Article
Medicine, Research & Experimental
Rostislav A. Petrov, Sofiia R. Mefedova, Emil Yu Yamansarov, Svetlana Yu Maklakova, Dmitrii A. Grishin, Elena Lopatukhina, Olga Y. Burenina, Anton Lopukhov, Sergey Kovalev, Yury Timchenko, Evgenia E. Ondar, Yan A. Ivanenkov, Sergei A. Evteev, Alexander N. Vaneev, Roman Timoshenko, Natalia L. Klyachko, Alexander S. Erofeev, Petr Gorelkin, Elena K. Beloglazkina, Alexander G. Majouga
Summary: The study developed covalent and low molecular weight docetaxel delivery systems conjugated with N-acetyl-D-galactosamine, showing excellent affinity to ASGPR and high cytotoxicity against hepatocellular carcinoma cells. The glycoconjugates also exhibited significantly increased water solubility and prodrug lability, as well as selective toxicity against hepatoma cells compared to control cell lines. Additionally, specific ASGPR-mediated cellular uptake of the conjugates and enhanced generation of reactive oxygen species in HepG2 cells were observed, highlighting the potential of ASGPR-directed taxane drugs for selective therapy of hepatocellular carcinoma.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Robert Peery, Qingbin Cui, Kwaku Kyei-Baffour, Sophia Josephraj, Caoqinglong Huang, Zizheng Dong, Mingji Dai, Jian-Ting Zhang, Jing-Yuan Liu
Summary: Survivin, an important protein upregulated in various cancers, is challenging to target for therapy. Inhibition of survivin dimerization has been found to promote its degradation and show potential for cancer treatment. LQZ-7F, a small-molecule inhibitor, exhibits strong biological activity and synergism in combination with docetaxel.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Prachi Bhave, Tasnia Ahmed, Serigne N. Lo, Alexander Shoushtari, Anne Zaremba, Judith M. Versluis, Joanna Mangana, Michael Weichenthal, Lu Si, Thierry Lesimple, Caroline Robert, Claudia Trojanello, Alexandre Wicky, Richard Heywood, Lena Tran, Kathleen Batty, Florentia Dimitriou, Anna Stansfeld, Clara Allayous, Julia K. Schwarze, Meghan J. Mooradian, Oliver Klein, Inderjit Mehmi, Rachel Roberts-Thomson, Andrea Maurichi, Hui-Ling Yeoh, Adnan Khattak, Lisa Zimmer, Christian U. Blank, Egle Ramelyte, Katharina C. Kaehler, Severine Roy, Paolo A. Ascierto, Olivier Michielin, Paul C. Lorigan, Douglas B. Johnson, Ruth Plummer, Celeste Lebbe, Bart Neyns, Ryan Sullivan, Omid Hamid, Mario Santinami, Grant A. McArthur, Andrew M. Haydon, Georgina Long, Alexander M. Menzies, Matteo S. Carlino
Summary: Acral melanoma is a rare subtype with poor prognosis, and there is a lack of prospective clinical trial evidence on the efficacy of checkpoint inhibitors in this population. The study found that initial anti-PD-1/ipilimumab combination had a significantly higher ORR compared to anti-PD-1 alone, but this benefit did not translate to improved OS in this retrospective cohort. Primary site did not impact treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Yurika Nakagawa-Saito, Yuta Mitobe, Shuhei Suzuki, Keita Togashi, Asuka Sugai, Chifumi Kitanaka, Masashi Okada
Summary: The deregulation of the FOXM1 transcription factor is a key change in ovarian cancer, and it contributes to the development and progression of the disease. A study investigated the effects of domatinostat, a HDAC inhibitor, on the expression of FOXM1 and the viability of ovarian cancer cells. Domatinostat was found to reduce the expression of FOXM1 and survivin, as well as the cell viability alone or in combination with other chemotherapeutic agents. These findings suggest that domatinostat may be a promising option for the treatment of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Valentin-Florian Rauca, Laura Patras, Lavinia Luput, Emilia Licarete, Vlad-Alexandru Toma, Alina Porfire, Augustin Catalin Mot, Elena Rakosy-Tican, Alina Sesarman, Manuela Banciu
Summary: The novel combination tumor-targeted treatment shows significant inhibitory effects on melanoma growth by enhancing anti-angiogenic effects and inducing apoptosis of tumor cells, with the potential to remodel the tumor microenvironment.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yongsheng Liu, Tianqi Xu, Anzhelika Vorobyeva, Annika Loftenius, Vitalina Bodenko, Anna Orlova, Fredrik Y. Frejd, Vladimir Tolmachev
Summary: Affibody molecules are artificial proteins that can target cancer-related molecular abnormalities. Clinical studies have shown that they can be used for radionuclide diagnostics and therapy. This study demonstrated that re-engineered Affibody molecules can increase the survival of mice with human tumors, and the combination of Affibody molecules and a monoclonal antibody was the most effective treatment.
Article
Chemistry, Medicinal
Jun-Jie Deng, Lu Liu, Yang Ge, Zhendong Song, Jie Huang, Guangjin Fan, Xiao-Feng Xiong
Summary: In this study, a series of imidazo[1,2-alpha]pyrazine derivatives were designed and synthesized as G alpha q/11 inhibitors. GQ352 showed selective anti-proliferative activity against UM cells. GQ352 inhibited UM tumorigenesis by suppressing downstream ERK phosphorylation and YAP dephosphorylation in the G alpha q/11 signaling pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Nicholas J. J. Vogelzang, James J. J. Rusthoven, James Symanowski, Claude Denham, E. Kaukel, Pierre Ruffie, Ulrich Gatzemeier, Michael Boyer, Salih Emri, Christian Manegold, Clet Niyikiza, Paolo Paoletti
Summary: The purpose of this study was to evaluate the efficacy of pemetrexed plus cisplatin in the treatment of patients with malignant pleural mesothelioma. The results showed that compared to cisplatin alone, the combination of pemetrexed and cisplatin can prolong the overall survival time, progression-free survival time, and improve the response rates in patients with malignant pleural mesothelioma. Addition of folic acid and vitamin B-12 can significantly reduce the toxicity of the treatment.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Veterinary Sciences
Gabriela F. Toledo, Marcia K. Nagamine, Victor Nowosh, Felippe T. Machado, Cristina O. Massoco, Nadja C. Souza-Pinto, Maria L. Z. Dagli
Summary: In this study, the effects of sodium dichloroacetate (DCA) and omeprazole (OMP) alone or in combination on canine oral mucosal melanoma (OMM) and human melanoma cells were evaluated. The combination of DCA and OMP significantly decreased cell viability and exhibited a dose-dependent relationship in both cell lines, showing a synergistic effect. This study may present a new repurposing strategy for cancer treatment.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Oncology
Dan Liu, Furong Kou, Jifang Gong, Zhiqiang Wang, Xiaotian Zhang, Jian Li, Yan Li, Jie Li, Jun Zhou, Ming Lu, Xicheng Wang, Zhihao Lu, Yanshuo Cao, Jianjun Zou, Xiaoyu Zhu, Ruihua Xu, Lin Shen
Summary: This study aimed to evaluate the use of pyrotinib in the treatment of pretreated HER2-positive gastric cancer patients, and the results showed acceptable toxicities for both pyrotinib alone and in combination with docetaxel.
Article
Oncology
Ping Yin, Xiaolin Ma, Yanfei Zhang, Yang Song, Yuntao Wang, Zhong Lu
Summary: Primary vaginal melanoma is rare and has a poor prognosis. Combined immunotherapy, radiotherapy, and anti-angiogenic therapy may be beneficial for patients with distant metastatic vaginal melanoma.
Article
Cell Biology
Markus Burkard, Heike Niessner, Christian Leischner, Alban Piotrowsky, Olga Renner, Luigi Marongiu, Ulrich M. Lauer, Christian Busch, Tobias Sinnberg, Sascha Venturelli
Summary: When administered parenterally at high doses, ascorbate acts as a prooxidant, generating hydrogen peroxide and inducing reactive oxygen species in cancer cells. In this study, high-dose ascorbate was evaluated for the treatment of B16F10 melanoma. The results showed that ascorbate, both as a monotherapy and in combination with PD1 inhibition, demonstrated efficacy in treating B16F10 melanoma.
Article
Biochemistry & Molecular Biology
Josune Alonso-Maranon, Alberto Villanueva, Josep Maria Piulats, Maria Martinez-Iniesta, Laura Sole, Juan Martin-Liberal, Sonia Segura, Ramon M. Pujol, Mar Iglesias, Anna Bigas, Fernando Gallardo, Lluis Espinosa
Summary: Chemotherapy has limited efficacy in treating invasive malignant melanoma (MM), but combination treatments involving DNA-damaging agents and BRAF inhibitors can increase tumor cell death and impede MM regrowth after treatment cessation. Pharmacologic inhibition of BRAF impairs ATM and DDR activation in MM cells, leading to sustained DNA damage.
Article
Engineering, Biomedical
Sepehr Salem Ghahfarrokhi, Hamed Khodadadi, Hamid Ghadiri, Fariba Fattahi
Summary: This paper proposes a computer-aided diagnosis system based on machine learning algorithms to classify various types of skin cancer. The system extracts the region of interest (ROI) of skin lesions using a new binary level set equation and regularization operation, and represents multiple aspects of skin lesions through various combinations of textures and nonlinear features. Multiple optimization algorithms are used to remove redundant or irrelevant features, and various machine learning algorithms are employed for classification. The results demonstrate the high performance of the proposed method in terms of accuracy, specificity, and sensitivity, and the efficiency compared to other similar works.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Immunology
Zike Yang, Huita Wu, Qing Lin, Xin Wang, Shijun Kang
Summary: In this study, PD-1 knockout T cells mediated by CRISPR/Cas9 system were found to undergo multiple rounds of homeostatic proliferation in lymphopenic mice. The number of IFN-gamma-releasing CTL was significantly increased and tumor growth was remarkably inhibited in lymphopenic mice receiving infusion of PD-1 knockout T cells. PD-L1 gene knockout on B16 melanoma cells could effectively enhance the antitumor immunity mediated by the homeostatic proliferation of T cells.
IMMUNOLOGY LETTERS
(2022)