期刊
CLINICAL CANCER RESEARCH
卷 21, 期 3, 页码 622-631出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-14-0365
关键词
-
类别
资金
- Cancer Research UK [A12790]
- Pancreatic Cancer UK
- US NIH [P01 CA084203]
- NIH Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre
- NIHR Liverpool Pancreas Biomedical Research Unit
- Medical Research Council
- Cancer Research UK
- Department of Health
- Eve Appeal
- Special Trustees of Bart's and the London
- Special Trustees of UCLH
- MRC [G9901012, G0801228] Funding Source: UKRI
- Medical Research Council [G9901012, G0801228] Funding Source: researchfish
- Pancreatic Cancer UK [2011 Grant - Pereira, RG2014_01_Pereria, 2011 Grant - Costello/Timms] Funding Source: researchfish
Purpose: Biomarkers for the early detection of pancreatic cancer are urgently needed. The primary objective of this study was to evaluate whether increased levels of serum CA19-9, CA125, CEACAM1, and REG3A are present before clinical presentation of pancreatic cancer and to assess the performance of combined markers for early detection and prognosis. Experimental Design: This nested case-control study within the UKCTOCS included 118 single and 143 serial serum samples from 154 postmenopausal women who were subsequently diagnosed with pancreatic cancer and 304 matched noncancer controls. Samples were split randomly into independent training and test sets. CA19-9, CA125, CEACAM1, and REG3A were measured using ELISA and/or CLIA. Performance of markers to detect cancers at different times before diagnosis and for prognosis was evaluated. Results: At 95% specificity, CA19-9 (> 37 U/mL) had a sensitivity of 68% up to 1 year, and 53% up to 2 years before diagnosis. Combining CA19-9 and CA125 improved sensitivity as CA125 was elevated (> 30 U/mL) in approximately 20% of CA19-9-negative cases. CEACAM1 and REG3A were late markers adding little in combined models. Average lead times of 20 to 23 months were estimated for test-positive cases. Prediagnostic levels of CA19-9 and CA125 were associated with poor overall survival (HR, 2.69 and 3.15, respectively). Conclusions: CA19-9 and CA125 have encouraging sensitivity for detecting preclinical pancreatic cancer, and both markers can be used as prognostic tools. This work challenges the prevailing view that CA19-9 is upregulated late in the course of pancreatic cancer development. (C) 2014 AACR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据