期刊
CLINICAL BIOCHEMISTRY
卷 45, 期 1-2, 页码 31-36出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2011.09.023
关键词
Procollagen III N-terminal peptide; Serum marker; Treatment response; Chronic hepatitis B; Entecavir
资金
- Ministry of Health, Welfare and Family Affairs, Republic of Korea [A050021]
Objectives: The aims of this study were to determine the changes in serum histologic surrogate markers and to identify the serum markers predicting treatment response in patients with chronic hepatitis B (CHB) during entecavir treatment. Design and methods: Sixty CHB patients who received entecavir for 12 months were included. We assessed serum markers of liver fibrosis and/or inflammation at baseline and after 12 months of entecavir treatment. Results: The procollagen III N-terminal peptide (PIIINP) and TIMP1, MMP2, hyaluronic acid and cytokeratin 18 fragment levels were significantly decreased and the haptoglobin level was significantly increased from baseline after entecavir treatment. Multivariate analysis identified PIIINP (P = 0.028) and the initial virologic response (P = 0.019) as independent predictors of HBeAg loss. Conclusion: During entecavir treatment, most serum markers of liver fibrosis and inflammation improved in patients with CHB. The PIIINP level at baseline and the initial virologic response are independent predictors of HBeAg loss. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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