Article
Biochemistry & Molecular Biology
Marine Hanse, Samina Akbar, Hamed Layeghkhavidaki, Frances T. Yen
Summary: Garcinia cambogia extract (GCE) can lower plasma triglyceride levels and promote weight loss, but may lead to compensatory mechanisms of increased liver and muscle lipids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jan Boren, Martin Adiels, Elias Bjornson, Niina Matikainen, Sanni Soderlund, Joel Ramo, Marcus Henricsson, Pietari Ripatti, Samuli Ripatti, Aarno Palotie, Rosellina M. Mancina, Mari Ainola, Antti Hakkarainen, Stefano Romeo, Chris J. Packard, Marja-Riitta Taskinen
Summary: Despite the higher liver fat content in PNPLA3-148M homozygotes, there was no increase in VLDL production. Equally, VLDL production was maintained at normal levels despite the putative impairment in cytosolic lipid hydrolysis in these subjects.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Ilaria Giretti, Rita D'Ascenzo, Alessio Correani, Luca Antognoli, Chiara Monachesi, Chiara Biagetti, Adriana Pompilio, Luisita Marinelli, Ilaria Burattini, Paola Cogo, Virgilio P. Carnielli
Summary: This study found that hypertriglyceridemia and lipid tolerance are common in preterm infants, particularly in infants with lower gestational age. Lipid tolerance is negatively associated with complications of prematurity.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds Jr, J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley
Summary: This study found that liver-specific deletion of CPT1a promotes sexually dimorphic steatotic liver disease (SLD) in mice, and new mechanisms by which females are protected from high-fat diet-induced liver injury were identified.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Stacey L. Borrego, Johannes Fahrmann, Jue Hou, Da-Wei Lin, Bruce J. Tromberg, Oliver Fiehn, Peter Kaiser
Summary: The study reveals that Met stress in triple-negative breast cancer cells leads to a global decrease in lipid abundances, except for triglycerides, and an increase in lipid droplets. Additionally, specific gene expression changes were observed in response to Met stress in the cells.
JOURNAL OF LIPID RESEARCH
(2021)
Editorial Material
Cell Biology
Maeve Long, Thomas G. McWilliams
Summary: Mitophagy induced by iron depletion leads to cellular metabolome rewiring and lipid droplet biosynthesis through DGAT1, promoting mitochondrial turnover. Inhibition of DGAT1 restricts mitophagy due to lysosomal dysfunction. Genetic depletion of DGAT1 in Drosophila impairs neuronal mitophagy and locomotor function, highlighting the physiological relevance.
Review
Virology
Yafei Qu, Weili Wang, Maggie Z. X. Xiao, Yuejuan Zheng, Qiming Liang
Summary: As intracellular parasites, viruses exploit cellular machinery and manipulate cellular metabolism pathways to replicate themselves. They also exploit cellular lipid metabolism by targeting the biogenesis, hydrolysis, and lipophagy of lipid droplets (LDs) during viral infection. This review summarizes the current understanding of how different viruses modulate cellular LDs, with a focus on Hepatitis C virus, Dengue virus, and SARS-CoV-2.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Gastroenterology & Hepatology
Geraldine J. Ooi, Peter J. Meikle, Kevin Huynh, Arul Earnest, Stuart K. Roberts, William Kemp, Benjamin L. Parker, Wendy Brown, Paul Burton, Matthew J. Watt
Summary: The study reveals that liver lipidome undergoes significant changes with worsening NAFLD, while the development of NASH does not lead to additional changes. Plasma lipid variables can serve as biomarkers for NAFLD, enhancing diagnostic accuracy and research in this field.
JOURNAL OF HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Psoriasis is a common skin disease affecting about 1%-3% of the general population, often accompanied by cardiometabolic disorders. Research indicates that lipid expression and metabolism disorders are more common in psoriatic patients, playing a significant role in the pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Pengxiang Zhao, Zichen Zhao, Ziwei Yu, Lupeng Chen, Yi Jin, Jian Wu, Zhuqing Ren
Summary: The study and synthesis of membrane organelles, particularly lipid droplets (LDs), are important for understanding molecular and metabolic processes and for applications in synthetic biology and drug delivery. LDs play a central role in cellular lipid metabolism and have been linked to metabolic diseases. However, the molecular mechanisms underlying LD functions are not fully understood. Synthetic biology offers new approaches to investigate LDs and has provided significant advancements in protein binding, lipid function, membrane dynamics, and enzymatic reactions.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Qiburi He, Yuhao Chen, Zhigang Wang, Hu He, Peng Yu
Summary: Fatty acids are essential nutrients for mammals and are obtained primarily from diet. Long-chain fatty acids enter cells through various mechanisms and are activated into acyl-CoA to target specific metabolic pathways. The main pathway for fatty acid catabolism is beta-oxidation, while fatty acid elongation occurs through a series of reactions. The crystal structures of phosphatidic acid phosphatase, membrane-bound fatty acid elongase-condensing enzyme, and other related proteins provide important insights into the utilization of long-chain fatty acids.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Nutrition & Dietetics
Emilio Balbuena, Junrui Cheng, Abdulkerim Eroglu
Summary: This study found that carotenoid-rich foods may have stronger efficacy in mitigating NAFLD compared to foods with low carotenoid levels, possibly due to the effects of carotenoids on fatty acid synthesis-related proteins and their potential to inhibit NAFLD by improving beta-oxidation.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Maria-Carmen Lopez de las Hazas, Andrea del Saz-Lara, Lidia Cedo, Maria Carmen Crespo, Joao Tome-Carneiro, Luis A. Chapado, Alba Macia, Francesco Visioli, Joan C. Escola-Gil, Alberto Davalos
Summary: HT supplementation in humanized mice resulted in systemic dyslipidemia, impaired glucose metabolism, increased body weight, and accumulation of triacylglycerols in different tissues. The expression of genes related to lipid metabolism, such as Pltp or Lpl, was also modulated by HT. Further studies are needed to fully understand the potential effects of HT consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
David G. Thomas, Ying Wei, Alan R. Tall
Summary: The study assessed the pleiotropic effects of lipid trait genetic variants and conducted multivariable Mendelian randomization (MR) analysis in coronary artery disease. Results indicated that 30% of lipid trait genetic variants have effects on metabolic syndrome traits, yet the associations of LDL-C, HDL-C, TGs, BMI, T2D, and SBP with CAD remained independent and robust to adjustment for directional pleiotropy. MR at loci linked to direct effects on HDL-C and TGs suggested specific causal effects of these factors on CAD.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
D. W. Yao, J. Ma, C. L. Yang, L. L. Chen, Q. Y. He, D. N. Coleman, T. Z. Wang, X. L. Jiang, J. Luo, Y. Ma, J. J. Loor
Summary: PTEN is a well-known tumor suppressor that plays a role in regulating cellular processes, including lipid metabolism. This study found that PTEN abundance decreased during peak lactation in goat mammary tissue. Overexpressing PTEN in isolated goat mammary epithelial cells led to downregulation of lipid metabolism-related genes and a shift towards lipolysis and fatty acid oxidation.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Jeremy Dufourt, Gwenaelle Bontonou, Aymeric Chartier, Camille Jahan, Anne-Cecile Meunier, Stephanie Pierson, Paul F. Harrison, Catherine Papin, Traude H. Beilharz, Martine Simonelig
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
David Kachaner, Damien Garrido, Haytham Mehsen, Karine Normandin, Hugo Lavoie, Vincent Archambault
NATURE COMMUNICATIONS
(2017)
Review
Biotechnology & Applied Microbiology
Jean-Philippe Parvy, Joseph A. Hodgson, Julia B. Cordero
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Cell Biology
Haytham Mehsen, Vincent Boudreau, Damien Garrido, Mohammed Bourouh, Myreille Larouche, Paul S. Maddox, Andrew Swan, Vincent Archambault
JOURNAL OF CELL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Muhammad-Kashif Zahoor, Mickael Poidevin, Caroline Lecerf, Damien Garrido, Jacques Montagne
MOLECULAR GENETICS AND GENOMICS
(2019)
Article
Biology
Jean-Philippe Parvy, Yachuan Yu, Anna Dostalova, Shu Kondo, Aline Kurjan, Philippe Bulet, Bruno Lemaitre, Marcos Vidal, Julia B. Cordero
Article
Genetics & Heredity
Talia Hatkevich, Vincent Boudreau, Thomas Rubin, Paul S. Maddox, Jean-Rene Huynh, Jeff Sekelsky
Article
Biochemistry & Molecular Biology
Emilie Pondeville, Nicolas Puchot, Jean-Philippe Parvy, Guillaume Carissimo, Mickael Poidevin, Robert M. Waterhouse, Eric Marois, Catherine Bourgouin
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Review
Cell Biology
Thomas Rubin, Nicolas Macaisne, Jean-Rene Huynh
Article
Multidisciplinary Sciences
Camille Jacqueline, Jean-Philippe Parvy, Marie-Lou Rollin, Dominique Faugere, Francois Renaud, Dorothee Misse, Frederic Thomas, Benjamin Roche
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Myreille Larouche, David Kachaner, Peng Wang, Karine Normandin, Damien Garrido, Changfu Yao, Maxime Cormier, Kristen M. Johansen, Jorgen Johansen, Vincent Archambault
Summary: Mitotic entry involves the inhibition of PP2A-B55/Tws, which is induced by Greatwall phosphorylation of Endos. The correct localization and phosphorylation of Tws and Endos play essential roles in mitotic regulation. The spatiotemporal regulation of Endos by Greatwall is conserved in humans and disruptions lead to mitotic defects.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Thomas Rubin, Nicolas Macaisne, Ana Maria Valles, Clara Guilleman, Isabelle Gaugue, Laurine Dal Toe, Jean-Rene Huynh
Summary: In Drosophila males, although meiosis differs significantly from females, similar molecular mechanisms are used to ensure proper pairing of centromeres.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Damien Garrido, Mohammed Bourouh, Eric Bonneil, Pierre Thibault, Andrew Swan, Vincent Archambault
Article
Genetics & Heredity
Maelle Devilliers, Damien Garrido, Mickael Poidevin, Thomas Rubin, Arnaud Le Rouzic, Jacques Montagne
Summary: The study demonstrates the use of fruit flies as a powerful model to study the link between growth and metabolism, showing that TORC1 and Ilp signaling can independently regulate overgrowth, and that cell-autonomous metabolic defects may trigger local compensatory pathways.