Article
Multidisciplinary Sciences
Kanako Watanabe, Tomoichiro Oka, Hirotaka Takagi, Sergei Anisimov, Shun-ichi Yamashita, Yoshinori Katsuragi, Masahiko Takahashi, Masaya Higuchi, Tomotake Kanki, Akihiko Saitoh, Masahiro Fujii
Summary: The host factor MYADM is identified as essential for PeV-A infection and is involved in virus entry into host cells in vitro. This finding advances our understanding of the pathogenesis of PeV-A.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Medicine, Research & Experimental
Lei Wang, Qing Sang
Summary: The study reported a novel causative gene MOS in patients with the EEAF phenotype, and established the relationship between MOS variants and human EEAF through a series of experiments, clarifying the role of MOS in human oocyte maturation and early embryo development. These findings suggest that MOS is a new diagnostic marker of EEAF and a potential therapeutic target for treatment of EEAF patients.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sara M. Steinmann, Anabel Sanchez-Martin, Elisabeth Tanzer, Antonio Cigliano, Giovanni M. Pes, Maria M. Simile, Laurent Desaubry, Jose J. G. Marin, Matthias Evert, Diego F. Calvisi
Summary: Hepatocellular carcinoma (HCC) is a deadly primary liver tumor with limited therapeutic options in advanced stages. This study investigates the role of eukaryotic initiation factor 4A1 (eIF4A1) in HCC and suggests the potential usefulness of pharmacological combinations of eIF4A and mTOR inhibitors in treating this aggressive tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhenzhen Liu, Jiangnan Pei, Xiaoyue Zhang, Chengjie Wang, Yao Tang, Haiyan Liu, Yi Yu, Shouling Luo, Weirong Gu
Summary: This study investigated the role of apolipoprotein A1 (APOA1) in the pathophysiology of preeclampsia (PE). The expression of APOA1 was found to be elevated in both plasma and placental tissues of PE patients. Importantly, the concentration of APOA1 was positively associated with systolic blood pressure during late gestation. Additionally, APOA1 was found to promote the proliferation and invasion of trophoblast, possibly through the activation of the transcription factor PPARγ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zi Wang, Pan Wang, Jieying Zhang, Han Gong, Xuchao Zhang, Jianhui Song, Ling Nie, Yuanliang Peng, Yanan Li, Hongling Peng, Yajuan Cui, Heng Li, Bin Hu, Jun Mi, Long Liang, Hong Liu, Ji Zhang, Mao Ye, Karina Yazdanbakhsh, Narla Mohandas, Xiuli An, Xu Han, Jing Liu
Summary: The study identified the important role of HES6 in human erythropoiesis and its influence on the interaction between GATA1 and FOG1. The study also discovered a positive feedback loop involving HES6, GATA1, and STAT1 in the regulation of erythropoiesis. These findings provide novel insights into the regulation of erythropoiesis and a potential therapeutic target for the management of polycythemia vera.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Heike Kroeger, Julia M. D. Grandjean, Wei-Chieh Jerry Chiang, Daphne D. Bindels, Rebecca Mastey, Jennifer Okalova, Amanda Nguyen, Evan T. Powers, Jeffery W. Kelly, Neil J. Grimsey, Michel Michaelides, Joseph Carroll, R. Luke Wiseman, Jonathan H. Lin
Summary: ER stress and UPR signaling contribute to human diseases, including severe congenital vision loss conditions like achromatopsia. Loss-of-function ATF6 variants lead to defective cone formation in the retina, highlighting the essential role of ATF6 in human cone development. Pharmacologic targeting of the ATF6 pathway may hold potential for treating blinding retinal diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Yu Izaki, Vishwa Jeet Amatya, Takahiro Kambara, Kei Kushitani, Yoshihiro Miyata, Morihito Okada, Yukio Takeshima
Summary: Lung neuroendocrine carcinomas (NECs), including small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC), have different treatment strategies from non-SCLC. This study identified Musashi-1 as a novel immunohistochemical marker that can aid in the diagnosis of lung NEC.
Article
Immunology
Yanli Liu, Wanmei Liang, Yabin Chang, Zehui He, Meijian Wu, Haozhi Zheng, Xinrong Ke, Minjia Lv, Qingqian Liu, Qinyu Liu, Waner Tang, Qiaoling Huang, Yu Lu, Min He, Qijun Yang, Chunpan Mo, Jiefan Wang, Kunwei Peng, Zhiqun Min, Hang Su, Jingqi Chen
Summary: This study explored the potential of CEP192 as a prognostic and therapeutic target in hepatocellular carcinoma (HCC). The expression of CEP192 was found to increase with tumor stage and was associated with poor clinicopathologic features, frequent recurrence, and higher mortality. It was also involved in the proliferation and self-renewal of hepatic progenitor-like cells. Additionally, CEP192 was highly correlated with tumor-associated cytokine ligand-receptor axes and the immunosuppressive tumor microenvironment, making it a potential predictor of response to immune checkpoint inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Emmanuel N. N. Paul, Tyler J. J. Carpenter, Sarah Fitch, Rachael Sheridan, Kin H. H. Lau, Ripla Arora, Jose M. M. Teixeira
Summary: By combining bulk and single-cell RNA sequencing, researchers have identified CRIP1 as a marker for myometrial stem/progenitor cells, which can be used to better understand the etiology of uterine fibroids.
COMMUNICATIONS BIOLOGY
(2023)
Article
Developmental Biology
Chunfang Xu, Weijie Zhao, Xixi Huang, Zhuxuan Jiang, Lu Liu, Liyuan Cui, Xinyi Li, Dajin Li, Meirong Du
Summary: Decidualization is a process where the endometrium transforms to support embryo development, with defective decidualization being linked to pregnancy complications. The study highlights the role of DUSP1 in regulating MAPK signaling in endometrial cells, showing its importance in safeguarding IGFBP1 expression and suggesting its involvement in the pathogenesis of recurrent miscarriage.
Article
Biochemistry & Molecular Biology
Huixia Yang, Thomas Kolben, Mirjana Kessler, Sarah Meister, Corinna Paul, Julia van Dorp, Sibel Eren, Christina Kuhn, Martina Rahmeh, Cornelia Herbst, Sabine Gabriele Fink, Gabriele Weimer, Sven Mahner, Udo Jeschke, Viktoria von Schoenfeldt
Summary: Aging is a main cause of oocyte quality decline, leading to potential failure of assisted reproductive technology. Through analysis of gene expression datasets, hundreds of age-related genes were identified in IVM-MII oocytes, involved in cellular metabolism, DNA replication, and histone modifications. Among these genes, FAM111A showed strong correlation with age, suggesting its potential as a novel marker for oocyte aging.
Article
Cell Biology
Lin Li, Chongying Zhu, Shouying Xu, Qiang Xu, Da Xu, Sishun Gan, Xingang Cui, Chao Tang
Summary: By studying the role of pseudouridine synthase 1 (PUS1) in renal cell carcinoma (RCC), it was found that PUS1 overexpression promotes RCC cell viability, migration, invasion, and colony formation, while downregulation of PUS1 has the opposite effects. These findings contribute to the understanding of RCC progression and provide potential targets for diagnosis and intervention.
Article
Cell Biology
Jingduo Li, Xiupeng Zhang, Zaiyu Hou, Siqi Cai, Yingxue Guo, Limei Sun, Ailin Li, Qingchang Li, Enhua Wang, Yuan Miao
Summary: This study reveals the important role of P130cas in FAK-YAP axis-mediated radioresistance in non-small cell lung cancer (NSCLC). P130cas promotes cell proliferation, alters the cell cycle profile, and enhances tumor growth. Furthermore, the study demonstrates that P130cas interacts with YAP and promotes its activation and nuclear translocation.
CELL DEATH & DISEASE
(2022)
Article
Pathology
Cecilia Taverna, Abbas Agaimy, Alessandro Franchi
Summary: The MDM2 gene plays a significant role in the development of nasopharyngeal carcinoma. MDM2 could be a valuable diagnostic marker to support the diagnosis of nasopharyngeal EBV positive NKSCC.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Endocrinology & Metabolism
Diem H. Tran, Rushendhiran Kesavan, Halie Rion, Mona Hoseini Soflaee, Ashley Solmonson, Divya Bezwada, Hieu S. Vu, Feng Cai, John A. Phillips, Ralph J. DeBerardinis, Gerta Hoxhaj
Summary: Research has shown that mitochondrial NADPH is crucial for proline biosynthesis in cells, with NAD kinase 2 (NADK2) activity being necessary for the production of mitochondrial NADP(+). Deficiency in mitochondrial NADPH leads to the inability of cells to synthesize proline, impacting nucleotide and protein synthesis, thereby impeding cell growth.
Article
Biochemistry & Molecular Biology
Silvia Lemma, Sofia Avnet, Michael Joseph Meade, Tokuhiro Chano, Nicola Baldini
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Oncology
Shiro Wakinoue, Tokuhiro Chano, Tsukuru Amano, Takahiro Isono, Fuminori Kimura, Ryoji Kushima, Takashi Murakami
Article
Oncology
Tsukuru Amano, Tokuhiro Chano, Takahiro Isono, Fuminori Kimura, Ryoji Kushima, Takashi Murakami
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Eiki Hanada, Susumu Kageyama, Ryosuke Murai, Shigehisa Kubota, Hiromi Ii, Susumu Nakata, Hiroko Kita, Akihiro Kawauchi, Tokuhiro Chano
ANTICANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Keiko Taniguchi, Hiromi Ii, Susumu Kageyama, Hiroko Takagi, Tokuhiro Chano, Akihiro Kawauchi, Susumu Nakata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Fumi Yoshino, Tsukuru Amano, Yajuan Zou, Jian Xu, Fuminori Kimura, Yoshio Furusho, Tokuhiro Chano, Takashi Murakami, Li Zhao, Naoki Komatsu
Article
Oncology
Hiroko Takagi, Hiromi Ii, Susumu Kageyama, Eiki Hanada, Keiko Taniguchi, Taku Yoshiya, Tokuhiro Chano, Akihiro Kawauchi, Susumu Nakata
ANTICANCER RESEARCH
(2019)
Article
Orthopedics
Michihito Ishizawa, Hidetoshi Okabe, Keiji Matsumoto, Shigeru Morimoto, Sinsuke Hukuda, Tokuhiro Chano
Summary: In schwannomas of the extremities showing target sign in T2-weighted images, histopathologically, the peripheral areas were suggested to be mucinous degeneration of the epineurium or perineurium, while the central areas were composed of truly neoplastic cells.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2021)
Article
Oncology
Shigehisa Kubota, Tetsuya Yoshida, Susumu Kageyama, Takahiro Isono, Takeshi Yuasa, Junji Yonese, Ryoji Kushima, Akihiro Kawauchi, Tokuhiro Chano
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Tsukuru Amano, Atsushi Murakami, Takashi Murakami, Tokuhiro Chano
Summary: Ovarian clear cell carcinomas (OCCCs) are resistant to conventional anti-cancer drugs and often arise from endometriosis associated with strong oxidative stress. The oxidative stress tolerance properties are involved in the survival and cancer stemness of OCCC cells. Therapeutic approaches need improvement, with multi-combinatorial treatments expected to improve patient outcomes.
Review
Health Care Sciences & Services
Tsukuru Amano, Tokuhiro Chano, Fumi Yoshino, Fuminori Kimura, Takashi Murakami
Article
Oncology
Sofia Avnet, Tokuhiro Chano, Annamaria Massa, Gloria Bonuccelli, Silvia Lemma, Luigi Falzetti, Giulia Grisendi, Massimo Dominici, Nicola Baldini
AMERICAN JOURNAL OF CANCER RESEARCH
(2019)
Article
Oncology
Takahiro Isono, Tokuhiro Chano, Tetsuya Yoshida, Ai Makino, Shohei Ishida, Masafumi Suzaki, Susumu Kageyama, Akihiro Kawauchi, Junji Yonese, Takeshi Yuasa
AMERICAN JOURNAL OF CANCER RESEARCH
(2019)
Meeting Abstract
Oncology
Keiko Taniguchi, Kengo Matsumura, Susumu Kageyama, Hiromi Ii, Eishi Ashihara, Tokuhiro Chano, Akihiro Kawauchi, Tatsuhiro Yoshiki, Susumu Nakata
Article
Oncology
Keiko Taniguchi, Kengo Matsumura, Hiromi Ii, Susumu Kageyama, Eishi Ashihara, Tokuhiro Chano, Akihiro Kawauchi, Tatsuhiro Yoshiki, Susumu Nakata
AMERICAN JOURNAL OF CANCER RESEARCH
(2018)
