Review
Medicine, Research & Experimental
Mehmet Ozansoy, Houda Mikati, Halil Aziz Velioglu, Burak Yulug
Summary: This review investigates the role of exosomes as possible mediators between chronic systemic inflammatory diseases and Alzheimer's disease. Exosomes carry pro-inflammatory molecules generated in the periphery and target glial and neuronal cells in the central nervous system, initiating chronic neuroinflammation and contributing to Alzheimer's disease pathology.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Lilian Gomes de Oliveira, Yan de Souza Angelo, Antonio H. Iglesias, Jean Pierre Schatzmann Peron
Summary: Neuroinflammatory and neurodegenerative diseases are major public health issues worldwide, with mitochondrial dysfunction playing a significant role. Regulation of mitochondrial dynamics is essential for CNS health maintenance, impacting the development and progression of neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Georgia Colleluori, Chiara Galli, Ilenia Severi, Jessica Perugini, Antonio Giordano
Summary: Obesity disease is caused by dysfunctional energy balance regulation, with the central nervous system as the master regulator. During early postnatal periods, when the brain is highly plastic and influenced by the environment, neural circuitry involved in this regulation matures. This phenomenon is considered an evolutionary strategy, adjusting metabolic functions to environmental cues. Individuals who experience early life stress (ELS) have a higher prevalence of obesity. Oxytocin plays a vital role in regulating energy balance and is closely linked to leptin. Both oxytocin and leptin impact neurodevelopment and are affected by ELS and obesity.
Review
Biochemistry & Molecular Biology
Andrea Gonzalez, Sandeep Kumar Singh, Macarena Churruca, Ricardo B. Maccioni
Summary: Alzheimer's disease is a neurodegenerative disease characterized by progressive cognitive impairment, apathy, and neuropsychiatric disorders. The main pathological features are tau oligomers and Aβ plaques. Protein kinases and phosphatases play a role in the hyperphosphorylation of tau and its self-assembly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anastasia Geladaris, Darius Haeusler, Martin S. Weber
Summary: Therapeutically controlling chronic progression in multiple sclerosis (MS) remains a major challenge, as the exact mechanisms causing progression are still unknown. Microglia may play a key role in driving disease progression of MS, providing a unique opportunity for the development of more effective therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Franck Paganelli, Giovanna Mottola, Julien Fromonot, Marion Marlinge, Pierre Deharo, Regis Guieu, Jean Ruf
Summary: The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. While HHCy is associated with inflammation and atherosclerosis, lowering homocysteine (HCy) levels does not significantly impact cardiovascular risk. However, the HCy degradation product hydrogen sulfide (H2S) may play a cardioprotective role in the cardiovascular system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Peripheral Vascular Disease
Floor M. E. G. Steegh, Anke. A. A. Keijbeck, Patrick. A. A. de Hoogt, Timo Rademakers, Alfons J. H. M. Houben, Koen. D. D. Reesink, Coen D. A. Stehouwer, Mat J. A. P. Daemen, Carine J. Peutz-Kootstra
Summary: Patients with CKD have an increased risk for cardiovascular morbidity and mortality. Renal and systemic capillary rarefaction occurs independently of the cause of renal function decline. Maintaining capillary integrity and homeostasis is crucial in the prevention and management of renal and cardiovascular disease.
Review
Pharmacology & Pharmacy
Meneerah Abdulrahman Aljafary, Ebtesam Abdullah Al-Suhaimi
Summary: Adiponectin plays a key role in regulating energy generation and storage as well as functioning as an endocrine tissue in the body. It has both pro-inflammatory and anti-inflammatory effects on the cardiovascular system, making it an important biomarker and potential therapeutic tool for metabolic syndromes and cardiovascular diseases. Adiponectin is known for its cardioprotective impact and its ability to regulate various metabolic processes.
Article
Multidisciplinary Sciences
Guangmei Wang, Katharina Dorn, Stefanie Siebeneichler, Martin Valldor, Volodymyr Smetana, Anja-Verena Mudring
Summary: Open framework materials like zeolites and metalorganic frameworks have attracted significant interest due to their unique structures and appealing functionalities. In this research, new inorganic framework materials were discovered, with scaffold based on octahedral transition metal building blocks instead of tetrahedral ones. These materials exhibit distinctive structural features and interesting properties.
Article
Computer Science, Interdisciplinary Applications
Carlos Sevilla-Salcedo, Vandad Imani, Vanessa Gomez-Verdejo, Jussi Tohka
Summary: This paper proposes a Bayesian multi-view latent variable model for jointly learning diagnosis, ventricle volume, and ADAS score in dementia. The model utilizes a semi-supervised formulation to impute missing values and combines information from multiple views. Experimental results demonstrate that the model outperforms baseline methods in imputation and simultaneous prediction of multiple tasks.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Wei Xu, Yuuya Nagata, Naoya Kumagai
Summary: Quinoline, a neglected synthon, has been successfully synthesized as a 'missing link' in the N4 macrocycle family. The resulting TEQs possess a highly rigid saddle shape and can coordinate a series of transition-metal cations. TEQ/Fe(II) complexes show catalytic activity in dehydrogenation and oxygenation reactions with low catalyst loadings.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Nutrition & Dietetics
Jonathan Bortz, Kevin C. Klatt, Taylor C. Wallace
Summary: This article discusses the factors influencing the risk of neurocognitive decline and Alzheimer's disease, with a focus on the interplay between cognitive aging, sex hormones, the cholinergic system, and essential nutrient choline. It highlights the neuroprotective effects of estrogen, particularly in interactions with the cholinergic system, and the potential impact on hormone replacement therapy and nutrient metabolism. The critical window hypothesis regarding estrogen's effects on the cholinergic system may have implications for future research in both preclinical and clinical settings.
ADVANCES IN NUTRITION
(2022)
Article
Environmental Sciences
Gerdien de Vries, Katharina Biely, Emile Chappin
Summary: In the next decade, transition researchers should incorporate perspectives, theories, and methods from the scientific field of psychology. An integrative research approach that spans the individual, group, and system levels, conducted in interdisciplinary research teams, is essential for more effective analysis and application of sustainability transition processes.
ENVIRONMENTAL INNOVATION AND SOCIETAL TRANSITIONS
(2021)
Article
Geriatrics & Gerontology
Rebecca M. Fleeman, Amanda M. Snyder, Madison K. Kuhn, Dennis C. Chan, Grace C. Smith, Nicole A. Crowley, Amy C. Arnold, Elizabeth A. Proctor
Summary: The APOE4 gene is the strongest and most common genetic risk factor for Alzheimer's disease, and its mechanism of risk is not fully understood. This study investigated the simultaneous effects of systemic metabolic changes and brain inflammation in mice carrying the APOE4 gene. The results showed that cytokine signatures in the brain can predict systemic metabolic outcomes, independent of AD proteinopathies, and these signatures are dependent on APOE genotype. This study is the first to establish a quantitative and predictive link between systemic metabolism and specific pathological cytokine signatures in the brain.
NEUROBIOLOGY OF AGING
(2023)
Review
Cell Biology
Mallikarjun Patil, Sarojini Singh, John Henderson, Prasanna Krishnamurthy
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic leading to severe health consequences, particularly cardiac injuries, with limited understanding of its pathogenesis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Yasaman Malekizadeh, Alison Holiday, Devon Redfearn, James A. Ainge, Gayle Doherty, Jenni Harvey
Article
Biochemistry & Molecular Biology
Gemma McGregor, Jenni Harvey
NEUROCHEMICAL RESEARCH
(2019)
Review
Neurosciences
Amy Alexander, Andrew J. Irving, Jenni Harvey
Article
Geriatrics & Gerontology
Gemma McGregor, Leigh Clements, Adham Farah, Andrew J. Irving, Jenni Harvey
NEUROBIOLOGY OF AGING
(2018)
Review
Neurosciences
Gemma McGregor, Jenni Harvey
Article
Biochemistry & Molecular Biology
Natasha Solovyova, Peter R. Moult, Bogdan Milojkovic, Jeremy J. Lambert, Jenni Harvey
JOURNAL OF NEUROCHEMISTRY
(2009)
Article
Neurosciences
Peter R. Moult, Alasdair Cross, Sandra D. Santos, Ana-Luisa Carvalho, Yvonne Lindsay, Christopher N. Connolly, Andrew J. Irving, Nicholas R. Leslie, Jenni Harvey
JOURNAL OF NEUROSCIENCE
(2010)
Editorial Material
Neurosciences
Peter J. Blair, Jenni Harvey
JOURNAL OF PHYSIOLOGY-LONDON
(2012)
Article
Geriatrics & Gerontology
Gayle H. Doherty, Dayne Beccano-Kelly, Shi Du Yan, Frank J. Gunn-Moore, Jenni Harvey
NEUROBIOLOGY OF AGING
(2013)
Article
Neurosciences
Peter R. Moult, Jenni Harvey
Review
Biology
Andrew J. Irving, Jenni Harvey
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2014)
Article
Multidisciplinary Sciences
Mary J. Palmer, Christopher Moffat, Nastja Saranzewa, Jenni Harvey, Geraldine A. Wright, Christopher N. Connolly
NATURE COMMUNICATIONS
(2013)
Review
Chemistry, Medicinal
Kirsty Hamilton, Jenni Harvey
Summary: Leptin plays a significant role in regulating synaptic function in the hippocampus, enhancing cognitive function and memory tasks. It also targets temporoammonic-CA1 synapses, which are important for spatial and episodic memory processes. Leptin may have neuroprotective effects in Alzheimer's disease and boosting its actions in the hippocampus could be beneficial for AD patients.
Article
Biochemistry & Molecular Biology
Gayle Doherty, Alison Holiday, Yasaman Malekizadeh, Cosmin Manolescu, Stephen Duncan, Iona Flewitt, Kirsty Hamilton, Beth MacLeod, James A. Ainge, Jenni Harvey
Summary: Key pathological features of Alzheimer's disease (AD) include the accumulation of amyloid beta (Aβ) and metabolic dysfunction. Impairments in the leptin system have been detected in AD patients, sparking interest in targeting this system for AD treatment. This study examines the cognitive enhancing and neuroprotective actions of six-amino acid peptides derived from leptin(116-130) in promoting synaptic plasticity and improving memory tasks. The hexamers replicate the effects of leptin in promoting AMPA receptor trafficking and preventing toxic effects of Aβ on hippocampal synapses and neuronal viability. These findings further support leptin and leptin-derived peptides as potential therapeutics for AD.
JOURNAL OF NEUROCHEMISTRY
(2023)
