期刊
CLINICAL BIOCHEMISTRY
卷 45, 期 6, 页码 412-415出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2012.01.008
关键词
MMP-8; Neutrophil collagenase; MMP-9; TIMP-1; Obesity; MPO; Neutrophil activation
资金
- Fundacdo de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG-Brazil)
- Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior (CAPES-Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq-Brazil)
- IEP-SCBH - Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte
Objectives: To compare the plasma concentrations of matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP (TIMP)-1, MMP-8, and myeloperoxidase (MPO) for obese and lean women. Design and methods: We recruited 30 lean and 36 obese women without comorbidities. The MMP-9, TIMP-1, and MMP-8 levels were measured using enzyme-linked immunosorbent assay (ELISA). MPO activity was assessed by a colorimetric assay. Results: Obese women had higher MMP-9 levels and MMP-9:TIMP-1 ratios than lean women. Conversely, the MMP-8 levels and MMP-8:TIMP-1 ratios in the obese women were significantly lower than those in the lean women despite neutrophil activation, which was assessed by MPO activity., Conclusion: We observed that MMP-9 and MMP-8 had distinct profiles, which suggested that these 2 enzymes play different roles in obesity. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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