Review
Cell Biology
Grace Y. Sun, Xue Geng, Tao Teng, Bo Yang, Michael K. Appenteng, C. Michael Greenlief, James C. Lee
Summary: Phospholipids, key components of cell membranes, are metabolized by phospholipases, with a focus on the roles of three major types of PLA2s in the nervous system.
Review
Medicine, Research & Experimental
Xuan Wei, Guangshan Huang, Jiyong Liu, Jinwen Ge, Wenli Zhang, Zhigang Mei
Summary: Cerebral ischemia, the leading cause of morbidity and mortality worldwide, is associated with various CNS disorders, including ischemic stroke, AD, PD, and epilepsy. The Hippo signaling pathway has been found to play a crucial role in these diseases, including oxidative stress, inflammation, blood-brain barrier damage, mitochondrial disorders, and neural cell death. Understanding the molecular basis of the Hippo signaling pathway is vital for identifying potential therapeutic targets for ischemia-associated CNS diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Weixuan Wang, Xin Zhong, Jiao Guo
Summary: Metabolic syndromes, such as T2DM and NAFLD, are increasing globally, and the role of 2-series prostaglandins in their pathogenesis is being increasingly studied.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Plant Sciences
Parul Sharma, Nita Lakra, Alisha Goyal, Yogesh K. Ahlawat, Abbu Zaid, Kadambot H. M. Siddique
Summary: Lipids play a crucial role in protecting plant cells and mediating responses to abiotic stress. Recent studies have shown that lipids can act as signal mediators in reducing stress responses and activating defense systems in plants. This review focuses on the synthesis of various signaling lipids and their roles in abiotic stress tolerance, providing valuable insights for further investigation into the interactions between plant lipids and abiotic stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Neurosciences
Shu-Hui Dou, Yu Cui, Shu-Ming Huang, Bo Zhang
Summary: This article reviews the abnormal levels of brain-derived neurotrophic factor (BDNF) in various central nervous system (CNS) diseases and suggests that BDNF may play a role in the pathogenesis of these diseases. It also discusses the potential treatment of these diseases by regulating BDNF signaling. The clinical application status of BDNF is briefly introduced.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Mahalaxmi Iyer, Mohana Devi Subramaniam, Dhivya Venkatesan, Ssang-Goo Cho, Matias Ryding, Morten Meyer, Balachandar Vellingiri
Summary: Parkinson's disease is a complex neurodegenerative disease characterized by depletion of midbrain dopaminergic neurons. Current challenges in PD research include finding therapies to stop or reverse disease progression, identifying reliable biomarkers, and improving understanding of the pathophysiological mechanisms. The RhoA-ROCK signaling pathway shows promise in potentially addressing PD symptoms and pathogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Neurosciences
Zhaoxun Liu, Tao Xiao, Hailan Liu
Summary: Leptin plays a critical role in regulating appetite, energy expenditure, and body weight, and is important for maintaining a healthy balance. Despite efforts to understand its mechanisms and develop therapeutic interventions, the effectiveness of targeting leptin signaling has been limited. In addition to the hypothalamus, other brain regions are also being increasingly investigated for their involvement in mediating leptin's effects.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Linda X. Wang, Mark R. Frey, Rohit Kohli
Summary: Bile acids not only play a crucial role in lipid digestion, but also act as signaling molecules in metabolic processes throughout the body. By binding to various receptors, bile acids regulate glucose and lipid metabolism, and promote glycogen synthesis. Recent studies have identified a novel intestinal protein that positively affects bile acid levels, providing a new target for treating metabolic and bile acid-related disorders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhi-Ru Chen, Jia-Bao Huang, Shu-Long Yang, Fen-Fang Hong
Summary: This article reviews the role of cholinergic signaling in AD and its correlation with other risk factors. Due to the complex and unclear pathogenesis of AD, effective methods to prevent and treat AD are currently unavailable, making research to discover novel therapeutic drugs crucial.
Review
Clinical Neurology
Kelli M. Money, T. Allen Barnett, Samuel Rapaka, Rebecca Osborn, Takashi Kitani, Daniel Fuguet, Faria Amjad, Jeffrey R. Clark, Debanjana Chakravarty, Matthew J. Copeland, Justin M. Honce, Princy N. Kumar, Rebecca N. Kumar, Fady Mousa-Ibrahim, Bilaal Sirdar, Rafal Sobota, Mengxuan Tang, Maureen K. Bolon, Eric J. Russell, Michael Wilson, Carlo Tornatore, Ayush Batra, Kenneth L. Tyler, Daniel M. Pastula
Summary: This study presents three cases of Monkeypox virus (MPXV)-associated central nervous system (CNS) disease during the 2022 outbreak, with imaging findings and treatment outcomes. The patients, previously healthy immunocompetent gay men in their 30s, developed a febrile illness followed by progressive neurologic symptoms and vesiculopustular rash. MPXV nucleic acid was detected in skin lesions of two patients, with the third patient having an epidemiological link to a confirmed case. Magnetic resonance imaging showed central spinal cord lesions and other brain abnormalities. All patients received tecovirimat treatment, and two also received immunotherapy. Good neurological recovery was observed in all cases.
ANNALS OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hao Xu, Lin Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and may progress to non-alcoholic steatohepatitis (NASH) or liver cancer. Studies have shown that the Notch signaling pathway plays a key role in the development of NAFLD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Medicine, Research & Experimental
Dickson Kofi Wiredu Ocansey, Jintao Yuan, Zhiping Wei, Fei Mao, Zhaoyang Zhang
Summary: Ferroptosis is a regulated form of cell death characterized by iron accumulation, lipid peroxidation, and excessive reactive oxygen species production. It plays a role in the development of inflammatory bowel disease (IBD) and could be a potential therapeutic target. Inhibiting the characteristic features of ferroptosis has shown promising outcomes in relieving IBD.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Review
Cell Biology
Rosa Vona, Elisabetta Iessi, Paola Matarrese
Summary: Cholesterol is crucial for cell membrane structure and plays a key role in regulating cell signaling pathways. Its homeostasis is tightly regulated and dysregulation may be linked to cardiovascular diseases and cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medical Laboratory Technology
Chunxia Chen, Xihe Tang, Zhaohui Lan, Wan Chen, Hua Su, Weidong Li, Yaoxuan Li, Xing Zhou, Hong Gao, Xinwei Feng, Ying Guo, Meicun Yao, Wenbin Deng
Summary: The study establishes a novel humanized animal model of CLUC AD, which reveals the abnormal impact of CLUC on GABAergic signaling and the development of AD-related pathologies. Increased expression of Gabra2 in chimeric mice and the reversibility of cognitive impairment with a GABA A receptor inhibitor suggest sphingolipid signaling over-activation as a potential mechanism of GABAergic signaling disorder.
TRANSLATIONAL RESEARCH
(2023)
Review
Medicine, General & Internal
Hong Sun, Rong Sun, Yulin Hua, Qianyi Lu, Xinyu Shao
Summary: TXNIP is a crucial regulator involved in redox reactions in various organs and tissues. Its expression in human kidneys and its impact on diabetic kidney disease (DKD) have been extensively studied. Modulating TXNIP could be a potential therapeutic approach for managing DKD.
FRONTIERS IN MEDICINE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Edward Dennis
Article
Biochemistry & Molecular Biology
Daiki Hayashi, Varnavas D. Mouchlis, Edward A. Dennis
Summary: This study reveals the unique substrate selectivity of human phospholipase A2s (PLA2) for different fatty acids, discussing the substrate preferences and active site properties of cytosolic cPLA2 enzymes, calcium-independent iPLA2 enzymes, and secreted sPLA2 enzymes.
JOURNAL OF LIPID RESEARCH
(2021)
Letter
Multidisciplinary Sciences
Harald C. Koefeler, Thomas O. Eichmann, Robert Ahrends, John A. Bowden, Niklas Danne-Rasche, Edward A. Dennis, Maria Fedorova, William J. Griffiths, Xianlin Han, Juergen Hartler, Michal Holcapek, Robert Jirasko, Jeremy P. Koelmel, Christer S. Ejsing, Gerhard Liebisch, Zhixu Ni, Valerie B. O'Donnell, Oswald Quehenberger, Dominik Schwudke, Andrej Shevchenko, Michael J. O. Wakelam, Markus R. Wenk, Denise Wolrab, Kim Ekroos
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Daiki Hayashi, Varnavas D. Mouchlis, Edward A. Dennis
Summary: Glycerophospholipids are major components of cell membranes with diverse fatty acyl chain compositions and polar head groups. Phospholipase A(2) enzymes play a critical role in metabolism by hydrolyzing glycerophospholipids, and different human PLA(2) enzymes show distinct preferences for sn-1 acyl chain linkages.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Multidisciplinary Sciences
Varnavas D. Mouchlis, Daiki Hayashi, Alexis M. Vasquez, Jian Cao, J. Andrew McCammon, Edward A. Dennis
Summary: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associates with lipoproteins in human plasma and hydrolyzes oxidized phospholipids. The mechanism of enzyme-membrane association and substrate specificity were studied using lipidomics and mass spectrometry techniques.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Maria A. Theodoropoulou, Anastasia Psarra, Martin Erhardt, Aikaterini Nikolaou, Anna-Dimitra D. Gerogiannopoulou, Dimitra Hadjipavlou-Litina, Daiki Hayashi, Edward A. Dennis, Andrea Huwiler, George Kokotos
Summary: The search for new drugs that can regulate the production of prostaglandin E-2 (PGE(2)) is crucial in the treatment of inflammatory diseases. In this study, we synthesized and evaluated a series of compounds, and identified N-acylated and N-alkylated 2-aminobenzothiazoles as potential leads. These compounds showed significant inhibition of PGE(2) generation in rat mesangial cells and demonstrated better anti-inflammatory activity than indomethacin. The findings suggest that N-acylated or N-alkylated 2-aminobenzothiazoles could be promising candidates for regulating PGE(2) formation.
Article
Multidisciplinary Sciences
Loren M. DeVito, Edward A. Dennis, Barbara B. Kahn, Gerald Shulman, Joseph L. Witztum, Sudeshna Sadhu, Joseph Nickels, Matthew Spite, Susan Smyth, Sarah Spiegel
Summary: Recent research has revealed the cellular and molecular functions of bioactive lipids as signaling molecules in regulating inflammation and lipid metabolism, which can help identify mechanisms targeted to prevent or treat cardiometabolic conditions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Edward A. Dennis
Summary: Lipids play important roles in chronic diseases, but defining the substrate specificity of lipid metabolism enzymes is challenging. This research focuses on how membranes interact with enzymes to regulate cell signaling and metabolic pathways. By using substrate lipidomics and molecular dynamics simulations, the study reveals the link between enzyme specificity and hydrophobic binding subsites for membrane phospholipid substrates.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Daiki Hayashi, Varnavas D. Mouchlis, Seika Okamoto, Tomoka Namba, Liuqing Wang, Sheng Li, Shuji Ueda, Minoru Yamanoue, Hirofumi Tachibana, Hiroyuki Arai, Hitoshi Ashida, Edward A. Dennis, Yasuhito Shirai
Summary: Alpha-tocopherol (alpha Toc), the active form of vitamin E, has both antioxidant and non-antioxidant effects. It has been discovered that the membrane-bound 67 kDa laminin receptor (67LR) serves as a receptor for alpha Toc, mediating the non-antioxidant effects such as DGK alpha activation. This study provides the first evidence of a membrane receptor for alpha Toc and one of the underlying mechanisms of its non-antioxidant function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Edward A. Dennis
Summary: The translation describes the author's laboratory research on lipids, focusing on phospholipases and lipidomics, and the evolution of the lipid field. The author also discusses the parallel side stories and activities that influenced their laboratory research and contributed to the development of the LIPID MAPS initiative.
Review
Chemistry, Multidisciplinary
Varnavas D. Mouchlis, Edward A. Dennis
Summary: Water-soluble proteins and membrane-bound proteins interact with membrane surfaces and bind specific lipid molecules. Phospholipases are important enzymes in biological membranes that catalyze hydrolysis reactions by interacting with membranes and extracting phospholipid substrates. The association of phospholipases with membranes induces conformational changes and stabilizes the enzymes in an active state.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Matthew J. Conroy, Robert M. Andrews, Simon Andrews, Lauren Cockayne, Edward A. Dennis, Eoin Fahy, Caroline Gaud, William J. Griffiths, Geoff Jukes, Maksim Kolchin, Karla Mendivelso, Andrea F. Lopez-Clavijo, Caroline Ready, Shankar Subramaniam, Valerie B. O'Donnell
Summary: LIPID MAPS is a systematic and standardized approach for organizing lipid structural and biochemical data, and it has become the accepted community standard. It provides databases, software tools, and educational resources. The recent expansion of LIPID MAPS includes richer metadata, improved interoperability, and programmatic access. In addition, LIPID MAPS collaborates with WikiPathways to curate pathway data and annotate lipids.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Pathology
Christina M. Mckenzie, Matt Marinkovich, Anibal G. Armien, Judy St. Leger, Aaron M. Armando, Edward A. Dennis, Oswald Quehenberger, Alison Righton
Summary: This study presents the pedigree analysis, clinical manifestations, gross, microscopic, ultrastructural, and lipidomic findings of four female superb bird-of-paradise (SBOP) siblings, revealing a primary inherited glycerolipid storage disease. These birds, offspring of closely related parents, displayed characteristic lesions including tissue distortion due to the accumulation of lipid vacuoles in various organs. Lipidomic profiling confirmed the presence of triacylglycerols in the cytoplasmic lipid deposits. Further investigations, such as genome sequencing and genotyping, are necessary to determine the underlying genetic mechanism of this disease.
VETERINARY PATHOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Varnavas D. Mouchlis, Edward A. Dennis
Summary: Water-soluble proteins and membrane-bound proteins bind specific lipid molecules on membrane surfaces. Phospholipases, especially PLA2, play an important role in hydrolyzing phospholipids. The interaction between PLA2 and membranes can induce conformational changes in PLA2 and activate it for catalysis. These studies provide insights into membrane-protein interactions and related biological functions.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
E. A. Dennis