Article
Biochemical Research Methods
Zhongping Su, Haiying Xu, Hui Zhang, Siran Jin, Ziqing Yang, Rui Yan, Zhiqiang Wang, Xiaodan Wu, Yingxue Jin
Summary: In this study, CuPPaCC conjugate was synthesized for ROS-mediated cancer therapy. CuPPaCC continuously produced cytotoxic ROS and oxygen through a photo-chemocyclo reaction, alleviated hypoxia, and inhibited HIF-1α expression. The results showed that CuPPaCC has excellent antitumor activity.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tae Heon Lee, Hye Jeong Kim, Bo-Ra Lee, Sang Bong Lee, Da-Sol Lee, Ye Ri Han, Kil Soo Kim, Young Kyu Song, Young Key Shim, Su-Jin Park, Dong-Won Kim, Yong Hyun Jeon
Summary: The unique ability of chlorophyll derivatives to accumulate in tumor tissues and cause a photodynamic effect under laser radiation has been successfully used in photodynamic therapy. Previous research on modified peripheral substituents in chlorophyll has shown that the presence and position of substituents in chlorin derivatives significantly affect biological activities. The synthesized MPPa derivatives with heterocyclic aromatic substituents or pyrazole moieties on the peripheral positions demonstrated photodynamic therapy effects in both in vitro and in vivo studies.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Lulu Zhou, Jinjin Chen, Yunhao Sun, Keke Chai, Zhounan Zhu, Chunhui Wang, Mengyao Chen, Wenmei Han, Xiaochun Hu, Ruihao Li, Tianming Yao, Hui Li, Chunyan Dong, Shuo Shi
Summary: The self-amplified nanocatalytic system (ZIF67/Ola/Lapa) effectively delivers the PARP inhibitor and NQO1-bioactivatable drug, offering a new paradigm for tumor-specific self-amplified chemodynamic therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Lei Hou, Yunchang Zhang, Ying Huang, Zhen Fang, Guangze Sang, Tianheng Chen, Zhiqiang Ma, Feng Yang
Summary: The synthesis of dual-mode antitumor molecules combining photodynamic therapy and chemotherapy has shown promising results in inhibiting tumor growth and metastasis. Compound 4, with favorable phototoxicity and dark toxicity, demonstrated the best inhibitory effect on tumor growth and migration, making it a potential photosensitizer and HDACi.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Fei Huang, Guiyan Han, Xingjie Zhang, Yu Li, Zhenyuan Miao, Jianzhong Yao
Summary: In this study, a novel chlorin-based photosensitizer was designed and synthesized for tumor photodynamic therapy. The photosensitizer showed high phototoxicity, high dark toxicity/phototoxicity ratio, and excellent PDT antitumor efficacy in vitro and in vivo.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Engineering, Biomedical
Zhongmin Geng, Fangjie Chen, Xinyue Wang, Lu Wang, Yan Pang, Jinyao Liu
Summary: Researchers have successfully used core-shell metal ion-drug nanoparticles to enhance the antitumor responses of immune checkpoint blockade therapy by combining chemotherapy and photodynamic therapy, showcasing improved drug delivery and stability, as well as strong anticancer effects in tumor-bearing mice.
Article
Chemistry, Medicinal
Ravindra R. Cheruku, Steven G. Turowski, Farukh A. Durrani, Walter A. Tabaczynski, Joseph Cacaccio, Joseph R. Missert, Leslie Curtin, Sandra Sexton, Ronald Alberico, Craig M. Hendler, Joseph A. Spernyak, Zachary Grossman, Ravindra K. Pandey
Summary: In this study, a tumor-avid chlorophyll a derivative, HPPH, currently undergoing clinical trials, was conjugated with Gd(III)tetraxetan (DOTA) moieties to create a conjugate with potential for both tumor imaging and photodynamic therapy (PDT). The conjugate showed tumor specificity and low organ toxicity in mice, indicating its potential as a cancer imaging and treatment agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Zeting Yuan, Chaolian Liu, Yuji Sun, Yue Li, Honglei Wu, Shuli Ma, Jing Shang, Yueping Zhan, Peihao Yin, Feng Gao
Summary: This study designed iRGD-modified nanoparticles to co-deliver mTHPC and BU, aiming to enhance the efficacy of photodynamic therapy (PDT) in colorectal cancer (CRC). The nanoparticles passively accumulated in tumor cells, with mTHPC inducing apoptosis and death under laser irradiation, while the sustained release of BU inhibited hypoxia and angiogenesis by targeting the SRC-3/HIF-1α pathway.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Fujun Yang, Qingyu Ji, Rui Liao, Shumeng Li, Yuequan Wang, Xuanbo Zhang, Shenwu Zhang, Haotian Zhang, Qiming Kan, Jin Sun, Zhonggui He, Bingjun Sun, Cong Luo
Summary: This study presents a facile dual-drug nanoassembly that enhances the efficacy of photodynamic therapy by inhibiting the proteasome. The engineered nanoassembly demonstrates multiple advantages, including simple fabrication, high drug co-loading efficiency, flexible dose adjustment, and favorable stability and enrichment.
CHINESE CHEMICAL LETTERS
(2022)
Article
Medicine, Research & Experimental
Shenwu Zhang, Ziyue Wang, Zhiqiang Kong, Yuequan Wang, Xuanbo Zhang, Bingjun Sun, Haotian Zhang, Qiming Kan, Zhonggui He, Cong Luo, Jin Sun
Summary: Carrier-free prodrug-nanoassemblies composed of homodimeric prodrugs driven by a photosensitizer have been developed for self-enhancing activation and chemo-photodynamic synergistic therapy. The nanoassemblies demonstrated potent antitumor activity in a 4T1 breast cancer BALB/c mice xenograft model through alleviating the aggregation-caused quenching effect and synergistically promoting prodrug activation using endogenous and externally induced reactive oxygen species.
Review
Chemistry, Multidisciplinary
Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng, Sheng Wang
Summary: Phototherapies have made significant progress in cancer treatment, but face challenges. Gas therapy, which improves the level of specific gas at the tumor site, shows potential to overcome these challenges. Nanomedicine-based gas-assisted phototherapy has emerged as a promising strategy to enhance treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Xiaolu Guo, Naidi Yang, Wenhui Ji, Hang Zhang, Xiao Dong, Zhiqiang Zhou, Lin Li, Han-Ming Shen, Shao Q. Yao, Wei Huang
Summary: Traditional cancer therapies such as surgery, chemotherapy, and radiotherapy have limited effectiveness, while photodynamic therapy, photothermal therapy, and chemodynamic therapy have shown promising results in cancer treatment due to their high selectivity, minimal resistance, and minimal toxicity.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xiangjie Luo, Xiaoqin Chi, Yaying Lin, Zhaoxuan Yang, Hongyu Lin, Jinhao Gao
Summary: The photosensitizer-conjugated camptothecin-based prodrug effectively targets cancer cell mitochondria, triggers ROS-responsive release of CPT, and induces mitochondrial damage, achieving high therapeutic efficacy for solid tumors.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Shasha He, Jing Liu, Chi Zhang, Jun Wang, Kanyi Pu
Summary: This study introduces a novel semiconducting polymer nano-regulator (SPNT) that can produce singlet oxygen under near-infrared photoirradiation, inducing immunogenic apoptosis. By regulating immune-related factors, SPNT-mediated combination photodynamic immunotherapy successfully suppressed tumor growth and lung metastasis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Otorhinolaryngology
Gal Shafirstein, Nestor R. Rigual, Hassan Arshad, Michele T. Cooper, David A. Bellnier, Gregory Wilding, Wei Tan, Mihai Merzianu, Barbara W. Henderson
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2016)
Article
Dermatology
Emily Oakley, Brian Wrazen, David A. Bellnier, Yusef Syed, Hassan Arshad, Gal Shafirstein
LASERS IN SURGERY AND MEDICINE
(2015)
Article
Dermatology
Emily Oakley, David A. Bellnier, Alan Hutson, Brian Wrazen, Hassan Arshad, Harry Quon, Gal Shafirstein
LASERS IN SURGERY AND MEDICINE
(2017)
Article
Respiratory System
Kassem Harris, Emily Oakley, David Bellnier, Gal Shafirstein
JOURNAL OF THORACIC DISEASE
(2017)
Review
Oncology
Gal Shafirstein, David Bellnier, Emily Oakley, Sasheen Hamilton, Mary Potasek, Karl Beeson, Evgueni Parilov
Article
Oncology
Shaila Mudambi, Paula Pera, Deschana Washington, Eva Remenyik, Eszter Fidrus, Gal Shafirstein, David Bellnier, Gyorgy Paragh
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2018)
Article
Oncology
Madeeha Shams, Barbara Owczarczak, Patricia Manderscheid-Kern, David A. Bellnier, Sandra O. Gollnick
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2015)
Article
Dermatology
Nathalie C. Zeitouni, Ulas Sunar, Daniel J. Rohrbach, Anne D. Paquette, David A. Bellnier, Yi Shi, Gregory Wilding, Thomas H. Foster, Barbara W. Henderson
DERMATOLOGIC SURGERY
(2014)
Article
Oncology
Lyudmila G. Burdelya, Anatoli S. Gleiberman, Ilia Toshkov, Semra Aygun-Sunar, Meghana Bapardekar, Patricia Manderscheid-Kern, David Bellnier, Vadim I. Krivokrysenko, Elena Feinstein, Andrei V. Gudkov
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2012)
Article
Chemistry, Medicinal
Xiang Zheng, Janet Morgan, Suresh K. Pandey, Yihui Chen, Erin Tracy, Heinz Baumann, Joseph R. Missert, Carrie Batt, Jennifer Jackson, David A. Bellnier, Barbara W. Henderson, Ravindra K. Pandey
JOURNAL OF MEDICINAL CHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Allison Marrero, Theresa Becker, Ulas Sunar, Janet Morgan, David Bellnier
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2011)
Article
Oncology
Gal Shafirstein, David A. Bellnier, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Lawrence Tworek, Alan Hutson, Joseph A. Spernyak, Sandra Sexton, Leslie Curtin, Steven G. Turowski, Hassan Arshad, Barbara Henderson
BRITISH JOURNAL OF CANCER
(2018)
Article
Chemistry, Medicinal
Sarah Chamberlain, Houston D. Cole, John Roque, David Bellnier, Sherri A. McFarland, Gal Shafirstein
Article
Dentistry, Oral Surgery & Medicine
Mirabelle Sajisevi, Nestor R. Rigual, David A. Bellnier, Mukund Seshadri
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2015)