Review
Chemistry, Medicinal
Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana
Summary: This review summarizes the biological activities and mechanisms of action of Andrographis paniculata and andrographolide in cardiovascular health, showing their protective effects against myocardial injury through various pathways. Further validation in human clinical trials is needed to confirm their therapeutic potential.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Rui Guan, Shun Xu, Zhimei Lu, Lirong Su, Libing Zhang, Wei Sun, Yu Zhang, Chunhong Jiang, Zhongqiu Liu, Lixin Duan, Aijia Ji
Summary: This study comprehensively analyzed the bZIP gene family in Andrographis paniculata, identifying 62 bZIPs and grouping them into 12 subfamilies. The analysis revealed that bZIPs in the same groups have similar composition, structure, and distribution. RNA-seq data provided a reference for selecting candidate bZIPs for further functional verification, and qRT-PCR analysis identified seven highly expressed ApbZIPs that may be involved in the regulation of andrographolide biosynthesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Plant Sciences
Maoyuan Jiang, Feiya Sheng, Zhen Zhang, Xiao Ma, Tianhui Gao, Chaomei Fu, Peng Li
Summary: Andrographis paniculata is widely used in subtropical regions for treating various ailments and has potential antiviral properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Debalina Das, Maumita Bandyopadhyay
Summary: Manipulation of pathway inhibitors and effective elicitors can enhance the production of andrographolide in in vitro callus cultures of Andrographis paniculata. The combination of silver nitrate and lovastatin plays a predominant role in andrographolide biosynthesis, with a positive correlation observed between chlorophyll content and andrographolide production.
Review
Plant Sciences
Zoya Malik, Rabea Parveen, Bushra Parveen, Sultan Zahiruddin, Mohammad Aasif Khan, Asifa Khan, Sheersh Massey, Sayeed Ahmad, Syed Akhtar Husain
Summary: This review emphasizes the medicinal importance of Andrographis paniculata and its phytoconstituent andrographolide, particularly focusing on its anticancer activity, mechanisms of action, biopharmaceutical properties, and development as an adjuvant therapy for cancer treatment. Various anticancer mechanisms of andrographolide have been identified, as well as efforts to improve its bioavailability through novel formulations.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Shao-Fen Jian, Xue-Jing Huang, Xiao-Nan Yang, Chu Zhong, Jian-Hua Miao
Summary: Increasing sulfur application rate enhances the accumulation of bioactive compounds in Andrographis paniculata, while affecting plant growth differently at different nitrogen levels. Metabolite analysis shows that high sulfur induces changes in TCA cycle and photorespiration, promoting nitrogen assimilation and sulfur metabolism, but inhibiting plant growth through increased carbohydrate consumption under low nitrogen conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Genetics & Heredity
Rongrong Zhang, Zhenzhen Chen, Libing Zhang, Wei Yao, Zhichao Xu, Baosheng Liao, Yaolei Mi, Han Gao, Chunhong Jiang, Lixin Duan, Aijia Ji
Summary: This study systematically identified WRKY transcription factors related to andrographolide biosynthesis and found that 7 WRKY genes may regulate the biosynthesis of andrographolide. This research lays a foundation for understanding the regulatory mechanism of andrographolide biosynthesis.
FRONTIERS IN GENETICS
(2021)
Article
Plant Sciences
Chu Zhong, Shao-Fen Jian, Dong-Liang Chen, Xue-Jing Huang, Jian-Hua Miao
Summary: The form of nitrogen affects the secondary metabolites of medicinal plants, with organic nitrogen sources enhancing andrographolide biosynthesis. Plants grown with organic nitrogen sources showed higher photosynthetic rates and increased starch accumulation, while ammonium decreased leaf SPAD value but increased photosynthetic rate and soluble sugar content.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Plant Sciences
Sya'ban Putra Adiguna, Jonathan Ardhianto Panggabean, Respati Tri Swasono, Siti Irma Rahmawati, Fauzia Izzati, Asep Bayu, Masteria Yunovilsa Putra, Carmen Formisano, Chianese Giuseppina
Summary: This study established the extraction and fractionation of Andrographis paniculata and quantified the andrographolide and its derivatives in each fraction. The 50% methanolic fraction exhibited the best cytotoxic, anti-inflammatory, and antihypertensive activities compared to other extracts. It also had the highest quantification of andrographolide and its derivatives.
Article
Plant Sciences
Jukrapun Komaikul, Sasiporn Ruangdachsuwan, Duangnapa Wanlayaporn, Somnuek Palabodeewat, Surat Punyahathaikul, Theeraporn Churod, Rattanathorn Choonong, Tharita Kitisripanya
Summary: This study evaluated the anti-HCoV-OC43 effect of andrographolide and A. paniculata extracts, and the correlation between andrographolide concentration and the anti-HCoV-OC43 activity. The results showed that both andrographolide and A. paniculata extracts exhibited antiviral activity against HCoV-OC43, but the antiviral activity of the extracts did not have a linear relationship with andrographolide concentration.
Review
Nutrition & Dietetics
Francesca Bosco, Stefano Ruga, Rita Citraro, Antonio Leo, Lorenza Guarnieri, Jessica Maiuolo, Francesca Oppedisano, Roberta Macri, Federica Scarano, Saverio Nucera, Irene Bava, Ernesto Palma, Carolina Muscoli, Juan Hancke, Giovambattista De Sarro, Vincenzo Mollace
Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are common worldwide. Aging process is the most significant risk factor, but genetic and environmental factors also play a role. Lifestyle and natural products containing antioxidant and anti-inflammatory properties can have preventive and therapeutic effects. Andrographis paniculata and its main constituent, andrographolide, have shown neuroprotective effects by modulating neurodegeneration and neuroinflammation.
Article
Biochemistry & Molecular Biology
Zenab Aldurrah, Farah Syazwani Mohd Kauli, Nurhidayah Abdul Rahim, Zurina Zainal, Adlin Afzan, Ragdhaa Hamdan Al Zarzour, Salizawati Muhamad Salhimi, Mohamad Shazeli Che Zain, Fauziahanim Zakaria
Summary: This study investigated the anti-depressive effect of A. paniculata extract and andrographolide in a zebrafish model of chronic unpredictable stress. The results showed that both A. paniculata and fluoxetine significantly reduced freezing duration, while fluoxetine also increased total distance travelled and contact duration. Andrographolide only decreased freezing duration and duration in a dark area. Further evaluation of the cellular and molecular mechanisms of andrographolide's anti-depressive effect is strongly recommended.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Agricultural Engineering
Poonam Kumari, Karuna Shanker, Akanksha Singh
Summary: This study investigated the bacterial endophytic diversity of Andrographis paniculata using culture-based and culture-independent high-throughput sequencing methods. The results revealed a high diversity of endophytic bacteria, with Bacillus being the most prevalent in the root and Pseudomonas dominating in the shoot tissues. Furthermore, isolated bacterial endophytes from different parts of the plant confirmed the dominance of Bacillus and Pseudomonas genera, and one specific strain, Micrococcus luteus (ASd6), significantly enhanced plant growth and andrographolide content.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Plant Sciences
Daonapa Chungloo, Rujira Tisarum, Thapanee Samphumphuang, Thanyaporn Sotesaritkul, Harminder Pal Singh, Teruhiro Takabe, Suriyan Cha-um
Summary: The study found that exogenous glycine betaine can help plants adapt to drought stress and promote the production of andrographolide compounds.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Pharmacology & Pharmacy
Wen-Wan Chao, Yueh-Hsiung Kuo, Bi-Fong Lin
Summary: The study demonstrated that bioactive compounds from Andrographis paniculata and its derivatives have potential in protecting EV71-infected cells, inhibiting cell apoptosis, and promoting immune responses, suggesting that they may be feasible for the development of anti-EV71 agents.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Jordan Carter, Kevin A. David, Athena Kritharis, Andrew M. Evens
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2020)
Article
Hematology
Pamela B. Allen, Hatice Savas, Andrew M. Evens, Ranjana H. Advani, Brett Palmer, Barbara Pro, Reem Karmali, Eric Mou, Jeffrey Bearden, Gary Dillehay, Robert A. Bayer, Robert M. Eisner, Joan S. Chmiel, Kaitlyn O'Shea, Leo I. Gordon, Jane N. Winter
Summary: Brief pembrolizumab monotherapy followed by AVD is highly effective and safe for patients with newly diagnosed classical Hodgkin lymphoma, including those with bulky disease.
Article
Oncology
Mansi R. Shah, Imraan Jan, Jeremy Johns, Kuldip Singh, Pallavi Kumar, Norma Belarmino, Kara J. Saggiomo, Carolyn Hayes, Kimyatta Washington, Deborah L. Toppmeyer, Bruce G. Haffty, Steven K. Libutti, Andrew M. Evens
Summary: Strict adherence to infection control protocols in outpatient and inpatient oncology units results in minimal environmental contamination with SARS-CoV-2.
Article
Oncology
Adam J. Olszewski, Lasse H. Jakobsen, Graham P. Collins, Kate Cwynarski, Veronika Bachanova, Kristie A. Blum, Kirsten M. Boughan, Mark Bower, Alessia Dalla Pria, Alexey Danilov, Kevin A. David, Catherine Diefenbach, Fredrik Ellin, Narendranath Epperla, Umar Farooq, Tatyana A. Feldman, Alina S. Gerrie, Deepa Jagadeesh, Manali Kamdar, Reem Karmali, Shireen Kassam, Vaishalee P. Kenkre, Nadia Khan, Seo-Hyun Kim, Andreas K. Klein, Izidore S. Lossos, Matthew A. Lunning, Peter Martin, Nicolas Martinez-Calle, Silvia Montoto, Seema Naik, Neil Palmisiano, David Peace, Elizabeth H. Phillips, Tycel J. Phillips, Craig A. Portell, Nishitha Reddy, Anna Santarsieri, Maryam Sarraf Yazdy, Knut B. Smeland, Scott E. Smith, Stephen D. Smith, Suchitra Sundaram, Adam S. Zayac, Xiao-Yin Zhang, Catherine Zhu, Chan Y. Cheah, Tarec C. El-Galaly, Andrew M. Evens
Summary: The BL-IPI provides robust discrimination of survival in adult BL, suitable for use as prognostication and stratification in trials. The high-risk group has suboptimal outcomes with standard therapy and should be considered for innovative treatment approaches.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Hematology
Adam J. Olszewski, Habibe Kurt, Andrew M. Evens
Summary: High-grade B-cell lymphoma, not otherwise specified (HGBL, NOS) is a recently introduced diagnostic category for aggressive B-cell lymphomas. It includes rare and heterogeneous tumors that cannot be classified as other well-defined lymphoma subtypes. Improved molecular diagnostics are needed to improve outcomes and treatment for patients.
Article
Oncology
Angela J. Fong, Andrew M. Evens, Elisa Bandera, Adana A. M. Llanos, Katie A. Devine, Shawna Hudson, Bo Qin, Lisa E. Paddock, Antoinette M. Stroup, Sara Frederick, Carissa Greco, Sharon L. Manne
Summary: This study aimed to characterize the preparedness for survivorship and evaluate the factors associated with it, including sociodemographic, medical, survivorship care transition experiences, practical and psychological factors. The findings revealed that many cancer survivors felt unprepared for survivorship and desired more information about follow-up tests and maintaining good health. Factors such as receiving chemotherapy, limited transition care planning, limited discussion of medical and psychosocial effects, high information needs, and financial hardship predicted low preparedness.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Hematology
Andrew M. Evens, Justin S. Brandt, Cody J. Peer, Tyler Yin, Dale Schaar, Faheem Farooq, Brett Mozarsky, William D. Figg, Elad Sharon
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Review
Oncology
Pallawi Torka, Eugene Przespolewski, Andrew M. Evens
Summary: The shortage of dacarbazine (DTIC) has caused a crisis in treating classical Hodgkin lymphoma. This review discusses strategies and proposes a treatment algorithm based on fitness and safety for receiving anthracyclines.
JCO ONCOLOGY PRACTICE
(2022)
Editorial Material
Oncology
Nicole Soriano, Kate Berlin, Leo I. Gordon
JCO ONCOLOGY PRACTICE
(2022)
Article
Hematology
Adam Yuh Lin, Bongseo Choi, Taehoon Sim, Eva Yang, Hyunjun Choi, Amir Behdad, Dong-Hyun Kim, Leo I. Gordon
Summary: This study investigates a novel mechanism of in situ vaccination in lymphoma. By combining cytosine guanine dinucleotide (CpG) deoxynucleotides with radiation therapy (RT) or photothermal therapy (PTT), an enhanced abscopal response and immune stimulation could be achieved. The results show that the combination of CpG deoxynucleotides with PTT significantly reduces tumor growth and increases CD8/CD4 and cytotoxic T-cell/regulatory T-cell ratios in the tumor microenvironment, as well as promoting effector memory T cells in lymph nodes and spleen.
Editorial Material
Oncology
Reem Karmali, Frederique St-Pierre, Leo Gordon
Article
Hematology
Jia Ruan, Jasmine Zain, Brett Palmer, Borko Jovanovic, Xinlei Mi, Alok Swaroop, Jane N. Winter, Leo I. Gordon, Reem Karmali, Jonathan Moreira, Adam M. Petrich, Barbara Pro
Summary: This study evaluated the combination of romidepsin and lenalidomide as initial treatment for PTCL and found that it is feasible and effective, showing promising overall response rates and survival outcomes.
Article
Oncology
Susan K. Parsons, Kristina S. Yu, Nicholas Liu, Supriya Kumar, Michelle A. Fanale, Katie Holmes, Carlos Flores, Andy Surinach, Darcy R. Flora, Andrew M. Evens
Summary: This study surveyed oncologists treating cHL to understand the treatment decision process, including the impact of PET/CT imaging.
JCO ONCOLOGY PRACTICE
(2023)
Article
Oncology
Andrew M. Evens, Kristina S. Yu, Nicholas Liu, Andy Surinach, Katherine Holmes, Carlos Flores, Michelle A. Fanale, Darcy R. Flora, Susan K. Parsons
Summary: This study aimed to understand the treatment preferences and decision-making of US physicians when it comes to frontline treatment for stage III/IV classic Hodgkin lymphoma (cHL). Results showed that the most common factors considered by physicians when selecting 1L cHL treatments were trial efficacy/safety data and national guidelines. Although treatment selection varied based on patient characteristics, overall survival (OS) was consistently cited as the most important attribute.
Article
Hematology
Andrew M. Evens, Alexey Danilov, Deepa Jagadeesh, Amy Sperling, Seo-Hyun Kim, Ryan Vaca, Catherine Wei, Daniel Rector, Suchitra Sundaram, Nishitha Reddy, Yong Lin, Umar Farooq, Christopher D'Angelo, David A. Bond, Stephanie Berg, Michael C. Churnetski, Amandeep Godara, Nadia Khan, Yun Kyong Choi, Maryam Yazdy, Emma Rabinovich, Gaurav Varma, Reem Karmali, Agrima Mian, Malvi Savani, Madelyn Burkart, Peter Martin, Albert Ren, Ayushi Chauhan, Catherine Diefenbach, Allandria Straker-Edwards, Andreas K. Klein, Kristie A. Blum, Kirsten Marie Boughan, Scott E. Smith, Brad M. Haverkos, Victor M. Orellana-Noia, Vaishalee P. Kenkre, Adam Zayac, Jeremy Ramdial, Seth M. Maliske, Narendranath Epperla, Parameswaran Venugopal, Tatyana A. Feldman, Stephen D. Smith, Andrzej Stadnik, Kevin A. David, Seema Naik, Izidore S. Lossos, Matthew A. Lunning, Paolo Caimi, Manali Kamdar, Neil Palmisiano, Veronika Bachanova, Craig A. Portell, Tycel Phillips, Adam J. Olszewski, Juan Pablo Alderuccio
Summary: The study found that patients with Burkitt lymphoma who received rituximab treatment had higher survival rates, while factors such as age, ECOG performance status, lactate dehydrogenase levels, and central nervous system involvement could affect patient survival.