Article
Biochemical Research Methods
Harold P. Frisch, Allan Sprau, Virginia F. McElroy, James D. Turner, Laura R. E. Becher, Wendy K. Nevala, Alexey A. Leontovich, Svetomir N. Markovic
Summary: The Cancer Immune Control Dynamics (CICD) model quantifies the complexity of the immune system through analyzing interactions between multiple biomarkers, providing initial evidence of differences in systemic immunity between cancer patients and healthy volunteers. The model-based analysis identified a network of immune cells and cytokines that play a role in sustaining immunity in advanced cancer, showcasing the potential for CICD-based tools to address cancer-specific immune parameters.
BMC BIOINFORMATICS
(2021)
Article
Oncology
Ji Hyun Lee, Sujin Hyung, Jeeyun Lee, Sang-Hee Choi
Summary: This study showed that visceral adiposity and systemic inflammation are significant prognostic factors in patients with unresectable or metastatic melanoma receiving immune checkpoint inhibitors. The prognostic impact of visceral adiposity is dependent on systemic inflammation status.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Xue Liao, Guidong Gong, Mengyuan Dai, Zhenyu Xiang, Jiezhou Pan, Xianglian He, Jiaojiao Shang, Anna Maria Blocki, Zongmin Zhao, C. Wyatt Shields IV, Junling Guo
Summary: Cell-based therapies have shown remarkable success in targeted drug delivery. In this study, a tumor-targeting cellular drug delivery system called MAGN was developed by engineering macrophages with biologically responsive nanosponges. The nanosponges are designed to release drugs in the acidic tumor microenvironment, enabling efficient tumor-targeted delivery and suppression of tumor burden and lung metastases.
Article
Oncology
Adi Kartolo, Jasna Deluce, Wilma M. Hopman, Linda Liu, Tara Baetz, Scott Ernst, John G. Lenehan
Summary: This study aimed to evaluate the optimal systemic therapy sequencing for patients with BRAF-mutated metastatic melanoma. The researchers found that patients who received first-line targeted therapy followed by second-line immunotherapy had the longest overall survival. Furthermore, they discovered that immunotherapy showed durable efficacy in advanced BRAF-mutated melanoma patients, regardless of treatment line.
Article
Immunology
Yunqin Shen, Lingjie Li, Wushi Chen, Qin Li, Yixuan Xu, Fang He, Caixia Wang, Zezhong Tian, Yanqiu Chen, Yan Yang
Summary: This study found that the deficiency of ApoE could aggravate airway inflammation and remodeling in mice with OVA-induced chronic asthma, suggesting that ApoE has a negative regulatory role in chronic asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Himanshu N. Bhatt, Rimpy Diwan, Edgar A. Borrego, Carlos Alberto Martinez Perez, Armando Varela-Ramirez, Raj Kumar, Renato J. Aguilera, Md Nurunnabi
Summary: Solid tumors are abnormal mass of tissue that affect organs and cause dysfunction. Delivering anticancer therapeutics to the deepest layers of solid tumors is a major challenge due to excessive extracellular matrix deposition. To address this, a Bimodal Light Assisted Skin Tumor and Metastasis Treatment (BLAST) was developed, combining photothermal and chemotherapeutic moieties to penetrate the tumor and prevent metastasis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Charmaine van Eeden, Desiree Redmond, Naima Mohazab, Maggie J. J. Larche, Andrew L. L. Mason, Jan Willem Cohen Tervaert, Mohammed S. S. Osman
Summary: This study aimed to assess the prevalence of ME/CFS in early limited cutaneous systemic sclerosis (lcSSc) patients and determine if alterations in mitochondrial gene expression and mtDNA integrity could be used to distinguish between fatigued and non-fatigued patients. ME/CFS-related symptoms were assessed through questionnaires, and the expression of mitochondrial gene transcripts and mtDNA integrity were quantified. The study found that SSc patients with ME/CFS could be differentiated from non-fatigued patients through mitochondrial gene analysis, specifically with reduced expression of ND4 and CyB and increased expression of Cox7C. ND4 and CyB expression were also correlated with disease severity indicators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Julian Steininger, Frank Friedrich Gellrich, Alexander Schulz, Dana Westphal, Stefan Beissert, Friedegund Meier
Summary: Malignant melanoma is a highly aggressive and metastatic skin cancer, with immunotherapy and targeted therapy showing significant improvement in treatment outcomes by enhancing immune responses and inhibiting abnormal cell growth.
Article
Oncology
Patrick Demkowicz, Renelle Pointdujour-Lim, Sofia Miguez, Yesung Lee, Bailey S. C. L. Jones, Christopher A. Barker, Marcus Bosenberg, David H. Abramson, Alexander N. Shoushtari, Harriet Kluger, Jasmine H. Francis, Mario Sznol, Mathieu F. Bakhoum
Summary: This study retrospectively analyzed clinical data of patients with metastatic uveal melanoma and found that female sex, treatment with immune checkpoint inhibitors, and the absence of liver metastasis were associated with better survival outcomes. These findings highlight the potential of immunotherapy in treating metastatic uveal melanoma.
Article
Veterinary Sciences
Jessica Soares Garcia, Victor Nowosh, Rossana Veronica Mendoza Lopez, Cristina de Oliveira Massoco
Summary: This study aimed to evaluate the impact of inflammatory indices in dogs with oral melanoma before treatment. The results suggest that CRP/ALB ratio and frequency of circulating Tregs may serve as potential prognostic markers in canine patients with oral melanoma.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
L. Susok, S. Said, D. Reinert, R. Mansour, C. H. Scheel, J. C. Becker, T. Gambichler
Summary: The pan-immune-inflammation value (PIV) and systemic immune-inflammation index (SII) in patients with cutaneous melanoma (CM) under immune checkpoint inhibitor (ICI) therapy do not seem to be significant predictors for clinical outcome measures of CM patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Immunology
Sanling Shi, Shuting Kong, Weicheng Ni, Yucheng Lu, Junfeng Li, Yuheng Huang, Jinxin Chen, Ken Lin, Yuanmiao Li, Jiayu Ke, Hao Zhou
Summary: The present study found that the systemic immune-inflammation index (SII) is associated with adverse prognosis in cardiovascular disease. This conclusion was drawn from a follow-up study of 744 patients diagnosed with acute coronary syndrome and chronic kidney disease, who were divided into high and low SII groups. The results showed that patients in the low SII group had higher survival rates and lower risk of major cardiovascular events compared to those in the high SII group. Multivariable analysis also revealed that a high SII level was independently associated with major cardiovascular events in ACS patients with CKD.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Alexej Ballhausen, Elizabeth Urias, Stephen K. Gruschkus, Michelle Williams, Maura S. Glover, Yong Qin, Dan S. Gombos, Sapna P. Patel
Summary: The study found that in uveal melanoma Class 1A patients, those with stage III disease and/or large COMS size are at elevated risk for metastasis. Combined clinical decision-making using AJCC stage and COMS size can have a significant impact on improving risk stratification and adapting follow-up intervals for Class 1A UM patients.
Article
Gastroenterology & Hepatology
Yuji Miyamoto, Takahiko Akiyama, Rikako Kato, Hiroshi Sawayama, Katsuhiro Ogawa, Naoya Yoshida, Hideo Baba
Summary: This study aimed to evaluate the associations between systems of evaluating pretreatment systemic inflammation and outcomes according to K-ras genotypes in patients with metastatic colorectal cancer. The results showed that systemic inflammation indices have stronger prognostic significance in patients with K-ras wild-type metastatic colorectal cancer.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Multidisciplinary Sciences
Thomas Vogl, Iris N. Kalka, Shelley Klompus, Sigal Leviatan, Adina Weinberger, Eran Segal
Summary: This study reveals distinct antibody responses against gut microbiota in patients with severe ME/CFS compared to healthy controls. Machine learning algorithms utilizing these differences provide improved molecular diagnostics for ME/CFS, indicating the involvement of the microbiota-immune axis in its pathogenesis.
Article
Medicine, General & Internal
Anthony H. Kashou, Jose R. Medina-Inojosa, Peter A. Noseworthy, Richard J. Rodeheffer, Francisco Lopez-Jimenez, Itzhak Zachi Attia, Suraj Kapa, Christopher G. Scott, Alexander T. Lee, Paul A. Friedman, Paul M. McKie
Summary: The study validated the effectiveness of an AI-ECG algorithm in detecting LVSD, showing high sensitivity and specificity, making it a potential screening tool.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Cardiac & Cardiovascular Systems
Scott A. Hubers, Siu-Hin Wan, Fadi W. Adel, Sherry L. Benike, John C. Jr Jr Burnett, Christopher Scott, Horng H. Chen
Summary: In patients with pre-heart failure, long-term tadalafil did not improve renal function or cardiorenal response after short-term volume load. This study does not support the use of PDEV inhibition to enhance renal response in patients with pre-heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Kathleen A. Young, Christopher G. Scott, Richard J. Rodeheffer, Horng H. Chen
Summary: The incidence of preclinical HF is high in a community population, with hypertension, obesity, and diastolic dysfunction being associated with its development.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Patricia A. Pellikka, Ratnasari Padang, Christopher G. Scott, Shannon M. E. Murphy, Rosalind Fabunmi, Jeremy J. Thaden
Summary: This study analyzed the association of managing provider type with cardiac specialist follow-up, AVR, and mortality for patients with newly diagnosed severe aortic stenosis (sAS). The results showed differences in rates of cardiac specialist follow-up and AVR and risk of mortality between primary care provider- versus cardiologist-managed patients with sAS. In addition, a lower likelihood of receiving follow-up and AVR was independently associated with higher mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Michelle Partogi, Simon Gaviria-Valencia, Mateo Alzate Aguirre, Nancy J. Pick, Huzefa M. Bhopalwala, Barbara A. Barry, Vinod C. Kaggal, Christopher G. Scott, Maya E. Kessler, Matthew M. Moore, Jay Mitchell, Rajeev Chaudhry, Robert P. Bonacci, Adelaide M. Arruda-Olson
Summary: A multidisciplinary team developed a rural-specific, team-based model of care intervention assisted by clinical decision support (CDS) technology using participatory design in a sociotechnical conceptual framework. The intervention included redesigned workflows and a novel CDS tool for the coordination and delivery of guideline recommendations by primary care teams in a rural clinic. The pilot trial demonstrated feasibility and potential for successful implementation of the sociotechnical intervention.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
LaPrincess C. Brewer, Janice Bowie, Joshua P. Slusser, Christopher G. Scott, Lisa A. Cooper, Sharonne N. Hayes, Christi A. Patten, Mario Sims
Summary: This study found that higher levels of religiosity/spirituality were associated with better cardiovascular health among African Americans, including various Life's Simple 7 indicators. Reinforcing religiosity/spirituality in lifestyle interventions may reduce cardiovascular disease risk among African Americans.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Oncology
Celine M. Vachon, Christopher G. Scott, Aaron D. Norman, Sadia A. Khanani, Matthew R. Jensen, Carrie B. Hruska, Kathleen R. Brandt, Stacey J. Winham, Karla Kerlikowske
Summary: The contribution of artificial intelligence (AI) algorithms to long-term risk prediction for advanced and interval breast cancers is unknown.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Immunology
Abinash Virk, Matthew G. Johnson, Daniel L. Roellinger, Christopher G. Scott, Priya Sampathkumar, Laura E. Breeher, Melanie Swift
Summary: This study aimed to understand if 2 or more mRNA vaccine doses provide additional protection in patients with prior COVID-19 infection, or if infection alone provides comparable protection. The results showed that vaccination was associated with a lower risk of COVID-19, including in those with prior infection. Therefore, vaccination should be encouraged for all, especially as new variants emerge and variant-specific booster vaccines become available.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Tomoko Ichiki, Valentina Cannone, Christopher G. Scott, Seethalakshmi R. Iyer, S. Jeson Sangaralingham, Kent R. Bailey, Jens P. Goetze, Yoshihisa Tsuji, Richard J. Rodeheffer, John C. Burnett
Summary: Males have lower levels of ANP and BNP and higher prevalence of cardiometabolic disease. The ANP gene variant rs5068 is associated with better metabolic function in males, while the BNP gene variant rs198389 is not associated with metabolic profile in the general population. ANP may play a more significant role in metabolic homeostasis, especially in males.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jwan A. Naser, Eunjung Lee, Christopher G. Scott, Austin M. Kennedy, Patricia A. Pellikka, Grace Lin, Sorin Pislaru, Barry A. Borlaug
Summary: This study aimed to investigate the prevalence and incidence of DD in patients with new-onset AF compared with SR. The results showed that patients with new-onset AF have high-risk features for HFpEF at diagnosis and accelerated progression in DD over time.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Li-Tan Yang, Zi Ye, Muhammad Wajih Ullah, Joseph J. Maleszewski, Christopher G. Scott, Ratnasari Padang, Sorin Pislaru, Vuyisile T. Nkomo, Sunil Mankad, Patricia A. Pellikka, Jae K. Oh, Veronique L. Roger, Maurice Enriquez-Sarano, Hector Michelena
Summary: This study aimed to assess lifetime morbidity and long-term survival in patients with bicuspid aortic valve (BAV) in the community. The results showed that BAV patients have a high lifetime morbidity burden, with a high incidence of complications such as aortic stenosis or regurgitation, aortic surgery, aortic aneurysm, infective endocarditis, and aortic dissection. Compared to patients with typical valvulo-aortopathy, patients with complex valvulo-aortopathy have lower survival rates.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jwan A. Naser, Hector Michelena, Grace Lin, Christopher G. Scott, Eunjung Lee, Austin M. Kennedy, Peter A. Noseworthy, Patricia A. Pellikka, Vuyisile T. Nkomo, Sorin Pislaru
Summary: The aim of this study was to investigate the incidence, risk factors, and clinical significance of atrial functional mitral regurgitation (AFMR) in patients with atrial fibrillation (AF) or sinus rhythm (SR). The results showed that the incidence rate of >mild AFMR was 2.6 per 100 person-year in new-onset AF and 0.7 per 100 person-year in SR. Age, sex, left atrial volume index (LAVI), and diastolic dysfunction (DD) were independent risk factors for incident AFMR. AFMR was associated with increased risk of all-cause death.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Oncology
Alison S. Rustagi, Christopher G. Scott, Stacey J. Winham, Kathleen R. Brandt, Aaron D. Norman, Matthew R. Jensen, John A. Shepherd, Carrie Hruska, John J. Heine, Vernon S. Pankratz, Karla Kerlikowske, Celine M. Vachon
Summary: The study showed that high alcohol intake and breast density increase the risk of breast cancer, with dense volume possibly mediating part of the alcohol-breast cancer association. Breast density did not modify the association between alcohol intake and breast cancer, suggesting that alcohol may increase breast cancer risk in part by increasing fibroglandular tissue.
JNCI CANCER SPECTRUM
(2021)
Article
Cardiac & Cardiovascular Systems
Li-Tan Yang, Giovanni Benfari, Mackram Eleid, Christopher G. Scott, Vuyisile T. Nkomo, Patricia A. Pellikka, Nandan S. Anavekar, Maurice Enriquez-Sarano, Hector Michelena
Summary: This study found that patients with BAV-AR were younger, underwent surgery more frequently, and had higher survival rates, primarily determined by age rather than valve anatomy. Patients with haemodynamically significant AR and age >50-55 years require a low threshold for surgical referral to prevent symptom development.
Article
Cardiac & Cardiovascular Systems
Nahoko Kato, Jeremy J. Thaden, William R. Miranda, Christopher G. Scott, Maurice E. Sarano, Kevin L. Greason, Patricia A. Pellikka
Summary: The study evaluated the impact of AVR on MR in patients with sAS, finding that MR improved in nearly 60% of patients after AVR, even in the majority of patients with organic MR. Various factors were associated with MR improvement, and post-operative improvement in organic MR was associated with better survival.