Review
Medicine, General & Internal
Liang Lu, Xueyan Wan, Yu Xu, Juan Chen, Kai Shu, Ting Lei
Summary: This review summarizes the research progress on clinical and biological factors, including predictive factors and biomarkers, for recurrent pituitary adenomas. Comprehensive models and grading methods can be used to predict the prognosis of pituitary adenomas and may be beneficial for predicting recurrence.
Review
Microbiology
Fengfei Sun, Junfeng Chen, Kai Liu, Meizhen Tang, Yuewei Yang
Summary: This article summarizes the existing knowledge of gut microbiota in captive and wild birds, highlighting the lack of research on the gut microbiota of wild birds. The article also discusses research hotspots and directions, aiming to contribute to the field of avian microbiology in the future.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Oncology
Nuno Jorge Lamas, Arnaud Martel, Sacha Nahon-Esteve, Samantha Goffinet, Adam Macocco, Corine Bertolotto, Sandra Lassalle, Paul Hofman
Summary: Uveal melanoma is the most common cancer that develops inside adult eyes, with a poor prognosis and limited treatment options. There is a need to find methods that can accurately predict the prognosis of the disease and effective therapeutic strategies. This article summarizes the current knowledge and challenges in the field of uveal melanoma research, and discusses potential future directions.
Review
Oncology
Maral Adel Fahmideh, Michael E. Scheurer
Summary: Brain tumors are the most common solid tumors in children, with factors such as tumor histology and demographics influencing their incidence and prognosis. Known risk factors for pediatric brain tumors include exposure to ionizing radiation and certain genetic syndromes, but there is also evidence of associations with factors like birth defects and maternal dietary compounds. Identifying genetic variants associated with susceptibility to brain tumors may help in developing risk prediction models for prevention.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Environmental Sciences
Francisco J. Tapiador, Anahi Villalba-Pradas, Andres Navarro, Eduardo Garcia-Ortega, Kyo-Sun Sunny Lim, Kwonil Kim, Kwang Deuk Ahn, Gyuwon Lee
Summary: Precipitation science is a growing research field that studies the water cycle from a broad perspective. It includes both modeling and observations. Future research directions in the field are still to be explored.
Review
Gastroenterology & Hepatology
R. Todd Stravitz, Robert J. Fontana, Constantine Karvellas, Valerie Durkalski, Brendan Mcguire, Jody A. Rule, Shannan Tujios, William M. Lee, Acute Liver Failure Study Grp
Summary: Acute liver failure (ALF) is a clinical syndrome characterized by rapid hepatocyte injury leading to liver failure without pre-existing cirrhosis. The Acute Liver Failure Study Group (ALFSG) was established in 1997 to study the causes, natural history, and management of ALF. Through clinical studies and collection of biosamples, significant findings have been made in the field. A recent conference was held to review ALFSG's accomplishments and discuss future research directions.
Article
Chemistry, Multidisciplinary
Alina Sigaeva, Neda Norouzi, Romana Schirhagl
Summary: This article introduces the NV center-based relaxometry technique, which utilizes the sensitivity of optical signals to detect properties based on the magnetic surroundings. The challenges of this technique, including controlling the location of sensing particles, reproducibility limitations, and biocompatibility issues, are discussed. The article also provides an outlook on new directions and future challenges in the field.
ACS CENTRAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Alina Sigaeva, Neda Norouzi, Romana Schirhagl
Summary: Nitrogen vacancy (NV) centers have the ability to change their optical properties based on their magnetic surroundings, resulting in a highly sensitive optical signal detection technique. Recent studies have demonstrated the use of NV center-based relaxometry for measurements in living cells at subcellular resolution. However, challenges in controlling the location of sensing particles, limitations in reproducibility, and biocompatibility issues need to be addressed. Future directions include exploring new diamond materials with NV centers, alternative defects, or entirely new materials to replace diamonds.
ACS CENTRAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Philip Home
Summary: Insulin therapy has a long history at the cutting edge of technological development, but faces unmet needs such as the inability to provide minute-to-minute control and mimic physiological insulin delivery. Approaches to overcome these barriers include closed-loop systems and modifying insulin formulations, yet face limitations due to fundamental challenges.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Psychology, Multidisciplinary
Ming Tao Wei, Zhi Yang, Yu Jie Bai, Ning Yu, Chun Xia Wang, Nan Wang, Yan Shuo Cui
Summary: This article reports on the evolution of breakdance and the lack of research on the impact of formal formative assessment on breakdance teaching and learning. The authors aim to contribute to the quality of breakdance teaching and learning by identifying the positive impact of recent research on formative assessment and designing a formal formative assessment task. The article presents a framework for formal formative assessment tasks and highlights the positive impact of formative assessment on dance education.
FRONTIERS IN PSYCHOLOGY
(2022)
Editorial Material
Hematology
Sergio Siragusa, Mariasanta Napolitano
Summary: In this study, Knoebl et al evaluated the effects of emicizumab on bleeding control in 12 patients with acquired hemophilia A (AHA). The results provide important insights for the treatment of this rare autoimmune bleeding disease.
Review
Gastroenterology & Hepatology
Hong Wei, Ting Yang, Jie Chen, Ting Duan, Hanyu Jiang, Bin Song
Summary: This review summarizes several prognostic imaging features at CT/MRI for patients with HCC and evaluates the effectiveness of LI-RADS in tumor biology and clinical outcome assessment. This system has the potential to improve the prognostic paradigm of HCC, allowing for individualized management and improved patient outcomes.
LIVER INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Orin Chisholm, Helen Critchley
Summary: The field of regulatory affairs is impacted by multiple forces, such as global megatrends, advances in science, digital disruption, and the COVID-19 pandemic. These forces are shaping the development and regulation of therapeutic products and require regulatory professionals to stay ahead of the trends and challenges. This article discusses the various trends impacting new therapies and offers insights for regulatory professionals to prepare for their impact on their work.
FRONTIERS IN MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Nuphar Veiga, Yael Diesendruck, Dan Peer
Summary: Designing a therapeutic modality with specific delivery to certain organs, tissues, or cell types is essential for efficient treatment and minimizing off-target side effects. Nanoparticles loaded with various drugs have emerged as a promising approach to achieve this goal. However, successful targeted delivery requires overcoming multiple biological barriers, such as systemic distribution, tissue penetration, and intracellular trafficking. Recent advances in understanding these barriers and functionalizing nanoparticles with targeting moieties have shown tremendous progress. Implementing new approaches like multi-functionalized nanocarriers and machine learning models can further enhance the design of safe and cell-specific nanoparticle delivery systems. This review critically examines the current progress in the field and proposes novel strategies to improve cell-specific delivery of therapeutic payloads.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Steffanie A. Strathdee, Graham F. Hatfull, Vivek K. Mutalik, Robert T. Schooley
Summary: Increasing antimicrobial resistance rates have prompted a resurgence in bacteriophage research as an alternative therapy. The ideal therapeutic phage should possess lytic properties, efficiently kill the bacterial host, and be well-characterized to ensure safety. This article reviews the current state of phage therapy, including biological mechanisms, clinical applications, challenges, and future directions involving naturally occurring and genetically modified or synthetic phages.
Article
Oncology
Melinda L. Telli, Charles Chu, Sunil S. Badve, Shaveta Vinayak, Daniel P. Silver, Steven J. Isakoff, Virginia Kaklamani, William Gradishar, Vered Stearns, Roisin M. Connolly, James M. Ford, Joshua J. Gruber, Sylvia Adams, Judy Garber, Nadine Tung, Chris Neff, Ryan Bernhisel, Kirsten M. Timms, Andrea L. Richardson
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Sunil S. Badve, Sanghee Cho, Yesim Gokmen-Polar, Yunxia Sui, Chrystal Chadwick, Elizabeth McDonough, Anup Sood, Marian Taylor, Maria Zavodszky, Puay Hoon Tan, Michael Gerdes, Adrian L. Harris, Fiona Ginty
Summary: Limited knowledge about DCIS cellular composition and its relationship with breast cancer events (BCE) was investigated using immunofluorescence multiplexing (MxIF). A total of 32 cellular biomarkers in FFPE DCIS tissue microarrays from 51 patients were analyzed, revealing significant correlations between ER, PR, HER2, and BCE. Clustering analysis identified 6 distinct cell groups, with clusters 2, 4 showing low BCE risk associations and cluster 6 showing increased risk. The continuous expression score (Escore) based on these clusters predicted likelihood of BCE, indicating the potential for novel biomarker analysis and prediction of BCE using this method. Further validation of Escore in a larger cohort is necessary.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Torsten O. Nielsen, Samuel C. Y. Leung, David L. Rimm, Andrew Dodson, Balazs Acs, Sunil Badve, Carsten Denkert, Matthew J. Ellis, Susan Fineberg, Margaret Flowers, Hans H. Kreipe, Anne-Vibeke Laenkholm, Hongchao Pan, Friderique M. Penault-Llorca, Mei-Yin Polley, Roberto Salgado, Ian E. Smith, Tomoharu Sugie, John M. S. Bartlett, Lisa M. McShane, Mitch Dowsett, Daniel F. Hayes
Summary: Ki67 immunohistochemistry (IHC) is commonly used in breast cancer as a proliferation marker, but its analytical validity has been questioned. The International Ki67 in Breast Cancer Working Group (IKWG) recommends careful preanalytical handling, adoption of a standardized visual scoring method, and participation in quality assurance and quality control programs. Clinical utility of Ki67 IHC in breast cancer care is currently limited to prognosis assessment in stage I or II breast cancer.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Oncology
Stefan Porubsky, Zoran V. Popovic, Sunil Badve, Yara Banz, Sabina Berezowska, Dietmar Borchert, Monika Brueggemann, Timo Gaiser, Thomas Graeter, Peter Hollaus, Katrin S. Huettl, Michaela Kotrova, Andreas Kreft, Christian Kugler, Fabian Lotscher, Burkhard Moller, German Ott, Gerhard Preissler, Eric Roessner, Andreas Rosenwald, Philipp Stroebel, Alexander Marx
Summary: Thymic hyperplasia with LESA-like features (LESA-like TH) is associated with lymphomas in 14% of cases and partially overlapping autoimmune diseases in 33% of cases. A hematologic and rheumatologic workup should be standard in patients diagnosed with LESA-like TH, particularly those with autoimmune diseases. Radiologists and clinicians should consider LESA-like TH as a potential differential diagnosis for mediastinal mass lesions in patients with autoimmune diseases.
Review
Oncology
Sunil S. Badve, Rachel Dougherty, Michael Balatico, Kenneth A. Kesler, Patrick Loehrer, Yesim Gokmen-Polar
Summary: Thymic carcinoma, a rare and aggressive tumor, accounts for less than 0.01% of all tumors. The incidence of second malignancies in patients with thymic carcinomas is similar to that reported for thymomas. Abnormalities in immunological surveillance may be responsible for this high incidence of second malignancies in thymic tumors.
Review
Oncology
Sunil S. Badve, Frederique Penault-Llorca, Jorge S. Reis-Filho, Regula Deurloo, Kalliopi P. Siziopikou, Corrado D'Arrigo, Giuseppe Viale
Summary: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer. Increased tumor-infiltrating lymphocyte counts have been found to be prognostic for survival in TNBC. Anti-PD-L1 and anti-PD-1 antibodies have been approved for the treatment of TNBC, and PD-L1 testing is becoming increasingly important in guiding treatment options.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Rafael Caparica, Yaohua Ma, Claudia De Angelis, Francois Richard, Christine Desmedt, Ahmad Awada, Martine Piccart, Edith A. Perez, Alvaro Moreno-Aspitia, Sunil Badve, E. Aubrey Thompson, Evandro de Azambuja
Summary: In this post-hoc analysis of the NCCTG-N9831 trial, a high expression of the beta 2AR gene (ADRB2) was associated with longer disease-free survival and identified patients who benefited from adjuvant trastuzumab in HER2-positive breast cancer.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Sherene Loi, Roberto Salgado, Sylvia Adams, Giancarlo Pruneri, Prudence A. Francis, Magali Lacroix-Triki, Heikki Joensuu, Maria Vittoria Dieci, Sunil Badve, Sandra Demaria, Robert Gray, Elisabetta Munzone, Damien Drubay, Jerome Lemonnier, Christos Sotiriou, Pirkko Liisa Kellokumpu-Lehtinen, Andrea Vingiani, Kathryn Gray, Fabrice Andre, Carsten Denkert, Martine Piccart, Elvire Roblin, Stefan Michiels
Summary: The importance of integrating biomarkers such as TILs into the TNM staging system for TNBC has been emphasized in the AJCC 8th Edition. Studies show that TILs can significantly influence the traditional pathological staging, suggesting that considering TILs in addition to stage can lead to better outcomes for TNBC patients.
Article
Oncology
Milan Radovich, Jeffrey P. Solzak, Chao J. Wang, Bradley A. Hancock, Sunil Badve, Sandra K. Althouse, Steven M. Bray, Anna Maria V. Storniolo, Tarah J. Ballinger, Bryan P. Schneider, Kathy D. Miller
Summary: The combination of gedatolisib and cofetuzumab pelidotin, targeting both the PI3K and Wnt pathways, demonstrates promising clinical activity in metastatic TNBC. This phase I clinical trial shows that the treatment is well tolerated and has potential efficacy in inhibiting disease progression.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Lan Zheng, Yesim Gokmen-Polar, Sunil S. Badve
Summary: The nonsurgical management of ductal carcinoma in situ (DCIS) is controversial with limited understanding of its long-term consequences. This study aimed to assess the risk of upstaging to invasive carcinoma and ipsilateral breast cancer events in patients eligible for nonsurgical management trials. The results showed that these patients had a significantly high risk of developing ipsilateral breast events within 5 years of diagnosis, indicating the need for better selection criteria to identify patients at very low risk for the development of invasive breast cancer (IBC).
Article
Pathology
Balazs Acs, Samuel C. Y. Leung, Kelley M. Kidwell, Indu Arun, Renaldas Augulis, Sunil S. Badve, Yalai Bai, Anita L. Bane, John M. S. Bartlett, Jane Bayani, Gilbert Bigras, Annika Blank, Henk Buikema, Martin C. Chang, Robin L. Dietz, Andrew Dodson, Susan Fineberg, Cornelia M. Focke, Dongxia Gao, Allen M. Gown, Carolina Gutierrez, Johan Hartman, Zuzana Kos, Anne-Vibeke Laenkholm, Arvydas Laurinavicius, Richard M. Levenson, Rustin Mahboubi-Ardakani, Mauro G. Mastropasqua, Sharon Nofech-Mozes, C. Kent Osborne, Frederique M. Penault-Llorca, Tammy Piper, Mary Anne Quintayo, Tilman T. Rau, Stefan Reinhard, Stephanie Robertson, Roberto Salgado, Tomoharu Sugie, Bert van der Vegt, Giuseppe Viale, Lila A. Zabaglo, Daniel F. Hayes, Mitch Dowsett, Torsten O. Nielsen, David L. Rimm
Summary: This study demonstrates certain comparability differences between core biopsy samples and corresponding resection specimens in Ki67 measurement, likely due to pre-analytical factors. Therefore, Ki67 immunohistochemistry should be tested on core biopsy samples as a priority to better reflect the biological status of the tumor.
Article
Oncology
Sunil S. Badve, Sanghee Cho, Xiaoyu Lu, Sha Cao, Soumya Ghose, Aye Aye Thike, Puay Hoon Tan, Idris Tolgay Ocal, Daniele Generali, Fabrizio Zanconati, Adrian L. Harris, Fiona Ginty, Yesim Gokmen-Polar
Summary: The study investigated the prognostic role of tumor-infiltrating lymphocytes (TILs) in ductal carcinoma in situ (DCIS) in multi-national cohorts from Asian and European women. It found that older women with circumferential TILs were less likely to develop second breast cancer events (BCE) at a 5-year follow-up. The spatial arrangement of TILs may serve as a better prognostic indicator in DCIS cases.
Editorial Material
Oncology
Sunil S. Badve
Summary: This article discusses the use of artificial intelligence methods for analyzing pathology slides. The authors describe a reliable second reader system that can differentiate in situ and advanced invasive carcinomas from non-neoplastic lesions of the breast.
Article
Oncology
Soumya Ghose, Sanghee Cho, Fiona Ginty, Elizabeth McDonough, Cynthia Davis, Zhanpan Zhang, Jhimli Mitra, Adrian L. Harris, Aye Aye Thike, Puay Hoon Tan, Yesim Gokmen-Polar, Sunil S. Badve
Summary: The authors developed a deep learning classification network to predict breast cancer events (BCEs) in patients with ductal carcinoma in situ (DCIS), providing early and accurate predictions for personalized therapy and avoiding over-treatment of low-risk patients.
Article
Pharmacology & Pharmacy
Sunil S. S. Badve, Yesim Gokmen-Polar
Summary: Cancer development and progression is a complex process influenced by the co-evolution of cancer cells and their microenvironment. Traditional anti-cancer therapy mainly targets cancer cells, but considering the complex interactions between the tumor and its microenvironment may improve drug efficacy.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
