期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 36, 页码 10587-10591出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502332
关键词
arylation; CC coupling; ketones; reaction mechanisms
资金
- NSERC
- FQRNT
- CGCC
- CNRS
- ANR [CD2I]
The -arylation of enolizable aryl ketones can be carried out with aryl halides under transition-metal-free conditions using KOtBu in DMF. The -aryl ketones thus obtained can be used for step- and cost-economic syntheses of fused heterocycles and Tamoxifen. Mechanistic studies demonstrate the synergetic role of base and solvent for the initiation of the radical process.
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