Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alina Kanikowska, Szymon Hryhorowicz, Anna Maria Rychter, Marcin A. Kucharski, Agnieszka Zawada, Katarzyna Iwanik, Piotr Eder, Ryszard Slomski, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Eosinophilic oesophagitis is a chronic allergic disease characterized by T-lymphocyte response inducing esophageal eosinophilic infiltration. Inflammation and tissue fibrosis lead to main symptoms like food impaction and dysphagia. The etiopathogenesis involves genetic and environmental factors, with non-IgE-mediated food allergies being a common trigger.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sujin Kim, Yunkwon Nam, Hyeon Soo Kim, Haram Jung, Seong Gak Jeon, Sang Bum Hong, Minho Moon
Summary: Alzheimer's disease is a neurodegenerative disease with cognitive and behavioral symptoms. Understanding and treating the alterations in neural circuits associated with these symptoms is crucial for AD treatment.
Review
Pathology
Shahrooz Amin Mozaffari, Ali Salehi, Elnaz Mousavi, Burhan Abdullah Zaman, Ali Eslambol Nassaj, Farnoosh Ebrahimzadeh, Hadi Nasiri, Zahra Valedkarimi, Ali Adili, Ghazaleh Asemani, Morteza Akbari
Summary: This article reviews the evidence that gut microbiota plays an important role in health and is linked to colorectal cancer development, and proposes SARS-CoV-2 as a potential contributor to CRC pathogenesis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Nutrition & Dietetics
Michelle A. Chernikova, Genesis D. Flores, Emily Kilroy, Jennifer S. Labus, Emeran A. Mayer, Lisa Aziz-Zadeh
Summary: There is a need for further research on the mechanisms underlying the relationship between gut microbiota, brain function, social behavior, and ASD development, particularly in individuals with gastrointestinal issues. By exploring the potential role of microbiota-targeted therapies in ASD, there is a possibility of informing new treatments aimed at modulating the gut microbiome system and alleviating behavioral and physiological symptoms in individuals with ASD.
Review
Oncology
Yi Li, Bing Wei, Xia Xue, Hongle Li, Jun Li
Summary: Changes in the esophageal microbiome are associated with the development and treatment outcomes of esophageal cancer, highlighting the importance of understanding its role in early detection and optimized treatment strategies.
CANCER BIOLOGY & MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tanay Kaymak, Petr Hruz, Jan Hendrik Niess
Summary: The esophagus is an understudied anatomical immune segment that may contribute to inflammatory esophageal diseases due to its unique anatomical and physiological characteristics.
Review
Microbiology
Cheng Ye, Chunlu Dong, Yanyan Lin, Huaqing Shi, Wence Zhou
Summary: This article critically reviews the evidence regarding the association between the human microbiome and biliary tract cancer. It explores potential mechanisms through which dysregulation of the microbiome could contribute to the development of biliary tract cancer, and discusses its role in chemotherapy and immunotherapy for this malignancy.
Article
Gastroenterology & Hepatology
Swathi Eluri, S. Ryanne Corder, Erin Kim, Manaswita Tappata, Craig C. Reed, Nicholas J. Shaheen, Evan S. Dellon
Summary: Approximately 10% of patients with active eosinophilic esophagitis have a normal-appearing esophagus on endoscopy, but this does not negate the need for biopsies; younger age, abdominal pain, and lack of dysphagia are independent predictors of a normal esophagus. Over time, the proportion of normal esophagus cases has decreased, indicating improved recognition of endoscopic findings.
Review
Oncology
Cuiwei Liu, Srivarshini C. Mohan, Jielin Wei, Ekihiro Seki, Manran Liu, Reva Basho, Armando E. Giuliano, Yanxia Zhao, Xiaojiang Cui
Summary: Breast cancer is the most common malignant disease in female patients worldwide and can spread to various parts of the body, including the liver. Understanding the biological basis of breast cancer liver metastasis is crucial for developing effective treatment and prevention strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Khyati Girdhar, Qian Huang, I. -Ting Chow, Tommi Vatanen, Claudia Brady, Amol Raisingani, Patrick Autissier, Mark A. Atkinson, William W. Kwok, C. Ronald Kahn, Emrah Altindis
Summary: This article investigates the potential role of Parabacteroides distasonis in the pathogenesis of type 1 diabetes (T1D). The study found that a peptide sequence from P. distasonis can activate T cells from T1D patients and nonobese diabetic mice. Colonization of the mouse colon with P. distasonis accelerates the development of T1D and elicits an immune response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Daniel Korn, Andrew J. Thieme, Vinicius M. Alves, Michael Yeakey, Joyce V. V. B. Borba, Stephen J. Capuzzi, Karamarie Fecho, Chris Bizon, Stephen W. Edwards, Rada Chirkova, Christine M. Colvis, Noel T. Southall, Christopher P. Austin, Eugene N. Muratov, Alexander Tropsha
Summary: COPs are a series of key molecular and cellular events underlying therapeutic effects of drug molecules, and their broader use with the help of biomedical knowledge graph mining is likely to accelerate drug discovery and repurposing efforts.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemistry & Molecular Biology
Betina Biagetti, Rafael Simo
Summary: Prolactinoma, with the highest incidence rate among functional pituitary tumors, presents a heterogeneous group with potential aggressive behavior. Clinical, radiological and pathology features play a role in prognosis, making it essential to study molecular pathways for better understanding and personalized therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Mariusz Sikora, Albert Stec, Magdalena Chrabaszcz, Joanna Giebultowicz, Emilia Samborowska, Radoslaw Jazwiec, Michal Dadlez, Malgorzata Olszewska, Lidia Rudnicka
Summary: The study showed an association between altered gut barrier in psoriasis patients and gastrointestinal symptoms, systemic inflammatory profile, and increased blood concentration of gut microbiota-derived metabolite TMAO. Modulation of intestinal barrier represents a potential therapeutic approach.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Gwendolyn Osborne, Fen Wu, Liying Yang, Dervla Kelly, Jiyuan Hu, Huilin Li, Farzana Jasmine, Muhammad G. Kibriya, Faruque Parvez, Ishrat Shaheen, Golam Sarwar, Alauddin Ahmed, Mahbub Eunus, Tariqul Islam, Zhiheng Pei, Habibul Ahsan, Yu Chen
Letter
Immunology
Jennifer Lighter, Michael Phillips, Sarah Hochman, Stephanie Sterling, Diane Johnson, Fritz Francois, Anna Stachel
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Medicine, General & Internal
Christopher M. Petrilli, Simon A. Jones, Jie Yang, Harish Rajagopalan, Luke O'Donnell, Yelena Chernyak, Katie A. Tobin, Robert J. Cerfolio, Fritz Francois, Leora I. Horwitz
BMJ-BRITISH MEDICAL JOURNAL
(2020)
Letter
Microbiology
Yaohua Yang, Wei Zheng, Qiuyin Cai, Martha J. Shrubsole, Zhiheng Pei, Robert Brucker, Mark Steinwandel, Seth R. Bordenstein, Zhigang Li, William J. Blot, Xiao-Ou Shu, Jirong Long
Letter
Medicine, General & Internal
Saul Blecker, Simon A. Jones, Christopher M. Petrilli, Andrew J. Admon, Himali Weerahandi, Fritz Francois, Leora I. Horwitz
JAMA INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Gbenga Ogedegbe, Joseph Ravenell, Samrachana Adhikari, Mark Butler, Tiffany Cook, Fritz Francois, Eduardo Iturrate, Girardin Jean-Louis, Simon A. Jones, Deborah Onakomaiya, Christopher M. Petrilli, Claudia Pulgarin, Seann Regan, Harmony Reynolds, Azizi Seixas, Frank Michael Volpicelli, Leora Idit Horwitz
Article
Multidisciplinary Sciences
Ian Ganly, Zhiheng Pei, Yuhan Hao, Yingfei Ma, Matthew Rosenthal, Zhenglin Wu, Jocelyn Migliacci, Bin Huang, Nora Katabi, Wenzhi Tseng, Stuart Brown, Yi-Wei Tang, Liying Yang
Summary: The study aimed to compare HPV genome in patients with OC-SCC to normal patients using metagenomic shotgun sequencing. In 50 OC-SCC cases, tongue was the most common subsite, with only 10% of cases testing positive for HPV, suggesting a rare presence of HPV genotypes in patients with oral cancer.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Anna Stachel, Kwesi Daniel, Dan Ding, Fritz Francois, Michael Phillips, Jennifer Lighter
Summary: A model was developed to predict COVID-19 patients at risk for mortality using machine learning and visualizations, aiding clinicians in understanding the disease model and mortality predictors.
BMJ HEALTH & CARE INFORMATICS
(2021)
Article
Gastroenterology & Hepatology
Elissa Lin, Xiaoyan Huang, Zhiheng Pei, Jonathan Gross, Violeta Popov
Summary: This case report discusses the effects of intragastric balloon therapy on NASH and demonstrates that improvement in histologic features persists at least 6 months after the therapy. Although data supporting the use of intragastric balloon therapy in treating NASH are limited, this case provides evidence of its potential benefits in improving metabolic parameters and markers of liver fibrosis.
ACG CASE REPORTS JOURNAL
(2021)
Article
Health Care Sciences & Services
Narges Razavian, Vincent J. Major, Mukund Sudarshan, Jesse Burk-Rafel, Peter Stella, Hardev Randhawa, Seda Bilaloglu, Ji Chen, Vuthy Nguy, Walter Wang, Hao Zhang, Ilan Reinstein, David Kudlowitz, Cameron Zenger, Meng Cao, Ruina Zhang, Siddhant Dogra, Keerthi B. Harish, Brian Bosworth, Fritz Francois, Leora I. Horwitz, Rajesh Ranganath, Jonathan Austrian, Yindalon Aphinyanaphongs
NPJ DIGITAL MEDICINE
(2020)
Article
Substance Abuse
Rachel Nolan-Kenney, Fen Wu, Jiyuan Hu, Liying Yang, Dervla Kelly, Huilin Li, Farzana Jasmine, Muhammad G. Kibriya, Faruque Parvez, Ishrat Shaheen, Golam Sarwar, Alauddin Ahmed, Mahbub Eunus, Tariqul Islam, Zhiheng Pei, Habibul Ahsan, Yu Chen
NICOTINE & TOBACCO RESEARCH
(2020)
Article
Medicine, General & Internal
Leora Horwitz, Simon A. Jones, Robert J. Cerfolio, Fritz Francois, Joseph Greco, Bret Rudy, Christopher M. Petrilli
Summary: A study in a three-hospital academic health system in New York showed a decrease in hospital mortality rates among COVID-19 patients, with adjusted mortality dropping from 25.6% in March to 7.6% in August. The standardized mortality ratio also decreased from 1.26 in March to 0.38 in August, indicating an improving trend in patient outcomes. These findings suggest that mortality from COVID-19 may be decreasing even after adjusting for patient characteristics.
JOURNAL OF HOSPITAL MEDICINE
(2021)