Article
Multidisciplinary Sciences
Bing Wei, Fengxin Wu, Wenqun Xing, Haibo Sun, Chi Yan, Chengzhi Zhao, Dongqing Wang, Xiaobing Chen, Yanli Chen, Mingming Li, Jie Ma
Summary: The novel panel of three established lung cancer methylation biomarkers showed high sensitivity and specificity in distinguishing between malignant and benign lung disease. It was effective in detecting lung cancer noninvasively and was not biased by age, gender, smoking, or the presence of other (nonlung) cancers.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jennifer A. Karlow, Siddhartha Devarakonda, Xiaoyun Xing, Hyo Sik Jang, Ramaswamy Govindan, Mark Watson, Ting Wang
Summary: This study identified recurrent methylation patterns in brain metastases of non-small cell lung cancer (NSCLC), which may serve as prognostic biomarkers and contribute to disease progression. The altered DNA methylation was associated with the loss of EZH2 occupancy at developmental genes and changes in epigenetic regulation.
Article
Multidisciplinary Sciences
Adam Nagy, Gyoengyi Munkacsy, Balazs Gyorffy
Summary: This study aimed to estimate the prognostic effect of cancer hallmark genes in multiple distinct cancer types. The results showed significant heterogeneity and tissue specificity in the correlation between these genes and survival, providing valuable information for future targeted therapy development in solid tumors.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
James A. Miller, Anna Tatakis, Robert M. Van Haren, Sangita Kapur, Peterson Pathrose, Mona Hemingway, Sandra L. Starnes
Summary: This study reports the outcomes of a structured multidisciplinary lung cancer screening program in an area of endemic histoplasmosis, successfully identifying patients with early-stage lung cancer with limited unnecessary surgical interventions.
ANNALS OF THORACIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Ignacio Jusue-Torres, Richies Tiv, Julio C. Ricarte-Filho, Apurva Mallisetty, Leglys Contreras-Vargas, Maria Jose Godoy-Calderon, Karam Khaddour, Kathleen Kennedy, Klara Valyi-Nagy, Odile David, Martha Menchaca, Anastasia Kottorou, Angelos Koutras, Foteinos Dimitrakopoulos, Khaled M. Abdelhady, Malek Massad, Israel Rubinstein, Lawrence Feldman, John Stewart, Takeshi Shimamura, Ludmila Danilova, Alicia Hulbert
Summary: The study aimed to assess the impact of MYO1E overexpression on non-small cell lung carcinoma (NSCLC) and investigate the association between DNA methylation, RNA expression of MYO1E, and survival/mortality risk in NSCLC patients. The results show a negative correlation between DNA methylation and RNA expression of MYO1E in both LUAD and LUSC subpopulations. Late-stage LUAD patients had lower DNA methylation and higher RNA expression of MYO1E, while no significant differences were observed in LUSC patients. Low DNA methylation and high RNA expression of MYO1E were associated with shorter median survival time and increased mortality risk in LUAD, but not in LUSC. This study suggests that changes in MYO1E methylation and expression play a crucial role in the pathogenesis of lung cancer, particularly in LUAD, and highlights the potential utility of MYO1E DNA methylation and RNA expression as predictors of survival for LUAD patients. Furthermore, MYO1E DNA methylation could be used as a circulating tumor marker in liquid biopsies due to its low normal expression in blood cells.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Lanlan Wang, Yali Ma, Wenjie Han, Qiumin Yang, Muhammad Jamil
Summary: By performing Whole Exome Sequencing (WES) on Pakistani lung cancer patients, this study identified clinically important pathogenic mutations in 6 DNA repair genes and revealed their potential implications on prognosis. Down-regulation of these mutated genes and hypermethylation in their promoters were observed, indicating a potential convergence of genetic and epigenetic factors driving genomic instability in lung cancer cells. These findings contribute to our understanding of lung cancer susceptibility and offer potential avenues for targeted therapeutic interventions in Pakistani patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Genetics & Heredity
Fatemeh Khatami, Alireza Gorji, Mahdi Khoshchehreh, Rahil Mashhadi, Mahin Ahmadi Pishkuhi, Alireza Khajavi, Alireza Namazi Shabestari, Seyed Mohammad Kazem Aghamir
Summary: This study aimed to assess the role of methylation in recurrent kidney stone formation. The results showed that promoter hypermethylation in vitamin D receptor and claudin 14 genes may play a crucial role in recurrent kidney stone formation.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Md Faqrul Hasan, Kavya Ganapathy, Jiao Sun, Ayman Khatib, Thomas Andl, Julia N. Soulakova, Domenico Coppola, Wei Zhang, Ratna Chakrabarti
Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Ricardo Ribeiro Gama, Lidia Maria Rebolho Batista Arantes, Bruna Pereira Sorroche, Pedro De Marchi, Matias Eliseo Melendez, Raiany Santos Carvalho, Marcos Alves de Lima, Andre Luiz Vettore, Andre Lopes Carvalho
Summary: This study evaluated the biological action of valproic acid in HNSCC patients and found that the use of valproic acid in oral rinse led to a significant decrease in DCC gene methylation.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Fang Liu, Xiaoling Lu, Xiaoxi Zhou, He Huang
Summary: APC gene promoter methylation in serum or sputum/BLAF is a potential biomarker for lung cancer diagnosis with high specificity. However, due to its low sensitivity, it may not be suitable for lung cancer screening in the general population.
Article
Multidisciplinary Sciences
Buze Chen, Xiaojuan Ding, Ailing Wan, Xin Qi, Xiaoman Lin, Haihong Wang, Wenyu Mu, Gang Wang, Junnian Zheng
Summary: TLX2 plays an important role in multiple tumors and its abnormal expression is associated with a poor overall survival rate in several cancer types. The most common type of alteration in TLX2 is amplification, and it co-occurs with alterations in other genes. TLX2 has high methylation levels in various tumors. Its expression is related to immune infiltration, immune checkpoint genes, and chemoresistance.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Lila Zhu, Xinyu Li, Ying Yuan, Caixia Dong, Mengyuan Yang
Summary: The APC gene, known as a tumor suppressor gene, has two promoters 1A and 1B. Research on APC has mainly focused on its loss-of-function variants causing familial adenomatous polyposis. However, hypermethylation of the APC CpG sequence is also associated with carcinogenesis in various cancers, especially in gastrointestinal tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuo Wu, Xing Lv, Yan Zhang, Xi Xu, Feng Zhao, Yao Zhang, Lizhan Chen, Haifeng Ou-Yang, Xinyu Ti
Summary: This study identified differential expression of m6A mRNA methylation and related genes in lung cancer, including SPP1 and pRB. These differences may be associated with the cell cycle, specific intracellular compartments, and certain disease pathways.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Zoia Rossokha, Liliia Fishchuk, Olga Lobanova, Viktoriia Vershyhora, Nataliia Medvedieva, Valeriy Cheshuk, Roman Vereshchako, Svitlana Podolska, Natalia Gorovenko
Summary: The clinical significance of RUNX3 gene hypermethylation in the pathogenetic mechanisms of breast cancer in women, with its cohypermethylation with the BRCA1 gene, was evaluated. Hypermethylation of the RUNX3 gene promoter region was significantly higher in breast cancer patients compared to the control group, as well as the cohypermethylation of RUNX3 and BRCA1 genes. These findings highlight the importance of further investigations into suppressor gene cohypermethylation in breast cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Amisha Bharti, Amrita Ghosh Kar, Deepika Singh, Mumtaz Ahmad Ansari, Mallika Tewari, Gopeshwar Narayan, Sunita Singh
Summary: This study investigated the expression profile and promoter methylation status of BNIP3 in gallbladder cancer (GBC). The results demonstrated a down regulation of BNIP3 and frequent hypermethylation of its promoter in GBC samples. The study suggests that promoter hypermethylation may be a common mechanism for the downregulation of BNIP3 in GBC.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Oncology
Julien D. F. Licchesi, William H. Westra, Craig M. Hooker, Emi O. Machida, Stephen B. Baylin, James G. Herman
Article
Oncology
John Wrangle, Emi Ota Machida, Ludmila Danilova, Alicia Hulbert, Noreli Franco, Wei Zhang, Sabine C. Gloeckner, Mathewos Tessema, Leander Van Neste, Hariharan Easwaran, Kornel E. Schuebel, Julien Licchesi, Craig M. Hooker, Nita Ahuja, Jun Amano, Steven A. Belinsky, Stephen B. Baylin, James G. Herman, Malcolm V. Brock
CLINICAL CANCER RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
David Komander, Francisca Reyes-Turcu, Julien D. F. Licchesi, Peter Odenwaelder, Keith D. Wilkinson, David Barford
Article
Biochemistry & Molecular Biology
Xiaomei Zhang, Yunsheng Yang, Xuefeng Liu, James G. Herman, Malcolm V. Brock, Julien D. F. Licchesi, Wen Yue, Xuetao Pei, Mingzhou Guo
Article
Biochemistry & Molecular Biology
Julien D. F. Licchesi, Juliusz Mieszczanek, Tycho E. T. Mevissen, Trevor J. Rutherford, Masato Akutsu, Satpal Virdee, Farid El Oualid, Jason W. Chin, Huib Ovaa, Mariann Bienz, David Komander
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
J. D. F. Licchesi, L. Van Neste, V. K. Tiwari, L. Cope, X. Lin, S. B. Baylin, J. G. Herman
Article
Biochemistry & Molecular Biology
Vijay K. Tiwari, Kelly M. McGarvey, Julien D. F. Licchesi, Joyce E. Ohm, James G. Herman, Dirk Schubeler, Stephen B. Baylin
Article
Biochemistry & Molecular Biology
Lee D. Harris, Janic Le Pen, Nico Scholz, Juliusz Mieszczanek, Natalie Vaughan, Simon Davis, Georgina Berridge, Benedikt M. Kessler, Mariann Bienz, Julien D. F. Licchesi
Summary: This study reveals that HECTD1 is a mammalian E3 ligase that assembles branched K29/K48 chains and establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages. Ubiquitin is a versatile posttranslational modification, with atypical ubiquitin chains like K29 and K33 just starting to emerge in terms of regulation and function. Additionally, the study identified 50 proteins as potential substrates of TRABID based on their interaction with catalytic dead TRABID constructs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Editorial Material
Physiology
Julien D. F. Licchesi, Heike Laman, Fumiyo Ikeda, Victor M. Bolanos-Garcia
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Oncology
Nico Scholz, Kathreena M. Kurian, Florian A. Siebzehnrubl, Julien D. F. Licchesi
FRONTIERS IN ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi
Summary: The cell cycle is regulated by protein phosphorylation and ubiquitylation. This study reveals a novel potential role for HECTD1 during mitosis, as its depletion leads to decreased cell number, increased proportion of cells with aligned chromosomes, and prolonged mitosis.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Physiology
Julien D. F. Licchesi, Heike Laman, Fumiyo Ikeda, Fleur M. Ferguson, Victor M. Bolanos-Garcia
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Robert Byrne, Thomas Mund, Julien D. F. Licchesi
Article
Oncology
Yuanzi Yu, Wenji Yan, Xuefeng Liu, Yan Jia, Baoping Cao, Yingyan Yu, Youyong Lv, Malcolm V. Brock, Jame G. Herman, Julien Licchesi, Yunsheng Yang, Mingzhou Guo
AMERICAN JOURNAL OF CANCER RESEARCH
(2014)