Review
Chemistry, Physical
Ekaterina V. Pokochueva, Dudari B. Burueva, Oleg G. Salnikov, Igor V. Koptyug
Summary: HET-PHIP has attracted significant research attention in recent years, showing major prospects for applications in biomedical MRI and industrial catalytic studies, despite the current need for further improvement in NMR signal enhancements.
Article
Chemistry, Physical
Oleg G. Salnikov, Nikita Chukanov, Larisa M. Kovtunova, Valerii Bukhtiyarov, Kirill Kovtunov, Roman Shchepin, Igor Koptyug, Eduard Y. Chekmenev
Summary: The efficiency of H-1 and C-13 hyperpolarization of acetate and pyruvate esters using heterogeneous hydrogenation and parahydrogen over Rh/TiO2 catalysts was investigated. Acetate esters surpassed pyruvates in hyperpolarization, and esters with a double bond in unsaturated alcoholic moieties were more efficient than those with a triple carbon-carbon bond. Among the compounds studied, propyl acetate yielded the maximum H-1 and C-13 NMR signal intensities.
Article
Chemistry, Multidisciplinary
Baptiste Joalland, Thomas Theis, Stephan Appelt, Eduard Y. Chekmenev
Summary: This study demonstrates the utility of Radiofrequency Amplification by Stimulated Emission Radiation (RASER) for background-free proton detection of hyperpolarized biomolecules in a clinically relevant magnetic field. The results show that RASER detection without radio-frequency excitation could pave the way to new applications in high-resolution NMR spectroscopy and in vivo spectroscopy and imaging.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Oleg G. Salnikov, Dudari B. Burueva, Larisa M. Kovtunova, Valerii I. Bukhtiyarov, Kirill V. Kovtunov, Igor V. Koptyug
Summary: In this study, the mechanism of methylenecyclobutane hydrogenation over titania-supported Rh, Pt, and Pd catalysts was investigated using parahydrogen-induced polarization (PHIP) technique. It was found that the reaction leads to the formation of a mixture of cyclic, linear, and branched compounds, and the temperature has a significant influence on the product composition.
Article
Chemistry, Multidisciplinary
Oleg G. Salnikov, Alexandra Svyatova, Larisa M. Kovtunova, Nikita Chukanov, Valerii Bukhtiyarov, Kirill Kovtunov, Eduard Y. Chekmenev, Igor Koptyug
Summary: This study presents H-1 hyperpolarized diethyl ether, which can be imaged on any clinical MRI scanner, achieving up to 1.3% nuclear spin polarization through heterogeneous hydrogenation and prolonging its lifetime. This approach has potential applications in anatomy and functional studies.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Analytical
Oleg G. Salnikov, Ivan A. Trofimov, Andrey N. Pravdivtsev, Kolja Them, Jan-Bernd Hoevener, Eduard Y. Chekmenev, Igor V. Koptyug
Summary: This research demonstrates the utility of using RASER to amplify nuclear magnetic resonance (NMR) signals of solute and solvent molecules in the liquid state. The study shows that parahydrogen-induced RASER can enhance nuclear spin polarization of protons and heteronuclei in a wide range of molecules. The experimental results are supported by control experiments and spin dynamics simulations. The enhanced NMR sensitivity achieved through RASER can have significant applications in mixture analysis, metabolomics, and structure determination.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Anil P. Jagtap, Salvatore Mamone, Stefan Gloeggler
Summary: The use of para-hydrogen to enhance 13C-enriched metabolites has provided a rapid pathway for producing hyperpolarized metabolites, which can be achieved at any given field. This opens up opportunities for many laboratories to utilize this technology.
MAGNETIC RESONANCE IN CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Christopher Nelson, Andreas B. Schmidt, Isaiah Adelabu, Shiraz Nantogma, Valerij G. Kiselev, Abubakar Abdurraheem, Henri de Maissin, Soeren Lehmkuhl, Stephan Appelt, Thomas Theis, Eduard Y. Chekmenev
Summary: The feasibility of Carbon-13 Radiofrequency (RF) Amplification by Stimulated Emission of Radiation (C-13 RASER) is demonstrated on a bolus of liquid hyperpolarized ethyl [1-C-13]acetate. The study successfully observed C-13 RASER signals and demonstrated its potential application on biomolecular carriers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sergey Korchak, Lukas Kaltschnee, Riza Dervisoglu, Loren Andreas, Christian Griesinger, Stefan Gloeggler
Summary: Nuclear magnetic resonance is often limited by low sensitivity, but hyperpolarization methods have been developed to overcome this issue. A new method combining para-hydrogen enhanced magnetic resonance with the RASER phenomenon can enhance signals significantly.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
B. Krasch, S. Mirz, A. Smolinski, O. Suess, R. Groessle
Summary: Precise knowledge about the kinetics of ortho-para catalysts and accurate ortho-para monitoring are necessary for the design of efficient hydrogen liquefaction plants and the production of accurate ortho-para hydrogen samples. Raman spectroscopy, as an independent measurement method of the ortho-para ratio, is not affected by other gas parameters and impurities, making it a superior technique for ortho-para monitoring compared to methods based on thermodynamic properties.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Chemistry, Physical
Pierrick Berruyer, Andrea Bertarello, Snaedis Bjoergvinsdottir, Moreno Lelli, Lyndon Emsley
Summary: Recently, methods based on the dynamics of 1H nuclear hyperpolarization in magic angle spinning (MAS) NMR experiments have been used to determine mesoscale structures in complex materials. However, these methods have low sensitivity and have only been feasible using indirect detection of 1H polarization through dilute heteronuclei. In this study, relayed-DNP (R-DNP) combined with fast MAS enables direct 1H detection, accelerating experiment times by a factor of 16. Varying the MAS rate allows for recording a series of independent R-DNP curves that can be jointly analyzed to accurately determine domain sizes.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Review
Biochemistry & Molecular Biology
Victor Ribay, Clement Praud, Marine P. M. Letertre, Jean-Nicolas Dumez, Patrick Giraudeau
Summary: Hyperpolarized NMR is a promising method to overcome the limited sensitivity of conventional NMR metabolomics in detecting minute metabolite concentrations in biological samples. This review discusses the utilization of dissolution dynamic nuclear polarization and parahydrogen-based techniques for molecular omics sciences, as well as recent advancements in combining hyperpolarization with fast multi-dimensional NMR and quantitative workflows. The review also proposes a comprehensive comparison of existing hyperpolarization techniques and addresses challenges in high throughput, sensitivity, and resolution for the general application of hyperpolarized NMR in metabolomics.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Nikita V. Chukanov, Roman V. Shchepin, Sameer M. Joshi, Mohammad S. H. Kabir, Oleg G. Salnikov, Alexandra Svyatova, Igor V. Koptyug, Juri G. Gelovani, Eduard Y. Chekmenev
Summary: NMR hyperpolarization techniques greatly increase nuclear spin polarization, leading to significant sensitivity gains for applications in high-resolution NMR spectroscopy and real-time metabolic imaging. Various hyperpolarization techniques exist, with a focus on targeting C-13 and N-15 sites in biocompatible agents. Long T-1 values of these sites allow hyperpolarized states to be retained for extended periods, with SABRE being a versatile low-cost technique for hyperpolarization of N-15 nuclei.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Amrit Venkatesh, Gilles Casano, Yu Rao, Federico De Biasi, Frederic A. Perras, Dominik J. Kubicki, Didier Siri, Sebastien Abel, Hakim Karoui, Maxim Yulikov, Olivier Ouari, Lyndon Emsley
Summary: The sensitivity of NMR spectroscopy is enhanced by DNP, where polarization is transferred from unpaired electrons to proton spins in solids. The efficiency of polarization transfer near the unpaired electron spins is unclear. Experimental results and numerical simulations show that strong hyperfine couplings to nearby protons determine high transfer rates, and fewer hydrogen atoms in TEKPol isotopologues lead to longer H-1 DNP build-up times. Based on this understanding, a new biradical, NaphPol, is designed and yields significantly increased NMR sensitivity, making it the best DNP polarizing agent in organic solvents to date.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Ana Sousa-Castillo, Andrea Marino-Lopez, Begona Puertolas, Miguel A. Correa-Duarte
Summary: Bioorthogonal chemistry has provided a powerful tool for performing biocompatible chemospecific reactions in living systems, particularly in the areas of genetic encoding systems, bioimaging, and cancer therapy. This Minireview focuses on recent advances in the use of heterogeneous catalysts for bioorthogonal reactions, discussing the synthetic strategies of Pd-, Au-, and Cu-based materials, their applications in activating caged fluorophores and prodrugs, and the potential of using external stimuli for targeted drug release in diseased tissues. The review also highlights future directions and challenges in this emerging field.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi-Maleh, Afshin Taheriazam, Sepideh Mirzaei, Mehrdad Hashemi, Kiavash Hushmandi, Pooyan Makvandi, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Arul Goel, Lingzhi Wang, Jun Ren, Yavuz Nuri Ertas, Alan Prem Kumar, Yuzhuo Wang, Navid Rabiee, Gautam Sethi, Zhaowu Ma
Summary: Nanomedicine has great potential in the treatment of bladder cancer, including improving drug efficacy, regulating gene expression, providing photodynamic and photothermal therapy, remodeling tumor microenvironment and infiltration of immune cells, timely diagnosis, and targeted therapy for bladder cancer.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Shadab Dabagh, Somayeh Asadi Haris, Yavuz Nuri Ertas
Summary: CuFe2O4, ZnFe2O4, and MnFe2O4 ferrite nanoparticles (NPs) were synthesized through the sol-gel method and showed pure cubic spinel structure. CuFe2O4 NPs exhibited significant antibacterial activity and MnFe2O4 NPs had the highest magnetization among all the NPs.
JOURNAL OF CLUSTER SCIENCE
(2023)
Editorial Material
Surgery
Sibel Emir Diltemiz, Yavuz Nuri Ertas, Christopher H. Contag, Nureddin Ashammakhi
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
Article
Engineering, Electrical & Electronic
Khalid Youssef, Greg Schuette, Yubin Cai, Daisong Zhang, Yikun Huang, Yahya Rahmat-Samii, Louis-S. Bouchard
Summary: Unlike areas such as computer vision and speech recognition, deep learning lacks a general approach suitable for radiofrequency systems. Existing approaches face problems in robustness, consistency, efficiency, repeatability, and scalability. In this article, a new deep learning approach based on multistage training is proposed and it shows significant improvement in radiofrequency sensing signal classification.
IEEE ANTENNAS AND PROPAGATION MAGAZINE
(2023)
Article
Food Science & Technology
Parisa Mohajeri, Abdollah Hematian Sourki, Alireza Mehregan Nikoo, Yavuz Nuri Ertas
Summary: Plantago psyllium L. seed gum (PPSG)/gelatine nanocomposites containing Cuminum cyminum essential oil (CCEO) were prepared via electrospinning and showed significant antibacterial properties against Staphylococcus aureus. The electrospun nanofibres containing at least 3% CCEO had the most inhibitory effect on the growth of S. aureus. These nanocomposites have the potential to be used as biodegradable materials in food packaging and edible coatings for food preservation.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Marziyeh Salehiabar, Mohammadreza Ghaffarlou, Ali Mohammadi, Navid Mousazadeh, Hossein Rahimi, Fatemeh Abhari, Hamid Rashidzadeh, Leila Nasehi, Hamed Rezaeejam, Murat Barsbay, Yavuz Nuri Ertas, Hamed Nosrati, Taras Kavetskyy, Hossein Danafar
Summary: This article introduces a novel bimetallic nanoparticle-based multifunctional nanoplatform that acts as an effective radiosensitizer and enhances treatment efficacy by combining chemotherapy and radiotherapy. By encapsulating CUR into CuFe2O4 nanoparticles modified by BSA and FA, tumor accumulation is increased and adverse effects are reduced. The nanoplatform exhibits excellent biosafety, tumor-killing ability, and radiosensitizing capacity in vitro, as well as high cancer suppression efficiency in vivo. The co-administration of CuFe2O4@BSA-FA-CUR nanoparticles with X-ray radiation leads to complete tumor ablation in treated mice without any mortality or radiation-induced normal tissue toxicity, highlighting their biosafety and potential for radiosensitization of malignant tumors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Afshin Taheriazam, Ghazaleh Gholamiyan Yousef Abad, Shima Hajimazdarany, Mohammad Hassan Imani, Setayesh Ziaolhagh, Mohammad Arad Zandieh, Seyedeh Delaram Bayanzadeh, Sepideh Mirzaei, Michael R. Hamblin, Maliheh Entezari, Amir Reza Aref, Ali Zarrabi, Yavuz Nuri Ertas, Jun Ren, Romina Rajabi, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Kiavash Hushmandi
Summary: Nanotechnology offers great potential in the field of nanomedicine for the treatment of various diseases, especially cancer. Graphene oxide nanoparticles have emerged as promising carbon-based nanocarriers for drug and gene delivery, photothermal therapy, overcoming chemotherapy resistance, and imaging. This review focuses on the biological functions of graphene oxide nanoparticles as regulators of apoptosis and autophagy, and their potential toxicity in major body organs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Mehrdad Hashemi, Fatemeh Ghadyani, Sahar Hasani, Yeganeh Olyaee, Behnaz Raei, Marzieh Khodadadi, Maryam Fallah Ziyarani, Fatemeh A. Basti, Alireza Tavakolpournegari, Arash Matinahmadi, Shokooh Salimimoghadam, Amir Reza Aref, Afshin Taheriazam, Maliheh Entezari, Yavuz Nuri Ertas
Summary: Cancer is a life-threatening disease characterized by abnormal proliferation and metastasis of cancer cells. Chemotherapy, the use of anti-cancer drugs, is a common treatment for cancer, but drug resistance can lead to treatment failure. To overcome this, nano-scale delivery systems like liposomes have been developed to reverse drug resistance and enhance the effectiveness of chemotherapy agents.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Fatemeh S. Majedi, Mohammad Mahdi Hasani-Sadrabadi, Timothy J. Thauland, Sundeep G. Keswani, Song Li, Louis-S. Bouchard, Manish J. Butte
Summary: A biodegradable macroporous scaffold implanted peritumourally releases inhibitors to suppress T-reg cells and attract and stimulate effector T cells, resulting in enhanced immune response, clearance of tumour cells, and prevention of recurrence. The scaffold can also deliver tumour-antigen-specific T cells into the tumour. This strategy offers a potential alternative to systemic therapies with reduced toxicities.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Hamed Nosrati, Marziyeh Salehiabar, Jalil Charmi, Kadir Yaray, Mohammadreza Ghaffarlou, Esra Balcioglu, Yavuz Nuri Ertas
Summary: Radiation therapy shows promising effectiveness against various cancers, and nanoparticles of high-atomic-number (high-Z) materials can enhance X-ray radiation therapy. In this study, bovine serum albumin capped gadolinium oxide and gold nanoparticles (Gd2O3@BSA-Au NPs) are developed as a bimetallic radiosensitizer to maximize radiation therapy within tumors. In vitro tests and evaluation in a breast cancer murine model confirm the radiosensitizing ability of the nanoparticles. Applying Gd2O3@BSA-Au NPs under X-ray irradiation significantly improves cancer therapy efficacy, as evidenced by studies on cell viability, proliferation, reactive oxygen species production, and in vivo anti-tumor effect.
ACS APPLIED BIO MATERIALS
(2023)
Review
Immunology
Vivek P. Chavda, Nidhi Raval, Soham Sheta, Lalitkumar K. Vora, Fatma Elrashdy, Elrashdy M. Redwan, Vladimir N. Uversky, Yavuz Nuri Ertas
Summary: The newly emerged SARS-CoV-2 is highly infectious and rapidly mutating, causing severe effects on various body organs. Multiple approaches, including medications and supportive devices, have been successfully used for the intervention of COVID-19. Hemadsorption devices are discussed in this report as part of supportive treatment for the cytokine storm associated with COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Biomaterials
Shadab Dabagh, Somayeh Asadi Haris, Yavuz Nuri Ertas
Summary: Polyethylene glycol (PEG) was used to functionalize zinc ferrite nanoparticles (NPs) synthesized by the hydrothermal process in order to improve biocompatibility and prevent aggregation. Various spectroscopy techniques confirmed the structure, size, morphology, and magnetic properties of the NPs. PEG coating resulted in spherical shape, increased stability, and decreased zeta potential of the NPs. High saturation magnetization indicated their potential for biomedical applications. The PEG-coated NPs showed negligible cytotoxicity and were successfully used as a contrast agent in magnetic resonance imaging (MRI).
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Shadab Dabagh, Somayeh Asadi Haris, Behzad Khatamsaz Isfahani, Yavuz Nuri Ertas
Summary: Fruit extracts were used to synthesize silver-decorated magnetite nanoparticles with a silica coating. The nanoparticles exhibited decreased magnetization with subsequent coating processes, but increased specific surface area with silica coating. The addition of silver atoms on the surface of the nanoparticles resulted in high antibacterial activity against E. coli and S. aureus. The nanoparticles also showed no cytotoxicity to cells and maintained antibacterial activity during consecutive magnetic separation and recycling.
ACS APPLIED BIO MATERIALS
(2023)
Article
Environmental Sciences
K. Youssef, K. Shao, S. Moon, L. -s. Bouchard
Summary: We introduce an interpretable superposable neural network (SNN) optimization method to assess landslide susceptibility, which achieves high accuracy and low model complexity. By training models on landslide inventories from three easternmost Himalaya regions, we confirm the superior performance of our SNN model compared to physically-based and statistical models. We identify slope and precipitation product, as well as hillslope aspect, as important contributors to landslide susceptibility.
COMMUNICATIONS EARTH & ENVIRONMENT
(2023)
Article
Optics
Mohamad Niknam, Robert N. Schwartz, Louis-S. Bouchard
Summary: We study quantum algorithmics with single spins and address technological challenges such as precision fabrication, rapid decoherence, atomic-scale addressing, and readout. By investigating fully polarized mesoscopic spin ensembles (spin-coherent states), we overcome atomic-scale challenges. In the limit where the ensembles are small compared to their separation, they can be treated as qubits with an effective coupling strength scaling with the number of spins. High-fidelity one- and two-qubit gate operations can be implemented if the spins within each ensemble are decoupled.
