期刊
JOURNAL OF LIPID RESEARCH
卷 56, 期 8, 页码 1511-1518出版社
ELSEVIER
DOI: 10.1194/jlr.M058933
关键词
brain glucose hypometabolism; long-chain n-3 polyunsaturated fatty acids; positron emission tomography imaging
资金
- Groupe Lipides et Nutrition (part of the Association Francaise pour l'Etude des Corps Gras)
- Centre National de la Recherche Scientifique/Museum National d'Histoire Naturelle
- Institut National de la Recherche Agronomique
Decreased brain content of DHA, the most abundant long-chain n-3 polyunsaturated fatty acid (n-3 LCPUFA) in the brain, is accompanied by severe neurosensorial impairments linked to impaired neurotransmission and impaired brain glucose utilization. In the present study, we hypothesized that increasing n-3 LCPUFA intake at an early age may help to prevent or correct the glucose hypometabolism observed during aging and age-related cognitive decline. The effects of 12 months' supplementation with n-3 LCPUFA on brain glucose utilization assessed by positron emission tomography was tested in young adult mouse lemurs (Microcebus murinus). Cognitive function was tested in parallel in the same animals. Lemurs supplemented with n-3 LCPUFA had higher brain glucose uptake and cerebral metabolic rate of glucose compared with controls in all brain regions. The n-3 LCPUFA-supplemented animals also had higher exploratory activity in an open-field task and lower evidence of anxiety in the Barnes maze.jlr Our results demonstrate for the first time in a nonhuman primate that n-3 LCPUFA supplementation increases brain glucose uptake and metabolism and concomitantly reduces anxiety.
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