Article
Medicine, General & Internal
Ying Zuo, Jia Zhong, Hua Bai, Bin Xu, Zhijie Wang, Weihua Li, Yedan Chen, Shi Jin, Shuhang Wang, Xin Wang, Rui Wan, Jiachen Xu, Kailun Fei, Jiefei Han, Zhenlin Yang, Hua Bao, Yang Shao, Jianming Ying, Qibin Song, Jianchun Duan, Jie Wang
Summary: This study investigates the molecular characteristics of pulmonary enteric adenocarcinoma (PEAC) and lung metastatic colorectal cancer (lmCRC). The results reveal that EGFR is the key driver mutation in PEAC, while KRAS and ERBB2 are more frequently observed. In lmCRC, KRAS and APC mutations are significantly enriched. Copy number variations in certain chromosome arms were also observed between PEAC and lmCRC. Additionally, a DNA methylation-based classifier consisting of eight differentially methylated regions (DMRs) was established, providing a reliable auxiliary diagnosis for PEAC and lmCRC.
Article
Multidisciplinary Sciences
Aroosha Raja, Muhammad Faraz Arshad Malik, Farhan Haq
Summary: The study identified that dysregulation of six genes in FGFs and IGF pathways in PDAC were significantly associated with clinical characteristics and overall survival. Overexpression of FGF14 was specifically linked to better overall survival in all three cohorts, making it a potential independent prognostic marker. FMN2 and PGR were identified as top genes correlated with FGF14, suggesting their potential as prognostic markers and new therapeutic targets in PDAC.
Article
Oncology
Anqi Lin, Ningning Zhou, Weiliang Zhu, Jiexia Zhang, Ting Wei, Linlang Guo, Peng Luo, Jian Zhang
Summary: Characterization of immunological and genomic differences between East Asian and Caucasian patients with small-cell lung cancer (SCLC) can provide important clinical therapies for East Asian patients. Immunogenicity and tumor mutation burden were higher in the East Asian cohort. Specific gene mutations were associated with survival in both cohorts.
CANCER CELL INTERNATIONAL
(2022)
Article
Health Care Sciences & Services
Alberto Izzotti, Gabriela Coronel Vargas, Alessandra Pulliero, Simona Coco, Irene Vanni, Cristina Colarossi, Giuseppina Blanco, Antonella Agodi, Martina Barchitta, Andrea Maugeri, Gea Oliveri Conti, Margherita Ferrante, Salvatore Sciacca
Summary: The study analyzed the interplay between miRNA expression and oncogene mutation, finding that miRNA analysis was more informative for predicting patient survival compared to mutation analysis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Genetics & Heredity
Si Shi, Shibin Chen, Menghang Wang, Bingchen Guo, Yaowu He, Hong Chen
Summary: This study evaluated the clinical significance of ATIRE events in LUAD and constructed a model for predicting survival. The study found that events involving ATIRE in LUAD were highly functional and clinically relevant.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Chris J. de Witte, Joachim Kutzera, Arne van Hoeck, Luan Nguyen, Ingrid A. Boere, Mathilde Jalving, Petronella B. Ottevanger, Christa van Schaik-van de Mheen, Marion Stevense, Wigard P. Kloosterman, Ronald P. Zweemer, Edwin Cuppen, Petronella O. Witteveen
Summary: In this study, the researchers explored the use of genomic information for stratifying treatment in ovarian cancer. By integrating clinical data, treatment response, survival data, and whole-genome sequencing profiles, they identified distinct ovarian cancer subgroups with different treatment responses and survival outcomes. This data may be used in the future for more personalized treatment choices in individuals with ovarian cancer.
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Carlos Martinez-Ruiz, James R. M. Black, Clare Puttick, Mark Hill, Jonas Demeulemeester, Elizabeth Larose Cadieux, Kerstin Thol, Thomas Jones, Selvaraju Veeriah, Cristina Naceur-Lombardelli, Antonia Toncheva, Paulina Prymas, Andrew Rowan, Sophia Ward, Laura Cubitt, Foteini Athanasopoulou, Oriol Pich, Takahiro Karasaki, David Moore, Roberto Salgado, Emma Colliver, Carla I. Castignani, Michelle Dietzen, Ariana Huebner, Maise Al Bakir, Miljana G. Tanic, Thomas B. K. Watkins, Emilia Lim, Ali Al-Rashed, Danny Lang, James Clements, Daniel J. Cook, Rachel Rosenthal, Gareth Wilson, Alexander G. Frankell, Sophie de Carne Trecesson, Philip East, Nnennaya Kanu, Kevin Litchfield, Nicolai Birkbak, Allan Hackshaw, Stephan Beck, Peter Van Loo, Mariam Jamal-Hanjani, Charles Swanton, Nicholas McGranahan
Summary: In this study, intratumour transcriptomic diversity in non-small cell lung cancer tumours was investigated using paired whole-exome and RNA sequencing data. It was found that the transcriptome plays a major role in driving intratumour heterogeneity, lung cancer evolution, and metastasis. The study also revealed the involvement of allele-specific expression and RNA-editing enzymes in these processes.
Article
Engineering, Environmental
Rongrong Fan, Lin Xu, Bowen Cui, Daochuan Li, Xueying Sun, Yuan Qi, Jianan Rao, Kai Wang, Cheng Wang, Kunming Zhao, Yanjie Zhao, Juncheng Dai, Wen Chen, Hongbing Shen, Yu Liu, Dianke Yu
Summary: This study found that fine particulate matter (PM2.5) exposure causes DNA mutations and abnormal gene expression leading to lung cancer. The mechanisms behind this association are still unknown. Through analyzing genomic and transcriptomic changes in a human bronchial epithelial cell-based model, it was discovered that PM2.5 exposure led to APOBEC mutational signatures and transcriptional activation of APOBEC3B and other potential oncogenes. Additionally, it was observed that in non-small cell lung cancers (NSCLCs) from Chinese cohorts, there was a higher prevalence of APOBEC mutational signatures in non-smoking NSCLCs compared to smoking NSCLCs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Qifeng Ding, Donglai Chen, Shanshan Shen, Wei Wang, Liangyan Chen, Shanzhou Duan, Yongbing Chen
Summary: This study aimed to investigate the potential of complex glandular patterns (CGP) in lymph node micrometastasis (LNMM) and to determine the clinical beneficiaries in stage I lung adenocarcinoma (LUAD) with CGP. The logistic regression model indicated that CGP was an independent predictor of LNMM. Adequate lymphadenectomy and adjuvant chemotherapy were associated with improved survival in CGP-present patients, especially in CGP-present/LNMM-positive subgroup.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Oncology
Yang Wang, Shilei Qin, Yuepei Liang, Ling Yan, Min Zheng, Yanwu Zeng, Leilei Lu
Summary: This study conducted genetic sequencing on Chinese lung cancer patients and found that high-grade tumors were more likely to have mutations in the TP53 and PIK3CA genes compared to low-grade tumors. Pathway analysis also revealed that high-grade tumors had more mutations in genes related to bacterial invasion, Epstein-Barr virus infection, and the Wnt signaling pathway. These findings suggest that high-grade lung cancer may be influenced by bacteria and EB virus, and may benefit more from immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Chiara Capitani, Ginevra Chioccioli Altadonna, Michele Santillo, Elena Lastraioli
Summary: Despite improvements in treatment, lung cancer continues to be a major global health problem. Adenocarcinoma is the most common subtype, while Small Cell Lung Cancer is the most challenging and difficult to treat. The standard care for these patients involves surgery, radiation therapy, and chemotherapy. The search for novel biomarkers that can aid in diagnosis and therapy is crucial.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Ming Li, Zhencong Chen, Tian Jiang, Xiaodong Yang, Yajing Du, Jiaqi Liang, Lin Wang, Junjie Xi, Miao Lin, Mingxiang Feng
Summary: A circadian rhythm signature based on ten-gene signatures could predict overall survival in both TCGA lung adenocarcinoma and lung squamous cell carcinoma. The oscillations driven by CCRGs could disrupt cancer cell metabolism and cellular functions, leading to suppression of critical cells in specific anti-tumor immunity processes. This study also found that CCRGs were evolutionarily conserved with low mutation rates, making it challenging to explore therapeutic targets.
Article
Oncology
Yong-Seok Kim, Der Sheng Sun, Juneyoung Ahn, Yongseon Kim, Jung-Sook Yoon, Hye Sung Won
Summary: This study provides insights into the genetic alterations associated with disease recurrence in early stage HER2-positive breast cancer, highlighting the activation of oncogenic signaling pathways related to cell proliferation, adhesion, cancer stemness, and noninflamed tumor microenvironment as risk factors for recurrence. These findings can aid in the development of effective risk-adapted therapeutic strategies.
Article
Oncology
Viswam S. Nair, Angela Bik-Yu Hui, Jacob J. Chabon, Mohammad S. Esfahani, Henning Stehr, Barzin Y. Nabet, Li Zhou, Aadel A. Chaudhuri, Jalen Benson, Kelsey Ayers, Harmeet Bedi, Meghan Ramsey, Ryan Van Wert, Sanja Antic, Natalie Lui, Leah Backhus, Mark Berry, Arthur W. Sung, Pierre P. Massion, Joseph B. Shrager, Ash A. Alizadeh, Maximilian Diehn
Summary: This study compared tumor-derived mutations in bronchoalveolar lavage (BAL) samples to matched plasma samples from non-small cell lung cancer (NSCLC) patients. The results showed that more tumor variants were detected in BAL cell-free DNA (cfDNA) than in plasma cfDNA, especially in early-stage disease. The study also found low levels of cancer-associated driver mutations in BAL cfDNA from controls, suggesting the presence of somatic mutations in nonmalignant airway cells. Targeted sequencing of BAL cfDNA is technically feasible and appears to be more sensitive than plasma profiling for detecting tumor-derived mutations.
Article
Oncology
Jos B. Poell, Leon J. Wils, Arjen Brink, Ralf Dietrich, Christine Krieg, Eunike Velleuer, Ilkay Evren, Elisabeth R. Brouns, Jan G. de Visscher, Elisabeth Bloemena, Bauke Ylstra, Ruud H. Brakenhoff
Summary: This study developed a noninvasive genetic assay to detect genetically altered fields in the oral cavity. The assay demonstrated high accuracy and predicted the development of oral squamous cell carcinoma in high-risk individuals. This method can be used for cancer screening in high-risk populations and to map the extent of lesions beyond what is visible.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Hematology
Jakoba J. Eertink, Gerben J. C. Zwezerijnen, Sanne E. Wiegers, Simone Pieplenbosch, Martine E. D. Chamuleau, Pieternella J. Lugtenburg, Daphne de Jong, Bauke Ylstra, Matias Mendeville, Ulrich Duehrsen, Christine Hanoun, Andreas Huettmann, Julia Richter, Wolfram Klapper, Yvonne W. S. Jauw, Otto S. Hoekstra, Henrica C. W. de Vet, Ronald Boellaard, Josee M. Zijlstra
Summary: This study investigated whether combining clinical, molecular genotype, and radiomics features can improve the outcome prediction of patients with aggressive B-cell lymphoma. The results showed that adding radiomics features improved the model performance and positive predictive values, aiding in the identification of poor prognosis patients.
Article
Clinical Neurology
Peter Hermann, Matthias Schmitz, Maria Cramm, Stefan Goebel, Timothy Bunck, Julia Schuette-Schmidt, Walter Schulz-Schaeffer, Christine Stadelmann, Jakob Matschke, Markus Glatzel, Inga Zerr
Summary: This study evaluated the application of CSF real-time quaking-induced conversion in Creutzfeldt-Jakob disease surveillance, investigating its test accuracy, influencing factors, and associations with disease incidence. The results showed that the overall sensitivity of the test for sporadic Creutzfeldt-Jakob disease was 90% and the specificity was 99%. Lower sensitivity was associated with early disease stage and longer survival, while false positives were more common in patients with inflammatory CNS diseases. The surveillance improved after the amendment of diagnostic criteria, with no significant changes in incidence during the COVID-19 pandemic.
JOURNAL OF NEUROLOGY
(2023)
Article
Oncology
G. Tjitske Los-de Vries, Phylicia Stathi, Ryanne Rutkens, Nathalie J. Hijmering, Jeroen A. C. W. Luijks, Patricia J. T. A. Groenen, Daphne de Jong, Bauke Ylstra, Margaretha G. M. Roemer
Summary: Primary and relapsed LBCL-IP have a common set of genetic alterations that support survival and proliferation, providing insight into the disease progression.
Article
Gastroenterology & Hepatology
Maarten te Groen, Lauranne A. A. P. Derikx, Lisa van Lierop, Bauke Ylstra, Frank Hoentjen, Iris D. Nagtegaal, Femke Simmer
Summary: The presence of previous colorectal neoplasia is the most significant indicator for the development of pouch neoplasia in inflammatory bowel disease. However, the underlying mechanism remains unknown. Our study found evidence of clonality between colorectal and pouch neoplasia in 30% of patients, suggesting that most pouch neoplasia develops independently from prior colorectal lesions.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Nanoscience & Nanotechnology
Dominik Kylies, Marina Zimmermann, Fabian Haas, Maria Schwerk, Malte Kuehl, Michael Brehler, Jan Czogalla, Lola C. Hernandez, Leonie Konczalla, Yusuke Okabayashi, Julia Menzel, Ilka Edenhofer, Sam Mezher, Hande Aypek, Bernhard Dumoulin, Hui Wu, Smilla Hofmann, Oliver Kretz, Nicola Wanner, Nicola M. Tomas, Susanne Krasemann, Markus Glatzel, Christoph Kuppe, Rafael Kramann, Bella Banjanin, Rebekka K. Schneider, Christopher Urbschat, Petra Arck, Nicola Gagliani, Marc van Zandvoort, Thorsten Wiech, Florian Grahammer, Pablo J. Saez, Milagros N. Wong, Stefan Bonn, Tobias B. Huber, Victor G. Puelles
Summary: Expansion microscopy physically enlarges biological specimens to achieve nanoscale resolution, but its applicability is limited due to the requirement of laser-based systems. A computational method called super-resolution radial fluctuations (SRRF) has been developed as an alternative. In this study, we introduce a workflow called expansion-enhanced super-resolution radial fluctuations (ExSRRF), which provides a resolution of up to 25 nm using LED-based widefield microscopy. ExSRRF enables molecular profiling of subcellular structures in complex clinical and experimental specimens and shows potential application in identifying pathological features.
NATURE NANOTECHNOLOGY
(2023)
Meeting Abstract
Oncology
Lotte Stegat, Jenny L. Rohwer, Damian Stichel, Daniel Schrimpf, Roland Coras, Melanie Pages, Arnault Tauziede-Espariat, Pascale Varlet, Volkmar H. Hans, Jochen Meyer, Jens Schittenhelm, Ori Staszewski, Edmund Cheesman, Markus Glatzel, Simone Schmid, Pieter Wesseling, Andrey Korshunov, Alexandra Sexton-Oates, Ulrich Schueller, Lenne-Triin Korgvee, Sabine Mueller, Adriana Olar, Matija Snuderl, Leonille Schweizer, Eleonora Aronica, Felix Sahm, Andreas von Deimling, Ingmar Blumcke, David T. W. Jones, David Capper, Annika K. Wefers
Article
Multidisciplinary Sciences
Marvin Petersen, Felix Leonard Naegele, Carola Mayer, Maximilian Schell, Elina Petersen, Simone Kuehn, Juergen Gallinat, Jens Fiehler, Ofer Pasternak, Jakob Matschke, Markus Glatzel, Raphael Twerenbold, Christian Gerloff, Goetz Thomalla, Bastian Cheng
Summary: Through comprehensive neuroimaging and neuropsychological assessments of 223 nonvaccinated individuals recovered from a mild to moderate SARS-CoV-2 infection, it was found that there were significant differences in measures of white matter microstructure between the post-SARS-CoV-2 group and the matched controls. However, a mild to moderate SARS-CoV-2 infection was not associated with neuropsychological deficits, significant changes in cortical structure, or vascular lesions several months after recovery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Neurosciences
Matthias Schmitz, Niccolo Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zerr
Summary: Alpha-synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are neurodegenerative diseases characterized by intracellular inclusions of misfolded alpha-synuclein. The pathological overlap between Parkinson's disease and dementia with Lewy bodies raises the question of whether they are the same or different diseases. Protein seeding assays, such as real-time quaking-induced conversion, can help distinguish between different types of alpha-synucleinopathies by analyzing the conversion properties of misfolded alpha-synuclein. Understanding the influence of different conformers of misfolded alpha-synuclein on disease progression and phenotype will be crucial for personalized medical treatment in the future.
TRANSLATIONAL NEURODEGENERATION
(2023)
Letter
Hematology
Wendy B. C. Stevens, G. Tjitske Los-de Vries, Carole Langois-Jacques, Andrew J. Clear, Phylicia Stathi, Birgitta Sander, Andreas Rosenwald, Maria Calaminici, Eva Hoster, Wolfgang Hiddemann, Philippe Gaulard, Gilles Salles, Wolfram Klapper, Luc Xerri, Catherine Burton, Reuben M. Tooze, Alexandra G. Smith, Christian Buske, David W. Scott, Yasodha Natkunam, Ranjana Advani, Laurie H. Sehn, John Raemaekers, John Gribben, Sandra Lockmer, Eva Kimby, Marie Jose Kersten, Delphine Maucort-Boulch, Bauke Ylstra, Erik van Dijk, Daphne de Jong
Article
Hematology
Patricia Johansson, Stefan Alig, Julia Richter, Christine Hanoun, Jan Rekowski, Jan Duerig, Bauke Ylstra, Daphne de Jong, Wolfram Klapper, Ash A. Alizadeh, Ulrich Duehrsen, Andreas Huettmann
Summary: In DLBCL, a positive interim PET scan predicts treatment failure, and combining it with the presence of an IgM gammopathy can improve prediction. The combination of interim PET and IgM gammopathy can dichotomize the population into high-risk and low-risk groups with significantly different outcomes. Only the interim PET result and IgM gammopathy status were significantly associated with outcome, making them important factors in risk-adapted treatment strategies.
ANNALS OF HEMATOLOGY
(2023)
Editorial Material
Hematology
Bauke Ylstra, Daphne de Jong
Summary: In this study, the authors demonstrate the usefulness of a dark zone signature (DZsig) for diagnosing aggressive B-cell lymphoma with DLBCL morphology, and highlight its strong prognostic value.
Article
Pathology
Tanya T. D. Soeratram, Hedde D. Biesma, Jacqueline M. P. Egthuijsen, Elma Meershoek-Klein Kranenbarg, Henk H. Hartgrink, Cornelis J. H. van de Velde, Aart Mookhoek, Erik van Dijk, Yongsoo Kim, Bauke Ylstra, Hanneke W. M. van Laarhoven, Nicole C. T. van Grieken
Summary: Tumor-infiltrating lymphocytes are important for the survival of gastric cancer patients, and T-cell densities in different regions of the tumor can serve as prognostic markers. CD8OIM and FOXP3TC are identified as key factors for survival, and the combination of their densities can stratify patients into distinct subgroups with different prognosis. These immune subgroups are independent predictors for cancer-specific survival in resectable gastric cancer.
Article
Cell Biology
Evangelos Prokakis, Shaishavi Jansari, Angela Boshnakovska, Maria Wiese, Kathrin Kusch, Christof Kramm, Christian Dullin, Peter Rehling, Markus Glatzel, Klaus Pantel, Harriet Wikman, Steven A. Johnsen, Julia Gallwas, Florian Wegwitz
Summary: This study identifies the essential role of RNF40 in supporting the aggressive behavior of triple-negative breast cancer by regulating gene transcription and promoting specific signaling pathways. Targeting RNF40 may have high therapeutic value in combating the malignant behavior of TNBC.
CELL DEATH & DISEASE
(2023)
Review
Microbiology
Fabian Heinrich, Kirsten D. Mertz, Markus Glatzel, Martin Beer, Susanne Krasemann
Summary: The emergence of COVID-19 has resulted in millions of deaths. Autopsies have greatly contributed to our understanding of disease pathology, highlighted the importance of virology research, and improved clinical practice.
NATURE MICROBIOLOGY
(2023)