Review
Radiology, Nuclear Medicine & Medical Imaging
Tone Hovda, Kaitlyn Tsuruda, Solveig Roth Hoff, Kristine Kleivi Sahlberg, Solveig Hofvind
Summary: The study reviewed mammograms for 1225 women with screen-detected breast cancer. Results showed that visible findings on prior screening mammograms were not necessarily indicative of screening failure. Some cases were classified as missed, aiming to improve the quality of breast cancer screening.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emily B. Ambinder, Emerson Lee, Derek L. Nguyen, Anna J. Gong, Orli J. Haken, Kale Visvanathan
Summary: This study reviewed mammographic screening data and found that the sensitivity for early-stage breast cancer detection was high. However, some interval breast cancers were missed. Interval breast cancers were more likely to occur in patients with dense breast tissue, higher stage, and unfavorable molecular features.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
R. G. Blanks, M. G. Wallis, R. J. Alison, R. M. Given-Wilson
Summary: Objective randomised controlled trials have demonstrated a reduction in breast cancer mortality through mammography screening, particularly in the detection of high-grade invasive cancers. The sensitivity for detecting small grade 3 invasive cancers is much lower compared to grade 1 and 2, highlighting the need for improved technologies and strategies in identifying these clinically significant malignancies.
EUROPEAN RADIOLOGY
(2021)
Article
Geriatrics & Gerontology
Lore Timmermans, Isabel De Brabander, Nancy Van Damme, Luc Bleyen, Patrick Martens, Koen Van Herck, Hubert Thierens, Klaus Bacher, Herman Depypere
Summary: This study investigates the relationship between breast density and tumour prognostic factors in screen-detected cancers and interval cancers. The results suggest that interval cancers are more aggressive compared to screen-detected cancers. The analysis also reveals differences in tumour characteristics based on breast density in both groups. The study data support arguments against changes in breast cancer screening programs with prolongation of screening intervals in low-density breasts.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucien E. M. Duijm, Mireille J. M. Broeders, Wikke Setz-Pels, Vivian van Breest Smallenburg, Hermen C. van Beek, Astrid B. Donkers-van Rossum, Marjan J. Slob, Toon P. Kuipers, Ritse M. Mann, Adri C. Voogd
Summary: The screening interval of biennial screening mammography has significant effects on the tumor characteristics and treatment outcomes. A longer screening interval may increase the cancer detection rate, but has no significant impact on other tumor characteristics.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Hsin-Ju Han, Yuan-Chia Chu, Jane Wang, Yi-Chen Lai, Ling-Ming Tseng, Chi-Cheng Huang
Summary: This study explored the characteristics of screening-detected breast cancers in Taiwan and found that breast cancers diagnosed through screening mammography had better tumor characteristics and treatment outcomes compared to those diagnosed through diagnostic mammography. However, screening-detected breast cancers were a mixture of women with and without symptoms, including false negative results.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Jeong Kim, Hak Hee Kim, Ki Hwan Kim, Woo Jung Choi, Eun Young Chae, Hee Jung Shin, Joo Hee Cha, Woo Hyun Shim
Summary: This study retrospectively analyzed mammography using an artificial intelligence (AI) software and found that AI provided added value in the detection of mammographically occult breast cancers. The clinicopathologic characteristics of the AI-detected cancers were also determined.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stamatia Destounis, Andrea Arieno, Amanda Santacroce
Summary: This study reviewed the outcomes of breast cancer screening using both digital breast tomosynthesis (DBT) and screening ultrasound (US). The detection rates of DBT and US were similar, with US detecting mainly invasive cancers and DBT detecting mainly in situ carcinoma. There were significant differences in lesion characteristics between DBT and US.
ACADEMIC RADIOLOGY
(2022)
Article
Oncology
Heera Yoen, Jung Min Chang
Summary: Despite recent advances in AI software for mammography screening, this study found that AI software-assisted mammography could provide additional value in identifying breast cancers detected through supplemental screening ultrasound, especially for cases with indiscernible abnormalities and interpretive errors.
JOURNAL OF BREAST CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin Daniaux, Leonhard Gruber, Wolfram Santner, Theresa Czech, Rudolf Knapp
Summary: Research shows that true and occult IBCs generally present with a more aggressive biological phenotype, characterized by smaller tumor size but lower doubling time and higher ki-67 index. Additionally, true and occult IBCs are associated with younger age and higher breast density compared to false-negative IBCs. Additional yearly ultrasound examinations in women at risk may help in earlier detection.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Shuxian Niu, Wenyan Jiang, Nannan Zhao, Tao Jiang, Yue Dong, Yahong Luo, Tao Yu, Xiran Jiang
Summary: In this study, digital mammography showed higher AUCs for predicting Luminal A and B subtypes compared to MRI, but lower AUCs for predicting HER2-enriched and TN subtypes. Additionally, peritumoral regions were found to provide complementary information to intratumoral regions for predicting molecular subtypes of breast cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoel Shoshan, Ran Bakalo, Flora Gilboa-Solomon, Vadim Ratner, Ella Barkan, Michal Ozery-Flato, Mika Amit, Daniel Khapun, Emily B. Ambinder, Eniola T. Oluyemi, Babita Panigrahi, Philip A. DiCarlo, Michal Rosen-Zvi, Lisa A. Mullen
Summary: The study evaluated the use of artificial intelligence (AI) in improving the efficiency of digital breast tomosynthesis (DBT) screening. It found that AI can reduce the workload of radiologists without compromising sensitivity and recall rate compared to expert interpretations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ga Ram Kim, Nariya Cho, Soo-Yeon Kim, Wonshik Han, Woo Kyung Moon
Summary: The study found that the performance of screening breast MRI in women with a personal history of breast cancer was sustained across multiple rounds. A first-degree family history of breast cancer, estrogen receptor- and progesterone receptor-negative primary cancers, and moderate or marked background parenchymal enhancement on MRI were independently associated with the risk of developing interval cancers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Clarisse Florence de Vries, Samantha Colosimo, Moragh Boyle, Gerald Lip, Lesley Anderson, Roger Staff, iCAIRD Radiology Collaboration
Summary: This study surveyed breast screening readers in the UK on their views of incorporating Artificial Intelligence (AI) technology into breast screening mammography. The results showed that readers supported AI as a partial replacement for human readers and preferred a graphical indication of the suspected tumor area as the AI representation option. National guidelines and independent prospective studies were considered crucial evidence prior to implementing AI.
INSIGHTS INTO IMAGING
(2022)
Editorial Material
Biochemistry & Molecular Biology
Nehmat Houssami, Karla Kerlikowske
Summary: AI has the potential to be a new tool in the risk assessment and screening of breast cancer, but its impact on relevant clinical outcomes needs to be prospectively evaluated.
Article
Oncology
Liisa Porra, Lauri Wendland, Tiina Seppala, Hanna Koivunoro, Hannu Revitzer, Jussi Tervonen, Leena Kankaanranta, Anu Anttonen, Mikko Tenhunen, Heikki Joensuu
Summary: The authors reviewed the results of 249 patients treated with boron neutron capture therapy (BNCT) at Helsinki University Hospital, Finland. They found that BNCT using l-boronophenylalanine-fructose (l-BPA-F) as the boron delivery agent was well tolerated and showed efficacy in the treatment of head and neck cancer and malignant glioma. They also described a new hospital BNCT facility that integrates a proton accelerator-based neutron source for treatment planning and positioning.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Oncology
Benjamin Z. Z. Sundqvist, Sami K. K. Kilpinen, Tom O. O. Boehling, Virve S. K. Koljonen, Harri J. J. Sihto
Summary: Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine malignancy with a poor prognosis and an unknown cell of origin. By studying the most variably expressed genes, we identified three distinct molecular subgroups of MCC with prognostic relevance. We propose that the dichotomic expression of epidermis-related genes might reflect both an epidermal and a nonepidermal origin for MCPyV-positive MCC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Jouko Levijoki, Lasse Saloranta, Johanna Tuunainen, Janne Kaskinoro, Sari Pappinen, Sandra Nourry, Anne-Marie Betat, Anne Maurin, Maarit Pakarinen, Sari Hakkinen, Johanna Tervapuro, Hertta Pihlasvaara, Christophe Drieu La Rochelle, Heikki Joensuu
Summary: Ocular administration of palonosetron as eye drops can effectively prevent and treat nausea and vomiting. This method provides a quick and convenient way to deliver the medication when intravenous administration is not possible.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Oncology
Heikki Joensuu, Eva Wardelmann, Mikael Eriksson, Annette Reichardt, Kirsten Sundby Hall, Jochen Schuette, Silke Cameron, Peter Hohenberger, Harri Sihto, Philipp J. Jost, Lars H. Lindner, Sebastian Bauer, Bengt Nilsson, Raija Kallio, Tommi Pesonen, Peter Reichardt
Summary: This study found that patients with KIT exon 11 deletion/indel mutation in gastrointestinal stromal tumor (GIST) had longer overall survival (OS) and recurrence-free survival (RFS) when treated with 3 years of adjuvant imatinib compared to 1 year of treatment. However, patients with KIT exon 9 mutation had poor OS regardless of the duration of adjuvant imatinib treatment.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kaisa Lehtomaki, Eetu Heerva, Pirkko-Liisa Kellokumpu-Lehtinen, Harri Mustonen, Tapio Salminen, Heikki Joensuu, Kethe Hermunen, Mogens Karsbol Boisen, Julia Sidenius Johansen, Caj Haglund, Pia Osterlund
Summary: Based on the analysis of clinical data from patients with colorectal cancer undergoing adjuvant chemotherapy, it was found that CEA levels transiently increased in about half of the patients during the treatment. Compared to patients with a persistent increase, those with transiently increased CEA had better outcomes in terms of disease-free survival and overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marko Salmikangas, Maria Laaksonen, Henrik Edgren, Marco Salgado, Anu Suoranta, Pirkko Mattila, Virve Koljonen, Tom Bohling, Harri Sihto
Summary: Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma with distinct genomic and transcriptomic profiles. In this study, transcriptomes of MCC tissue samples were analyzed to identify genes associated with outcome prediction and tumorigenesis. NCAN expression was found to be common in MCC and associated with improved survival. Further research is needed to understand the role of NCAN in MCC tumorigenesis.
Article
Multidisciplinary Sciences
Jodi M. Carter, Saranya Chumsri, Douglas A. Hinerfeld, Yaohua Ma, Xue Wang, David Zahrieh, David W. Hillman, Kathleen S. Tenner, Jennifer M. Kachergus, Heather Ann Brauer, Sarah E. Warren, David Henderson, Ji Shi, Yi Liu, Heikki Joensuu, Henrik Lindman, Roberto A. Leon-Ferre, Judy C. Boughey, Minetta C. Liu, James N. Ingle, Krishna R. Kalari, Fergus J. Couch, Keith L. Knutson, Matthew P. Goetz, Edith A. Perez, E. Aubrey Thompson
Summary: The use of spatial immunobiomarker quantitation is being actively explored in the prognosis and prediction of therapy in triple-negative breast cancer (TNBC). In this study, high-plex quantitative digital spatial profiling was used to analyze the immune protein microenvironments in treatment-naive TNBC. The results show that immune protein profiles differ significantly in intraepithelial and adjacent stromal microenvironments, and the enrichment of certain immune proteins is associated with better outcomes, highlighting the importance of spatial microenvironments in predicting the prognosis of TNBC.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Sherif Samer Attalla, Jonathan Boucher, Hailey Proud, Tarek Taifour, Dongmei Zuo, Virginie Sanguin-Gendreau, Chen Ling, Gabriella Johnson, Vincent Li, Robin B. Luo, Hellen Kuasne, Vasilios Papavasiliou, Logan A. Walsh, Mark Barok, Heikki Joensuu, Morag Park, Philippe P. Roux, William J. Muller
Summary: The tumor-immune microenvironment (TIME) plays a crucial role in therapeutic response, and this study reveals the association of HER2A16 variant with poor clinical outcome in breast cancer and the immune cold phenotype of HER2A16 tumors. ENPP1 is identified as a functional regulator of the immune cold microenvironment, and targeting ENPP1 may have therapeutic potential in aggressive HER2 positive breast cancer.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Dermatology
Anna-stiina Merilaeinen, Maria Von Willebrand-Backman, Harri Sihto, Virve Koljonen
Summary: This study retrospectively examined the records of patients with eccrine porocarcinoma and found that there was no significant difference between wide local excision only and wide local excision with sentinel lymph node biopsy groups. Further studies and international collaboration are needed.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Gastroenterology & Hepatology
Anil K. Giri, Mervi Aavikko, Linnea Wartiovaara, Toni Lemmetyinen, Juha Karjalainen, Juha Mehtonen, Kimmo Palin, Niko Valimaki, Max Tamlander, Riikka Saikkonen, Auli Karhu, Ekaterina Morgunova, Benjamin Sun, Heiko Runz, Priit Palta, Shuang Luo, Heikki Joensuu, Tomi P. Makela, Iiro Kostiainen, Camilla Schalin-Jantti, Aarno FinnGen, Aarno Palotie, Lauri A. Aaltonen, Saara Ollila, Mark J. Daly
Summary: This study is the largest genome-wide association study on small intestinal neuroendocrine tumors (SI-NETs) to date, and it identified 6 significant loci associated with SI-NET risk. Four of these loci are novel, and one of the top hits is a missense variant in the LGR5 gene, a marker of adult intestinal stem cells.
Article
Oncology
Michael C. Heinrich, Christopher L. Corless, George D. Demetri, Charles D. Blanke, Margaret von Mehren, Heikki Joensuu, Laura S. Mcgreevey, Chang-Jie Chen, Annick D. van den Abbeele, Brian J. Druker, Beate Kiese, Burton Eisenberg, Peter J. Roberts, Samuel Singer, Christopher D. M. Fletcher, Sandra Silberman, Sasa Dimitrijevic, Jonathan A. Fletcher
Summary: This study found that most GISTs have activating mutations in KIT or PDGFRA, and the occurrence of these mutations is related to clinical response to imatinib. PDGFRA mutations can explain the response and sensitivity to imatinib in some GISTs without KIT mutations.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Robert Hugh Jones, Karim Fizazi, Nicholas D. James, Teuvo L. Tammela, Nobuaki Matsubara, Frank Priou, Philippe Beuzeboc, Thierry Lesimple, Petri Bono, Vesa Kataja, Jorge A. Garcia, Andrew Protheroe, Neal Shore, John Aspegren, Heikki Joensuu, Iris Kuss, Sabine Fiala-Buskies, Egils Vjaters
Summary: This study of long-term darolutamide treatment found that it was well tolerated in patients with metastatic castration-resistant prostate cancer, with no new safety signals observed.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Jenni Niinimaeki, Harri Sihto, Johanna Arola, Tiina Vesterinen
Summary: This study identified biomarkers for pulmonary carcinoids (PCs) using RNA sequencing and immunohistochemistry. HSP90 was found to have a prognostic role in PC tumors and may possess therapeutic potential in the future.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
Kirsi Toivanen, Sami Kilpinen, Kalle Ojala, Nanna Merikoski, Sami Salmikangas, Mika Sampo, Tom Bohling, Harri Sihto
Summary: By analyzing the RNA sequences and signaling pathways of liposarcoma samples, we identified subtype-specific genes and their expression patterns. PDE3A modulators were found to have potential as drugs for treating myxoid liposarcoma. Further studies are needed to develop these drugs for clinical use.