Article
Nutrition & Dietetics
Simon Hsu, David K. Prince, Kayleen Williams, Norrina B. Allen, Gregory L. Burke, Andrew N. Hoofnagle, Xiaohui Li, Kiang J. Liu, Robyn L. McClelland, Erin D. Michos, Bruce M. Psaty, Steven J. Shea, Kenneth M. Rice, Jerome Rotter, David Siscovick, Russell P. Tracy, Karol E. Watson, Bryan R. Kestenbaum, Ian H. de Boer
Summary: The study found that only participants with a baseline 25(OH)D level below 20 ng/mL had a significant reduction in parathyroid hormone (PTH) with vitamin D supplementation.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medical Laboratory Technology
Konstantinos Makris, Harjit P. Bhattoa, Etienne Cavalier, Karen Phinney, Christopher T. Sempos, Candice Z. Ulmer, Samuel D. Vasikaran, Hubert Vesper, Annemieke C. Heijboer
Summary: Vitamin D and its metabolites play a crucial role in bone metabolism, and accurate measurement and standardization are still challenging tasks that require further research and regulation.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Johanna E. Camara, Stephen A. Wise, Andrew N. Hoofnagle, Emma L. Williams, Graham D. Carter, Julia Jones, Carolyn Q. Burdette, Grace Hahm, Federica Nalin, Adam J. Kuszak, Joyce Merkel, Ramon A. Durazo-Arvizu, Pierre Lukas, Etienne Cavalier, Christian Popp, Christian Beckert, Jan Schultess, Glen Van Slooten, Carole Tourneur, Camille Pease, Ravi Kaul, Alfredo Villarreal, Fiona Ivison, Ralf Fischer, Jody M. W. van den Ouweland, Chung S. Ho, Emmett W. K. Law, Jean-Nicolas Simard, Renaud Gonthier, Brett Holmquist, Marcelo Cidade Batista, Heather Pham, Alex Bennett, Sarah Meadows, Lorna Cox, Eugene Jansen, Dilshad Ahmed Khan, Kimberly Robyak, Michael H. Creer, Mark Kilbane, Patrick J. Twomey, James Freeman, Neil Parker, Jinyun Yuan, Robert Fitzgerald, Sohail Mushtaq, Michael W. Clarke, Norma Breen, Christine Simpson, Christopher T. Sempos
Summary: The study conducted by VDSP evaluated the commutability of SRMs and PT/EQA samples for the determination of serum total 25(OH)D. Results showed that some SRM and PT/EQA samples were deemed non-commutable with specific assays within certain concentration ranges.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Ophthalmology
Federico Zicarelli, Giovanni Ometto, Giovanni Montesano, Samuele Motta, Luca De Simone, Luca Cimino, Giovanni Staurenghi, Aniruddha Agarwal, Francesco Pichi, Alessandro Invernizzi
Summary: Posterior segment inflammation can be objectively graded through OCT scans. The density of vitreous cells and the VIT/RPE-relative intensity decrease significantly over time. Cell density is correlated with clinical grading, showing a significant increase at each grade of the NEI scale. On the other hand, VIT/RPE-relative intensity is positively correlated with the overall clinical grade, but there is no significant difference when comparing contiguous grades of the NEI scale. Infectious uveitis has a higher cell density. The interclass correlation coefficient between manual and automatic assessment is 0.83 for cell density and 0.423 for the VIT/RPE-relative intensity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Nutrition & Dietetics
Stephen P. J. Brooks, W. M. Nimal Ratnayake, Isabelle Rondeau, Eleonora Swist, Kurtis Sarafin, Hope A. Weiler
Summary: This study examined the vitamin D status of South Asian and European children in Canada and found that South Asian children had lower vitamin D levels. Lower vitamin D levels were also associated with children who had a BMI in the overweight/obese range. Additionally, South Asian children had lower vitamin D intake.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Jiayu Huang, Qian Zhao, Jiao Li, Jinfeng Meng, Shangbin Li, Weichen Yan, Jie Wang, Changjun Ren
Summary: This study found that neonates with hyperbilirubinemia had lower vitamin D levels compared to term neonates without hyperbilirubinemia, indicating that neonates with lower vitamin D levels may be at higher risk for developing hyperbilirubinemia.
Article
Infectious Diseases
Jens Becker, Mireille Meylan
Summary: This study compared two widespread methods for quantifying antimicrobial treatment incidence and found good agreement on class and drug levels, with some discrepancies observed for specific drugs such as tylosin and sulfadimidine. The TIDDD method showed mostly good agreement, especially for parenteral treatments.
Article
Biochemistry & Molecular Biology
Dae-Hyun Ko, Sun-Hee Jun, Youngwon Nam, Sang H. Song, Minje Han, Yeo-Min Yun, Kyunghoon Lee, Junghan Song
Summary: A multiplex LC-MS/MS method was developed to determine bioavailable vitamin D and VMR, showing differences in bioavailable vitamin D levels among different ethnicities. The new method was robust and reliable, suitable for routine clinical samples.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Muzaitul Akma Mustapa Kamal Basha, Hazreen Abdul Majid, Nuguelis Razali, Aswir Abd Rashed, Hussin Muhammad, Abqariyah Yahya
Summary: The study revealed a longitudinal relationship between maternal vitamin D deficiency during pregnancy and neonatal vitamin D deficiency at birth. Further trials are needed to confirm this association.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Chaofan Geng, Zhenzhen Yang, Xiumei Kong, Pengfei Xu, Hongju Zhang
Summary: This study found a relationship between vitamin D levels and poorer sleep quality in patients with Restless Legs Syndrome (RLS). However, the causal relationship between vitamin D deficiency and RLS is still inconclusive. Future research could explore the effects of vitamin D supplementation as a therapeutic strategy for sleep disorders in RLS patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Philip R. Fischer, Christopher T. Sempos, John M. Pettifor, David R. Fraser, Craig F. Munns, Ramon A. Durazo-Arvizu, Tom D. Thacher
Summary: This study examines the association between serum 1,25(OH)2D levels and the risk of nutritional rickets in children with low-calcium diets. The results show that higher levels of serum 1,25(OH)2D are independently associated with an increased risk of nutritional rickets in this population.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Antonio Facciorusso, Robert A. Adler, Neil Binkley, Jens Bollerslev, Roger Bouillon, Felipe F. Casanueva, Giulia Martina Cavestro, Marlene Chakhtoura, Caterina Conte, Lorenzo M. Donini, Peter R. Ebeling, Angelo Fassio, Stefano Frara, Claudia Gagnon, Giovanni Latella, Claudio Marcocci, Jeffrey I. Mechanick, Salvatore Minisola, Rene Rizzoli, Ferruccio Santini, Joseph L. Shaker, Christopher Sempos, Fabio Massimo Ulivieri, Jyrki K. Virtanen, Nicola Napoli, Anne L. Schafer, John P. Bilezikian
Summary: Bariatric surgery is associated with a decrease in 25(OH) vitamin D levels and increased risk of skeletal complications. Guidelines for assessing and supplementing vitamin D in bariatric patients before and after surgery are lacking. This systematic review and meta-analysis provide recommendations for vitamin D management in bariatric patients based on published experience. Vitamin D levels should be assessed pre- and postoperatively in all bariatric surgery patients, and high-dose supplementation is recommended after surgery.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Nutrition & Dietetics
Christopher T. Sempos, Ramon A. Durazo-Arvizu, Philip R. Fischer, Craig F. Munns, John M. Pettifor, Tom D. Thacher
Summary: The study found a significant association between serum 25(OH)D and nutritional rickets in Nigerian children, and showed that the vitamin D requirement to prevent nutritional rickets varies inversely with calcium intake. The use of multivariable modeling is essential in defining vitamin D requirements.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Zsolt Gall, Brigitta Csukor, Melinda Urkon, Lenard Farczadi, Melinda Kolcsar
Summary: This study confirmed that 25(OH)D3 can be detected in human hair, but further investigations are needed to determine its use as a biomarker since no correlation was found between serum 25(OH)D3 concentrations, supplementation, sun exposure, and hair 25(OH)D3 concentrations levels.
Article
Hematology
Minjeong Nam, Mina Hur, Hyunkyung Lee, Hanah Kim, Mikyoung Park, Hee-Won Moon, Yeo-Min Yun
Summary: The study compared the measurement of blood type antibodies using automated column agglutination technology and tube test, finding high agreement and correlation between the two methods for most blood types. Modified CAT showed superior performance in terms of risk analysis, turnaround time, and cost.
Article
Medical Laboratory Technology
Gun-Hyuk Lee, Sumi Yoon, Minjeong Nam, Hanah Kim, Mina Hur
Summary: This study comprehensively evaluated the performance of CellaVision DC-1, including its turnaround time. DC-1 showed excellent precision and qualitative performance, making it suitable for small to medium-volume laboratories. However, in some cell classes, DC-1 may add unnecessary workload for cell verification.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Hyun Suk Yang, Mina Hur, Seungho Lee
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medical Laboratory Technology
Tae Hwan Lee, Minjeong Nam, Jong Do Seo, Hanah Kim, Hae-Rim Kim, Mina Hur, Yeo-Min Yun, Hee -Won Moon
Summary: T cell responses to ChAdOx1-nCoV-19 and BNT162b2 vaccinations were evaluated using an interferon gamma (IFN-gamma) release assay (IGRA). Initially, ChAdOx1-nCoV-19 and BNT162b2 vaccinated individuals showed stronger T cell responses compared to unvaccinated controls. The T cell response decreased over time but significantly increased after the administration of a BNT162b2 booster dose. Changes in the T cell response were less significant than changes in the anti-receptor-binding domain IgG antibody titer. The study provides baseline data for T cell responses after SARS-CoV-2 vaccination and suggests the usefulness of IGRA in monitoring immunogenicity.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Minjeong Nam, Mina Hur, Hanah Kim, Tae-Hwan Lee, Gun-Hyuk Lee, Sumi Yoon, Seungman Park, Sung Yong Kim, Mark Hong Lee
Summary: This study compared clinical outcomes in ABO-compatible and incompatible hematopoietic stem cell transplantation (HSCT) recipients, and found that ABO-incompatible patients with high recipient-derived isoagglutinin (RDI) levels had unfavorable outcomes in terms of survival, acute GVHD grade IV, and red blood cell (RBC) transfusion. The high RDI group was independently associated with increased risk of death, RBC transfusion, and poor platelet (PLT) engraftment. Therefore, high RDI levels can serve as a marker for predicting unfavorable outcomes in ABO-incompatible HSCT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Mikyoung Park, Mina Hur, Hanah Kim, Chae Hoon Lee, Jong Ho Lee, Hyung Woo Kim, Minjeong Nam, Seungho Lee
Summary: This study demonstrated that sST2 could be a useful biomarker to predict ICU admission, ventilator use, ECMO use, and 30-day mortality in hospitalized COVID-19 patients. sST2 may be implemented as a prognostic COVID-19 biomarker in clinical practice.
Letter
Medical Laboratory Technology
Eunju Shin, Hanah Kim, Mina Hur, Hyunkyung Lee, In-Sook Sohn, Kyoung Un Park, Dong Hee Seo
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Hanah Kim, Gun-Hyuk Lee, Sumi Yoon, Mina Hur, Hyeong Nyeon Kim, Mikyoung Park, Seung Wan Kim
Summary: This study compared the performance of the EasyCell assistant with manual microscopic review and the Pentra DX Nexus in terms of WBC differentials and PLT count. The results showed that the EasyCell assistant performed well in both aspects, and showed improvement after user verification.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Eun-Jung Cho, Tae-Dong Jeong, Sollip Kim, Hyung-Doo Park, Yeo-Min Yun, Sail Chun, Won-Ki Min
Summary: In order to ensure valid results in medical big data research, it is important to have high-quality laboratory input. This study aimed to establish a strategy for evaluating the quality of laboratory results suitable for big data research using KEQAS data. The acceptance rate and bias of different test items were analyzed, showing significant differences based on the quality grade for each criterion.
ANNALS OF LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Gun-Hyuk Lee, Hanah Kim, Mina Hur, Kyeong A. So, Dong Woo Shin, Yun Ji Hong, Kyoung Un Park
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Pathology
Dong Woo Shin, Gun-Hyuk Lee, Hanah Kim, Kyeong A. So, Yun Ji Hong, Mina Hur, Kyoung Un Park
Summary: This study identified three DNT individuals by analyzing the family members of a DNT proband, and found that DNT is serologically indistinguishable from D+. Recommendations for prophylaxis and genotyping were proposed for DNT individuals and partial D family members.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Editorial Material
Medical Laboratory Technology
Sun Young Cho, Mina Hur
ANNALS OF LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Sollip Kim, Eun-Jung Cho, Tae-Dong Jeong, Hyung-Doo Park, Yeo-Min Yun, Kyunghoon Lee, Yong-Wha Lee, Sail Chun, Won-Ki Min
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Sung-Eun Cho, Jungsun Han, Ju-Hee Park, Euna Park, Geun Young Kim, Jun Hyung Lee, Ahram Yi, Sang Gon Lee, Eun Hee Lee, Yeo-Min Yun
Summary: Ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) assay shows acceptable performance and a lower limit of quantitation (LLOQ) compared to immunoassays for quantifying serum total testosterone, enabling the quantitation of low testosterone concentrations.
ANNALS OF LABORATORY MEDICINE
(2023)
