Article
Plant Sciences
Yu Fan Zhang, Zhi Hong Zhang, Ming Yue Li, Jing Ying Wang, Yue Xing, MyongHak Ri, Cheng Hua Jin, Guang Hua Xu, Lian Xun Piao, Hong Xiang Zuo, Hong Lan Jin, Juan Ma, Xuejun Jin
Summary: Britannin inhibits the expression of PD-L1 in tumor cells, which leads to the inhibition of tumor cell proliferation and angiogenesis, as well as enhancement of T cell activity, demonstrating its anticancer effects.
Article
Plant Sciences
Lei Peng, Juhua Dan, Wenhui Huang, Lei Sang, Hao Tian, Zhiming Li, Wanyi Li, Jing Liu, Ying Luo
Summary: This study reveals that CCM and MPRC2-8 have complementary activities, including antitumor activity and TERT-activating activity, which could potentially improve tumor-free longevity.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Fisheries
Li Li, Shan Nan Chen, Nan Li, P. Nie
Summary: This study identified and characterized Nmi in mandarin fish, showing its involvement in antiviral and interferon-induced immune responses. Nmi interacts with NIDs and CC domains to perform its functions, playing a crucial role in interferon-stimulated response.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Ruonan Wu, Yanru Chen, Jing Zhou, Yebang Tan
Summary: A series of double-hydrophilic diblock copolymers of N-acryloylmorpholine (NAMO) and N-isopropylacrylamide (NIPAm) with varying degree of polymerization were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization. These copolymers exhibited temperature sensitivity and solvent responsiveness, and showed potential as viscosity reducers and emulsifiers in heavy oil/water systems.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Yiran Jiao, Haobo Li, Yan Jiao, Shi-Zhang Qiao
Summary: By using density functional theory (DFT) calculations, the activity and selectivity landscape on 54 MXene surfaces were constructed, and it was found that the activity of the C-N coupling step is mainly determined by the *CO adsorption strength, while the selectivity relies more on the co-adsorption strength of *N and *CO. Based on these findings, an ideal C-N coupling MXene catalyst should have moderate *CO adsorption and stable *N adsorption. Through the machine learning-based approach, data-driven formulas for describing the relationship between adsorption strengths and atomic physical chemistry features were identified, and 162 MXene materials were screened without time-consuming DFT calculations. Several potential catalysts, such as Ta2W2C3, were predicted with good C-N coupling performance and verified by DFT calculations. The study incorporated machine learning methods for the first time to provide an efficient high-throughput screening method for selective C-N coupling electrocatalysts, which could be extended to a wider range of electrocatalytic reactions for green chemical production.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Mahmoud Sayed, Feiyan Xu, Panyong Kuang, Jingxiang Low, Shengyao Wang, Liuyang Zhang, Jiaguo Yu
Summary: The photoreduction of CO2 into energy-rich products is a sustainable solution for global energy and environmental crisis with the use of Mn ions as ionized cocatalyst to promote the process. The design of core-triple shell Mn, C-codoped ZnO hollow spheres as efficient photocatalysts demonstrates promising CO2 conversion performance, highlighting the importance of ionized cocatalyst in sustainable energy production.
NATURE COMMUNICATIONS
(2021)
Article
Materials Science, Biomaterials
Alexandra Sousa, Vegard Boroy, Agnethe Baeverud, Kjersti Julin, Annette Bayer, Morten Strom, Mona Johannessen, Natasa Skalko-Basnet, Sybil Obuobi
Summary: Nucleic acid-based materials have great potential for antimicrobial drug delivery. This study focuses on the stability and antibacterial properties of micellar nanocarriers derived from amphiphilic DNA strands against bacterial biofilms. By using a cationic amphiphilic antibiotic, the stability of the micelles is enhanced, their antibacterial activity remains intact, and they can penetrate bacterial biofilms and impact their metabolic activity. The PMB micelles are also highly safe and biocompatible, making them suitable for application against P. aeruginosa biofilm-colonized skin wounds.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Medicinal
Hengju Ge, Di Zhang, Muran Shi, Xiaoyuan Lian, Zhizhen Zhang
Summary: Streptoglutarimide H (SGH) was identified as a new glutarimide from marine-derived actinomycete with in vitro antiglioma activity. SGH was found to significantly inhibit lung cancer cell proliferation by downregulating cell cycle-related proteins, glycolytic enzymes, and important cancer transcription factors. The potent anticancer activity and multiple mechanisms suggest SGH as a novel antitumor compound against lung cancer cells.
Article
Chemistry, Physical
Vishal Jose, Jean Marie Vianney Nsanzimana, Huimin Hu, Jinho Choi, Xin Wang, Jong-Min Lee
Summary: Compositional and structural engineering of metal-metalloid materials can enhance their electrocatalytic performance, with heterointerfaces between N-doped carbon and cobalt boride nanosheets yielding efficient and stable systems for the oxygen reduction reaction. The best-performing electrocatalyst exhibits significant advantages compared to commercial Pt/C, making it suitable for assembling zinc-air batteries.
ADVANCED ENERGY MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Fei Wang, Jian Mao
Summary: The study indicates that N-doped graphene does not exhibit NRR performance, but graphene with graphitic-N and pyridine-N can catalyze HER, and pyrrole-N in graphene will be converted into NH3, making N-doped graphene unsuitable as NRR electrocatalysts.
DIAMOND AND RELATED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Anastasia Balakina, Svyatoslav Gadomsky, Tatyana Kokovina, Tatyana Sashenkova, Denis Mishchenko, Alexei Terentiev
Summary: Using a novel method, new N-hydroxybutanamide derivatives were synthesized and evaluated for their ability to inhibit matrix metalloproteinases (MMPs) and their cytotoxicity. One derivative showed significant inhibition of MMPs and low toxicity towards cancer cells. In a mouse model, it demonstrated antitumor and antimetastatic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anita Bulakowska, Jaroslaw Slawinski, Rafal Halasa, Anna Hering, Magdalena Gucwa, J. Renata Ochocka, Justyna Stefanowicz-Hajduk
Summary: In this study, ten new N-(4-chloro-2-mercapto-5-methylphenylsulfonyl)cinnamamide derivatives were synthesized. These compounds showed antimicrobial activity against Staphylococcus and Enterococcus species, inhibited biofilm formation, and exhibited cytotoxic activity on cancer cells. The results suggest that these synthesized derivatives have potential as antimicrobial therapeutic agents.
Article
Chemistry, Organic
Julie A. Wilson, Zi Jie Lin, Isabelle Rodriguez, Thong Ta, Luke Martz, Dominic Fico, Shanina S. Johnson, John D. Gorden, Kerri L. Shelton, Lauren B. King
Summary: A series of N,N'-bis-substituted triazolium salts were synthesized and tested for their antimicrobial activities against a panel of representative ESKAPE pathogens. Compounds 7 and 12 exhibited significant antimicrobial activities against all pathogens, including a vancomycin-resistant strain of Enterococcus faecium and a multidrug resistant strain of Acinetobacter baumannii. The structure activity relationship of N,N'-bis-substituted triazolium salts suggests a potential selectivity of gram-positive or gram-negative bacteria based on the heterocycle center, highlighting their potent antimicrobial properties against multiple ESKAPE bacterial pathogens.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yazhou Zhou, Ruihu Lu, Xiafang Tao, Zijie Qiu, Guangbo Chen, Juan Yang, Yan Zhao, Xinliang Feng, Klaus Muellen
Summary: By incorporating phosphorus atoms into the second coordination sphere, the OER activity of Fe-N-C is boosted, enabling its potential application in rechargeable Zn-air batteries.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Jing Lei, Xiaoqing Sun, Yan Jin, Chunli Xu, Baoxin Li
Summary: This study found that atomically dispersed zinc ions on nitrogen-doped carbon material exhibited high catalytic activity in the luminol-H2O2 chemiluminescence reaction. The zinc-nitrogen-carbon single-atom catalysts were easily prepared through simple pyrolyzation of inexpensive precursors. The mechanism of zinc SAC-catalyzed chemiluminescence reaction was investigated in detail. The monatomic dispersion of zinc ions changed their catalytic performance from no activity to high activity, demonstrating the uniqueness of monatomic metal catalysts over conventional metal ions.
ANALYTICAL CHEMISTRY
(2022)
Article
Hematology
Luis Veloza, Doriane Cavalieri, Edoardo Missiaglia, Albane Ledoux-Pilon, Bettina Bisig, Bruno Pereira, Christophe Bonnet, Elsa Poullot, Leticia Quintanilla-Martinez, Romain Dubois, Francisco Llamas-Gutierrez, Celine Bossard, Roland De Wind, Fanny Drieux, Juliette Fontaine, Marie Parrens, Jeremy Sandrini, Virginie Fataccioli, Marie-Helene Delfau-Larue, Adrien Daniel, Faustine Lhomme, Lauriane Clement-Filliatre, Francois Lemonnier, Anne Cairoli, Pierre Morel, Sylvie Glaisner, Bertrand Joly, Abderrazak El Yamani, Kamel Laribi, Emmanuel Bachy, Reiner Siebert, David Vallois, Philippe Gaulard, Olivier Tournilhac, Laurence de Leval
Summary: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell lymphoma, commonly seen in Asia. This study investigated 71 European MEITL patients and found that the majority of patients presented with gastrointestinal involvement and had emergency surgery. The tumors were morphologically classified into typical and atypical groups, with a homogeneous immunophenotypic profile. MYC expression and TP53 mutation were correlated with atypical morphology and poor outcome, while aberrant B-cell marker expression correlated with better survival. MEITL is an aggressive disease with high clinical risk.
Letter
Pathology
Benjamin Champion, Siaw Ming Chai, Mayank Bhandari, Dilini Gunawardena
Article
Automation & Control Systems
Ali Ahmadi Dastjerdi, Alessandro Astolfi, Niranjan Saikumar, Nima Karbasizadeh, Duarte Valerio, S. Hassan HosseinNia
Summary: This article presents a closed-loop frequency analysis tool for reset control systems. It provides sufficient conditions for the existence of steady-state response and shows that the steady-state response for periodic inputs is periodic with the same period as the input. The framework presented in this article allows for the computation of steady-state response and defines a notion of closed-loop frequency response, including high order harmonics.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2023)
Review
Nutrition & Dietetics
Laura Pedretti, Serena Massa, Davide Leardini, Edoardo Muratore, Sofia Rahman, Andrea Pession, Susanna Esposito, Riccardo Masetti
Summary: Children with cancer are at high risk for nutritional problems, but the importance of nutrition in their treatment is underestimated. This review explores the impact of nutrition on treatment outcomes and the need for a standardized approach to nutritional care in pediatric cancer patients.
Article
Biochemistry & Molecular Biology
Michele Fiore, Alberto Taddia, Valentina Indio, Salvatore Nicola Bertuccio, Daria Messelodi, Salvatore Serravalle, Jessica Bandini, Filippo Spreafico, Daniela Perotti, Paola Collini, Andrea Di Cataldo, Gianandrea Pasquinelli, Francesca Chiarini, Maura Fois, Fraia Melchionda, Andrea Pession, Annalisa Astolfi
Summary: Clear cell sarcoma of the kidney (CCSK) is a rare pediatric renal tumor with worse prognosis than Wilms' tumor. This study aims to investigate the molecular differences between metastatic and localized BCOR-ITD-positive CCSK at diagnosis. The findings suggest that metastatic CCSKs have an overexpression of genes related to the MAPK signaling pathway, and FGF3 may play a role in the acquisition of a more aggressive phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fanny Seraphine Krebs, Bianca Moura, Edoardo Missiaglia, Veronica Aedo-Lopez, Olivier Michielin, Petros Tsantoulis, Bettina Bisig, Mounir Trimech, Vincent Zoete, Krisztian Homicsko
Summary: The development of targeted therapies for non-BRAF p.Val600-mutant melanomas remains challenging as Triple wildtype (TWT) melanomas lacking BRAF, NRAS, or NF1 mutations are heterogeneous in their genomic drivers. MAP2K1 mutations are enriched in BRAF-mutant melanomas and function as resistance mechanisms to BRAF inhibition. This case study illustrates the difficulties in combining MEK1 and CDK4/6 inhibitors in the presence of resistance to MEK inhibitor monotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Carmen Ciavarella, Ilenia Motta, Francesco Vasuri, Teresa Palumbo, Anthony Paul Lisi, Alice Costa, Annalisa Astolfi, Sabrina Valente, Piera Versura, Eugenio F. Fornasiero, Raffaella Mauro, Mauro Gargiulo, Gianandrea Pasquinelli
Summary: The failure of arteriovenous fistulas due to intimal hyperplasia is a serious problem for patients undergoing hemodialysis. This study investigated the role of the PPAR-gamma in regulating intimal hyperplasia and found that the PPAR-gamma agonist pioglitazone had a negative effect on cell proliferation and migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sara Mongiorgi, Alessia De Stefano, Stefano Ratti, Valentina Indio, Annalisa Astolfi, Irene Casalin, Andrea Pellagatti, Stefania Paolini, Sarah Parisi, Michele Cavo, Andrea Pession, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Jacqueline Boultwood, Carlo Finelli, Lucio Cocco, Matilde Y. Follo
Summary: This study found that high levels of miR-192-5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide. Moreover, miR-192-5p specifically targets and inhibits BCL2, possibly regulating proliferation and apoptosis and leading to the identification of new therapeutic targets.
CLINICAL EPIGENETICS
(2023)
Review
Genetics & Heredity
Angela Schipani, Margherita Nannini, Annalisa Astolfi, Maria A. Pantaleo
Summary: Loss of function of succinate dehydrogenase complex is a characteristic of 20-40% of KIT/PDGFRA-negative GIST. Half of SDH-deficient GIST patients lack SDHx mutations and are caused by hypermethylation of SDHC promoter. The remaining 50% have mutations in SDH subunits, with SDHA mutations being the most common.
Review
Pediatrics
Egidio Candela, Michele Zagariello, Valeria Di Natale, Rita Ortolano, Francesca Righetti, Valentina Assirelli, Giacomo Biasucci, Alessandra Cassio, Andrea Pession, Federico Baronio
Article
Pharmacology & Pharmacy
Sofia Gasperini, Giulia Greco, Sabrina Angelini, Patrizia Hrelia, Carmela Fimognari, Monia Lenzi
Summary: Chestnut bark extract has antimutagenic and antioxidant effects, which can counteract mutagenicity in the early stages of cancer.
Review
Biochemistry & Molecular Biology
Alice Costa, Livia Gozzellino, Margherita Nannini, Annalisa Astolfi, Maria Abbondanza Pantaleo, Gianandrea Pasquinelli
Summary: Visceral sarcomas are a rare subtype of soft tissue sarcomas, and understanding their development mechanisms and developing personalized therapies are urgent clinical needs. However, the complex genomic profiles and lack of reliable preclinical models present challenges.
Article
Pediatrics
Laura Bruni, Alessandra Cassio, Valeria Di Natale, Federico Baronio, Rita Ortolano, Andrea Pession, Bianca Maria Piraccini, Iria Neri
Summary: An infant with citrullinemia started standard treatment at birth but developed severe skin lesions at 4 months of age. The patient had a deficiency of plasma amino acids and faced compliance issues due to linguistic barriers.
Article
Oncology
Sara Bobisse, Valentina Bianchi, Janos L. Tanyi, Apostolos Sarivalasis, Edoardo Missiaglia, Remy Petremand, Fabrizio Benedetti, Drew A. Torigian, Raphael Genolet, David Barras, Alexandra Michel, Spyridon A. Mastroyannis, Emese Zsiros, Denarda Dangaj Laniti, Zoi Tsourti, Brian J. Stevenson, Christian Iseli, Bruce L. Levine, Daniel E. Speiser, David Gfeller, Michal Bassani-Sternberg, Daniel J. Powell Jr, Carl H. June, Urania Dafni, Lana E. Kandalaft, Alexandre Harari, George Coukos
Summary: The study demonstrates that vaccination with tumor-pulsed dendritic cells enhances neoantigen recognition in ovarian cancer patients. Additionally, adoptive transfer of vaccine-primed, ex vivo-expanded autologous T cells further amplifies immune responses and leads to epitope spreading with novel neopeptide reactivities in patients who experience clinical benefit, suggesting reinvigoration of tumor-sculpting immunity.
Article
Biochemistry & Molecular Biology
Giulia Sita, Agnese Graziosi, Camilla Corrieri, Luca Ghelli, Sabrina Angelini, Pietro Cortelli, Patrizia Hrelia, Fabiana Morroni
Summary: Alzheimer's disease, the most common type of dementia, is closely associated with aging. The endoplasmic reticulum (ER) is compromised in Alzheimer's disease due to the accumulation of beta-amyloid and phosphorylated Tau protein, leading to the activation of the Unfolded Protein Response (UPR). This study investigates the role of UPR in a mouse model of Alzheimer's disease and identifies dysregulation of protein kinase RNA-like ER kinase (PERK), inositol-requiring protein 1 alpha (IRE1 alpha), and activating transcription factor 6 (ATF-6) pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)