Review
Oncology
Alexandra M. Zaborowski, Des C. Winter, Lydia Lynch
Summary: Colorectal cancer is the second leading cause of cancer-related death worldwide. Immunooncology has shown promising results in clinical practice and understanding the tumor-immune microenvironment has enabled the development of individualized treatment. By combining chemotherapy and immunotherapies, there is potential for unprecedented disease control, survivorship, and cure rates.
BRITISH JOURNAL OF CANCER
(2021)
Editorial Material
Cell Biology
Gayathri Anandappa, Michael J. Overman
Summary: In a recent study, Amodio and colleagues discovered a method to modulate immunosurveillance in colorectal tumors by manipulating DNA mismatch repair heterogeneity. They found that enriching the MMR deficient component using 6-thioguanine can improve tumor control in murine models.
CELL REPORTS MEDICINE
(2023)
Review
Oncology
Zhaohui Jin, Frank A. Sinicrope
Summary: dMMR/MSI-H in non-metastatic CRC has important prognostic and predictive value, guiding patient management and treatment decisions in clinical practice.
Review
Oncology
Nuria Mulet-Margalef, Jenniffer Linares, Jordi Badia-Ramentol, Mireya Jimeno, Carolina Sanz Monte, Jose Luis Manzano Mozo, Alexandre Calon
Summary: About 5-15% of colorectal cancers have deficiencies in mismatch repair machinery and high microsatellite instability (dMMR/MSI-H), rendering the tumor immune microenvironment more susceptible to immunotherapy. While immunomodulating drugs have improved treatment for dMMR/MSI-H CRC patients, there is a significant portion that shows resistance due to unknown molecular traits. This review discusses the current understanding of dMMR/MSI-H CRC and its therapeutic implications, as well as efforts to identify resistance mechanisms and predictive biomarkers.
Article
Biochemical Research Methods
Xiaokang Wang, Jinfeng Liu, Danwen Wang, Maohui Feng, Xiongzhi Wu
Summary: This study identified four molecular subtypes of colorectal cancer patients based on epigenetically regulated gene expression profiles, each with distinct clinical and molecular features. These subtypes provide valuable information for further research on treatment and prognosis in CRC.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Multidisciplinary Sciences
Yan Sun, Hongping Li, Zhiming Ma, Jianfei Wang, Huiyu Yang, Xiaopeng Zhang, Bingrong Liu
Summary: This study identified three immune subtypes (high, moderate, and low) in colorectal cancer samples and investigated their associations with patient prognosis. Differential gene expression and immunomodulators were also analyzed between the subtypes.
Review
Oncology
Camille Evrard, Jerome Alexandre
Summary: Endometrial cancers are highly affected by microsatellite instability, showing sensitivity to immunotherapy and requiring molecular biology for better understanding. The phenotype is poorly understood in ovarian cancer but does exist. Examination of literature reveals the importance of deficient mismatch repair/microsatellite instability in gynecological cancers and the potential therapeutic and prognostic implications.
Article
Oncology
Meeri Kastinen, Paeivi Sirnio, Hanna Elomaa, Maarit Ahtiainen, Sara A. Vayrynen, Karl-Heinz Herzig, Sanna Merilainen, Raila Aro, Reetta Haivala, Tero Rautio, Juha Saarnio, Erkki-Ville Wirta, Olli Helminen, Toni T. Seppala, Teijo Kuopio, Jan Bohm, Anne Tuomisto, Jukka-Pekka Mecklin, Markus J. Makinen, Juha P. Vayrynen
Summary: This study analyzed data from 1413 patients with colorectal cancer and found associations between tumor necrosis percentage and tumor characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis. The results showed that high tumor necrosis percentage is associated with shorter colorectal cancer-specific survival, independent of other factors. Tumor necrosis is therefore considered an important prognostic factor in colorectal cancer.
BRITISH JOURNAL OF CANCER
(2023)
Review
Biotechnology & Applied Microbiology
Xiao-Jing Luo, Qi Zhao, Jia Liu, Jia-Bo Zheng, Miao-Zhen Qiu, Huai-Qiang Ju, Rui-Hua Xu
Summary: The therapeutic strategies for stage II/III colorectal cancer patients post-surgery are still debated, with the need for better biomarkers to stratify patients for adjuvant chemotherapy. Recent advances in sequencing and high-throughput technologies have led to the discovery of novel genetic and epigenetic biomarkers that could aid in prognosis and treatment responses in CRC.
Article
Multidisciplinary Sciences
Xin Hu, Liuxing Wu, Yanxin Yao, Junfu Ma, Xiangchun Li, Hongru Shen, Luyang Liu, Hongji Dai, Wei Wang, Xinlei Chu, Chao Sheng, Meng Yang, Hong Zheng, Fengju Song, Kexin Chen, Ben Liu
Summary: This study comprehensively reveals the regulatory effect of eRNA on tumor immune cell infiltration and outcome in gastric cancer. It proposes eRNA as a potential prognostic index and biomarker in the response of immunotherapy. The different subtypes with distinct eRNA expression patterns show significant differences in survival rate, immune cell infiltration, and immunotherapy response.
Article
Oncology
Kuo-Hsing Chen, Chia-Lang Hsu, Yu-Li Su, Chang-Tsu Yuan, Liang-In Lin, Jia-Huei Tsai, Yi-Hsin Liang, Ann-Lii Cheng, Kun-Huei Yeh
Summary: This study found that the immune contexture in the tumor microenvironment is closely associated with prognosis in patients with metastatic BRAF V600E mutant colorectal cancer. High expression of immune genes and complement activation are correlated with poor prognosis, and the complement score is strongly correlated with tumor-associated macrophage M2 signatures.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Shaorui Rui, Dong Wang, Yong Huang, Jingyun Xu, Hailang Zhou, Hesong Zhang
Summary: New biomarkers related to microsatellite instability were identified through gene differential expression analysis and single-cell sequencing. The SLC4A4 gene was found to be positively correlated with microsatellite instability and has a tumor suppressor role in colorectal cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Lu-Ping Yang, Teng-Jia Jiang, Ming-Ming He, Yi-Hong Ling, Zi-Xian Wang, Hao-Xiang Wu, Zhen Zhang, Rui-Hua Xu, Feng Wang, Shu-Qiang Yuan, Qi Zhao
Summary: In this study, whole-exome sequencing was performed on 103 primary tumor samples from patients with sporadic synchronous colorectal cancer (SCRC). The study revealed unique molecular features and mutation frequencies in SCRC, and neutrally evolving SCRC tumors were associated with higher heterogeneity and better prognosis.
CELL REPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vitaly Shubin, Yury Shelygin, Sergey Achkasov, Oleg Sushkov, Ilya Nazarov, Alexey Ponomarenko, Iuliia Alimova, Anna Loginova, Aleksey Tsukanov
Summary: The aim of this study was to determine the characteristics of Russian patients with microsatellite instability (MSI) tumors. The results showed that patients with MSI tumors differed in the age of diagnosis, tumor localization, time of cancer recurrence, and stage of the disease. Patients whose tumors had MSI status had higher overall and disease-free survival rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sofia Edin, Bjorn Gylling, Xingru Li, Asa Stenberg, Anna Lofgren-Burstrom, Carl Zingmark, Bethany van Guelpen, Ingrid Ljuslinder, Agnes Ling, Richard Palmqvist
Summary: This study investigates the tumor immune cell infiltration in relation to well-established molecular markers of colorectal cancer (CRC). The results show an association between higher immune cell infiltration and microsatellite instability, and opposite relationships of BRAF and KRAS mutations with tumor infiltration of cytotoxic T cells. The positive prognostic importance of cytotoxic T cells is found in wild-type as well as KRAS and BRAF-mutated CRCs in both cohorts.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Harry H. Yoon, David Tougeron, Qian Shi, Steven R. Alberts, Michelle R. Mahoney, Garth D. Nelson, Suresh G. Nair, Stephen N. Thibodeau, Richard M. Goldberg, Daniel J. Sargent, Frank A. Sinicrope
CLINICAL CANCER RESEARCH
(2014)
Article
Oncology
Dan Sha, Adam M. Lee, Qian Shi, Steven R. Alberts, Daniel J. Sargent, Frank A. Sinicrope, Robert B. Diasio
CLINICAL CANCER RESEARCH
(2014)
Article
Oncology
Winson Y. Cheung, Qian Shi, Michael O'Connell, James Cassidy, Charles D. Blanke, David J. Kerr, Jeff Meyers, Eric Van Cutsem, Steven R. Alberts, Greg Yothers, Daniel J. Sargent
CLINICAL COLORECTAL CANCER
(2013)
Article
Oncology
Jocelin Huang, Suresh G. Nair, Michelle R. Mahoney, Garth D. Nelson, Anthony F. Shields, Emily Chan, Richard M. Goldberg, Sharlene Gill, Morton S. Kahlenberg, James T. Quesenberry, Stephen N. Thibodeau, Thomas C. Smyrk, Axel Grothey, Frank A. Sinicrope, Thomas A. Webb, Gist H. Farr, Barbara A. Pockaj, Jeffrey L. Berenberg, Margaret Mooney, Daniel J. Sargent, Steven R. Alberts
CLINICAL COLORECTAL CANCER
(2014)
Article
Medicine, Research & Experimental
Daniel J. Sargent, Sumithra J. Mandrekar
Article
Medicine, Research & Experimental
Ming-Wen An, Sumithra J. Mandrekar, Martin J. Edelman, Daniel J. Sargent
CONTEMPORARY CLINICAL TRIALS
(2014)
Article
Oncology
Yan Liu, Saskia Litiere, Elisabeth G. E. de Vries, Daniel Sargent, Lalitha Shankar, Jan Bogaerts, Lesley Seymour
EUROPEAN JOURNAL OF CANCER
(2014)
Article
Oncology
Saskia Litiere, Elisabeth G. E. de Vries, Lesley Seymour, Dan Sargent, Lalitha Shankar, Jan Bogaerts
EUROPEAN JOURNAL OF CANCER
(2014)
Article
Pharmacology & Pharmacy
Sin-Ho Jung, Daniel J. Sargent
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2014)
Article
Oncology
Sumithra J. Mandrekar, Ming-Wen An, Jeffrey Meyers, Axel Grothey, Jan Bogaerts, Daniel J. Sargent
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Article
Oncology
Dan Rosmarin, Claire Palles, David Church, Enric Domingo, Angela Jones, Elaine Johnstone, Haitao Wang, Sharon Love, Patrick Julier, Claire Scudder, George Nicholson, Anna Gonzalez-Neira, Miguel Martin, Daniel Sargent, Erin Green, Howard McLeod, Ulrich M. Zanger, Matthias Schwab, Michael Braun, Matthew Seymour, Lindsay Thompson, Benjamin Lacas, Valerie Boige, Nuria Ribelles, Shoaib Afzal, Henrik Enghusen, Soren Astrup Jensen, Marie-Christine Etienne-Grimaldi, Gerard Milano, Mia Wadelius, Bengt Glimelius, Hans Garmo, Milena Gusella, Thierry Lecomte, Pierre Laurent-Puig, Eva Martinez-Balibrea, Rohini Sharma, Jesus Garcia-Foncillas, Zdenek Kleibl, Alain Morel, Jean-Pierre Pignon, Rachel Midgley, David Kerr, Ian Tomlinson
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Article
Health Care Sciences & Services
Jeff A. Sloan, Daniel J. Sargent, Paul J. Novotny, Paul A. Decker, Randolph S. Marks, Heidi Nelson
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2014)
Article
Multidisciplinary Sciences
Hanna K. Sanoff, Lindsay A. Renfro, Pradeep Poonnen, Pratibha Ambadwar, Daniel J. Sargent, Richard M. Goldberg, Howard McLeod
Article
Mathematical & Computational Biology
A. S. C. Conlon, J. M. G. Taylor, D. J. Sargent
STATISTICS IN MEDICINE
(2014)
Article
Computer Science, Interdisciplinary Applications
L. A. Renfro, Q. Shi, Y. Xue, J. Li, H. Shang, D. J. Sargent
COMPUTATIONAL STATISTICS & DATA ANALYSIS
(2014)