Review
Oncology
Said M. Afify, Aung Ko Ko Oo, Ghmkin Hassan, Akimasa Seno, Masaharu Seno
Summary: The PI3K/AKT/mTOR pathway is a crucial regulator of cell proliferation and survival, with dysregulation leading to cancer development. Many drugs targeting this pathway are in clinical trials, but further understanding of the signaling mechanism is necessary for better therapeutic efficacy.
EXPERT REVIEW OF ANTICANCER THERAPY
(2021)
Editorial Material
Oncology
Emily C. Erickson, Alex Toker
Summary: There is a pressing need to develop improved biomarker strategies for patient selection and to assess patient responses to PI3K pathway inhibitors in order to address unresolved issues surrounding the efficacy and tolerability of these compounds in cancer patients.
Article
Psychology, Multidisciplinary
Yueting Ji, Haiyang Liu, Shengming Liu, Minya Xu, Zixiang Lin
Summary: The current study examined the relationship between narcissism and creativity evaluation in the organizational context using a new perspective. Findings revealed an inverted U-shaped relationship between narcissism and creativity evaluation, with personal reputation mediating this curvilinear relationship. Additionally, this relationship was only significant when narcissists had low political skill. Theoretical and practical implications, limitations, and future directions are discussed.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Cell Biology
Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu
Summary: The study revealed that high expression of E2F2 in gastric cancer is associated with poor prognosis, and it promotes cancer cell migration and invasion by inhibiting autophagy through the PI3K/Akt/mTOR pathway. E2F2 may also modulate tumor immunity.
Article
Biology
Suresh Mickymaray, Faiz Abdulaziz Alfaiz, Anand Paramasivam, Vishnu Priya Veeraraghavan, Nanthini Devi Periadurai, Krishna Mohan Surapaneni, Guangfeng Niu
Summary: The study demonstrated that Rhaponticin exhibited potent anticancer effects against human osteosarcoma cells, especially MG-63 cells, by inducing cytotoxicity, inhibiting cell growth, and inducing apoptosis through various biological mechanisms.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Peirong Cai, Qihang Zhu, Qianying Cao, Yuni Bai, Hui Zou, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Jianchun Bian
Summary: The study demonstrates that allicin and quercetin can enhance the antioxidant capacity of lead-poisoned chicken livers, reducing tissue damage. They alleviate oxidative damage and apoptosis through the PI3K signaling pathway, with a stronger effect seen in combination.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Oncology
Fabiana Conciatori, Erica Salvati, Ludovica Ciuffreda, Senji Shirasawa, Italia Falcone, Francesco Cognetti, Gianluigi Ferretti, Massimo Zeuli, Donatella Del Bufalo, Chiara Bazzichetto, Michele Milella
Summary: Soluble factors produced by stromal fibroblasts can influence the sensitivity of tumor cells to molecularly targeted drugs. This influence depends on the genetic mutations and PTEN protein status of the tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Velina S. Atanasova, Angelika Riedl, Marcus Strobl, Julia Flandorfer, Daniela Unterleuthner, Claudia Weindorfer, Patrick Neuhold, Simone Stang, Markus Hengstschlaeger, Michael Bergmann, Helmut Dolznig
Summary: Colorectal cancer (CRC) is the second deadliest cancer in the world, with frequent mutations in the PI3K/AKT/MTOR and MAPK pathways. Treatment options targeting these pathways for CRC patients are currently lacking. In this study, we analyzed the response of CRC cells to a combination of small molecular inhibitors targeting these pathways and identified a novel, efficient therapy that induced cell death and proliferation stop in vitro based on the genetic background of the cells. These preclinical findings show promise for the development of a mutation-specific targeted therapy for CRC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Hui Shan, Xin Zhang, Yalu Mi, Jihui Jia, Bo Wang, Qing Yang
Summary: This study identifies eriodictyol as the most effective anti-gastric cancer flavonoid from Polygoni orientalis Fructus (POF) and investigates its potential targets in gastric cancer. Eriodictyol exhibits inhibitory effects on gastric cancer cell viability, suppresses colony formation, induces cell apoptosis, and inhibits tumor growth in vivo. Network pharmacology analysis suggests that the PI3K/AKT signaling pathway may be a potential target for eriodictyol in gastric cancer.
Article
Biochemistry & Molecular Biology
Zhun Wei, Kezhou Xia, Di Zheng, Changtian Gong, Weichun Guo
Summary: This study demonstrated that overexpression of RILP inhibits proliferation and impairs metastasis in osteosarcoma cells by restraining the PI3K/AKT/mTOR signaling pathway and promoting autophagy. Grb10 was identified as a potential target of RILP in regulating the PI3K/AKT pathway. Targeting RILP may be a promising strategy for osteosarcoma treatment.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaohui Hao, Yixuan Jin, Yiyang Zhang, Shifeng Li, Jie Cui, Hailan He, Lingli Guo, Fang Yang, Heliang Liu
Summary: Studies have shown that c-Src regulates the development of silicosis-induced lung fibrosis through the PI3K/AKT pathway, and Src kinase inhibitors may be potentially effective for the treatment of silicosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Political Science
Nic Fishman, Nicholas T. Davis
Summary: This study used network analysis to explore the belief network properties of different populations with varying levels of political knowledge. The findings suggest that belief network density increases faster among those with higher knowledge levels, and symbolic preferences are more central in belief networks.
AMERICAN JOURNAL OF POLITICAL SCIENCE
(2022)
Article
Cell Biology
Shreya Udawant, Carl Litif, Alma Lopez, Bonnie Gunn, Erin Schuenzel, Megan Keniry
Summary: The study compared the role of the PI3K/AKT/mTOR pathway in GBM tumor metabolism, revealing that PI3K-impacted glycolytic genes are over-expressed and associated with poor prognosis in GBM patients.
Review
Oncology
Yan Peng, Yuanyuan Wang, Cheng Zhou, Wuxuan Mei, Changchun Zeng
Summary: Cancer is a global public health issue that hinders the improvement of life expectancy worldwide. Current therapeutic options are insufficient, necessitating targeted treatments. Understanding the association between the PI3K/AKT/mTOR pathway and tumorigenesis, as well as the development of therapies targeting this pathway, is crucial for clinical decision-making.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiao-qiang Li, Bo-Chuan Liu, Xiao-bing Jiang, Wen-wen Gao, Bo Rong, Yao Wei, Feng-lu Wang, Hai-kang Zhao, Liang Zhang
Summary: The study reveals that up-regulation of PTPN21 is correlated with glioma and predicts poor survival rate in patients. Silencing PTPN21 has significant anti-cancer effects in glioma cells, inhibiting proliferation, arresting cell cycle, suppressing metastasis, and enhancing chemosensitivity. Mechanistically, PTPN21 mediates the EGFR/PI3K/AKT pathway in glioma.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Rodrigo Leite de Oliveira, Rene Bernards
Article
Gastroenterology & Hepatology
Cun Wang, Hui Wang, Cor Lieftink, Aimee du Chatinier, Dongmei Gao, Guangzhi Jin, Haojie Jin, Roderick L. Beijersbergen, Wenxin Qin, Rene Bernards
Review
Oncology
Giulia De Conti, Matheus Henrique Dias, Rene Bernards
Summary: Drug resistance is a major obstacle in cancer therapy, with drug-tolerant persister cells playing a key role in resisting treatment. Designing specific therapies to prevent drug resistance development is a challenge, focusing on the characteristics and evolution of these drug-tolerant persister cells.
Review
Oncology
Matheus Henrique Dias, Rene Bernards
Summary: Paradoxical interventions deliberately reinforce pathological behavior in psychotherapy to improve clinical condition. Targeted cancer therapies can selectively inhibit activated oncogenic pathways, but in advanced cancers, they provide only modest benefits due to resistance.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Federica Di Nicolantonio, Pietro Paolo Vitiello, Silvia Marsoni, Salvatore Siena, Josep Tabernero, Livio Trusolino, Rene Bernards, Alberto Bardelli
Summary: Progress in precision medicine for colorectal cancer has been slower compared to other solid tumor types, but novel targeted therapy strategies based on tumor biology are emerging due to better translational models. The availability of patient-derived CRC models and in vitro/in vivo analyses has led to significant advances in the field over the past decade. Successful personalized treatment in CRC now involves considering the intrinsic biology of CRC cells in addition to molecular profiles of individual tumors.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Cun Wang, Ying Cao, Chen Yang, Rene Bernards, Wenxin Qin
Summary: Functional genetic screens play a crucial role in uncovering new genes, identifying therapeutic targets, and guiding the development of new therapeutic strategies in liver cancer biology.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, Rene Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn
Summary: DNA damage inhibits RNA polymerase II from elongating, but also triggers genome-wide transcriptional responses. Particularly, promoter-bound Pol II is degraded in a GSK3 signaling-mediated response, which is crucial for cells to cope with DNA damage-induced transcription stress.
NATURE COMMUNICATIONS
(2022)
Letter
Cell Biology
Xuhui Ma, Shanshan Wu, Botai Li, Qianqian Zhang, Jianming Zhang, Wenming Liu, Hexin Yan, Rene Bernards, Wenxin Qin, Cun Wang
Review
Biotechnology & Applied Microbiology
Haojie Jin, Liqin Wang, Rene Bernards
Summary: In the past two decades, advancements in understanding the genetic defects underlying cancer have led to the development of numerous targeted cancer drugs. However, resistance to single-agent therapies remains a major hurdle. Rational drug combinations based on a deep understanding of the molecular mechanisms associated with therapy resistance hold great potential in cancer treatment. This article discusses the mechanisms of resistance to targeted therapies and the identification of effective drug combinations to overcome resistance, as well as the challenges in clinically developing these combinations and future perspectives.
NATURE REVIEWS DRUG DISCOVERY
(2023)
Review
Gastroenterology & Hepatology
Chen Yang, Hailin Zhang, Linmeng Zhang, Andrew X. Zhu, Rene Bernards, Wenxin Qin, Cun Wang
Summary: This review summarizes the latest clinical advances in the treatment of advanced hepatocellular carcinoma, including molecular-targeted monotherapies, immuno-oncology monotherapies, combination therapies and novel therapeutic approaches.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Oncology
Rene Bernards
Summary: The emergence of new targeted cancer drugs necessitates a complete overhaul in the design of early clinical trials. Rene Bernards explores the need for novel clinical trial designs and the ongoing efforts to achieve this. These innovative trials have the potential to provide similar outcomes for cancer patients with reduced side effects and a decreased cost of cancer care.
MOLECULAR ONCOLOGY
(2023)
Editorial Material
Oncology
Kevin M. Ryan, Jane Smith, Rene Bernards
Summary: The formation of organizations and societies in scientific research facilitates communication, collaboration, and career development. Partnerships between organizations can further enhance these benefits. This article highlights a new partnership between the European Association for Cancer Research (EACR) and Molecular Oncology, a journal owned by the Federation of European Biochemical Societies (FEBS).
MOLECULAR ONCOLOGY
(2023)
Review
Oncology
Liqin Wang, Lina Lankhorst, Rene Bernards
Summary: This review discusses how senescence can be induced in cancer cells and how the distinctive features of senescent cancer cells can be exploited for selective eradication. It also explores activation of the host immune system as an attractive way to clear senescent cancer cells, and the potential benefits of a sequential treatment approach with pro-senescence therapy followed by senolytic therapy.
NATURE REVIEWS CANCER
(2022)
Article
Oncology
Floris H. Groenendijk, Tina Treece, Erin Yoder, Paul Baron, Peter Beitsch, William Audeh, Winand N. M. Dinjens, Rene Bernards, Pat Whitworth
Article
Oncology
Rodrigo Leite de Oliveira, Liqin Wang, Rene Bernards
MOLECULAR & CELLULAR ONCOLOGY
(2018)