Article
Veterinary Sciences
Liujun Zhang, Huandi Wang, Wen Li, Xing Feng, Fangfang Han, Yina Zhang, Jing Chen, Deyi Liu, Pingan Xia
Summary: This study found that anti-PRRSV antibodies in pigs can enhance PRRSV infection by activating Fc gamma receptors and PRRSV receptors. Sialoadhesin and CD163 may play important roles in the ADE of PRRSV infection.
VETERINARY SCIENCES
(2022)
Review
Immunology
Yuyue Zuo, Guo-Min Deng
Summary: Studies have shown that Fc gamma receptors play dual roles in bone erosion in inflammatory arthritis, with the potential to serve as therapeutic targets against bone erosion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Hannes Vietzen, Vera Danklmaier, Alexander Zoufaly, Elisabeth Puchhammer-Stockl
Summary: This study investigates the role of genetic variants in activating natural killer (NK) cell receptors in contributing to the severity of COVID-19. The study shows that the high-affinity variant of the Fc gamma RIIIa receptor is over-represented in hospitalized and deceased patients with COVID-19, while the low-affinity variant is more common in patients with mild COVID-19. Additionally, functional assays reveal that hospitalized patients with COVID-19 exhibit significantly higher proinflammatory ADCC responses, particularly in NK cells expressing the high-affinity variant of the Fc gamma RIIIa receptor.
GENETICS IN MEDICINE
(2022)
Article
Immunology
Adrian Elter, Desislava Yanakieva, David Fiebig, Kerstin Hallstein, Stefan Becker, Ulrich Betz, Harald Kolmar
Summary: This study introduces a novel Fc-tamed antibody format, which reduces off-target toxicity by blocking the Fc gamma R-binding sites of antibodies, resulting in decreased activation and improved safety profiles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Karuppiah Chockalingam, Anil Kumar, Jianxun Song, Zhilei Chen
Summary: In this study, we discovered four novel anti-human CD20 monoclonal antibodies from chickens. These antibodies showed significantly enhanced antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity compared to rituximab, a commonly used antibody. One of the antibodies also demonstrated specificity for a novel hCD20 epitope. These antibodies have potential as monotherapy candidates to improve clinical outcomes in lymphoid malignancies and can be used for the development of next-generation CD20-mediated immunotherapies.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Wu, Yanping Ma, Yifan Nie, Jingya Wang, Guoqing Feng, Le Hao, Wen Huang, Yugu Li, Zhenxing Liu
Summary: In this study, a soluble form of Fc gamma RI alpha (MsFc gamma RI alpha) was cloned from the largemouth bass, and its distribution and function were investigated. The results showed that MsFc gamma RI alpha is widely distributed in the spleen, head kidney, and intestine of largemouth bass. It was found to be involved in the acute phase response to bacteria and could enhance phagocytosis through interaction with a complement receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Abdellatif Bouayad
Summary: Recent data have shown that Fc?Rs play various roles in immune responses against SARS-CoV-2 virus. They bridge the gap between antibody specificity and effector cells and can provide cell-mediated immune protection. These interactions can be beneficial in eliminating the virus but may also enhance viral uptake and cause excessive inflammation. This article discusses the key features of Fc?Rs, their effector functions, clinical relevance, and factors influencing immune responses in COVID-19 and vaccination, as well as potential therapies targeting Fc?R signaling.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Clinical Neurology
Ho Jin Kim, Orhan Aktas, Kristina R. Patterson, Schaun Korff, Amy Kunchok, Jeffrey L. Bennett, Brian G. Weinshenker, Friedemann Paul, Hans-Peter Hartung, Daniel Cimbora, Michael A. Smith, Nanette Mittereder, William A. Rees, Dewei She, Bruce A. C. Cree
Summary: The study shows similar clinical outcomes between NMOSD patients with F158 and V158 allele genotypes treated with approved Inebilizumab.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Immunology
Yuko Nakajima-Kato, Masato Komai, Tadashi Yoshida, Akiko Kanai
Summary: In this study, a Fc-modified anti-Haptoglobin monoclonal antibody was developed and found to have comparable efficacy to IVIG but at considerably lower doses. In vitro experiments demonstrated its binding activity to Fc gamma receptors and inhibitory activity in the ADCC reaction. Furthermore, a cynomolgus monkey ITP model was successfully established, and the antibody showed therapeutic effects with only a single dose. This Fc-modified anti-Haptoglobin monoclonal antibody could be a valuable alternative to IVIG for ITP treatment.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Infectious Diseases
Abdou Khadre Dit Jadir Fall, Celia Dechavanne, Audrey Sabbagh, Andre Garcia, David Courtin, Florence Migot-Nabias
Summary: A study in Benin showed that young Fulani individuals have a natural protection against malaria, and specific polymorphisms in the IgG3 heavy chain and Fc gamma receptors may be involved in this protection. Carrying the G3m6(+) allele and specific haplotypes were associated with an increased risk of malaria infection.
INFECTION GENETICS AND EVOLUTION
(2023)
Editorial Material
Hematology
Barbara Eichhorst
Summary: In this study, Shanafelt et al confirm the continued superiority of ibrutinib plus rituximab (IR) over the prior standard treatment for fit patients with CLL. They also provide important data on the tolerability of continuous treatment with BTK inhibitor.
Article
Multidisciplinary Sciences
Benoit Gamain, Carine Brousse, Nathan E. Rainey, Bere K. Diallo, Clara-Eva Paquereau, Alexandra Desrames, Jolita Ceputyte, Jean-Philippe Semblat, Olivier Bertrand, Stephane Gangnard, Jean-Luc Teillaud, Arnaud Chene
Summary: This study proposes a novel immunotherapeutic approach to redirect preexisting antibodies against EBV to target cells, which shows promising results in improving survival and achieving complete cancer remission in animal models.
Article
Immunology
Melissa M. Lemke, Robert M. Theisen, Emily R. Bozich, Milla R. McLean, Christina Y. Lee, Ester Lopez, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold
Summary: This study uses an ordinary differential equation model to quantitatively assess the influence of IgG1 allotypes and Fc gamma R polymorphisms on IgG-Fc gamma RIIIa complex formation in vaccine-relevant settings. The results demonstrate that specific vaccine interventions can enhance IgG-Fc gamma RIIIa complex formation in different genetic backgrounds.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Maria Bethke, Georg Varga, Toni Weinhage, Harshana Sabharwal, Karin Mellgren, Gerrit Randau, Meike Rolfing, Helmut Wittkowski, Dirk Foell, Ulf Michgehl, Birgit Burkhardt
Summary: Rituximab treatment has shown effects on patient's immune response, including decreased Fc-gamma receptor II levels, decreased serum levels of proinflammatory marker proteins S100A8/A9 and S100A12, and reduction in the cytolytic natural killer (NK) cell population. These findings help in understanding tumor defense mechanisms and could improve the treatment of pediatric patients with mature aggressive B-cell lymphoma.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Medicine, General & Internal
Martin Simkovic, Pavel Vodarek, Monika Motyckova, Dominika ecsiova, Petra Rozsivalova, Heidi Mocikova, Pavla Stepankova, Alice Sykorova, Katerina Hrochova, Filip Vrbacky, David Belada, Pavel Zak, Lukas Smolej
Summary: The RCD regimen is an effective treatment option for elderly patients with relapsed CLL, with significant predictors of shorter PFS being TP53 deletion/mutation, advanced Rai stage, and >= 2 previous lines of treatment. The addition of cyclophosphamide to the R-Dex regimen maintains similar efficacy, even with a 50% reduction in the dexamethasone dose.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Mariavita Ciccarone, Stefan Hohaus, Alessandro Pulsoni, Paola Cavaceppi, Simona Franzo, Raffaella Fabbri, Laura Cudillo, Roberta Battistini, Alice Di Rocco, Ombretta Annibali, Maria Christina Cox, Ida Provenzano, Elisabetta Abruzzese, Daniela Renzi, Cristiano Tesei, Paola Anticoli Borza, Annarosa Cuccaro, Alessandro Andriani, Gianna Maria D'Elia, Antonio Facchiano, Paolo Marchetti, Maria Cantonetti
EUROPEAN JOURNAL OF CANCER CARE
(2020)
Article
Oncology
Cristina Capuano, Chiara Pighi, Roberta Maggio, Simone Battella, Stefania Morrone, Gabriella Palmieri, Angela Santoni, Christian Klein, Ricciarda Galandrini
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Oncology
Carlo Visco, Alice Di Rocco, Andrea Evangelista, Francesca Maria Quaglia, Maria Chiara Tisi, Lucia Morello, Vittorio Ruggero Zilioli, Chiara Rusconi, Stefan Hohaus, Roberta Sciarra, Alessandro Re, Cristina Tecchio, Annalisa Chiappella, Ana Marin-Niebla, Rory McCulloch, Guido Gini, Tommasina Perrone, Luca Nassi, Elsa Pennese, Piero Maria Stefani, Maria Christina Cox, Valentina Bozzoli, Alberto Fabbri, Valentina Polli, Simone Ferrero, Maria Isabel Alvarez De Celis, Antonello Sica, Luca Petrucci, Luca Arcaini, Simon Rule, Mauro Krampera, Umberto Vitolo, Monica Balzarotti
Summary: This study evaluated outcomes of salvage therapy in patients with mantle cell lymphoma, showing significantly higher complete remission rate in the R-BAC treatment group, and higher progression-free survival in the ibrutinib and R-BAC treatment groups. Ibrutinib treatment in early-progressors was associated with reduced risk of death.
Article
Oncology
Maria Christina Cox, Sveva Maria Nusca, Francesca Di Landro, Gabriella Marsilli, Giulia Stella, Matilde Sigona, Federica Ponzelli, Jasmine Passerini Desideri, Francesca Di Gregorio, Flavia Santoboni, Mario Vetrano, Donatella Trischitta, Renato Manno, Maria Chiara Vulpiani
Summary: This study demonstrates that supervised Exercise-Training during chemotherapy is feasible and safe, even in patients aged 65 and above. Furthermore, it may improve the provision of care.
LEUKEMIA & LYMPHOMA
(2021)
Article
Oncology
Francesco Merli, Stefano Luminari, Alessandra Tucci, Annalisa Arcari, Luigi Rigacci, Eliza Hawkes, Carlos S. Chiattone, Federica Cavallo, Giuseppina Cabras, Isabel Alvarez, Alberto Fabbri, Alessandro Re, Benedetta Puccini, Allison Barraclough, Marcia Torresan Delamain, Simone Ferrero, Sara Veronica Usai, Angela Ferrari, Emanuele Cencini, Elsa Pennese, Vittorio Ruggero Zilioli, Dario Marino, Monica Balzarotti, Maria Christina Cox, Manuela Zanni, Alice Di Rocco, Arben Lleshi, Barbara Botto, Stefan Hohaus, Michele Merli, Roberto Sartori, Guido Gini, Luca Nassi, Gerardo Musuraca, Monica Tani, Chiara Bottelli, Sofia Kovalchuk, Francesca Re, Leonardo Flenghi, Annalia Molinari, Giuseppe Tarantini, Emanuela Chimienti, Luigi Marcheselli, Caterina Mammi, Michele Spina
Summary: The study prospectively validated the use of a simplified geriatric assessment (sGA) for older patients with DLBCL and developed a new Elderly Prognostic Index (EPI) based on the sGA groups, International Prognostic Index, and hemoglobin levels to predict overall survival.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Stefania Capone, Angelo Raggioli, Michela Gentile, Simone Battella, Armin Lahm, Andrea Sommella, Alessandra Maria Contino, Richard A. Urbanowicz, Romina Scala, Federica Barra, Adriano Leuzzi, Eleonora Lilli, Giuseppina Miselli, Alessia Noto, Maria Ferraiuolo, Francesco Talotta, Theocharis Tsoleridis, Concetta Castilletti, Giulia Matusali, Francesca Colavita, Daniele Lapa, Silvia Meschi, Maria Capobianchi, Marco Soriani, Antonella Folgori, Jonathan K. Ball, Stefano Colloca, Alessandra Vitelli
Summary: The study introduced a novel replication-defective gorilla adenovirus-vectored vaccine encoding the pre-fusion stabilized Spike protein of SARS-CoV-2, which showed high immunogenicity in mice and macaques. The research highlighted the superiority of the pre-fusion stabilized Spike antigen in inducing ACE2-interfering, SARS-CoV-2-neutralizing antibodies. Selection of the vector backbone and preliminary data identified GRAd-COV2 as a potential COVID-19 vaccine candidate, supporting its translation into a phase I clinical trial.
Review
Oncology
Cristina Capuano, Chiara Pighi, Simone Battella, Davide De Federicis, Ricciarda Galandrini, Gabriella Palmieri
Summary: NK cells play a crucial role in cancer immunotherapy based on tumor-targeting monoclonal antibodies by interacting with IgG-opsonized tumor cells through the CD16 receptor. Activated NK cells not only exert cytotoxic functions but also produce a range of cytokines and chemokines to enhance adaptive immune responses. Strategies aiming to enhance NK cell-mediated antitumor functions in tumor-targeting monoclonal antibody regimens include mAb manipulation strategies and the potential exploitation of memory NK cells with unique characteristics.
Review
Oncology
Maria Christina Cox, Guido Bocci
Summary: Novel drugs are changing the treatment approach for non-Hodgkin lymphomas, with chemotherapy still being a key part of treatment for aggressive subtypes. Metronomic chemotherapy, involving long-term low dose drug administration, shows potential for more effective and tolerable combinations. This approach has been little explored in NHLs but has shown promising results in pre-clinical studies.
Article
Cell Biology
Simone Lanini, Stefania Capone, Andrea Antinori, Stefano Milleri, Emanuele Nicastri, Roberto Camerini, Chiara Agrati, Concetta Castilletti, Federica Mori, Alessandra Sacchi, Giulia Matusali, Roberta Gagliardini, Virginia Ammendola, Eleonora Cimini, Fabiana Grazioli, Laura Scorzolini, Federico Napolitano, Maria M. Plazzi, Marco Soriani, Aldo De Luca, Simone Battella, Andrea Sommella, Alessandra M. Contino, Federica Barra, Michela Gentile, Angelo Raggioli, Yufang Shi, Enrico Girardi, Markus Maeurer, Maria R. Capobianchi, Francesco Vaia, Mauro Piacentini, Guido Kroemer, Alessandra Vitelli, Stefano Colloca, Antonella Folgori, Giuseppe Ippolito
Summary: Safe and effective COVID-19 vaccines are crucial for ending the pandemic. A vaccine called GRAd-COV2, based on a gorilla adenovirus and expressing the spike protein of SARS-CoV-2, has been evaluated for safety and immunogenicity in healthy younger and older adults.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Cristina Capuano, Chiara Pighi, Simone Battella, Fabio Pulcinelli, Cristina Santoro, Antonietta Ferretti, Ombretta Turriziani, Davide De Federicis, Cinzia Fionda, Giuseppe Sciume, Ricciarda Galandrini, Gabriella Palmieri
Summary: The in vivo establishment and long-term persistence of a heterogeneous memory or an adaptive NK cell pool play a functional adaptation role to human cytomegalovirus infection in humans. The FcεRIγ(-) NKG2C(+)CD57(+) memory NK cell subset, whose abundance is associated with anti-HCMV antibody levels, expands robustly and selectively in response to mAb-opsonized targets or ITP-derived platelets, demonstrating superior CD16-dependent IFNγ production. The lack of FcεRIγ chain contributes to the higher responsivity to CD16 engagement in NKG2C(+)CD57(+) memory cells.
Letter
Oncology
M. Christina Cox, Luigi Marcheselli, Giorgia Scafetta, Carlo Visco, Stefan Hohaus, Ombretta Annibali, Gerardo Musuraca, Alberto Fabbri, Maria Cantonetti, Sabrina Pelliccia, Robel Papotti, Luigi Petrucci, Monica Tani, Roberta Battistini, Annalisa Arcari, Stefano Luminari, Gianluca Lopez, Eleonora Alma, Livio Pupo, Giuseppe Carli, Francesco Marchesi, Francesca Re, Stefania Scarpino, Emanuele S. G. D'amore, Luigi M. Larocca, Antonella Bianchi, Giuseppina Pepe, Fiammetta Natalino, Paola Anticoli-Borza, Natalia Cenfra, Alessandro Andriani, Elisabetta Abruzzese, Cristiano Tesei, Lorenzo Leoncini, Silvia Asioli, Luigi Ruco, Arianna Di Napoli