期刊
CLINICAL BIOCHEMISTRY
卷 44, 期 13, 页码 1085-1089出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2011.06.981
关键词
Osteoporosis; RANKL; Bone mineral density; Genetics; High resolution melting
资金
- Ministry of Higher Education, Science and Technology of Slovenia [P3-0298, J3-2330]
Objectives: Peroxisome proliferator-activated receptor. (PPAR.), an essential transcription factor for adipogenesis, has been implicated in pathogenesis of osteoporosis. The association of three single nucleotide polymorphisms in the PPARG gene with hip fracture risk, bone mineral density (BMD) and biochemical markers of bone turnover was investigated in the elderly. Design and methods: Six hundred sixty-seven elderly Slovenians were genotyped for SNPs rs12497191, rs1801282 and rs3856806. BMD and biochemical markers of bone turnover were measured. Haplotypes ACC, AGT and GCC, defined by rs12497191, rs1801282 and rs3856806 were assigned. Influence of genotype on fracture risk was assessed in 72 non-traumatic hip fracture cases and 272 controls. Results: The rs12497191 G allele alone or in haplotype was associated with lower risk of non-traumatic hip fracture and higher serum receptor activator of nuclear factor kappa B ligand. Conclusions: The rs12497191 genotype could contribute to the incidence of non-traumatic hip fractures in the elderly. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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