Article
Neurosciences
Lu Wang, Han-Yu Yang, Cai-Xia Zang, Jun-Mei Shang, Hui Liu, Zi-Hong Zhang, Fang-Yu Yuan, Cheng Ju, Fang-Yuan Li, Xiu-Qi Bao, Dan Zhang
Summary: The study revealed the crucial role of macrophage receptor with collagenous structure (Marco) in regulating neuroinflammation, with Toll-like receptor 2 (TLR2) acting as an important co-receptor of Marco to potentiate the neuroinflammatory response through interaction with the SRCR domain of Marco. Knocking down TLR2 resulted in decreased Marco expression, indicating the direct binding of TLR2 to the SRCR domain of Marco in regulating neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hany N. Azzam, Marwa O. El-Derany, Sara A. Wahdan, Reham M. Faheim, Gouda K. Helal, Ebtehal El-Demerdash
Summary: The metabolic/hypoxial axis plays an important role in the development of tamoxifen resistance in breast cancer patients. Plasma levels of TUG-1 and miR-186 are elevated in tamoxifen resistant patients, while SIRT3, PPAR-1 alpha, and HIF-1 alpha are deficient. TUG-1 and HIF-1 alpha can be used as predictors of tamoxifen resistance in breast cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Jiayang Liu, Tongyang Xu, Danjie Pan, Jiajun Fan, Xiting Huang, Weili Zhao, Xiaochun Dong, Shaohui Zhang, Kudelaidi Kuerban, Xuan Huang, Songna Wang, Huaning Chen, Yunpeng He, Yi Zhun Zhu, Congjun Wang, Li Ye
Summary: The vWF A3-SIRP alpha Fc fusion protein has tumor-targeting ability and exhibits improved anti-tumor immunotherapeutic efficacy compared to SIRP alpha Fc.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Bernhard Friedrich, Stefan Lyer, Christina Janko, Harald Unterweger, Regine Brox, Sarah Cunningham, Silvio Dutz, Nicola Taccardi, Floris J. Bikker, Katrin Hurle, Heidi Sebald, Malte Lenz, Erdmann Spiecker, Lars Fester, Holger Hackstein, Richard Strauss, Aldo R. Boccaccini, Christian Bogdan, Christoph Alexiou, Rainer Tietze
Summary: This study demonstrates an efficient strategy for the clearance of bacterial pathogens in bloodstream infections using magnetic particles conjugated with specific peptides, resulting in reduced cytokine release. The approach shows good compatibility with cells and blood, without interfering with host structures. It also has the potential to shorten diagnostic times for bloodstream infections and accelerate targeted antibiotic therapy.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Ahmed K. Aladhami, Christian A. Unger, Shannon L. Ennis, Diego Altomare, Hao Ji, Marion C. Hope, Kandy T. Velazquez, Reilly T. Enos
Summary: Macrophage-derived TNF-alpha does not play a significant role in the development of obesity, but can reduce TNF-alpha gene expression and circulating levels in adipose tissue, as well as modulate specific signaling pathway gene expression.
Article
Pharmacology & Pharmacy
Shixin Duan, Xinyi Lou, Shiyi Chen, Hongchao Jiang, Dongxin Chen, Rui Yin, Mengkai Li, Yuseng Gou, Wenjuan Zhao, Lei Sun, Feng Qian
Summary: This study reveals the importance of the LMO7/PFKFB3/JMJD3 axis in modulating macrophage function and IBD pathogenesis. The findings suggest that LMO7 directly degrades PFKFB3 through K48-mediated ubiquitination in pro-inflammatory macrophages, leading to the inhibition of macrophage activation and attenuation of murine colitis.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Mi-Aie Hwang, Misun Won, Joo-Young Im, Mi-Jung Kang, Dae-Hyuk Kweon, Bo-Kyung Kim
Summary: Our study aimed to investigate the impact of macrophages on the invasive ability of gastric cancer cells and explore its potential mechanism. Through transcriptome analysis, we found that integrin alpha V gene expression increased in AGS cells cocultured with RAW264.7 cells. Additionally, AGS cells cocultured with RAW264.7 cells exhibited increased adhesion and invasion compared to cells cultured alone. This increased invasion was inhibited by knockdown of integrin alpha V.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Xiaoqian Sun, Yanqin Li, Qiong Deng, Yueyao Hu, Jianteng Dong, Wei Wang, Yong Wang, Chun Li
Summary: Macrophages undergo metabolic reprogramming, which influences their inflammatory function. In ischemic heart disease, the polarization and metabolic shifts of macrophages can affect the balance of inflammatory effects and determine disease progression and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Michal Marczyk, Vignesh Gunasekharan, David Casadevall, Tao Qing, Julia Foldi, Raghav Sehgal, Naing Lin Shan, Kim R. M. Blenman, Tess A. O'Meara, Sheila Umlauf, Yulia Surovtseva, Viswanathan Muthusamy, Jesse Rinehart, Rachel J. Perry, Richard Kibbey, Christos Hatzis, Lajos Pusztai
Summary: This study examines the expression patterns of isozymes in cancer and identifies potential therapeutic targets. It shows that the loss of isozyme diversity in cancer can be exploited for anticancer therapy.
Article
Multidisciplinary Sciences
Madeleine M. LaRue, Seth Parker, Joseph Puccini, Michael Cammer, Alec C. Kimmelman, Dafna Bar-Sagi
Summary: Tumor-associated macrophages play a role in remodeling the extracellular matrix, which affects the growth and development of tumors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Oncology
Nazli Dizman, Elizabeth I. Buchbinder
Summary: The review article discusses the role of the CD47/SIRPα axis in cancer, summarizes the efficacy and safety of therapeutics targeting CD47 or SIRPα, and explores the potential future implementation of these treatments for various cancer types.
Article
Oncology
Zhuan Li, Songming Chen, Xiang He, Siyuan Gong, Lunquan Sun, Liang Weng
Summary: Tumor-associated macrophages (TAMs) play a crucial role in facilitating tumor progression and are associated with poor prognosis in lung cancer patients. Metabolic changes induced by solute carrier family 3 member 2 (SLC3A2) in lung cancer cells were found to affect TAM polarization. The knockdown of SLC3A2 altered the metabolism of lung cancer cells and led to changes in multiple metabolites, including arachidonic acid, in the tumor microenvironment. Arachidonic acid was shown to be responsible for SLC3A2-mediated macrophage polarization towards the M2 type.
Review
Immunology
Quxing Wei, Yanyue Deng, Qianqian Yang, Angyu Zhan, Lexun Wang
Summary: Macrophages play diverse roles in physiological and pathological conditions, particularly in metabolic disorders, and have become promising targets for diagnosis and therapy. Due to their heterogeneity and polarization, the phenotypes and functions of macrophages in metabolic disorders are complex. The development of specific molecular markers in macrophage research has greatly contributed to understanding their role in metabolic disorders. This review analyzes commonly used and novel macrophage markers related to metabolic disorders, aiming to improve their utilization in research.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Yan Dong, Siyan Zhang, Xiaotong Gao, Dandan Yin, Tingting Wang, Zhelong Li, Zhuo Wan, Mengying Wei, Ying Luo, Guodong Yang, Li Liu
Summary: The study identified that HIF1α activation in tumor-associated macrophages played a crucial role in immune suppressive microenvironment, and epigenetically silenced Hif1α macrophages inhibited tumor growth and angiogenesis. This research offers a promising strategy for reprogramming tumor microenvironment through epigenetically reprogrammed macrophages.
BIOACTIVE MATERIALS
(2021)
Article
Cell Biology
Qiuhua Yang, Qian Ma, Jiean Xu, Zhiping Liu, Jianqiu Zou, Jian Shen, Yaqi Zhou, Qingen Da, Xiaoxiao Mao, Sarah Lu, David J. Fulton, Neal L. Weintraub, Zsolt Bagi, Mei Hong, Yuqing Huo
Summary: The deficiency of Prkaa1 in myeloid cells impacts the expression of genes involved in glucose and lipid metabolism, compromises macrophages' metabolic abilities, reduces their recruitment in various tissues, and ultimately leads to a deceleration in the development of related metabolic disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Estibaliz Glaria, Annabel F. Valledor
Article
Fisheries
Rosemary Thwaite, Concepcion Berbel, Manuel Aparicio, Debora Torrealba, Mireia Pesarrodona, Antonio Villaverde, Juan Jose Borrego, Manuel Manchado, Nerea Roher
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Estibaliz Glaria, Nicole A. Letelier, Annabel F. Valledor
CURRENT OPINION IN PHARMACOLOGY
(2020)
Article
Oncology
Jose M. Carbo, Theresa E. Leon, Joan Font-Diaz, Juan Vladimir De la Rosa, Antonio Castrillo, Felix R. Picard, Daniel Staudenraus, Magdalena Huber, Lidia Cedo, Joan Carles Escola-Gil, Lucia Campos, Latifa Bakiri, Erwin F. Wagner, Carme Caelles, Thomas Stratmann, Jo A. Van Ginderachter, Annabel F. Valledor
Summary: The study demonstrated that synthetic LXR agonist TO901317 inhibits tumor growth in a murine model of Lewis lung carcinoma, with antitumor effects reliant on functional LXR activity in host cells. By reducing the abundance and expression of certain factors in Tregs and TAMs, the LXR pathway exerts a comprehensive control over TAM responses in the tumor microenvironment.
Article
Fisheries
J. Moraleda-Prados, M. Caballero-Huertas, A. Valdivieso, S. Joly, J. Ji, N. Roher, L. Ribas
Summary: The study found significant hypomethylation levels in immune genes post LPS exposure in zebrafish, impacting sex differentiation and gene expression. This research provides initial evidence of possible epigenetic interactions between the immune and reproductive systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Oncology
Joan Font-Diaz, Alba Jimenez-Panizo, Carme Caelles, Maria dM Vivanco, Paloma Perez, Ana Aranda, Eva Estebanez-Perpina, Antonio Castrillo, Mercedes Ricote, Annabel F. Valledor
Summary: Nuclear receptors are important transcription factors that regulate gene expression, influencing cell proliferation, differentiation, and apoptosis, and are significant for cancer intervention.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karen Alejandra Mendez-Lara, Nicole Letelier, Nuria Farre, Elena M. G. Diarte-Anazco, Nuria Nieto-Nicolau, Elisabeth Rodriguez-Millan, David Santos, Victor Pallares, Joan Carles Escola-Gil, Tania Vazquez del Olmo, Enrique Lerma, Mercedes Camacho, Ricardo P. Casaroli-Marano, Annabel F. Valledor, Francisco Blanco-Vaca, Josep Julve
Article
Chemistry, Multidisciplinary
Hector Lopez-Laguna, Julieta M. Sanchez, Jose Vicente Carratala, Mauricio Rojas-Pena, Laura Sanchez-Garcia, Eloi Parlade, Alejandro Sanchez-Chardi, Eric Volta-Duran, Naroa Serna, Olivia Cano-Garrido, Sandra Flores, Neus Ferrer-Miralles, Veronica Nolan, Ario de Marco, Nerea Roher, Ugutz Unzueta, Esther Vazquez, Antonio Villaverde
Summary: The approach is based on controlled coordination between Zn2+ ions and His residues in His-tagged proteins, allowing for spontaneous and reproducible protein assembly as nanoscale oligomers. This green biofabrication procedure can be straightforwardly applied to a wide range of protein species for their conversion into their respective nanostructured formats.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Biology
Lucia Sanjurjo, Iris A. Schulkens, Pauline Touarin, Roy Heusschen, Ed Aanhane, Kitty C. M. Castricum, Tanja D. De Gruijl, Ulf J. Nilsson, Hakon Leffler, Arjan W. Griffioen, Latifa Elantak, Rory R. Koenen, Victor L. J. L. Thijssen
Summary: The study reveals that specific chemokine-galectin interactions can modulate the immunoregulatory function of galectins, affecting their glycan-binding activity and specificity. In particular, binding of CXCL4 changes the carbohydrate binding site of galectin-1, increasing its apoptotic activity on CD8(+) T cells.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lucia Sanjurjo, Esmee C. Broekhuizen, Rory R. Koenen, Victor L. J. L. Thijssen
Summary: Galectins, a family of glycan-binding proteins, play a role in shaping the immune microenvironment by directly affecting immune cell activity and survival, as well as indirectly affecting immune response through binding to cytokines. Galectin-cytokine heterodimers, known as galectokines, add complexity to immune homeostasis regulation. This article summarizes current knowledge on galectokine formation and function, describes mechanisms by which galectokines shape the immune microenvironment, and discusses outstanding questions and challenges for future research on the role of galectokines in immunomodulation.
Article
Fisheries
Mauricio Rojas-Pena, Patricia Aceituno, Maria E. Salvador, Marlid Garcia-Ordonez, Mariana Teles, Maria Del Mar Ortega-Villaizan, Luis Perez, Nerea Roher
Summary: Spring viremia of carp (SVC) is a vaccine orphan disease that mainly affects juvenile carp. Researchers have developed a platform based on nanostructured recombinant proteins that provides excellent protection against SVC virus. The platform can induce antiviral response and provide effective protection through oral administration in carp.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alba Jimenez-Panizo, Andrea Alegre-Marti, Theophilus T. Tettey, Gregory Fettweis, Montserrat Abella, Rosa Anton, Thomas A. Johnson, Sohyoung Kim, R. Louis Schiltz, Israel Nunez-Barrios, Joan Font-Diaz, Carme Caelles, Annabel F. Valledor, Paloma Perez, Ana M. Rojas, Juan Fernandez-Recio, Diego M. Presman, Gordon L. Hager, Pablo Fuentes-Prior, Eva Estebanez-Perpina
Summary: The glucocorticoid receptor (GR) has diverse conformations and can form different dimeric structures. Non-canonical dimerization modes play a crucial role in the receptor's function, especially contacts formed by specific residues. These findings are important for understanding the mechanism of glucocorticoid action and drug design.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Irene Brandts, Roger Sola, Marlid Garcia-Ordonez, Alex Gella, Albert Quintana, Beatriz Martin, Anna Esteve-Codina, Mariana Teles, Nerea Roher
Summary: Nanoplastics (NPs) can accumulate in different environmental compartments and provoke effects in living organisms, including fish cells. In this study, the interaction between polystyrene (PS)-NPs and fish cells was investigated. It was found that PS-NPs can enter cells through endocytosis, phagocytosis, or passive transport, and they co-localize with lysosomes but not with mitochondria once internalized. PS-NPs do not trigger ROS production or alter mitochondrial respiration, but they interfere with lipid metabolism, peroxisomes, and PPAR signaling. In macrophages, PS-NPs modulate polarization towards the M2-like phenotype.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Multidisciplinary
Jan Grzelak, Mariana Teles, Nerea Roher, Alba Grayston, Anna Rosell, Marti Gich, Anna Roig
Summary: This study investigates the potential applications of rod-shaped mesoporous silica nanoparticles (MSR) in liver imaging and therapy. The results demonstrate that these magnetic MSR particles are not cytotoxic and can be successfully taken up by liver cells. The rods can penetrate fibrous tissues or mucus layers more efficiently than spherical particles.
Article
Chemistry, Multidisciplinary
Irene Brandts, Marlid Garcia-Ordonez, Lluis Tort, Mariana Teles, Nerea Roher
ENVIRONMENTAL SCIENCE-NANO
(2020)
