology is likely to provide valuable insights into oncogenesis and its prevention and treatments.
Article
Toxicology
Manyu Gu, Shuyi Wang, Wandi Cao, Dejian Yan, Yi Cao
Summary: This study compared the adverse effects of P25 particles and nanobelts on endothelial cells, showing that nanobelts were more effective in increasing intracellular Ti element concentrations and inducing endothelial activation. Both P25 particles and nanobelts reduced the generation of intracellular NO and the expression of KLF2 and KLF4.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Liyan Fan, David R. Sweet, Domenick A. Prosdocimo, Vinesh Vinayachandran, Ernest R. Chan, Rongli Zhang, Olga Ilkayeva, Yuan Lu, Komal S. Keerthy, Chloe E. Booth, Christopher B. Newgard, Mukesh K. Jain
Summary: The skeletal muscle Kruppel-like factor 15 (KLF15) plays a critical role in coordinating pathways central to systemic lipid homeostasis, regulating lipid uptake, mitochondrial transport, and utilization. Deletion of skeletal muscle-specific KLF15 leads to elevated circulating lipids, insulin resistance/glucose intolerance, and increased lipid deposition in white adipose tissue and liver, which can be ameliorated by a diet rich in short-chain fatty acids.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Oncology
Szymon Grochans, Anna Maria Cybulska, Donata Siminska, Jan Korbecki, Klaudyna Kojder, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: Glioblastoma multiforme (GBM) is a highly aggressive malignancy with a median overall survival of approximately 15 months. This review analyzes the pathogenesis and epidemiological data of GBM, including age, gender, and tumor location. The data suggest that GBM is a higher-grade primary brain tumor and is significantly more common in men. Despite advancements in medicine, the risk of being diagnosed with glioma increases with age and median survival remains low. Additionally, the influence of stimulants, certain medications (such as NSAIDs), cell phone use, and exposure to heavy metals on GBM is difficult to determine clearly.
Article
Biochemistry & Molecular Biology
Ying Wang, Kaijuan Lu, Weibing Li, Zhigang Wang, Jing Ding, Zeyu Zhu, Zhipeng Li
Summary: The study revealed a tumor-promoting role of miR-200c-3p in gastric cell carcinoma (GCC), which may be achieved by targeting KLF6 and regulating the growth and metastasis of GCC cells.
Review
Biochemistry & Molecular Biology
Makoto Abe, Naoya Saeki, Yuki Ikeda, Shinsuke Ohba
Summary: Kruppel-like factors (KLFs), a group of zinc finger-containing transcription factors, play crucial roles in transcription regulation, cell proliferation, cellular differentiation, stem cell maintenance, and tissue and organ pathogenesis. Recent studies have shown that KLF family molecules have significant effects on skeletal cells, influencing their differentiation and function. This review provides an overview of the unique roles of each KLF in skeletal cells during normal development and skeletal pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Huilun Wang, Yanhong Guo, Haocheng Lu, Yonghong Luo, Wenting Hu, Wenying Liang, Minerva T. Garcia-Barrio, Lin Chang, Anna Schwendeman, Jifeng Zhang, Y. Eugene Chen
Summary: Atherosclerosis is influenced by KLF14 expression in macrophages, which plays a role in promoting cholesterol efflux and suppressing inflammatory response. Activation of KLF14 by perhexiline can inhibit inflammation and increase cholesterol efflux in a KLF14-dependent manner without triggering hepatic lipogenesis, representing a potential new therapeutic approach for preventing or treating atherosclerosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Oncology
Rui Miao, Dong Huang, Kaitao Zhao, Yang Li, Xiaomei Zhang, Yi Cheng, Na Guo
Summary: This study evaluated the expression level of VAV3 in glioblastoma and found that it was overexpressed and associated with patient survival. Knocking down VAV3 inhibited the migration, invasion, and proliferation of glioblastoma cells and decreased the self-renewal capacity of stem cells. Bioinformatics analysis showed that VAV3 was a target gene of miR-218 and overexpression of VAV3 reversed the tumor suppressor effect of miR-218.
MOLECULAR MEDICINE REPORTS
(2023)
Review
Neurosciences
Wentao Hu, Hongyu Liu, Ze Li, Jialin Liu, Ling Chen
Summary: This study aimed to assess the impact of multiple factors on glioblastoma multiforme (GBM) immunotherapy prognosis and investigate the potential predictors. The results showed that factors such as O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, gross total resection, and no baseline steroid use were associated with favorable overall survival (OS) and progression-free survival (PFS) following immunotherapy. On the other hand, a Karnofsky Performance Status score < 80 and undergoing two prior relapses were associated with worse OS. Age, gender, tumor programmed death-ligand 1 expression, and history of chemotherapy did not affect survival outcomes. Notably, immunotherapy significantly improved OS among patients undergoing two prior relapses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Oncology
Raffaella Iurlaro, Inja Waldhauer, Ester Planas-Rigol, Ester Bonfill-Teixidor, Alexandra Arias, Valeria Nicolini, Anne Freimoser-Grundschober, Isabel Cuartas, Alba Martinez-Moreno, Francisco Martinez-Ricarte, Esteban Cordero, Marta Cicuendez, Simona Casalino, Xavier Guardia-Reyes, Linda Fahrni, Thomas Poschinger, Virginie Steinhart, Marine Richard, Stefanie Briner, Joerg Mueller, Franz Osl, Johannes Sam, Sara Colombetti, Marina Bacac, Christian Klein, Estela Pineda, Luis Reyes-Figueroa, Alberto Di Somma, Josep Gonzalez, Paolo Nuciforo, Joan Carles, Maria Vieito, Josep Tabernero, Pablo Umana, Joan Seoane
Summary: T-cell bispecific antibodies (TCB) are engineered molecules that can bind both the T-cell receptor and tumor-specific antigens, showing potential therapeutic effects for EGFRvIII mutation in glioblastoma (GBM). We designed and developed a novel EGFRvIII-TCB with specificity and potent antitumor activity, promoting T-cell activation and cytokine secretion for tumor cell killing, as well as T-cell recruitment into tumors. In GBM animal models, including humanized orthotopic patient-derived xenograft models, EGFRvIII-TCB induced tumor regression. These results support the clinical testing of EGFRvIII-TCB.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Elise Maubert, Valerie Weber, Aurelien Voissiere, Yvain Gerard, Veronique Dedieu, Francoise Degoul, Jean-Michel Chezal, Emmanuel Chautard, Elisabeth Miot-Noirault
Summary: This study demonstrated the potential interest of combining HAP ICF05016 with EBR for the management of EMC. The strategy enhanced EBR efficacy at a lower dose and improved survival without side effects, showing promising results in preclinical studies.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Oncology
J. Biau, E. Thivat, E. Chautard, D. Stefan, M. Boone, B. Chauffert, C. Bourgne, D. Richard, I Molnar, S. Levesque, R. Bellini, F. Kwiatkowski, L. Karayan-Tapon, P. Verrelle, C. Godfraind, X. Durando
Summary: This phase 1 trial aimed to determine the maximum tolerated dose of a p38-MAPK inhibitor, ralimetinib, in combination with radiotherapy and chemotherapy for newly diagnosed GBM patients. The study found that the MTD of ralimetinib was 100 mg/12 h, with the main dose-limiting toxicities being hepatic cytolysis and rash.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
L. Brun, G. Dupic, V Chassin, E. Chautard, J. Moreau, V Dedieu, T. Khalil, P. Verrelle, M. Lapeyre, J. Biau
Summary: The study aimed to compare dosimetric results of four plans for hypofractionated stereotactic radiotherapy (HFSRT) for large brain metastases, finding that NovalisTx (R) VMAT HFSRT provided the best dosimetric compromise for >= 25 mm diameter brain metastases in terms of target coverage, sparing of healthy brain tissue, and low-dose delivery compared to DCA.
CANCER RADIOTHERAPIE
(2021)
Article
Oncology
Elisa Le Boiteux, Franck Court, Pierre-Olivier Guichet, Catherine Vaurs-Barriere, Isabelle Vaillant, Emmanuel Chautard, Pierre Verrelle, Bruno M. Costa, Lucie Karayan-Tapon, Anne Fogli, Philippe Arnaud
Summary: HOX gene deregulation may contribute to the development of adult glioma by leading to widespread upregulation of HOX genes, possibly through escape from DNA hypermethylation at CpG island promoters. The study provides a comprehensive description of epigenetic changes at HOX clusters and their contribution to transcriptional changes observed in adult glioma, as well as identifying potential 'master' HOX proteins that may contribute to the tumorigenic potential of glioma stem cells.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Elodie Jouberton, Sebastien Schmitt, Aurelie Maisonial-Besset, Emmanuel Chautard, Frederique Penault-Llorca, Florent Cachin
Summary: This article reviews the use of [F-18]ML-10 as a radiotracer for evaluating tumor response to treatment through apoptosis. While most studies suggest its good ability to target apoptotic cells, an increase in apoptosis during treatment did not correlate with the radiotracer tumoral uptake.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marie-Elisa Pinson, Franck Court, Aymeric Masson, Yoan Renaud, Allison Fantini, Ophelie Bacoeur-Ouzillou, Marie Barriere, Bruno Pereira, Pierre-Olivier Guichet, Emmanuel Chautard, Lucie Karayan-Tapon, Pierre Verrelle, Philippe Arnaud, Catherine Vaurs-Barriere
Summary: In addition to the consequences of retrotransposition, L1 retrotransposons affect the host genome through their antisense promoter. The study found widespread expression of LCT in normal brain and glioma samples, with the transcriptional activities of L1 antisense promoters and their host loci being coupled.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Elisa Le Boiteux, Pierre-Olivier Guichet, Konstantin Masliantsev, Bertille Montibus, Catherine Vaurs-Barriere, Celine Gonthier-Gueret, Emmanuel Chautard, Pierre Verrelle, Lucie Karayan-Tapon, Anne Fogli, Franck Court, Philippe Arnaud
Summary: The overexpression of long non-coding RNA HOXA-AS2 in Glioma Stem Cells (GSCs) contributes to their aggressiveness by promoting proliferation and modulating the inflammation pathway through the regulation of key transcription factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Y. Tao, J. Biau, X. S. Sun, C. Sire, L. Martin, M. Alfonsi, J. B. Prevost, A. Modesto, C. Lafond, J. M. Tourani, J. Miroir, M. C. Kaminsky, A. Coutte, X. Liem, E. Chautard, E. Vauleon, F. Drouet, A. Ruffer, J. F. Ramee, G. Waksi, A. Pechery, M. Wanneveich, J. Guigay, A. Auperin, J. Bourhis
Summary: This study aimed to evaluate the potential synergistic effect of pembrolizumab with radiotherapy compared with a standard-of-care cetuximab-radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). The results showed that pembrolizumab concomitant with radiotherapy did not improve tumor control and survival compared with cetuximab-radiotherapy, but it appeared to be less toxic in unfit patients with LA-SCCHN.
ANNALS OF ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Terrance J. Haanen, Caitlin M. O'Connor, Goutham Narla
Summary: Protein phosphatase 2A (PP2A) is an enzyme that regulates protein phosphorylation and has anti-cancer effects. In cancer, the activity and heterotrimer formation of PP2A are regulated by various mechanisms, which can bias its activity towards oncogenic functions. Therapeutic approaches such as molecular glues and disruptors can be used to treat cancer.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Letter
Oncology
Florence Nguyen-Khac, Audrey Bidet, Marie-Berengere Troadec, Lauren Veronese, Nathalie Auger, Agnes Daudignon, Nathalie Nadal, Dominique Penther, Lucienne Michaux, Marina Lafage-Pochitaloff, Christine Lefebvre
Article
Oncology
Eve Faugeras, Lauren Veronese, Gaelle Jeannin, Henri Janicot, Sebastien Bailly, Jacques-Olivier Bay, Bruno Pereira, Anne Cayre, Frederique Penault-Llorca, Florent Cachin, Patrick Merle, Andrei Tchirkov
Summary: In patients with advanced non-small cell lung cancer (NSCLC), short telomeres, high levels of telomerase, and aberrant expression of shelterin genes TRF2, RAP1, and TIN2 are significantly associated with shorter survival. The determination of telomere parameters in NSCLC could be useful for individualized treatment decisions.
Article
Oncology
Gwendoline Soler, Zangbewende Guy Ouedraogo, Carole Goumy, Benjamin Lebecque, Gaspar Aspas Requena, Aurelie Ravinet, Justyna Kanold, Lauren Veronese, Andrei Tchirkov
Summary: Acute leukemia is a severe disease with rare occurrences, and genetic characterization plays an important role in its diagnosis and treatment. This study evaluated the performance of optical genome mapping (OGM) as a diagnostic tool for acute leukemia and found that OGM provided accurate genetic descriptions and simplified the workflow. It also detected additional genetic alterations of clinical interest. OGM shows promise as an alternative to current multiple cytogenetic testing in acute leukemia.
Article
Medicine, Research & Experimental
Matthieu Decamp, Emilie Klein, Catherine Godon, Valentin Lestringant, Pauline Roynard, Olivier Theisen, Melanie Jimenez-Pocquet, Catherine Roche-Lestienne, Audrey Bidet, Lauren Veronese
Summary: Myeloproliferative neoplasms and other hematopoietic cancers have an indolent course, and the identification of acquired genetic abnormalities is crucial for patient management and early detection of high-risk patients. Cytogenetic abnormalities also play an important role in the diagnosis, prognosis, and follow-up of these diseases.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jean-Baptiste Gaillarda, Elise Chapirob, Agnes Daudignond, Nathalie Nadale, Dominique Pentherf, Jasmine Chauzeixg, Florence Nguyen-Khacb, Lauren Veroneseh, Christine Lefebvrej
Summary: Mature T-cell and natural killer (NK)-cell neoplasms are a highly heterogeneous group of lymphomas with overlapping clinical and genetic features. Advances in molecular techniques have improved our understanding of the genetic alterations involved in these pathologies and provided recommendations for diagnosis.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Oncology
Rita A. Avelar, Amy Armstrong, Goutham Narla, Analisa DiFeo
CLINICAL CANCER RESEARCH
(2020)