期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 98, 期 1, 页码 15-22出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.3RU0115-012R
关键词
pulmonary fibrosis; hepatic fibrosis; cardiac fibrosis; skin fibrosis
资金
- Zhejiang Provincial Natural Science Foundation of China [LY13H090014]
- Scientific Research Fund of Zhejiang Provincial Education Department [Y201327689]
- Natural Science Foundation of Ningbo City [2013A610205, 2014A610241]
- General Project of Social Development in Ningbo City [2013C50054]
- Scientific Innovation Team Project of Ningbo [2011B82014]
- K.C. Wong Magna Fund in Ningbo University
IL-33, a new member of the IL-1F, is widely expressed throughout the body and can be up-regulated by stimulation with proinflammatory factors. It has been identified as a functional ligand for the plasma membrane receptor complex that is a heterodimer consisting of membrane-bound ST2L, which is a member of the IL-1R family, and IL-1RAcP. IL-33 is crucial for the induction of Th2 immune responses. Additionally, under other circumstances, it can also act as an endogenous danger signal. Recently, many studies have demonstrated that IL-33 may be related to the development and progression of fibrotic diseases. It has proinflammatory effects in some fibrotic diseases but has anti-inflammatory effects in others. In this review, the biologic characteristics of IL-33 and the role of the IL-33/ST2 signaling pathway in various fibrotic diseases will be discussed. We hope this overview will provide new insights for the treatment of these diseases.
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