Review
Cell Biology
Yinan Chen, Yang Liu, Xiang Gao
Summary: Cardiovascular diseases are the leading cause of deaths worldwide, and single-cell omics technologies have been increasingly important in aiding our understanding of cardiovascular biology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Behavioral Sciences
Miguel Fuentes-Ramos, Marta Alaiz-Noya, Angel Barco
Summary: Transcription and epigenetic changes play vital roles in neuronal response to stimulation, impacting enduring changes in animal behavior such as learning and memory. Yet, understanding the specific epigenetic changes occurring in these cells and their contribution to memory persistence remains a challenge despite recent research progress.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Oncology
Yi Li, Lihui Sun, Xiangyang Guo, Na Mo, Jinku Zhang, Chong Li
Summary: Most etiology studies of bladder cancer focus on genetic changes, surgery is the main treatment but chemotherapy is needed due to high recurrence rates, and there are differences in chemosensitivity among patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Patrick R. Lawler, Deepak L. Bhatt, Lucas C. Godoy, Thomas F. Luscher, Robert O. Bonow, Subodh Verma, Paul M. Ridker
Summary: Systemic vascular inflammation plays crucial roles in the progression and destabilization of ASCVD, requiring more individualized approaches for successful clinical translation. High-sensitivity C-reactive protein may serve as a clinical measure of inflammation.
EUROPEAN HEART JOURNAL
(2021)
Review
Cell Biology
Tamer Butto, Kanak Mungikar, Peter Baumann, Jennifer Winter, Beat Lutz, Susanne Gerber
Summary: In the last decade, there has been a significant increase in nuclei-based studies, especially in combination with next-generation sequencing. These studies aim to understand the molecular states in heterogeneous cell populations using more affordable sequencing approaches and optimized nuclei isolation methods. While these powerful new methods offer unprecedented insights, it is important to consider the associated challenges critically. This article provides a comprehensive overview of the rise of nuclei-based studies and discusses their advantages and disadvantages, with a specific focus on their utility for transcriptomic sequencing analyses. Improving experimental designs and using various strategies appropriately will lead to biologically accurate and meaningful information.
Article
Multidisciplinary Sciences
Ricardo Castro-Hernandez, Tea Berulava, Maria Metelova, Robert Epple, Tonatiuh Pena Centeno, Julia Richter, Lalit Kaurani, Ranjit Pradhan, M. Sadman Sakib, Susanne Burkhardt, Momchil Ninov, Katherine E. Bohnsack, Markus T. Bohnsack, Ivana Delalle, Andre Fischer
Summary: This study used methylated RNA immunoprecipitation sequencing to investigate the role of N6-methyladenosine (m6A) in synaptic plasticity during cognitive decline. It was found that m6A levels decrease in aged animals and Alzheimer's disease (AD) patients. Common m6A changes were observed in transcripts related to synaptic function, and reduced m6A levels were shown to impair synaptic protein synthesis and function. These findings suggest that m6A RNA methylation plays a role in cognitive decline associated with aging and AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Beatriz E. Garcia-Gomez, Juan A. Salazar, Maria Nicolas-Almansa, Mitra Razi, Manuel Rubio, David Ruiz, Pedro Martinez-Gomez
Summary: Fruit ripening in plants involves complex processes that require the coordinated change in expression of hundreds to thousands of genes and various biochemical and physiological signal cascades. In Prunus species, ripening includes carbohydrate conversion, fruit firmness reduction, color changes, acidity decrease, and aroma increase, all of which are regulated at molecular levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Onat Kadioglu, Mohamed E. M. Saeed, Nuha Mahmoud, Shaymaa S. Hussein Azawi, Martina Rincic, Thomas Liehr, Thomas Efferth
Summary: Several genes were found to be overexpressed in B16-F10 cells, including Nr5a1/sf1 and Hoxb8 which are known to be linked with tumor progression and metastasis. Additionally, B16-F10 cells acquired additional chromosomal aberrations compared to B16-F1 cells. The study identified numerous novel genes and genomic aberrations that may serve as potential targets for future treatment strategies.
Article
Multidisciplinary Sciences
Kevin M. Magnaye, Selene M. Clay, Jessie Nicodemus-Johnson, Katherine A. Naughton, Janel Huffman, Matthew C. Altman, Daniel J. Jackson, James E. Gern, Douglas K. Hogarth, Edward T. Naureckas, Steven R. White, Carole Ober
Summary: Maternal asthma is a consistent risk factor for asthma in children, potentially impacting diverse epigenetically mediated pathways leading to distinct subtypes of severe asthma in adults, including hard-to-treat T2-low asthma. Analysis shows differences in DNA methylation patterns between mothers with and without asthma in genes related to impaired T cell signaling and response to pathogens. These findings may have implications for understanding and treating different subtypes of asthma.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Fahd Alhamdan, Kristina Laubhahn, Christine Happle, Anika Habener, Adan C. Jirmo, Clemens Thoelken, Raffaele Conca, Ho-Ryun Chung, Gesine Hansen, Daniel P. Potaczek, Bianca Schaub, Ruth Grychtol, Holger Garn
Summary: Optimal pre-analytical conditions for blood sample processing and isolation of selected cell populations are crucial for obtaining robust and reproducible results in transcriptomic and epigenomic studies. This pilot study investigated the effects of CD4(+) T-cell processing timing from the peripheral blood of atopic and non-atopic adults on their transcriptomic and epigenetic profiles. The results showed significant differences in gene expression and acetylation profiles between immediately processed CD4(+) T-cells from atopic and healthy subjects, while the profiles of delayed processed cells were more similar.
Editorial Material
Psychology, Applied
LaVerne Brown, Barbara Cohen, Rebecca Costello, Olga Brazhnik, Zorina S. Galis
Summary: The National Institutes of Health have gathered input to understand resilience in human health and biomedical sciences. They propose that resilience refers to a system's ability to recover, adapt, or resist stressors. They have developed a Resilience Research Design (ResD) Tool to guide researchers in identifying key features in resilience research.
Article
Oncology
Apostolia M. Tsimberidou, Elena Fountzilas, Leonidas Bleris, Razelle Kurzrock
Summary: Transcriptomics is a valuable tool in understanding cancer mechanisms and identifying biomarkers. It enables the analysis of gene expression and identification of molecular alterations in tumor tissue, which can be used for clinical interventions. It also has applications in predicting and prognosticating biomarkers, improving risk stratification, and understanding the impact of genomic alterations. Additionally, transcriptomics can be used to identify markers predicting response to immunotherapy in clinical trials.
SEMINARS IN CANCER BIOLOGY
(2022)
Editorial Material
Cell & Tissue Engineering
Jun Takahashi
Summary: Pluripotent stem cells have introduced cell replacement therapy, and to enhance its effectiveness, combining cell transplantation with gene therapy, medication, and rehabilitation is being explored as the next frontier of regenerative medicine.
Review
Environmental Sciences
Abed El Rahman Hassoun, Ashley Bantelman, Donata Canu, Steeve Comeau, Charles Galdies, Jean-Pierre Gattuso, Michele Giani, Michael Grelaud, Iris Eline Hendriks, Valeria Ibello, Mohammed Idrissi, Evangelia Krasakopoulou, Nayrah Shaltout, Cosimo Solidoro, Peter W. W. Swarzenski, Patrizia Ziveri
Summary: This paper systematically analyzes the current status, trends, and gaps in ocean acidification (OA) research in the Mediterranean region. It highlights uneven geographic research capacity, poor quantification of the carbonate system in coastal zones, and the lack of studies on certain organism groups. The paper also points out the overall scarcity of socio-economic, paleontological, and modeling studies, as well as the absence of consistent OA policies in the Mediterranean Sea. Recommendations are provided to address these knowledge gaps.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Endocrinology & Metabolism
Saula Vigili de Kreutzenberg, Alessandra Giannella, Giulio Ceolotto, Elisabetta Faggin, Roberta Cappellari, Marta Mazzucato, Chiara Fraccaro, Giuseppe Tarantini, Angelo Avogaro, Gian Paolo Fadini
Summary: This study discovered the presence of excessive myeloid calcifying cells in diabetic vascular disease and explored the molecular and cellular pathways linking coronary calcification with calcification by myeloid cells. The results showed that high glucose triggers a new pathway through the JAK/STAT cascade, involving the regulation of SIRT7 by miR-125b-5p, which drives calcification by myeloid cells.
Article
Cardiac & Cardiovascular Systems
Betul Toprak, Stephanie Brandt, Jan Brederecke, Francesco Gianfagna, Julie K. K. Vishram-Nielsen, Francisco M. Ojeda, Simona Costanzo, Christin S. Borschel, Stefan Soderberg, Ioannis Katsoularis, Stephan Camen, Erkki Vartiainen, Maria Benedetta Donati, Jukka Kontto, Martin Bobak, Ellisiv B. Mathiesen, Allan Linneberg, Wolfgang Koenig, Maja-Lisa Lochen, Augusto Di Castelnuovo, Stefan Blankenberg, Giovanni de Gaetano, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Teemu Niiranen, Tanja Zeller, Renate B. Schnabel
Summary: The study aims to find reliable circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning techniques. Fourteen routinely available biomarkers reflecting different pathophysiological pathways were examined in relation to incident AF. NT-proBNP was identified as the strongest blood-based predictor of incident AF.
Editorial Material
Cardiac & Cardiovascular Systems
Dominik Linz, Renate B. Schnabel
Article
Health Care Sciences & Services
Ludovic Trinquart, Chunyu Liu, David McManus, Christopher Nowak, Honghuang Lin, Nicole L. Spartano, Belinda Borrelli, Emelia J. Benjamin, Jonne M. Murabito
Summary: This study aimed to evaluate the impact of smartphone messaging interventions on remote transmission of blood pressure (BP) and heart rate (HR) data. The results showed that personalized notifications increased longitudinal adherence to BP and HR transmission, suggesting that personalized messaging is an effective tool in promoting adherence to mobile health systems in cardiovascular research.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ben Freedman, Renate B. Schnabel
Summary: Screening for atrial fibrillation in high-risk populations could contribute to stroke prevention, although randomized trials are underpowered. However, the encouraging results from meta-analysis and the potential of consumer-facing wearable devices to detect unknown atrial fibrillation are notable, even though they are mostly used by individuals at low risk of stroke.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Hoffmann, Sabine Hanss, Monika Kraus, Jens Schaller, Christian Schaefer, Dana Stahl, Stefan D. Anker, Gabriele Anton, Thomas Bahls, Stefan Blankenberg, Arne Blumentritt, Leif-Hendrik Boldt, Steffen Cordes, Steffen Desch, Wolfram Doehner, Marcus Doerr, Frank Edelmann, Ingo Eitel, Matthias Endres, Stefan Engelhardt, Jeanette Erdmann, Katharina Eulenburg, Volkmar Falk, Stephan B. Felix, Derk Frank, Thomas Franke, Norbert Frey, Tim Friede, Lars Geidel, Lisa Germans, Ulrich Grabmaier, Martin Halle, Joerg Hausleiter, Vera Jakobi, Ahmad-Fawad Jebran, Alexander Jobs, Stefan Kaeaeb, Mahir Karakas, Hugo A. Katus, Alexandra Klatt, Christoph Knosalla, Joachim Krebser, Ulf Landmesser, Mahsa Lee, Kristin Lehnert, Stephanie Lesser, Katrin Leyh, Roberto Lorbeer, Stephanie Mach-Kolb, Benjamin Meder, Eike Nagel, Christian H. Nolte, Abdul S. Parwani, Astrid Petersmann, Miriam Puls, Henriette Rau, Maximilian Reiser, Otto Rienhoff, Tabea Scharfe, Mario Schattschneider, Heiko Scheel, Renate B. Schnabel, Andreas Schuster, Boris Schmitt, Tim Seidler, Moritz Seiffert, Barbara-Elisabeth Staehli, Adriane Stas, Thomas J. Stocker, Lukas von Stuelpnagel, Holger Thiele, Rolf Wachter, Reza Wakili, Tanja Weis, Kerstin Weitmann, Heinz-Erich Wichmann, Philipp Wild, Tanja Zeller, Wolfgang Hoffmann, Elisabeth Maria Zeisberg, Wolfram-Hubertus Zimmermann, Dagmar Krefting, Titus Kuehne, Annette Peters, Gerd Hasenfuss, Steffen Massberg, Thomas Sommer, Stefanie Dimmeler, Thomas Eschenhagen, Matthias Nauck
Summary: The German Centre for Cardiovascular Research (DZHK) aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics for people with cardiovascular disease. The DZHK designed a research platform to standardize data and sample collections across all studies and ensure compliance with legal regulations and FAIR principles. The platform includes web-based and central units for data management, as well as a Public Open Data strategy to enable interdisciplinary use of data and samples.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nefeli Grammatika Pavlidou, Shokoufeh Dobrev, Kira Beneke, Franziska Reinhardt, Simon Pecha, Eric Jacquet, Issam H. Abu-Taha, Constanze Schmidt, Niels Voigt, Markus Kamler, Renate B. Schnabel, Istvan Baczko, Anne Garnier, Hermann Reichenspurner, Viacheslav O. Nikolaev, Dobromir Dobrev, Cristina E. Molina
Summary: In this study, it was found that upregulation of PDE8B isoforms in cAF patients reduces I-Ca,I-L through direct interaction with the Cav1.2(alpha 1C) subunit. Thus, upregulated PDE8B2 may serve as a novel molecular mechanism for the proarrhythmic reduction of I-Ca,I-L in cAF.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Christin S. Boerschel, Alfredo Ortega-Alonso, Aki S. Havulinna, Pekka Jousilahti, Marko Salmi, Sirpa Jalkanen, Salomaa Veikko, Teemu Niiranen, Renate B. Schnabel
Summary: This study used a proteomics approach to analyze the role of a cytokine biomarker in predicting atrial fibrillation (AF) in the community. The results found that high concentrations of certain cytokines and CRP, NT-proBNP were associated with an increased risk of AF. However, these associations were primarily explained by clinical risk factors and did not improve risk prediction for AF.
Article
Cardiac & Cardiovascular Systems
Simon Pecha, Djemail Ismaili, Bastiaan Geelhoed, Michael Knaut, Hermann Reichenspurner, Thomas Eschenhagen, Renate B. Schnabel, Torsten Christ, Ursula Ravens
Summary: This study investigated the impact of age and sex on the shape of atrial action potentials (APs). The results showed that AP duration increased with age, while women had smaller APs. These findings may have important clinical implications for the prevention and treatment of atrial fibrillation.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Tanja Charlotte Frederiksen, Christina Catherine Dahm, Sarah R. Preis, Honghuang Lin, Ludovic Trinquart, Emelia J. Benjamin, Jelena Kornej
Summary: There is a bidirectional relationship between atrial fibrillation (AF) and myocardial infarction (MI) due to shared risk factors and mechanisms. This review discusses the pathogenesis, prevention, and management of AF in patients with MI and of MI in patients with AF.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Joonatan Palmu, Christin S. Boerschel, Alfredo Ortega-Alonso, Lajos Marko, Michael Inouye, Pekka Jousilahti, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C. Humphrey, Jon G. Sanders, Friederike Gutmann, Dominik Linz, Veikko Salomaa, Aki S. Havulinna, Sofia K. Forslund, Rob Knight, Leo Lahti, Teemu Niiranen, Renate B. Schnabel
Summary: This study found that the gut microbiome composition is associated with the risk of atrial fibrillation (AF). Certain microbial genera were found to be related to the occurrence and prediction of AF. These findings establish the basis for using microbiome profiling in predicting AF risk, but further research is needed before microbiome sequencing can be used in prevention and targeted treatment of AF.
Article
Cardiac & Cardiovascular Systems
Christoph Kondziella, Nina Fluschnik, Jessica Weimann, Benedikt Schrage, Peter Moritz Becher, Felix Memenga, Alexander M. Bernhardt, Stefan Blankenberg, Hermann Reichenspurner, Paulus Kirchhof, Renate B. Schnabel, Christina Magnussen
Summary: This study aimed to investigate the impact of sex on selection for and outcomes after heart transplantation. It was found that male heart transplant recipients differed from females in terms of cardiac etiology, cardiovascular risk factors, and treatment. Even after adjusting for multiple factors, male heart transplant recipients still had a higher risk of cardiac allograft vasculopathy and malignancy.
Article
Medicine, General & Internal
Apurv Soni, Carly Herbert, Honghuang Lin, Yi Yan, Caitlin Pretz, Pamela Stamegna, Biqi Wang, Taylor Orwig, Colton Wright, Seanan Tarrant, Stephanie Behar, Thejas Suvarna, Summer Schrader, Emma Harman, Chris Nowak, Vik Kheterpal, Lokinendi V. Rao, Lisa Cashman, Elizabeth Orvek, Didem Ayturk, Laura Gibson, Adrian Zai, Steven Wong, Peter Lazar, Ziyue Wang, Andreas Filippaios, Bruce Barton, Chad J. Achenbach, Robert L. Murphy, Matthew L. Robinson, Yukari C. Manabe, Shishir Pandey, Andres Colubri, Laurel O'Connor, Stephenie C. Lemon, Nisha Fahey, Katherine L. Luzuriaga, Nathaniel Hafer, Kristian Roth, Toby Lowe, Timothy Stenzel, William Heetderks, John Broach, David D. McManus
Summary: This prospective cohort study evaluated the performance of rapid antigen tests (Ag-RDTs) for detecting SARS-CoV-2 among symptomatic and asymptomatic participants. The results showed that for symptomatic participants, testing twice with Ag-RDTs 48 hours apart resulted in a sensitivity of 93.4%, while for asymptomatic participants, testing three times with a 48-hour interval improved the sensitivity to 79.0%.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Amelie H. Ohlrogge, Jan Brederecke, Renate B. Schnabel
Summary: The global burden of AF/AFL is increasing in all income groups, with a more pronounced growth in middle-income countries. Risk factor distribution varies between income groups and factors such as medical doctor rate and life expectancy are correlated with prevalence of AF/AFL.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychiatry
Xuzhi Wang, Chathurangi H. Pathiravasan, Yuankai Zhang, Ludovic Trinquart, Belinda Borrelli, Nicole L. Spartano, Honghuang Lin, Christopher Nowak, Vik Kheterpal, Emelia J. Benjamin, David D. McManus, Joanne M. Murabito, Chunyu Liu
Summary: This study found an association between depressive symptom trajectories and subsequent physical activity collected by mHealth devices. Antecedent depressive symptom trajectories predicted lower levels of physical activity in the future.
JMIR MENTAL HEALTH
(2023)
Article
Clinical Neurology
Maerit Jensen, Anna Suling, Andreas Metzner, Renate B. Schnabel, Katrin Borof, Andreas Goette, Karl Georg Haeusler, Antonia Zapf, Karl Wegscheider, Larissa Fabritz, Hans-Christoph Diener, Gotz Thomalla, Paulus Kirchhof
Summary: Patients with atrial fibrillation and a history of stroke are at high risk of recurrent stroke and cardiovascular complications. The EAST-AFNET 4 trial showed that early rhythm control was associated with a lower risk of cardiovascular outcomes in such patients. This subgroup analysis further confirms the safety and efficacy of early rhythm control in patients with a history of stroke.