Article
Chemistry, Medicinal
Ji-Su Kim, Hyun-Ju Kim, Eun-Byeol Lee, Ji-Hye Choi, Jieun Jung, Hwan-Hee Jang, Shin-Young Park, Ki-Chan Ha, Yu-Kyung Park, Jong-Cheon Joo, Sung-Hyen Lee
Summary: This study investigated the effects of Allium hookeri (AH) on glycemia in prediabetic subjects. The results showed that AH supplementation moderately reduced blood glucose and insulin levels, and improved insulin sensitivity.
Article
Biochemistry & Molecular Biology
Sa Guo, Hui Ouyang, Wendi Du, Junmao Li, Mi Liu, Shilin Yang, Mingzhen He, Yulin Feng
Summary: The study demonstrates that Gynura procumbens (GP) can improve type 2 diabetes by activating the PI3K/Akt signaling pathway to improve insulin resistance and glucose metabolism.
Article
Multidisciplinary Sciences
Zhipan Wu, Haitao Gong, Yuhang Shen, Haote Han, Wei Zhu, Jingkui Tian, Hua Fan, Shouxin Li
Summary: Sugar beet has been found to have hypoglycemic and hypolipidemic effects, potentially mediated through the activation of the IRS-1/PI3K/AKT and AMPK/ACC signaling pathways.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2022)
Article
Biochemistry & Molecular Biology
Kavitha Velagapudi, Naveena Lavanya Latha Jeevigunta, Vijaya Lakshmi Bodiga
Summary: Zinc is essential for various biological processes, including tumor cell maintenance and apoptosis. Zinc homeostasis is influenced by multiple factors, such as alcohol consumption. Research shows that decreased zinc levels during precancerous lesion formation in the colon may affect cell proliferation and DNA integrity.
Article
Endocrinology & Metabolism
Maria Florencia Battistone, Karina Miragaya, Amelia Rogozinski, Monica Aguero, Analia Alfieri, Maria Carolina Ballarino, Laura Boero, Karina Danilowicz, Sabrina Diez, Marina Donoso, Patricia Fainstein-Day, Alejandra Furioso, Natalia Garcia-Basavilbaso, Mariela Glerean, Debora Katz, Monica Loto, Susana Mallea-Gil, Marcela Martinez, Maria Isabel Sabate, Marisa Servidio, Patricia Slavinsky, Graciela Stalldecker, Soledad Sosa, Grabriela Szuman, Julieta Tkatch, Ignacio Caldo, Daniela Lubieniecki, Mirtha Guitelman
Summary: The study found an increased risk of preneoplastic colonic lesions and colorectal carcinoma in patients with acromegaly compared to a control group, with insulin resistance being the only statistically significant associated factor among patients with colonic polyps. The results support the recommendation to perform screening colonoscopy at the time of diagnosis of acromegaly.
Article
Food Science & Technology
Suzuka Uomoto, Keisuke Takesue, Saori Shimizu, Natsuno Maeda, Kanami Oshima, Emika Hara, Mio Kobayashi, Yasunori Takahashi, Makoto Shibutani, Toshinori Yoshida
Summary: We investigated the role of ER-phagy in NAFLD-related hepatocarcinogenesis in HFD-fed and/or PB-treated rats by clustering the expression levels of p62 and FAM134B in preneoplastic hepatic lesions. The results showed that PB administration increased clusters with high levels of p62, while HFD feeding increased clusters with high levels of both p62 and FAM134B. The combination of HFD feeding with PB counteracted each other's effects and the cluster composition resembled that of the control group.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Wei Han, Muhan Li, Mengyi Yang, Si Chen, Yuanyuan Lu, Tiantian Tang, Rui Wang, Chenguang Zhang, Kemin Qi
Summary: This study investigated the effects of folic acid on body weight gain in obesity and gut microbiota-associated branched-chain amino acids (BCAAs) and mitochondrial function. The results showed that folic acid supplementation reversed the negative effects of high-fat diet on body weight gain, BCAA concentrations, and gene expression related to mitochondrial function in conventional mice. However, folic acid supplementation had little effect on BCAA concentrations and gene expression in germ-free mice. The study also found a correlation between adipose and hepatic mitochondrial DNA C/N ratio and BCAA concentrations, which were closely associated with specific gut bacteria.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2023)
Article
Otorhinolaryngology
Tetsuya Terada, Ryo Kawata, Masaaki Higashino, Yoshitaka Kurisu, Hiroko Kuwabara, Yoshinobu Hirose
Summary: This study summarized the diagnosis and treatment outcomes of basal cell adenocarcinoma (BCAC) of the parotid gland, a rare low-grade malignancy, and found that fine-needle aspiration cytology (FNAC) and frozen section biopsy (FSB) are useful for diagnosing and determining the malignancy grade of BCAC.
AURIS NASUS LARYNX
(2021)
Article
Orthopedics
Nobuhiro Okuno, Shuhei Otsuki, Jo Aoyama, Kosuke Nakagawa, Tomohiko Murakami, Kuniaki Ikeda, Yoshinobu Hirose, Hitoshi Wakama, Tomohiro Okayoshi, Yoshinori Okamoto, Yoshiaki, Masashi Neo
Summary: The study demonstrated that the peptide hydrogel scaffold KI24RGDS can promote repair and regeneration of meniscus in a rabbit model, showing significant healing effects. The hydrogel is highly biocompatible and biodegradable, mimicking the three-dimensional structure of the extracellular matrix and promoting cell adhesion and proliferation.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Letter
Medicine, Research & Experimental
Ryo Kawata, Ichita Kinoshita, Shuji Omura, Masaaki Higashino, Shuji Nishikawa, Tetsuya Terada, Shin-Ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose, Takeshi Tochizawa
Article
Oncology
Kazuki Nishimura, Kyosuke Nishio, Kensuke Hirosuna, Kazumasa Komura, Takuo Hayashi, Wataru Fukuokaya, Ayako Ura, Taizo Uchimoto, Ko Nakamura, Tatsuo Fukushima, Yusuke Yano, Nobushige Takahashi, Keita Nakamori, Shoko Kinoshita, Tomohisa Matsunaga, Takeshi Tsutsumi, Takuya Tsujino, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Kiyoshi Takahara, Teruo Inamoto, Yoshinobu Hirose, Takahiro Kimura, Shin Egawa, Haruhito Azuma
Summary: The efficacy of pembrolizumab for patients previously treated with chemoradiation therapy (CRT) was found to be similar to those treated with total cystectomy (TC). Enhanced tumor regression might be expected with concurrent administration of chemotherapy and programmed cell death protein 1/PD-L1 inhibitor.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, Research & Experimental
Shigeru Kawabata, Yamato Yoshikawa, Yoshitaka Kurisu, Kensuke Tajiri, Teruyo Kida, Yoshinobu Hirose
Summary: This study describes a case of conjunctival epithelial hyperplasia and performs immunohistochemical analysis on both the lesion and intact conjunctival epithelium. Specific cytokeratin staining features were found in conjunctival epithelial hyperplasia, along with evidence of squamous metaplasia. The findings contribute to the diagnosis and further understanding of conjunctival epithelial hyperplasia as a pathological entity.
BIOMEDICAL REPORTS
(2022)
Article
Rheumatology
Shogo Matsuda, Takuya Kotani, Hiroko Kuwabara, Takayasu Suzuka, Takao Kiboshi, Yumiko Wada, Takaaki Ishida, Youhei Fujiki, Hideyuki Shiba, Kenichiro Hata, Takeshi Shoda, Yoshinobu Hirose, Tohru Takeuchi
Summary: This study investigates the pathomechanism of microscopic polyangiitis (MPA) complicated by interstitial lung disease (ILD) using serum biomarker profile and pulmonary histopathology. The activation of M2 macrophages, Th2 cells, and B cells plays a key role in the pathomechanism of MPA-ILD. Classification of MPA-ILD based on serum biomarker profile would be useful in predicting the disease activity and the complications of severe infection in MPA-ILD.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Otorhinolaryngology
Masataka Taniuchi, Ryo Kawata, Tetsuya Terada, Masaaki Higashino, Hiromi Nishimura, Yoshitaka Kurisu, Hiroko Kuwabara, Yoshinobu Hirose
Summary: This study found that the histological grade of Mucoepidermoid carcinoma (MEC) is related to prognosis, with a significant difference in survival rate between low/intermediate and high-grade cases. Fine-needle aspiration cytology had a low accuracy in assessing the grade of MEC.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Rheumatology
Shogo Matsuda, Takuya Kotani, Reiko Wakura, Takayasu Suzuka, Hiroko Kuwabara, Takao Kiboshi, Yumiko Wada, Hideyuki Shiba, Kenichiro Hata, Takeshi Shoda, Yoshinobu Hirose, Tohru Takeuchi
Summary: The study found that nailfold videocapillaroscopy (NVC) is a useful tool for assessing the disease activity and treatment response in ANCA-associated vasculitis (AAV).
Article
Gastroenterology & Hepatology
Takeshi Ogura, Yoshinobu Hirose, Saori Ueno, Atsushi Okuda, Nobu Nishioka, Akira Miyano, Yoshitaro Yamamoto, Kazuya Ueshima, Kazuhide Higuchi
Summary: The use of SpyBite MAX forceps in diagnosing indeterminate biliary stricture can result in larger tissue samples and reduce the need for multiple forceps biopsies, thereby improving diagnostic accuracy.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Pediatrics
Shoichi Ishikawa, Tohru Ogihara, Shigeo Yamaoka, Jun Shinohara, Shigeru Kawabata, Yoshinobu Hirose, Daisuke Nishioka, Akira Ashida
Summary: This study investigated the therapeutic effects of compound A, a non-steroidal selective glucocorticoid-receptor agonist and modulator, in a bleomycin-induced alveolar simplification model. The results showed that compound A improved lung inflammation, inhibited the arrest of alveolar maturation, and had fewer adverse effects compared to traditional glucocorticoids. These findings suggest that compound A may be a promising candidate for the therapy of bronchopulmonary dysplasia.
PEDIATRIC RESEARCH
(2023)
Article
Oncology
Toshinori Kobayashi, Mitsuaki Ishida, Hisanori Miki, Masahiko Hatta, Madoka Hamada, Yoshinobu Hirose, Mitsugu Sekimoto
Summary: The tumor microenvironment, including the desmoplastic reaction (DR) and tumor deposits (TD), plays important roles in the progression and invasion of colorectal cancer (CRC). This study revealed a significant association between immature type DR and the presence of TD, suggesting a close relationship between lymphovascular invasion, DR, tumor budding, and TD.
Article
Medicine, General & Internal
Kosei Kimura, Shigeru Kawabata, Hiroyo Oku, Ayana Ikari, Tomo Tominaga, Saki Takai, Junna Sakane, Michiaki Tanaka, Chinatsu Aoki, Monika Ota, Erika Minami, Yoshinobu Hirose, Sang-Woong Lee, Mitsuhiko Iwamoto
Summary: This article presents a case of primary breast neuroendocrine tumor (BNET) occurring in the axilla of a man. The clinical and histopathological features, as well as the treatment for this rare case, are discussed.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Article
Otorhinolaryngology
Akiko Ozaki, Ryo Kawata, Ichita Kinoshita, Masaaki Higashino, Tetsuya Terada, Shin-ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose
Summary: This study aimed to clarify the clinical characteristics of adenoid cystic carcinoma (AdCC) of salivary glands and examine factors associated with recurrence and prognosis by histopathological grade classification. The results showed that patients in grade III had significantly higher age, proportions of patients with lymph node metastasis (cN+, pN+), and perineural invasion. Lower-grade groups showed higher rates of correct histopathological type on fine-needle aspiration cytology (FNAC). Five-year disease-specific survival and disease-free survival rates were significantly lower in grade III. High-stage and perineural invasion were associated with more distant metastases.
ACTA OTO-LARYNGOLOGICA
(2023)
Review
Oncology
Daisuke Takeuchi, Mitsuaki Ishida, Emi Yasuda, Koichi Ueda, Yoshinobu Hirose
Summary: In this study, we analyzed the clinicopathological features of ocular and extraocular sebaceous carcinoma and found that in situ lesions were present in some cases. Immunohistochemical analysis showed the expression of androgen receptor and adipophilin in sebaceous carcinoma. The study also demonstrated sebaceous differentiation in in situ lesions of extraocular sebaceous carcinoma for the first time, suggesting its possible origin from progenitor cells in the sebaceous duct or interfollicular epidermis.
Review
Cell Biology
Yoshinobu Hirose, Kohei Taniguchi
Summary: The metabolic phenotype of tumors differs greatly from surrounding normal tissue, and the importance of this heterogeneity is increasingly recognized. This review classifies metabolic phenomena in colorectal cancer (CRC) into extrinsic and intrinsic factors, identifying their impact on tumor function. The study redefines characteristics of specific metabolism-related factors in CRC and emphasizes the significance of tumor budding as a form of metabolic heterogeneity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)