Article
Hematology
Serena Matis, Anna Grazia Recchia, Monica Colombo, Martina Cardillo, Marina Fabbi, Katia Todoerti, Sabrina Bossio, Sonia Fabris, Valeria Cancila, Rosanna Massara, Daniele Reverberi, Laura Emionite, Michele Cilli, Giannamaria Cerruti, Sandra Salvi, Paola Bet, Simona Pigozzi, Roberto Fiocca, Adalberto Ibatici, Emanuele Angelucci, Massimo Gentile, Paola Monti, Paola Menichini, Gilberto Fronza, Federica Torricelli, Alessia Ciarrocchi, Antonino Neri, Franco Fais, Claudio Tripodo, Fortunato Morabito, Manlio Ferrarini, Giovanna Cutrona
Summary: A specific miRNA (miR-146b-5p) in chronic lymphocytic leukemia (CLL) regulates the expression of IL-12R(31 and the expansion of leukemic cells, thus playing a role in the pathogenesis and treatment of CLL.
Article
Oncology
Katarzyna Skorka, Michal Chojnacki, Marta Masternak, Agnieszka Karczrnarczyk, Edyta Subocz, Ewa Wawrzyniak, Krzysztof Giannopoulos
Summary: NOTCH1(mut) serves as a new prognostic marker in chronic lymphocytic leukaemia (CLL). This study compared droplet digital PCR (ddPCR) and amplification-refractory mutation system PCR (ARMS-PCR) for NOTCH1(mut) assessment in untreated CLL patients. The findings suggest that using ddPCR for detecting NOTCH1(mut) may significantly enhance prognostic stratification in CLL patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sylwia Chocholska, Michal Zarobkiewicz, Agata Szymanska, Natalia Lehman, Justyna Wos, Agnieszka Bojarska-Junak
Summary: The aim of this study was to investigate the expression of miR-17 similar to 92 cluster members in CLL patients. The study provides new evidence regarding the heterogeneity of miR-17 similar to 92 cluster members' expression in CLL patients. High miR-20a expression can be considered an independent favorable prognostic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
T. N. Obukhova, M. Kislova, E. A. Nikitin, M. A. Kislitsyna, B. Biderman, M. K. Tagirova, A. B. Sudarikov, V. V. Ptushkin, V. G. Savchenko
Summary: 13q14 deletion is the most common chromosomal abnormality in CLL and determines the most favorable prognosis, however, the loss of tumor suppressor RB1 may negatively affect the overall survival in CLL patients undergoing immunochemotherapy.
GEMATOLOGIYA I TRANSFUZIOLOGIYA
(2022)
Article
Oncology
Farnaz Baghaei Vaji, Arash Boroumand Nasr, Ali Rezvani, Hossein Ayatollahi, Sajad Goudarzi, Soroush Lavasani, Ramin Bagheri
Summary: This meta-analysis investigated the prognostic effect of ATM mutations in chronic lymphocytic leukemia patients. The results showed a significant association between ATM mutations and adverse prognosis, although further randomized controlled prospective studies with a larger number of patients with different types of ATM mutations are needed to confirm these findings.
Article
Oncology
Justyna Wos, Sylwia Chocholska, Wioleta Kowalska, Waldemar Tomczak, Agata Szymanska, Agnieszka Karczmarczyk, Agnieszka Szuster-Ciesielska, Agnieszka Wojciechowska, Agnieszka Bojarska-Junak
Summary: TEMs, characterized by the phenotype of CD14+CD16+Tie2+, have been identified as a new immunosuppressive force in tumors and are associated with unfavorable prognosis in CLL patients. Despite not being an independent predictor of survival, TEM can serve as an important complement to other prognostic indicators in CLL patients.
Article
Biochemistry & Molecular Biology
Kristan V. Piroeva, Charlotte Mcdonald, Charalampos Xanthopoulos, Chelsea Fox, Christopher T. Clarkson, Jan-Philipp Mallm, Yevhen Vainshtein, Luminita Ruje, Lara C. Klett, Stephan Stilgenbauer, Daniel Mertens, Efterpi Kostareli, Karsten Rippe, Vladimir B. Teif
Summary: This study compared the nucleosome positions in chronic lymphocytic leukemia (CLL) patients and healthy individuals, and found significant changes in nucleosome positioning in CLL. The spacing between nucleosomes was shortened, and changes in nucleosome occupancy were linked to chromatin remodeling and reduced DNA methylation. Nucleosome positioning can be used to classify CLL subtypes and monitor disease progression.
Article
Immunology
Bihui Pan, Yue Li, Zhangdi Xu, Yi Miao, Hua Yin, Yilin Kong, Xinyu Zhang, Jinhua Liang, Yi Xia, Li Wang, Jianyong Li, Jiazhu Wu, Wei Xu
Summary: A novel prognostic model related to ferroptosis was established for CLL, which can be used for prognostic prediction. The model may also facilitate the development of new clinical ferroptosis-targeted therapies in patients with CLL.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhangdi Xu, Bihui Pan, Yi Miao, Yue Li, Shuchao Qin, Jinhua Liang, Yilin Kong, Xinyu Zhang, Jing Tang, Yi Xia, Huayuan Zhu, Li Wang, Jianyong Li, Jiazhu Wu, Wei Xu
Summary: This study aimed to investigate the prognostic role of XPO1 and the therapeutic effect of Selinexor in chronic lymphocytic leukemia (CLL). The results showed that XPO1 was highly expressed in CLL patients and was associated with poor prognosis. Selinexor, an inhibitor of XPO1, induced apoptosis in CLL cells and had inhibitory effects on cell proliferation and cell cycle progression. Downregulation of NF-kappa B and FOXO pathways was observed in CLL cells treated with Selinexor.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Barbara Eichhorst, Carsten U. Niemann, Arnon P. Kater, Moritz Fuerstenau, Julia von Tresckow, Can Zhang, Sandra Robrecht, Michael Gregor, Gunnar Juliusson, Patrick Thornton, Philipp B. Staber, Tamar Tadmor, Vesa Lindstrom, Caspar da Cunha-Bang, Christof Schneider, Christian B. Poulsen, Thomas Illmer, Bjoern Schoettker, Thomas Noesslinger, Ann Janssens, Ilse Christiansen, Michael Baumann, Henrik Frederiksen, Marjolein van der Klift, Ulrich Jaeger, Maria B. L. Leys, Mels Hoogendoorn, Kourosh Lotfi, Holger Hebart, Tobias Gaska, Harry Koene, Lisbeth Enggaard, Jereon Goede, Josien C. Regelink, Anouk Widmer, Florian Simon, Nisha De Silva, Anna-Maria Fink, Jasmin Bahlo, Kirsten Fischer, Clemens-Martin Wendtner, Karl A. Kreuzer, Matthias Ritgen, Monika Brueggemann, Eugen Tausch, Mark-David Levin, Marinus van Oers, Christian Geisler, Stephan Stilgenbauer, Michael Hallek
Summary: In fit patients with CLL, venetoclax-obinutuzumab, with or without ibrutinib, showed superior results compared to chemoimmunotherapy as a first-line treatment, with higher rates of undetectable minimal residual disease and progression-free survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Hematology
Freda K. Stevenson, Francesco Forconi, Thomas J. Kipps
Summary: Research into chronic lymphocytic leukemia has led to significant improvements in the assessment and treatment of patients, with designer drugs now successfully targeting tumor cells based on their biology. Classifying CLL into unmutated (U) and mutated (M) diseases based on the mutational status of IGHV sequences reveals distinct origins, biology, and clinical behaviors for each. Despite advances, challenges such as cell-escape strategies and immunosuppression remain, necessitating continued research into CLL biology.
Article
Hematology
Fabienne Meier-Abt, Junyan Lu, Ester Cannizzaro, Marcel F. Pohly, Sandra Kummer, Sibylle Pfammatter, Laura Kunz, Ben C. Collins, Ferran Nadeu, Kwang Seok Lee, Peng Xue, Myriam Gwerder, Michael Roiss, Jennifer Huellein, Sebastian Scheinost, Sascha Dietrich, Elias Campo, Wolfgang Huber, Ruedi Aebersold, Thorsten Zenz
Summary: This study uncovered mutations affecting protein expression in CLL and identified signaling pathways associated with trisomy 12. STAT2 protein expression was linked to specific drug responses, providing a protein expression reference map for CLL.
Review
Oncology
Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer
Summary: Telomeres play a crucial role in chronic lymphocytic leukemia (CLL), with their dysfunction shaping the disease progression. Members of the shelterin complex and TERT activation are closely associated with CLL cell survival and proliferation.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Yu Nie, Xiaoya Yun, Ya Zhang, Xin Wang
Summary: Metabolic reprogramming plays a vital role in the initiation and progression of chronic lymphocytic leukemia (CLL). This review summarizes the critical metabolic processes in CLL and discusses the regulation of metabolism by cells in the microenvironment and oncogenes/tumor suppressor regulators. Targeting metabolic enzymes or signal pathways may impede the progression of CLL.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Rachel A. Harris, Jadd M. Stevens, Diane L. Pickering, Pamela A. Althof, Lynette M. Smith, Jennifer N. Sanmann, Bhavana J. Dave
Summary: This study examined the frequency and characteristics of 14q32 deletions in chronic lymphocytic leukemia (CLL) cases, finding an association between 14q32 deletions and CLL prognosis. The importance of comprehensive testing in understanding the implications of 14q32 deletions in CLL was underscored in this investigation.
Article
Oncology
Brian Parkin, Peter Ouillette, Mehmet Yildiz, Kamlai Saiya-Cork, Kerby Shedden, Sami N. Malek
CLINICAL CANCER RESEARCH
(2015)
Article
Gastroenterology & Hepatology
Michael L. Volk, Nathan Goodrich, Jennifer C. Lai, Christopher Sonnenday, Kerby Shedden
LIVER TRANSPLANTATION
(2015)
Article
Hematology
Mehmet Yildiz, Hongxiu Li, Denzil Bernard, Nisar A. Amin, Peter Ouillette, Sian Jones, Kamlai Saiya-Cork, Brian Parkin, Kathryn Jacobi, Kerby Shedden, Shaomeng Wang, Alfred E. Chang, Mark S. Kaminski, Sami N. Malek
Article
Chemistry, Multidisciplinary
Jungkap Park, Gus R. Rosania, Kerby A. Shedden, Mandee Nguyen, Naesung Lyu, Kazuhiro Saitou
CHEMISTRY CENTRAL JOURNAL
(2009)
Article
Biochemical Research Methods
Kerby Shedden, Qian Li, Fangyi Liu, Young Tae Chang, Gus R. Rosania
Article
Biochemical Research Methods
Kerby Shedden, Gus R. Rosania
Article
Computer Science, Information Systems
David A. Hanauer, Mohammed Saeed, Kai Zheng, Qiaozhu Mei, Kerby Shedden, Alan R. Aronson, Naren Ramakrishnan
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Letter
Oncology
K. Shedden, Y. Li, P. Ouillette, S. N. Malek
Article
Medicine, Research & Experimental
Nan Zheng, Hobart Ng Tsai, Xinyuan Zhang, Kerby Shedden, Gus R. Rosania
MOLECULAR PHARMACEUTICS
(2011)
Article
Multidisciplinary Sciences
Newaj M. Abdullah, Gus R. Rosania, Kerby Shedden
Article
Chemistry, Multidisciplinary
Gus R. Rosania, Kerby Shedden, Nan Zheng, Xinyuan Zhang
JOURNAL OF CHEMINFORMATICS
(2013)
Article
Multidisciplinary Sciences
Kyu Han Lee, Aubree Gordon, Kerby Shedden, Guillermina Kuan, Sophia Ng, Angel Balmaseda, Betsy Foxman
Article
Biology
Shih-Hao Huang, Kerby Shedden, Hsin-wen Chang
Summary: In data analysis using dimension reduction methods, we propose an easily-applied approach to infer the dimension of the reduced subspace, which performs well when combined with popular dimension reduction methods.
Article
Orthopedics
Ying Li, Nahbee Jong, Michelle S. Caird, Allison Tenfelde, Philip Nowicki, Kerby Shedden, Virginia S. Nelson, Frances A. Farley
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2015)