Review
Emergency Medicine
Brit Long, Stephen Y. Liang, Michael Gottlieb
Summary: Disasters can cause mass casualties, including crush injury and crush syndrome. Emergency clinicians need to have a focused understanding of these conditions as they are at the forefront of evaluating and treating these patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Pediatrics
Bahriye Atmis, Aysun K. Bayazit, Cagla Cagli Piskin, Emel Saribas, Ferhat Can Piskin, Sevcan Bilen, Ozden Ozgur Horoz, Faruk Ekinci, Ikbal Turker, Hasan Ali Telefon, Ilker Unal, Hayri Levent Yilmaz, Nejat Narli, Dincer Yildizdas
Summary: This study analyzed the clinical and laboratory findings of pediatric earthquake victims with crush syndrome in Turkey and found that elevated creatine kinase levels, body area crushed percentage, and increased phosphorus levels can predict the need for dialysis treatment, while time under the rubble is not indicative of dialysis requirement.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Medicine, Research & Experimental
Daisuke Usuda, Shintaro Shimozawa, Hiroki Takami, Yoshinobu Kako, Taigo Sakamoto, Junya Shimazaki, Junichi Inoue, Shinichi Nakayama, Yuichi Koido, Jiro Oba
Summary: Disasters and accidents have been occurring more frequently in recent years, leading to mass casualty events and crush syndrome (CS) in many cases. However, our current knowledge and treatments for CS have not been updated for over ten years. This review aims to provide an overview and update on CS for prehospital providers and emergency clinicians.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Critical Care Medicine
Yahua Liu, Mengyang Yu, Li Chen, Jing Liu, Xin Li, Chengying Zhang, Xueyuan Xiang, Xiaoxue Li, Qi Lv
Summary: This systematic literature review examines the different animal models used in crush syndrome research and their benefits, providing valuable information for future studies. The review found that the two primary methods for inducing crush syndrome in animal models are chemical and physical methods. Various animal species have been used, with small animals more suitable for mechanism and efficacy studies, and large animals better for clinical application-related research. Compressing a specific muscle with heavy objects is the most effective method, but careful consideration must be given to the selection of appropriate anesthetics and analgesics due to the burden on animals.
Article
Pediatrics
Deniz Karakaya, Aysun Caltik Yilmaz, Tulin Gungor, Bahriye Uzun Kenan, Evra Celikkaya, Evrim Kargin Cakici
Summary: This study evaluated the risk factors for acute kidney injury (AKI) in pediatric patients with crush syndrome (CS) and developed a new scoring system for dialysis indication. Results showed that renal score, CPK level, and presence of myoglobinuria were the best markers for kidney replacement therapy (KRT) in pediatric CS patients.
PEDIATRIC NEPHROLOGY
(2023)
Review
Medicine, General & Internal
Yu Luo, Chunli Liu, Duo Li, Bofan Yang, Jie Shi, Xiaoqin Guo, Haojun Fan, Qi Lv
Summary: Crush syndrome, caused by external compression and commonly seen in disasters like earthquakes and traffic accidents, is a wide-ranging syndrome with various clinical complications. It is the second leading cause of death in disasters and is characterized by hyperkalemia, myoglobinuria, and acute kidney injury. Early diagnosis and prognosis evaluation are crucial in reducing mortality rates.
Article
Multidisciplinary Sciences
Ou Qiao, Xinyue Wang, Yuru Wang, Ning Li, Yanhua Gong
Summary: This review aims to summarize the evidence of ferroptosis in CS-AKI and its related molecular mechanism, discuss the therapeutic significance of ferroptosis in CS-AKI, and open up new ideas for the treatment of CS-AKI.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Critical Care Medicine
Qi Lv, Manman Long, Xin Wang, Jie Shi, Pengtao Wang, Xiaoqin Guo, Jie Song, Adam C. Midgley, Haojun Fan, Shike Hou
Summary: This study demonstrated the correlation between extrusion pressure and the severity of crush injury, as well as the increase in blood serum markers. The increase in extrusion pressure led to organ damage in kidney, muscle, and lung tissues. The identification of treatment candidate alpha 1-AGP was shown to protect against crush syndrome-induced acute kidney injury.
Article
Pediatrics
Feryal Karahan, Selma Unal, Ozlem Tezol, Serra Surmeli Doven, Fatma Durak, Mehmet Alakaya, Merve Misirlioglu, Edanur Yesil, Isa Killi, Hakan Kurt, Gul Altunkopru
Summary: This study aimed to share the experience of anticoagulant thromboprophylaxis in pediatric patients with earthquake-related crush syndrome. The decision for thromboprophylaxis was made by adapting the guideline for the prevention of perioperative VTE in adolescent patients. The VTE rate in pediatric patients with earthquake-related crush syndrome was 2.1% with the decision-making algorithm used for thromboprophylaxis.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Koshu Okubo, Kentaro Takayama, Hiroshi Kawakami, Kiriko Iida, Hiroaki Miyauchi, Yoshimi Roppongi, Hiroaki Ikeyama, Matsuhiko Hayashi, Seitaro Fujishima, Junichi Sasaki, Junji Haruta, Yoshio Hayashi, Junichi Hirahashi
Summary: Crush syndrome induced by skeletal muscle compression causes fatal rhabdomyolysis-induced acute kidney injury (RIAKI), which requires intensive care, including hemodialysis. Access to crucial medical supplies is highly limited while treating earthquake victims trapped under fallen buildings, lowering their chances of survival. Developing a compact, portable, and simple treatment method for RIAKI remains an important challenge.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Hematology
Murat Aslan, Deniz Ozel Bilgi
Summary: This study analyzed the development and treatment management of acute kidney injury in patients with crush syndrome, and found that most patients can be treated with high volume intravenous fluid without the need for renal replacement therapy.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Medicine, General & Internal
Mustafa Yalin, Fatih Golgelioglu
Summary: This study investigated the impact of fasciotomy on mortality and morbidity in children and adults with crush-related acute kidney injury (AKI) following the 2023 Kahramanmaras earthquakes. The results showed that fasciotomy did not increase the risk of death in both pediatric and adult patients with crush-induced AKI. The study also found a significant correlation between the number of fasciotomy incisions and the development of sepsis.
MEDICINA-LITHUANIA
(2023)
Article
Engineering, Biomedical
Tania L. Lopez-Silva, Carlo D. Cristobal, Cheuk Sun Edwin Lai, Viridiana Leyva-Aranda, Hyun Kyoung Lee, Jeffrey D. Hartgerink
Summary: The study demonstrates that MDPs enhance neurite outgrowth and promote a multicellular pro-regenerative response in peripheral nerve injury.
Article
Medicine, General & Internal
Hongjiao Gao, Qiao Xiang, Jindie Li, Meng Yu, Yalin Lan, Junqiang Ba, Yan Liu, Haoming Tian
Summary: Patients with Sheehan's syndrome are prone to elevated serum muscle enzymes, which may be associated with hypothyroidism and hyponatremia. Routine monitoring of serum muscle enzymes is important for patient management.
Article
Orthopedics
Chen Yu, Xiaoxu Wang, Jian Qin
Summary: Necrostatin-1 (Nec-1) can reduce peripheral nerve lesions and protect Schwann cells and axons by inhibiting necroptosis. It also reduces inflammation and oxidative stress by inhibiting RIP1.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Lin Yu, Qinhuai Lai, Lantu Gou, Jiafu Feng, Jinliang Yang
Summary: SCLC, an aggressive malignant tumor, faces challenges of chemotherapy resistance and systemic toxicity, with limited effectiveness in targeted therapy and immunotherapy; therefore, emphasis on prevention and early diagnosis is crucial, along with understanding the pathogenesis of SCLC and exploring new treatment strategies.
JOURNAL OF DRUG TARGETING
(2021)
Article
Oncology
Lin Yu, Qinhuai Lai, Qian Feng, Yuanmeng Li, Jiafu Feng, Bei Xu
Summary: This study revealed that lipid metabolism may play a crucial role in the progression from chronic gastritis to gastric cancer. Hexadecasphinganine, linoleamide, and N-Hydroxy arachidonoyl amine were identified as candidate diagnostic markers for chronic gastritis and gastric cancer. Additionally, changes in serum lipid levels, including total cholesterol, high-density lipoprotein cholesterol, and apolipoprotein A1, were observed with disease progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yuwei Yang, Bin Ge, Yan Liu, Jiafu Feng
Summary: This study investigates the roles of NGAL, CysC, and sCr in diagnosing AKI secondary to liver cirrhosis. Results suggest that NGAL may outperform sCr and CysC, with uNGAL being a more reliable indicator for diagnosing AKI.
Article
Biochemistry & Molecular Biology
Yuan-Meng Li, Qian Feng, Wen-Qiang Jiang, Bi-Tao Wu, Jia-Fu Feng
Summary: Serum levels of t-25(OH)D, 25(OH)D-3, C-3-epi, f-25(OH)D, and BAVD decrease gradually in CKD patients with the progression of CKD stages. Different methods for evaluating VitD storage in CKD patients yield different results, but simultaneous detection of various VitD components can accurately assess VitD status in vivo.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Pediatrics
Mateus A. de Souza, Jessica K. Hartmann, Laira F. F. Zottis, Thiago K. K. Gama, Ernani B. da Rosa, Paulo R. G. Zen, Rafael F. M. Rosa
Summary: Mosaic trisomy 8 is a condition with wide phenotypic and cytogenetic variability, where patients may present with various symptoms and congenital anomalies. This report highlights a case of a male patient with mosaic trisomy 8 and laryngotracheomalacia, leading to respiratory issues and malformations. While some literature describes similar cases, further studies are needed to fully understand the potential relationship between these conditions.
JOURNAL OF PEDIATRIC GENETICS
(2021)
Article
Genetics & Heredity
Maiara A. Floriani, Andressa S. Santos, Bruna L. Diniz, Andressa B. Glaeser, Paulo R. Gazzola Zen, Rafael F. Machado Rosa
Summary: This study aimed to investigate the occurrence and association of genetic alterations related to MMS in CHD pediatric patients in a reference healthcare institution in southern Brazil. The results revealed the presence of MMS in 11 out of 207 patients, with heterozygous deletion in the 22q11.2 chromosome region being the most prevalent genetic alteration.
MOLECULAR SYNDROMOLOGY
(2023)
Article
Cell Biology
Jia-Fu Feng, Wen-Yu Yang, Yao-Dong Wang, Gang Xie, Bei Xu, Chun-Mei Dai, Bin Zhang, Xiao-Han Li, Jun Wang, Yu-Wei Yang
Summary: This study reveals the tumor-suppressive role of circ_000829 in renal cell carcinoma (RCC), which is achieved by regulating the SRSF1-mediated alternative splicing of SLC39A14 mRNA.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Pediatrics
Bruna Lixinski Diniz, Desiree Deconte, Kerolainy Alves Gadelha, Andressa Barreto Glaeser, Bruna Baierle Guarana, Andreza Avila de Moura, Rafael Fabiano Machado Rosa, Paulo Ricardo Gazzola Zen
Summary: Congenital heart defects (CHDs) are commonly found in individuals with 22q11.2 deletion syndrome (22q11.2DS). It is important to choose the right cytogenetic technology and provide accurate interpretation of clinical findings for diagnosis. This systematic review updates the research on CHDs in 22q11.2DS patients and describes the investigation process and valuable tools for future investigations.
JOURNAL OF PEDIATRIC GENETICS
(2023)
Article
Neurosciences
Bianca Soares Carlotto, Patricia Trevisan, Valentina Oliveira Provenzi, Fabiano Pasqualotto Soares, Rafael Fabiano Machado Rosa, Marileila Varella-Garcia, Paulo Ricardo Gazzola Zen
Summary: This study examined the heterogeneity of PDGFRA, KIT, and KDR gene amplification in GBM and its association with clinical parameters. It found that amplification of all three genes, age = 60 years, and total tumor resection were statistically associated with poor prognosis. The study revealed a more complex tumoral heterogeneity in GBM than previously described, highlighting the need for considering this complexity in devising more effective therapies.
NEUROMOLECULAR MEDICINE
(2023)
Article
Genetics & Heredity
Livia Polisseni Cotta Nascimento, Rafaella Mergener, Marcela Rodrigues Nunes, Victoria Feitosa Muniz, Juliana Rossi Catao, Ana Kalise Boettcher da Silveira, Luiza Emy Dorfman, Carla Graziadio, Paulo Ricardo Gazzola Zen
Summary: We report the first case of a child with 16p11.2 microduplication syndrome showing increased fluid in the cisterna magna on MRI, which could not be differentiated as Blake's Pouch Cyst or Mega Cisterna Magna through imaging examination. The molecular duplication was diagnosed using chromosomal microarray analysis with SNP. This finding represents a possible extension of the phenotype not yet reported or a coincidence in a child with multiple malformations, as there is no previous mention of the association between 16p11.2 microduplication and the presence of BPC or MCM in neuroimaging exams in the available literature.
Article
Medicine, General & Internal
Marina da Rocha Besson, Mateus dos Santos, Eliaquim Beck Fernandes, Isadora Bueloni Ghiorzi, Mauricio Rouvel Nunes, Paulo Ricardo Gazzola Zen, Rafael Fabiano Machado Rosa
Summary: This retrospective study aimed to evaluate the frequency and types of chromosomal abnormalities (CAs) in patients with secondary amenorrhea (SA) in South Brazil. The results showed that 32.6% of SA patients had CAs, mostly related to short stature and additional findings, predominantly involving the X chromosome and compatible with Turner syndrome.
SAO PAULO MEDICAL JOURNAL
(2023)
Article
Pediatrics
Gabriela Rangel Brandao, Amanda Thum Welter, Gabriel Dotta Abech, Carla Bastos da Costa Almeida, Caio Seiti Mestre Okabayashi, Kerolainy Alves Gadelha, Paulo Ricardo Gazzola Zen, Rafael Fabiano Machado Rosa
Summary: Trisomy 21 is the most common chromosomal aneuploidy, and congenital heart disease (CHD) is highly prevalent among these patients. Ebstein anomaly (EA) is a rare CHD characterized by tricuspid valve dysplasia. The co-occurrence of both conditions is considered rare, with good prognosis but potential electrophysiological anomalies.
JOURNAL OF PEDIATRIC GENETICS
(2021)
Article
Medicine, General & Internal
Mauricio Rouvel Nunes, Tiago Godoi Pereira, Henry Victor Dutra Correia, Simone Travi Canabarro, Ana Paula Vanz, Paulo Ricardo Gazzola Zen, Rafael Fabiano Machado Rosa
Summary: Turner Syndrome (TS) is a rare genetic disease with clinical manifestations including short stature, nail abnormalities, and low posterior hairline. This study in southern Brazil found that patients with TS were often diagnosed late, and a small proportion were undergoing further evaluation, potentially leading to underdiagnosis of abnormalities. Early diagnosis and comprehensive evaluation are crucial for the effective management of TS patients.
SAO PAULO MEDICAL JOURNAL
(2021)
Article
Genetics & Heredity
Desiree Deconte, Catarine Benta Lopes dos Santos, Camila Ohomoto de Morais, Tatiane Mayumi Yonamine, Leticia Thais Nogueira, Maria Angelica Tosi Ferreira, Vinicius Bonetti Franceschi, Andre Luis Soares Longhi, Rolando Andre Rios Villacis, Silvia Regina Rogatto, Rodrigo Ligabue-Braun, Paulo Ricardo Gazzola Zen, Rafael Fabiano Machado Rosa, Marilu Fiegenbaum
Summary: Marshall-Smith syndrome (MSS) is a rare genetic condition with a variety of clinical features, some of which may be underestimated. This study describes a patient with unusual clinical manifestations and a novel NFIX variant not previously reported in the literature. The findings suggest potential mechanisms for impaired NFIX protein function in MSS.
Article
Pediatrics
Bruna Lixinski Diniz, Andressa Barreto Glaeser, Desiree Deconte, Bruna Baierle Guarana, Rafael Fabiano Machado Rosa, Paulo Ricardo Gazzola Zen
Summary: Ectopic calcification in soft tissue is associated with pseudohypoparathyroidism (PHP) and 22q11DS; Investigation of parathyroid function should be considered for patients with 22q11DS, especially in children.
JOURNAL OF PEDIATRIC GENETICS
(2021)