Review
Physiology
Xueli Liu, Bin Zhu, Yujie Li, Xinyue Liu, Sheng Guo, Chenglong Wang, Sen Li, Dingxuan Wang
Summary: Angiogenesis and VEGF play crucial roles in tendon healing, but the effects of exogenous VEGF application are controversial and require further research.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Oana Gabriela Trifanescu, Laurentia Nicoleta Gales, Bogdan Cosmin Tanase, Serban Andrei Marinescu, Raluca Alexandra Trifanescu, Iuliana Maria Gruia, Mihai Andrei Paun, Laura Rebegea, Radu Mitrica, Luiza Serbanescu, Rodica Maricela Anghel
Summary: VEGF and malondialdehyde are important prognostic markers in ovarian cancer, especially in macroscopic residual disease, and there is a positive correlation between angiogenesis and oxidative stress.
Review
Biochemistry & Molecular Biology
Xi Guo, Hong Yi, Tin Chiu Li, Yu Wang, Huilin Wang, Xiaoyan Chen
Summary: VEGF is a well-known angiogenic factor that plays a critical role in embryo implantation by enhancing embryo development and facilitating interactions between the embryo and endometrium. Changes in VEGF expression are correlated with reproductive failure, including recurrent implantation failure and recurrent miscarriage. This study aimed to clarify the role of VEGF in embryo implantation by reviewing recent literature and exploring its effects and underlying mechanisms.
Article
Medicine, Research & Experimental
Benjamin M. Kahn, Alfredo Lucas, Rohan G. Alur, Maximillian D. Wengyn, Gregory W. Schwartz, Jinyang Li, Kathryn Sun, H. Carlo Maurer, Kenneth P. Olive, Robert B. Faryabi, Ben Z. Stanger
Summary: Through studying the tumor vascular environment, the use of the endothelial index (EI) and vascular microenvironment signatures (VMS) can better assess tumor vascular density, which is associated with prognosis in certain cancer types. These findings suggest that these metrics may enable more precise deployment of antiangiogenesis therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Rajya L. Gurung, Liesel M. FitzGerald, Ebony Liu, Bennet J. McComish, Georgia Kaidonis, Bronwyn Ridge, Alex W. Hewitt, Brendan J. Vote, Nitin Verma, Jamie E. Craig, Kathryn P. Burdon
Summary: This study identified genetic determinants associated with anti-VEGF treatment response in patients with DME through a genome-wide association study. Multiple genetic loci were found to predict treatment outcomes, potentially leading to personalized treatment approaches for managing DME.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Ochuwa Adiketu Babah, Oyesola Oyewole Ojewunmi, Akinniyi Adediran Osuntoki, Melissa A. Simon, Bosede Bukola Afolabi
Summary: The study aimed to investigate the association between VEGF gene polymorphisms and endometriosis in Nigerian women. Results showed no significant difference in VEGF levels between cases and controls, and the distribution of VEGF gene polymorphisms was also not significantly different between endometriosis patients and controls.
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Biochemistry & Molecular Biology
Barbara Vizio, Ornella Bosco, Ezio David, Gian Paolo Caviglia, Maria Lorena Abate, Martina Schiavello, Angela Pucci, Antonina Smedile, Gianluca Paraluppi, Renato Romagnoli, Enrico Lupia, Graziella Bellone, Giuseppe Montrucchio
Summary: The study revealed that THPO and VEGF-A expression levels were significantly elevated in tumor tissues compared to liver cirrhosis tissues in HCC patients. There was a linear correlation between THPO and VEGF-A transcripts in HCC, indicating a potential interdependent regulation between the two growth factors in promoting cellular growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Giovanni Vitale, Alessia Cozzolino, Pasqualino Malandrino, Roberto Minotta, Giulia Puliani, Davide Saronni, Antongiulio Faggiano, Annamaria Colao
Summary: Neuroendocrine neoplasms are tumors originating from neuroendocrine cells in different organs, with dysregulation of receptor tyrosine kinases playing a crucial role in their development and progression. Research on the role of the fibroblast growth factor receptor system in NENs and the potential of FGFR selective inhibitors shows promising anti-tumor activity in advanced NEN patients, with further studies needed for confirmation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Review
Orthopedics
Chao Zhang, Lin Wang, Chuang Xiong, Runhan Zhao, Hao Liang, Xiaoji Luo
Summary: This meta-analysis of 22 studies involving 1144 patients suggests that elevated VEGF expression is significantly associated with poor prognosis and adverse clinicopathological characteristics in patients with osteosarcoma, indicating its potential role as a predictive biomarker.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Yolanda Fernandez-Cladera, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Agustin F. Gonzalez-Rivero, Antonia De Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between VEGF and sVEGFR with SLE disease-related features and found that serum levels of VEGF and sVEGFR in SLE patients were associated with disease damage, with musculoskeletal manifestations being the most commonly associated feature.
Review
Pediatrics
Monica G. Hasmasanu, Lucia M. Procopciuc, Melinda Matyas, Gabriela I. Zonda, Gabriela C. Zaharie
Summary: In this study, the relationship between VEGF genetic polymorphisms and neonatal pathology was investigated. The results suggest that VEGF genetic polymorphisms are associated with neonatal pathology, particularly retinopathy of prematurity.
Article
Biochemistry & Molecular Biology
Emily R. Mahoney, Logan Dumitrescu, Annah M. Moore, Francis E. Cambronero, Philip L. De Jager, Mary Ellen Koran, Vladislav A. Petyuk, Rena A. S. Robinson, Sandeep Goyal, Julie A. Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman
Summary: The study revealed that the VEGF gene family plays a complex role in neuroprotection and is associated with cognitive performance, cognitive decline, and Alzheimer's disease pathology.
MOLECULAR PSYCHIATRY
(2021)