Biased agonism at chemokine receptors: obstacles or opportunities for drug discovery?
出版年份 2015 全文链接
标题
Biased agonism at chemokine receptors: obstacles or opportunities for drug discovery?
作者
关键词
-
出版物
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 99, Issue 6, Pages 901-909
出版商
Wiley
发表日期
2015-12-24
DOI
10.1189/jlb.2mr0815-392r
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Gaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessors
- (2015) Terry Kenakin BRITISH JOURNAL OF PHARMACOLOGY
- Biased Signaling at Chemokine Receptors
- (2015) Jenny Corbisier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function
- (2015) Abhishek Tripathi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Abstract 1076: Antagonists of the chemokine receptor CCR4 reverse the tumor-promoting microenvironment of renal cancer
- (2015) Chiara Berlato et al. CANCER RESEARCH
- Reduction of Regulatory T Cells by Mogamulizumab, a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients with Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome
- (2014) X. Ni et al. CLINICAL CANCER RESEARCH
- Bivalent Ligands Targeting Chemokine Receptor Dimerization: Molecular Design and Functional Studies
- (2014) Christopher Arnatt et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons
- (2014) Philipp Abe et al. DEVELOPMENT
- Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists
- (2014) Laura Ajram et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- CCR4 and its ligands: from bench to bedside
- (2014) O. Yoshie et al. INTERNATIONAL IMMUNOLOGY
- Distinct Conformations of the Chemokine Receptor CCR4 with Implications for Its Targeting in Allergy
- (2014) J. M. Viney et al. JOURNAL OF IMMUNOLOGY
- Bias in chemokine receptor signalling
- (2014) Annelien J.M. Zweemer et al. TRENDS IN IMMUNOLOGY
- Biased and G Protein-Independent Signaling of Chemokine Receptors
- (2014) Anne Steen et al. Frontiers in Immunology
- Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma
- (2013) Takashi Ishida et al. CANCER SCIENCE
- In vivo regulation of chemokine activity by post-translational modification
- (2013) Eva AV Moelants et al. IMMUNOLOGY AND CELL BIOLOGY
- CCL17/thymus and activation-regulated chemokine induces calcitonin gene–related peptide in human airway epithelial cells through CCR4
- (2013) Kandace Bonner et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors
- (2013) Sudarshan Rajagopal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Internalization of CCR4 and Inhibition of Chemotaxis by K777, a Potent and Selective CCR4 Antagonist
- (2013) Takashi Sato et al. PHARMACOLOGY
- Engagement of Two Distinct Binding Domains on CCL17 Is Required for Signaling through CCR4 and Establishment of Localized Inflammatory Conditions in the Lung
- (2013) Sandra Santulli-Marotto et al. PLoS One
- -Arrestin-Dependent Activation of the Cofilin Pathway Is Required for the Scavenging Activity of the Atypical Chemokine Receptor D6
- (2013) E. M. Borroni et al. Science Signaling
- Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study
- (2013) Anthony Cahn et al. BMC Pharmacology & Toxicology
- Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation
- (2012) Anne O. Watts et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Chemokine Superfamily Revisited
- (2012) Albert Zlotnik et al. IMMUNITY
- Modulation in Selectivity and Allosteric Properties of Small-Molecule Ligands for CC-Chemokine Receptors
- (2012) Stefanie Thiele et al. JOURNAL OF MEDICINAL CHEMISTRY
- Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells
- (2012) K E Luker et al. ONCOGENE
- D6: the ‘crowd controller’ at the immune gateway
- (2012) Kit Ming Lee et al. TRENDS IN IMMUNOLOGY
- CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration
- (2011) Fabien M. Décaillot et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In vivo imaging of ligand receptor binding with Gaussia luciferase complementation
- (2011) Kathryn E Luker et al. NATURE MEDICINE
- Anti-inflammatory therapeutics for the treatment of atherosclerosis
- (2011) Israel F. Charo et al. NATURE REVIEWS DRUG DISCOVERY
- Functional Selectivity and Biased Receptor Signaling
- (2010) T. Kenakin JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Selectively Engaging -Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance
- (2010) J. D. Violin et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Different Effects of the Different Natural CC Chemokine Receptor 2b Ligands on -Arrestin Recruitment, G i Signaling, and Receptor Internalization
- (2010) Y. A. Berchiche et al. MOLECULAR PHARMACOLOGY
- CXCR7 Functions as a Scavenger for CXCL12 and CXCL11
- (2010) Ulrike Naumann et al. PLoS One
- CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling
- (2009) A. Levoye et al. BLOOD
- RecognitionVersusAdaptive Up-regulation and Degradation of CC Chemokines by the Chemokine Decoy Receptor D6 Are Determined by Their N-terminal Sequence
- (2009) Benedetta Savino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands
- (2009) B. A. Zabel et al. JOURNAL OF IMMUNOLOGY
- Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice
- (2009) Rory R Koenen et al. NATURE MEDICINE
- -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7
- (2009) S. Rajagopal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
- (2009) D. A. Zidar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CXC and CC Chemokines Form Mixed Heterodimers
- (2008) Irina V. Nesmelova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PositiveVersusNegative Modulation of Different Endogenous Chemokines for CC-chemokine Receptor 1 by Small Molecule Agonists through AllostericVersusOrthosteric Binding
- (2008) Pia C. Jensen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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