Review
Oncology
Xia Gan, Yonghong Liu, Xueni Wang
Summary: Glioblastomas, a type of brain tumor, have a higher incidence in males compared to females, and this difference may be attributed to the androgen receptor signaling axis. Drug research targeting the androgen receptor for the treatment of glioblastoma has shown that androgen receptor antagonists, in combination with other drugs, can have anti-tumor effects. Additionally, small molecule compounds targeting the androgen receptor have also shown promising results in reducing glioblastoma growth.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Chang Lu, Qiuyang Zhang, Huiying Zhang, Xiumiao Li, Qin Jiang, Jin Yao
Summary: Anlotinib has shown promise in inhibiting ocular neovascularization by reducing avascular areas and pathological neovascular tufts in animal models, suggesting its potential as a therapeutic candidate for eye diseases in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Nomi Zalcman, Mijal Gutreiman, Tal Shahar, Michael Weller, Iris Lavon
Summary: The study demonstrates the involvement of EGFR signaling in AR activation in glioblastoma, showing that inhibiting EGFR signaling can reduce AR nuclear translocation. Combination therapy of EGFR and AR antagonists has synergistic therapeutic efficacy in cells overexpressing EGFR and EGFRvIII.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Noelia Geribaldi-Doldan, Irati Hervas-Corpion, Ricardo Gomez-Oliva, Samuel Dominguez-Garcia, Felix A. Ruiz, Irene Iglesias-Lozano, Livia Carrascal, Ricardo Pardillo-Diaz, Jose L. Gil-Salu, Pedro Nunez-Abades, Luis M. Valor, Carmen Castro
Summary: GBM is a common and aggressive primary brain tumor with poor prognosis. GSCs, which are resistant to current treatments, have been identified as the origin of GBM. Targeting PKC may be an effective approach to treat recurrent GBM.
Article
Pharmacology & Pharmacy
Ying Jiang, Chunhui Huang, Yaqi Huang, Lifan Long, Guowu Wu, Fengqiu Guo, Chuan Huang, Siming Liu, Zhengguang Zhu, Shaoyu Wu, Zhonghuang Li, Jiajie Zhang, Shanhe Wan
Summary: Targeting EGFR with the inhibitor SMUZ106 has shown promising anti-tumor effects for glioblastoma (GBM). In this study, SMUZ106 was found to inhibit the growth and proliferation of GBM cells through various experiments, including MTT, clone formation, and flow cytometry. The selectivity and inhibitory activity of SMUZ106 to EGFR were confirmed using Western blotting, molecular docking, and kinase spectrum screening methods. In vivo experiments demonstrated that SMUZ106 hydrochloride has a high bioavailability and low toxicity, and it significantly inhibited GBM growth.
Review
Immunology
Fenge Li, Huancheng Wu, Xueming Du, Yimo Sun, Barbara Nassif Rausseo, Amjad Talukder, Arjun Katailiha, Lama Elzohary, Yupeng Wang, Zhiyu Wang, Gregory Lizee
Summary: The EGFR gene is frequently overexpressed and mutated in various solid tumors, and peptide vaccines targeting mutated EGFR have shown promising clinical efficacy and safety profiles.
Correction
Biochemistry & Molecular Biology
Jeong-Yub Kim, Hee-Jin Kim, Chan-Woong Jung, Byung-Il Choi, Dae-Hee Lee, Myung-Jin Park
Summary: A correction to this paper has been published.
Article
Chemistry, Analytical
Yanli Zhu, Jikai Wang, Haitao Xie, Chengxiao Fu, Jiecan Zhou, Hailing Liu, Pengfei Zeng, Yiyang Sun
Summary: This article presents a new aptasensing platform for sensitive and specific detection of malignancy-associated biomarkers. The platform utilizes alkaline-earth sulfide nanodots as fluorescent labels, which can be excited by near-infrared light, to achieve low detection limits and reliable quantification. Additionally, the platform enables visual analysis and detection of target analytes through color transformation.
ANALYTICAL CHEMISTRY
(2022)
Article
Cell Biology
Junfeng Bi, Atif Khan, Jun Tang, Aaron M. Armando, Sihan Wu, Wei Zhang, Ryan C. Gimple, Alex Reed, Hui Jing, Tomoyuki Koga, Ivy Tsz-Lo Wong, Yuchao Gu, Shunichiro Miki, Huijun Yang, Briana Prager, Ellis J. Curtis, Derek A. Wainwright, Frank B. Furnari, Jeremy N. Rich, Timothy F. Cloughesy, Harley I. Kornblum, Oswald Quehenberger, Andrey Rzhetsky, Benjamin F. Cravatt, Paul S. Mischel
Summary: The study identified SMPD1 as a drug target in GBM, and found that the antidepressant fluoxetine can inhibit SMPD1 activity, kill GBM cells, and enhance the effects of temozolomide treatment, leading to complete tumor regression. Real-world evidence also showed significantly increased survival in GBM patients treated with fluoxetine.
Article
Biochemistry & Molecular Biology
Marwa F. Ahmed, Eman Y. Santali, Radwan El-Haggar
Summary: Newly designed and synthesized piperazine-chalcone hybrids and related pyrazoline derivatives show promising anticancer activity and strong enzyme inhibitory activity against VEGFR-2. Further investigations reveal that compounds Vd and Ve have significant effects on cell cycle and induce apoptosis effectively in vitro.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yuran Qiu, Xiaolan Yin, Xinyi Li, Yuanhao Wang, Qiang Fu, Renhua Huang, Shaoyong Lu
Summary: Dual-targeting therapeutics, which combine allosteric and orthosteric drugs, have shown promise in overcoming drug-resistance issues and improving treatment efficacy. Occupancy of the orthosteric sites by therapeutics can enhance allosteric ligand binding and increase the potency of allosteric drugs. Through extensive molecular dynamics simulations and reversed allosteric communication, the molecular mechanism of how osimertinib alters the conformation and reshapes the allosteric site of EGFR mutant has been elucidated, providing insights for future clinical applications of dual-targeting therapeutics.
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Review
Endocrinology & Metabolism
Giovanni Vitale, Alessia Cozzolino, Pasqualino Malandrino, Roberto Minotta, Giulia Puliani, Davide Saronni, Antongiulio Faggiano, Annamaria Colao
Summary: Neuroendocrine neoplasms are tumors originating from neuroendocrine cells in different organs, with dysregulation of receptor tyrosine kinases playing a crucial role in their development and progression. Research on the role of the fibroblast growth factor receptor system in NENs and the potential of FGFR selective inhibitors shows promising anti-tumor activity in advanced NEN patients, with further studies needed for confirmation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Robotics
Claire A. G. J. Huijnen, Hanneke A. M. D. Verreussel-Willen, Monique A. S. Lexis, Luc P. de Witte
Summary: Research findings suggest that robots, specifically KASPAR, can enhance interactions with children with autism spectrum disorder by increasing non-verbal imitation and maintaining attention. Children showed more positive verbal responses to human teachers compared to KASPAR, but demonstrated greater non-verbal behaviors and spontaneous verbal utterances with the robot.
INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS
(2021)
Article
Geriatrics & Gerontology
Sarah Abdi, Luc de Witte, Mark Hawley
Summary: The study found that some emerging technologies, such as voice activated devices and AI-enabled apps, have potential to meet the care needs of older people. However, other technologies like robotics and virtual reality face technical and acceptability issues that may hinder adoption by older people.
Article
Health Care Sciences & Services
Tourkiah Alessa, Mark S. Hawley, Nouf Alsulamy, Luc de Witte
Summary: This study evaluated the acceptance and usability of a selected app in the context of Saudi Arabia. It found moderate app usability with some issues related to accessibility, navigation, and incomplete tasks, while participants stressed the importance of practice and training for more proficient use. Despite some improvements needed, the app was generally acceptable and engaged users in self-management of hypertension, suggesting potential for larger-scale studies if suggestions for enhancements are considered in future app development.
JMIR MHEALTH AND UHEALTH
(2021)
Review
Environmental Sciences
Shivani Gupta, Agnes Meershoek, Luc De Witte
Summary: The research findings show that the government-aided wheelchair provision system in India is flawed, with insufficient wheelchair services and limited access to mobility devices for users. Therefore, there is a need to expand coverage, improve production and supply, and establish partnerships between various agencies to enhance access and support users' rights to personal mobility.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Public, Environmental & Occupational Health
Alice Spann, Joana Vicente, Sarah Abdi, Mark Hawley, Marieke Spreeuwenberg, Luc de Witte
Summary: Combining work and care can be challenging, but technologies can help working carers better manage their responsibilities and alleviate stress. Barriers to using technology include limited digital skills, privacy concerns, and cost. More research is needed to explore how technologies can address the needs of working carers effectively.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Health Care Sciences & Services
Tourkiah Alessa, Mark Hawley, Luc de Witte
Summary: The study identified 5 potentially effective and secure hypertension self-management apps, with Cora Health being rated the most suitable by participants. Both doctors and patients showed interest in using hypertension apps, but lack of awareness hindered their usage. Participants preferred apps with intuitive interfaces, clear visual design, in-depth features, and educational content.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Rehabilitation
Sarah Abdi, Irene Kitsara, Mark S. Hawley, L. P. de Witte
Summary: Limited access to assistive technology is a global challenge, but emerging technologies have the potential to bridge some of the gaps. This study identified seven enabling technologies relevant to the AT field, with only a small fraction of patents specifically related to AT. The results suggest enormous potential for new AT solutions leveraging emerging technological advances.
ASSISTIVE TECHNOLOGY
(2021)
Article
Rehabilitation
Jiban Karki, Simon Rushton, Sunita Bhattarai, Gift Norman, Shagoofa Rakhshanda, Luc De Witte
Summary: This paper critically reviews the processes for providing Assistive Technology (AT) services to Persons with Disabilities (PWD) in Bangladesh, India, and Nepal. The study found that the AT service delivery processes are suboptimal in all three countries and improvements are needed. Although it is easier for PWDs in India and Nepal to access AT than for those in Bangladesh, all three countries are failing to uphold the human rights of PWDs. The paper concludes by recommending a more holistic approach to AT service delivery, with a single door service delivery system, free of cost at the point of service.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2022)
Review
Rehabilitation
Satish Mishra, Ariane Laplante-Levesque, Giulia Barbareschi, Luc De Witte, Sarah Abdi, Alice Spann, Chapal Khasnabis, Michael Allen
Summary: This scoping review summarizes the evidence on the prevalence, access, and coverage of assistive technology (AT) in the World Health Organisation European Region. The study found limited data on AT prevalence and coverage, highlighting the need for agreed-upon definitions and standards for data collection to build a more representative picture of AT needs and coverage.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2022)
Review
Gerontology
Jennifer MacRitchie, Georgia A. Floridou, Justin Christensen, Renee Timmers, Luc de Witte
Summary: Creative arts-based activities can benefit older adults living with mild cognitive impairment or dementia, and technology has the potential to assist in delivering these activities. A scoping review examines the literature on technology-assisted creative arts activities for older adults with dementia, and highlights the need for future research and collaboration to further develop and evaluate these technologies.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2023)
Article
Sociology
Alice Spann, Camille Allard, Annie-Claude Harvey, Katherine Zwerger, Marieke Spreeuwenberg, Mark Hawley, Luc de Witte
Summary: The study shows that autonomy in work for family carers of dementia patients is crucial for them to manage care-related emergencies effectively. The level of autonomy varies from none to complete, with different impacts in different situations. Having the freedom to take breaks, schedule time, and choose a location at work can help carers better handle emergencies.
COMMUNITY WORK & FAMILY
(2022)
Review
Rehabilitation
Jiban Karki, Simon Rushton, Sunita Bhattarai, Luc De Witte
Summary: This paper critically reflects on the access to Assistive Technology (AT) services for persons with disabilities (PWD) in Nepal, India, and Bangladesh. The study finds that AT service provisions in these countries are poorly developed, with major weaknesses in terms of accessibility, eligibility, reachability, and affordability. To overcome these barriers, increased community-level awareness, government funding, and a community-based, medically informed flexible social model of AT services are recommended.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Rehabilitation
Bart G. Geilen, Luc de Witte, Gift Norman, Carolin Elizabeth George
Summary: This study investigated the current state of wheelchair services in Bangalore Rural district and identified areas for improvement. The overall satisfaction was described as more or less satisfied, with wheelchair users being less satisfied with the services compared to the wheelchair itself. The skills of wheelchair users were strongly correlated with satisfaction scores. Differences in satisfaction between genders were observed and related to multiple factors. It is suggested that wheelchairs should be easy to use and accompanied by training programs to improve user skills.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2022)
Article
Management
Cristian T. Ghergu, Agnes Meershoek, Preeti Sushama, Onno C. P. van Schayck, Luc P. de Witte
Summary: This study examines the application of a co-designing model to address indoor air pollution in marginalized communities of urban India, finding that bringing together end-users, designers, and researchers can enhance the exchange of knowledge and technical expertise for improved design. Managing and negotiating suitability issues are key to project implementation, which requires continuous exploration, negotiation, and adjustment.
Article
Rehabilitation
Shivani Gupta, Luc P. de Witte, Agnes Meershoek
Summary: Persons with disabilities in rural India lack the opportunity to lead an independent life and participate in community activities. The research reveals that a complex interplay of personal, social, and environmental factors leads to increased dependency and feelings of worthlessness among disabled individuals. Recommendations include reducing dependency on families, changing community attitudes towards disability, and enhancing self-esteem of persons with disabilities.
DISABILITY & SOCIETY
(2021)