Lipoprotein (a) in calcific aortic valve disease: from genomics to novel drug target for aortic stenosis

Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic ValveCLINICAL PERSPECTIVE

(2015) Rihab Bouchareb et al.   CIRCULATION

Executive Summary: Heart Disease and Stroke Statistics—2015 Update:

(2015) Dariush Mozaffarian et al.   CIRCULATION

Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans

(2015) Mark J. Graham et al.   JOURNAL OF LIPID RESEARCH

Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis

(2015) Romain Capoulade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study

(2015) Sotirios Tsimikas et al.   LANCET

Calcific Aortic Valve Disease

(2014) Katherine E. Yutzey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis: A Prospective Mendelian Randomization Study and Replication in a Case-Control Cohort

(2014) B. J. Arsenault et al.   Circulation-Cardiovascular Genetics

18F-Sodium Fluoride Uptake Is a Marker of Active Calcification and Disease Progression in Patients With Aortic Stenosis

(2014) Marc R. Dweck et al.   Circulation-Cardiovascular Imaging

Association of Low-Density Lipoprotein Cholesterol–Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis

(2014) J. Gustav Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Reduction in Lipoprotein(a) With PCSK9 Monoclonal Antibody Evolocumab (AMG 145)

(2014) Frederick J. Raal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart Disease and Stroke Statistics—2014 Update

(2013) Alan S. Go et al.   CIRCULATION

MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma

(2013) Philipp Wiesner et al.   JOURNAL OF LIPID RESEARCH

Aortic Stenosis in the Elderly

(2013) Ruben L.J. Osnabrugge et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Elevated Expression of Lipoprotein-Associated Phospholipase A2 in Calcific Aortic Valve Disease

(2013) Ablajan Mahmut et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population

(2013) Pia R. Kamstrup et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Associations with Valvular Calcification and Aortic Stenosis

(2013) George Thanassoulis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mendelian Randomization: How Genetics Is Pushing the Boundaries of Epidemiology to Identify New Causes of Heart Disease

(2012) George Thanassoulis   CANADIAN JOURNAL OF CARDIOLOGY

Lipid Lowering on Progression of Mild to Moderate Aortic Stenosis: Meta-analysis of the Randomized Placebo-Controlled Clinical Trials on 2344 Patients

(2011) Koon K. Teo et al.   CANADIAN JOURNAL OF CARDIOLOGY

Identification of a Danger-Associated Peptide From Apolipoprotein B100 (ApoBDS-1) That Triggers Innate Proatherogenic Responses

(2011) Daniel F.J. Ketelhuth et al.   CIRCULATION

Assessment of Valvular Calcification and Inflammation by Positron Emission Tomography in Patients With Aortic Stenosis

(2011) Marc Richard Dweck et al.   CIRCULATION

The Roles of Lipid Oxidation Products and Receptor Activator of Nuclear Factor-κB Signaling in Atherosclerotic Calcification

(2011) Linda Demer et al.   CIRCULATION RESEARCH

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2

(2011) Alexandra Kadl et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antisense Oligonucleotide Lowers Plasma Levels of Apolipoprotein (a) and Lipoprotein (a) in Transgenic Mice

(2011) Esther Merki et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress

(2010) Tracie A. Seimon et al.   Cell Metabolism

Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis

(2010) Kwan Leung Chan et al.   CIRCULATION

Associations of Long-Term and Early Adult Atherosclerosis Risk Factors With Aortic and Mitral Valve Calcium

(2010) George Thanassoulis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relationship of Oxidized Phospholipids on Apolipoprotein B-100 Particles to Race/Ethnicity, Apolipoprotein(a) Isoform Size, and Cardiovascular Risk Factors

(2009) Sotirios Tsimikas et al.   CIRCULATION

‘Deep phenotyping’: characterizing populations in the era of genomics and systems biology

(2009) Russell P Tracy   CURRENT OPINION IN LIPIDOLOGY

Mendelian Randomization

(2009) George Thanassoulis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pro-Osteogenic Phenotype of Human Aortic Valve Interstitial Cells Is Associated With Higher Levels of Toll-Like Receptors 2 and 4 and Enhanced Expression of Bone Morphogenetic Protein 2

(2009) Xiaoping Yang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

(2009) Robert Clarke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH

A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma

(2008) Claes Bergmark et al.   JOURNAL OF LIPID RESEARCH

Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis

(2008) Anne B. Rossebø et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidant Generation Predominates Around Calcifying Foci and Enhances Progression of Aortic Valve Calcification

(2007) Marcel Liberman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY