Article
Biochemistry & Molecular Biology
Jennifer L. Bailey, Hardy Hang, Anik Boudreau, Carrie M. Elks
Summary: The study found that OSM induces adipocyte lipolysis via the p66Shc-ERK pathway, inhibiting the suppression of lipolysis by insulin, and inducing phosphorylation of inhibitory IRS1 residues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daenique H. A. Jengelley, Meijing Wang, Ashok Narasimhan, Joseph E. Rupert, Andrew R. Young, Xiaoling Zhong, Daniel J. Horan, Alexander G. Robling, Leonidas G. Koniaris, Teresa A. Zimmers
Summary: Musculoskeletal diseases can harm overall health and survival, with the Interleukin-6 family of cytokines, particularly IL-6, playing a role. Oncostatin M (OSM) has negative effects on muscle, bone, and the heart, causing muscle atrophy, bone loss, and cardiac dysfunction.
Article
Biochemistry & Molecular Biology
Anibal Garza Carbajal, Andrea Ebersberger, Alina Thiel, Luiz Ferrari, Jeremy Acuna, Stephanie Brosig, Joerg Isensee, Katharina Moeller, Maike Siobal, Stefan Rose-John, Jon Levine, Hans-Georg Schaible, Tim Hucho
Summary: Hyperalgesic priming is characterized by enhanced nociceptor sensitization by pronociceptive mediators, with PGE(2) as a prototypical example. In this study, the cytokine OncostatinM was identified as an inducer of priming through a novel mechanism involving cAMP/PKA to ERK signaling. This finding sheds light on the complex cellular mechanisms underlying the transition to chronic pain.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Oncology
Kyoko Nakamura, Ankur Karmokar, Paul M. Farrington, Neil H. James, Antonio Ramos-Montoya, Susan J. Bickerton, Gareth D. Hughes, Timothy M. Illidge, Elaine B. Cadogan, Barry R. Davies, Simon J. Dovedi, Viia Valge-Archer
Summary: The combination of AZD7648 with radiotherapy induced complete tumor regressions in a significant proportion of mice, dependent on CD8T cells and modulating an anticancer immune response. Immunological consequences included a reduction in T-cell PD-1 expression, increased NK-cell granzyme B expression, and elevated type I IFN signaling.
CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Arvydas Strazdauskas, Sonata Trumbeckaite, Valdas Jakstas, Justina Kamarauskaite, Liudas Ivanauskas, Rasa Baniene
Summary: This study analyzed the oxidation of cardiolipin during renal ischemia in vivo. The results showed that the levels of the dominant species of cardiolipin decreased after ischemia, and multiple cardiolipin oxidation products were produced. These findings suggest that cardiolipin levels are altered and harmful lipid signaling molecules may induce more damage to mitochondria during ischemia.
Article
Orthopedics
Jun Yang, Guanghui Chen, Tianqi Fan, Xiaochen Qu
Summary: M1 macrophage-derived OSM induces osteogenic differentiation of LF cells through the JAK2/STAT3 signaling pathway.
Article
Oncology
Masanobu Shiga, Jun Miyazaki, Kozaburo Tanuma, Yoshiyuki Nagumo, Takayuki Yoshino, Shuya Kandori, Hiromitsu Negoro, Takahiro Kojima, Ryota Tanaka, Naoko Okiyama, Yasuhiro Fujisawa, Miyuki Watanabe, Sho Yamasaki, Hideyasu Kiyohara, Makoto Watanabe, Taka-aki Sato, Hideaki Tahara, Hiroyuki Nishiyama, Ikuya Yano
Summary: The study found that cationic liposome TDM (Lip-TDM) exhibited superior anti-tumor effects compared to BCG in mouse models of bladder cancer, colon cancer, and melanoma, without causing weight loss or granuloma formation. The anti-tumor effect of Lip-TDM depends on CD8(+) T cells and macrophage-inducible C-type lectin (Mincle).
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Franz Nurnberger, Daniela Ott, Rebecca Classen, Christoph Rummel, Joachim Roth, Stephan Leisengang
Summary: This study investigated the effects of systemic inflammation induced by LPS on DRG, showing enhanced expression of inflammatory mediators and cyclooxygenase-2, as well as increased neuronal responses to capsaicin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Zaira Colin-Val, Carlos Daniel Vera-Marquez, Manuel Alejandro Herrera-Rodriguez, Maria del Pilar Ramos-Godinez, Alejandro Lopez-Saavedra, Agustina Cano-Martinez, Diana Xochiquetzal Robledo-Cadena, Sara Rodriguez-Enriquez, Francisco Correa, Norma Laura Delgado-Buenrostro, Yolanda I. Chirino, Rebeca Lopez-Marure
Summary: Cardiovascular diseases are the leading cause of death worldwide. Food-grade TiO2 (E171) has been found to be toxic to cardiac cells and may contribute to the development of heart diseases.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lei Yu, Yuxi Chen, Shaohui Yuan, Yang Cao, Zhenggang Bi
Summary: Peiminine suppressed proliferation and metastasis, induced cell cycle arrest, apoptosis, and autophagy in osteosarcoma cells, depending on intracellular ROS generation and JNK pathway activation. Furthermore, peiminine significantly inhibited xenograft tumor growth in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Minchao Lv, Qingxin Xu, Bei Zhang, Zhiqiang Yang, Jun Xie, Jinku Guo, Feixiong He, Wei Wang
Summary: The study revealed that imperatorin induces autophagy and cell cycle arrest through the PTEN-PI3K-AKT-mTOR/p21 signaling pathway by targeting and up-regulating PTEN in human osteosarcoma cells. Therefore, imperatorin is an ideal candidate for the clinical treatment of osteosarcoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Oleg Vetrovoy, Viktor Stratilov, Peter Nimiritsky, Pavel Makarevich, Ekaterina Tyulkova
Summary: The study found that prenatal severe hypoxia can lead to a gradual decrease in glutamate levels in the rat hippocampus, affecting neuronal cell number and spatial memory. It also impacts gene expression related to glutamate metabolism and recycling, while increasing the expression of metabotropic glutamate receptor and synaptophysin. Excessive glutamate sensitivity in PSH rats does not compensate for glutamate deficiency, playing a significant role in cognitive decline and early neuronal loss.
NEUROCHEMICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Chen
Summary: The study suggests that Licochalcone A (LCA) has great therapeutic potential for esophageal cancer (EC) by regulating the p53 signaling pathway to induce cell cycle arrest and apoptosis. In vitro experiments showed that LCA inhibited EC cell proliferation, migration, and invasion, and promoted apoptosis. In vivo experiments demonstrated that LCA administration inhibited tumor growth without causing significant toxicities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Shahab Ghaderi, Alireza Komaki, Iraj Salehi, Zahra Basir, Masome Rashno
Summary: This study demonstrates that lead exposure leads to cognitive decline, while chrysin can improve cognitive function and alleviate neuronal damage. The potential mechanisms of chrysin may include improving hippocampal synaptic function, modulating inflammatory status, reducing lead concentration, and preventing neuronal loss.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Dermatology
Nicolas Chiarante, Maite Duhalde Vega, Federico Valli, Elsa Zotta, Hellen Daghero, Tatiana Basika, Mariela Bollati-Fogolin, Maria C. Garcia Vior, Julieta Marino, Leonor P. Roguin
Summary: The study demonstrated that Pc9-T1107 photodynamic therapy has significant antitumor effects in a murine colon carcinoma model, delaying tumor growth and inducing apoptotic cell death and immune response.
LASERS IN SURGERY AND MEDICINE
(2021)
Article
Oncology
Antoine Freuchet, Apolline Salama, Severine Bezie, Laurent Tesson, Severine Remy, Romain Humeau, Hadrien Regue, Celine Serazin, Lea Flippe, Part Peterson, Nadege Vimond, Claire Usal, Severine Menoret, Jean-Marie Heslan, Franck Duteille, Frederic Blanchard, Magali Giral, Marco Colonna, Ignacio Anegon, Carole Guillonneau
Summary: This study highlights the crucial role of IL-34 in immune homeostasis and CD4(+) Treg suppressive function. The study also demonstrates the therapeutic potential of IL-34 in human transplantation and autoimmunity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kyle MacDonald, Fernando Botelho, Ali A. A. Ashkar, Carl D. D. Richards
Summary: This study found that the interaction between type I interferons (IFNs) and oncostatin M (OSM) signaling enhances cell responses in lung inflammation. Ifnar1-deficient mice and cells showed reduced response to OSM, suggesting the important role of type I interferons in regulating lung infection and inflammation.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Correction
Medicine, General & Internal
Hannah C. Beird, Stefan S. Bielack, Adrienne M. Flanagan, Jonathan Gill, Dominique Heymann, Katherine A. Janeway, J. Andrew Livingston, Ryan D. Roberts, Sandra J. Strauss, Richard Gorlick
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Medicine, General & Internal
Hannah C. Beird, Stefan S. Bielack, Adrianne M. Flanagan, Jonathan Gill, Dominique Heymann, Katherine A. Janeway, J. Andrew Livingston, Ryan D. Roberts, Sandra J. Strauss, Richard Gorlick
Summary: Osteosarcoma is the most common primary malignant bone tumor with a bimodal incidence peaking at 18 and 60 years of age. It is more common in males and is driven by genetic factors related to bone formation leading to malignant progression and metastasis. Screening is currently focused on high-risk groups, and the prognosis for patients with metastatic disease remains poor.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Cell Biology
Anais Defois, Nina Bon, Alexandre Charpentier, Melina Georget, Nicolas Gaigeard, Frederic Blanchard, Antoine Hamel, Denis Waast, Jean Armengaud, Ophelie Renoult, Claire Pecqueur, Yves Maugars, Marie-Astrid Boutet, Jerome Guicheux, Claire Vinatier
Summary: This study reveals a strong association between inflammation and metabolic dysregulation in osteoarthritic chondrocytes. Inflammation affects metabolic-related genes and leads to increased glycolysis and decreased mitochondrial respiration in osteoarthritic chondrocytes. These findings provide important insights for further understanding the mechanisms of osteoarthritis.
CELL COMMUNICATION AND SIGNALING
(2023)
Letter
Dermatology
Magali Croquette, Alicia Faugeroux, Clemence Fonlupt, Julie Godet, Eric Frouin, Martine Garcia, Francois-Xavier Bernard, Sevda Cordier-Dirikoc, Nathalie Pedretti, Guillaume Larid, Laure Favot, Pascal Roblot, Damien Boutin, Ewa Hainaut-Wierzbicka, Dominique Heymann, Jean-Claude Lecron, Franck Morel, Jean-Francois Jegou
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Endocrinology & Metabolism
Isidora Panez-Toro, Javier W. Munoz-Garcia, Jorge Vargas-Franco, Axelle Renodon-Corniere, Marie-Francoise Heymann, Frederic Lezot, Dominique Heymann
Summary: This article provides an overview of recent developments in the treatment of osteosarcoma, including targeting signaling pathways, immune checkpoint inhibitors, drug delivery strategies, and identification of new therapeutic targets.
CURRENT OSTEOPOROSIS REPORTS
(2023)
Article
Oncology
Lisa Oliver, Arturo alvarez-Arenas, Celine Salaud, Juan Jimenez-Sanchez, Gabriel F. Calvo, Juan Belmonte-Beitia, Stephanie Blandin, Luciano Vidal, Victor Perez, Dominique Heymann, Francois M. Vallette
Summary: Glioblastoma (GBM) is an incurable disease and personalized treatments are expected to be the key to therapeutic success due to the heterogeneity, complexity, and plasticity of GBM tumors. This study developed a 3D biosphere model using patient-derived cells (PDCs) from GBM and cancer-activated fibroblasts (CAFs) to mimic GBM progression and response to treatment. The co-culture of PDCs with CAFs showed similar growth and morphology to patients, and the response to standard therapy (Temozolomide and irradiation) was also consistent with GBM patients. This method provides a simple and reproducible way to obtain 3D cultures and has the potential for precision and personalized medicine.
Article
Biochemistry & Molecular Biology
Perrine Jacquot, Javier Munoz-Garcia, Maurine Fleury, Denis Cochonneau, Remi Gaussin, Elise Enouf, Caroline Roze, Emilie Ollivier, Mathieu Cinier, Dominique Heymann
Summary: Re-education of the tumor microenvironment with immune checkpoint inhibitors (ICI) has been a significant breakthrough in cancer treatment, but low response rates and immune-related adverse events (irAEs) remain challenges. A bispecific Nanofitin was engineered using anti-epidermal growth factor receptor (EGFR) and anti-programmed cell death ligand 1 (PDL1) modules to increase selectivity and safety. The study demonstrated that the bispecific Nanofitin elicited EGFR-directed PDL1 blockade, highlighting its potential in enhancing the safety and selectivity of PDL1 checkpoint inhibition.
Article
Engineering, Biomedical
Fabien Nativel, Audrey Smith, Jeremy Boulestreau, Charles Lepine, Julie Baron, Melanie Marquis, Caroline Vignes, Yoan Le Guennec, Joelle Veziers, Julie Lesoeur, Francois Loll, Boris Halgand, Denis Renard, Jerome Abadie, Benoit Legoff, Frederic Blanchard, Olivier Gauthier, Claire Vinatier, Anne des Rieux, Jerome Guicheux, Catherine Le Visage
Summary: Osteoarthritis is an inflammatory joint disease affecting cartilage, subchondral bone, and joint tissues. In this study, human adipose stromal cells were successfully encapsulated in alginate microgels and shown to retain their metabolic activity and ability to respond to inflammatory stimuli. When injected into a rabbit model of post-traumatic OA, the encapsulated cells exhibited properties matching those of non-encapsulated cells and showed a tendency toward decreased OA severity. These findings demonstrate the feasibility, safety, and efficacy of injecting cells encapsulated in microgels for long-term treatment of OA.
MATERIALS TODAY BIO
(2023)
Article
Pharmacology & Pharmacy
Nolwenn Dubois, Javier Munoz-Garcia, Dominique Heymann, Axelle Renodon-Corniere
Summary: Consuming high dietary glucose and having hyperglycemia can lead to chronic complications. This study investigated the effects of long-term exposure to high glucose on the intestinal barrier. The results showed that high glucose induced morphological changes and disrupted the structure of junction proteins. It also affected the functionalities of the intestinal barrier, and these alterations were more pronounced in co-culture models.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Yi Pu, Lu Li, Haoning Peng, Lunxu Liu, Dominique Heymann, Caroline Robert, Francois Vallette, Shensi Shen
Summary: Drug-tolerant persister (DTP) cell populations have been discovered in antibiotic-resistant bacterial biofilms and have also been identified in cancer cells. They are linked with treatment resistance and targeting these cells may offer new treatment opportunities.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Camille Jubelin, Javier Munoz-Garcia, Denis Cochonneau, Emilie Ollivier, Francois Vallette, Marie-Francoise Heymann, Lisa Oliver, Dominique Heymann
Summary: This study reaffirms the relevance of simpler 3D culture methods, such as the Liquid Overlay Technique (LOT), for producing highly reproducible spheroids in the context of drug cytotoxicity measurements. The morphology of spheroids generated in round-bottom multiwell plates was found to be more repeatable than those generated in flat-bottom plates. The IC50 of doxorubicin on MNNG/HOS cells grown in 3D was significantly higher than in 2D cultures, indicating the potential of 3D models for drug response measurements.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell & Tissue Engineering
Emilie Hascoet, Frederic Blanchard, Claudine Blin-Wakkach, Jerome Guicheux, Philippe Lesclous, Alexandra Cloitre
Summary: Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that lead to increased bone resorption. They have immunopathogenic similarities and a common inflammatory environment. Periodontal dysbiosis, triggered by periodontal pathogens, can promote or sustain bone resorption in inflamed joints in RA. Understanding the pathogenic mechanisms of osteoclasts and their precursors in these diseases could lead to the identification of new therapeutic targets for inflammatory bone resorption.
Review
Oncology
Camille Jubelin, Javier Munoz-Garcia, Denis Cochonneau, Emilie Moranton, Marie-Francoise Heymann, Dominique Heymann
Summary: Sarcomas are a family of cancers originating in the mesenchyme, and the presence of CSCs in osteosarcomas plays a crucial role in drug resistance, tumor recurrence, and treatment failure.
CANCER DRUG RESISTANCE
(2022)