Article
Immunology
Niyati Mehta, Nijee S. S. Luthra, Daniel M. M. Corcos, Giamila Fantuzzi
Summary: Parkinson's disease (PD) is the fastest growing neurological disease worldwide, with no disease-modifying treatments available. Physical exercise is currently the most promising treatment to slow disease progression. Chronic inflammation is associated with the onset, progression, and symptom severity of PD, and C-reactive protein (CRP) should be used as the primary biomarker for monitoring inflammation and disease progression and severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Arik Sheinenzon, Mona Shehadeh, Regina Michelis, Ety Shaoul, Ohad Ronen
Summary: This study examined the correlation between albumin levels and inflammatory indices in hospitalized patients, showing negative correlations between albumin and CRP/white blood cell levels and positive correlations with platelets/hemoglobin levels. The strongest negative correlation between albumin and CRP was found in the Internal Medicine departments. Linear regression analysis revealed a minor effect of CRP on albumin levels, particularly at very high CRP levels. Further exploration of the mechanisms underlying this negative correlation is needed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biology
Shanwen Chen, Yunfan Jin, Siqi Wang, Shaozhen Xing, Yingchao Wu, Yuhuan Tao, Yongchen Ma, Shuai Zuo, Xiaofan Liu, Yichen Hu, Hongyan Chen, Yuandeng Luo, Feng Xia, Chuanming Xie, Jianhua Yin, Xin Wang, Zhihua Liu, Ning Zhang, Zhenjiang Zech Xu, Zhi John Lu, Pengyuan Wang
Summary: The utility of cell-free nucleic acids in monitoring cancer has been recognized. By profiling cfRNAs in plasma samples, human and microbe-derived plasma cfRNAs were found to have diagnostic value for cancer detection. Adding microbial features improved the accuracy of tumor classification.
Article
Immunology
Lina Wirestam, Sofia Pihl, Muna Saleh, Jonas Wettero, Christopher Sjowall
Summary: This study aimed to determine pregnancy-specific reference intervals for CRP and PTX3, finding that these two markers are correlated during pregnancy and both increase in the third trimester. Elevations of CRP and PTX3 during the later phase of pregnancy may occur in the absence of infection, highlighting the importance of considering pregnancy-specific reference values.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Ross McD Young, Bruce Lawford, Rebecca Mellor, Charles P. Morris, Joanne Voisey
Summary: The study aimed to examine the relationship between CRP levels and PTSD in trauma-exposed Australian Vietnam veterans. Results showed higher serum CRP levels in PTSD patients compared to non-PTSD individuals, but this association was not significant after adjusting for BMI and triglycerides. There was no significant association found between CRP SNPs and PTSD or CRP levels.
Article
Oncology
Johannes Wach, Agi Guresir, Valeri Borger, Patrick Schuss, Albert Becker, Christoph Coch, Marie-Therese Schmitz, Michael Holzel, Marieta Toma, Ulrich Herrlinger, Hartmut Vatter, Erdem Guresir
Summary: Baseline CRP level serves as an independent predictor of progression-free survival in sporadic VS patients, with higher CRP levels associated with faster disease progression.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Chemistry, Analytical
Huilin Gao, Yongchang Bai, Baixun He, Cherie S. Tan
Summary: In this study, a label-free functionalized aptamer sensor attached to an electrode with gold nanoparticles and carboxylated graphene oxide was used to measure C-reactive protein (CRP) levels. The adapted sensor showed a broad linear range, superior stability, specificity, and reproducibility, making it suitable for complex applications with interfering substances.
Article
Dentistry, Oral Surgery & Medicine
Bansari Shah, Monali Shah, Maria Geisinger, Muhammad H. A. Saleh, Mohamed Meghil, Hom-Lay Wang
Summary: This study demonstrated that scaling and root planing (SRP) can significantly reduce levels of CRP.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Immunology
Ahmed Sheriff, Stefan Kayser, Patrizia Brunner, Birgit Vogt
Summary: CRP is a well-known acute phase protein in humans that helps eliminate pathogens and dead cells, but may have negative effects on internal wounds. In COVID-19, CRP is associated with lung ischemia and bleeding, suggesting a potential additional influence on severe cases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Silvia Fraga, Sara Soares, Ana Cristina Santos, Henrique Barros
Summary: Children who experience physical abuse from their parents are more likely to have elevated levels of high sensitivity C-reactive protein (hs-CRP), with a positive correlation between the severity of violence and hs-CRP levels. This suggests that parental violence may have a negative impact on children's health, influencing inflammatory processes even at an early age.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Immunology
Michael Drozd, Mar Pujades-Rodriguez, Ann W. Morgan, Patrick J. Lillie, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon
Summary: Systemic inflammation assessed using C-reactive protein is common in many chronic diseases and is associated with increased long-term risk of fatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
Sarah E. Twardowski, Jean Wactawski-Wende, Kathleen M. Hovey, Christopher A. Andrews, Hailey R. Banack, Michael J. LaMonte, Amy E. Millen
Summary: The study found a negative association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations and salivary CRP concentrations in postmenopausal women, which attenuated after adjusting for other factors. However, there was no significant association between 25[OH]D and serum CRP concentrations.
Article
Cell Biology
Chris P. Verschoor, Caitlyn Vlasschaert, Michael J. Rauh, Guillaume Pare
Summary: This study demonstrates that there is a strong association between circulating C-reactive protein (CRP) and age and health-related traits in older adults, and this association is more pronounced in EIS (comprehensive epigenetic inflammation score) than CRP. Additionally, experimental results show that EIS reflects the cellular response to chronic inflammation. Therefore, EIS has the potential to be a clinically relevant tool for stratifying patient risk of adverse outcomes prior to treatment or following illness.
Review
Nutrition & Dietetics
Stefan Zivkovic, Gorica Maric, Natasa Cvetinovic, Danijela Lepojevic-Stefanovic, Bojana Bozic Cvijan
Summary: Cardiovascular diseases (CVD) are the leading cause of death worldwide. Lipid-lowering agents used in the treatment of CVD may also have anti-inflammatory and immunomodulatory properties. This review aims to evaluate the anti-inflammatory properties of currently available lipid-lowering medications, dietary supplements, and novel drugs.
Article
Immunology
Raid S. Al-Baradie, Shuang Pu, Donghui Liu, Yasmin Zeinolabediny, Glenn Ferris, Coral Sanfeli, Ruben Corpas, Elisa Garcia-Lara, Suliman A. Alsagaby, Bader M. Alshehri, Ahmed M. Abdel-hadi, Fuzail Ahmad, Psalm Moatari, Nima Heidari, Mark Slevin
Summary: mCRP accumulation in brain tissues is closely associated with neurodegenerative processes related to injury and inflammation, likely playing a direct role in promoting tissue damage and supporting the progression of AD after injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hospitality, Leisure, Sport & Tourism
Yiannis Michailidis, Christoforos Ganotakis, Nikos Motsanos, Thomas Metaxas
Summary: This study investigated the effect of HIIT training on the performance of soccer players under the age of 17. The results showed that a short-term HIIT program can improve acceleration, agility, and repeated sprint ability performance.
INTERNATIONAL JOURNAL OF SPORTS SCIENCE & COACHING
(2023)
Article
Biochemistry & Molecular Biology
Zoi Skaperda, Ioannis D. Kyriazis, Fotios Tekos, Maria Alvanou, Paraskevi-Maria Nechalioti, Sotiria Makri, Angeliki Argyriadou, Sotiria Vouraki, Theodoros Kallitsis, Maria Kourti, Valasi Irene, Georgios Arsenos, Demetrios Kouretas
Summary: The study aimed to assess the resting values of oxidative stress in lambs and kids reared in Greece and the correlation between redox biomarkers in blood and other tissues. The results showed that lambs and kids at different weight categories had varying levels of antioxidant defense systems. Blood redox biomarkers were associated with the ones measured in other tissues. These findings suggest that blood antioxidant parameters can be used as potential biomarkers to predict tissue antioxidant status and improve meat quality.
Review
Obstetrics & Gynecology
Arunika Das, Aspasia Destouni
Summary: The post-reproductive phase or menopause in females is triggered by a physiological timer that depends on a threshold of follicle number in the ovary. However, reproductive senescence appears to be decoupled from chronological age and is instead thought to be a function of physiological ageing. Although many biological hallmarks of general ageing are well characterized, the precise mechanisms underlying the programmed ageing of the female reproductive system remain elusive. Recent large scale genomics studies are providing insights into this process.
HUMAN REPRODUCTION
(2023)
Article
Chemistry, Multidisciplinary
Andreas Fousekis, Konstantinos Fousekis, Georgios Fousekis, Nikolaos Vaitsis, Ioannis Terzidis, Kosmas Christoulas, Yiannis Michailidis, Athanasios Mandroukas, Thomas Metaxas
Summary: This study aimed to investigate the relationship between the acute: chronic workload ratio (ACWR) and the incidence of non-contact injuries. The external load of injured and non-injured soccer players with similar characteristics was compared, taking into account both the four and two weeks preceding an injury. Through GPS evaluation, physical characteristics were recorded and analyzed over one season for a total of 35 professional soccer players. The study found that ACWR is related to the occurrence of injury, but the threshold for ACWR can vary depending on the comparison of load between the last two weeks and the four weeks before the injury.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Maria Kourti, Maria V. V. Alvanou, Zoi Skaperda, Fotis Tekos, Georgios Papaefstathiou, Panagiotis Stathopoulos, Demetrios Kouretas
Summary: An extract from brine samples obtained through the Greek style debittering process of Kalamon olive fruits showed strong antioxidant capacity and DNA-protective activity. The extract consisted mainly of hydroxytyrosol, verbascoside, and tyrosol. In cell-free assays, the extract demonstrated radical scavenging ability, while in cell cultures, it exhibited cell type specific responses and protected against H2O2-induced DNA damage. Overall, this study highlights the potential of table olive wastewaters as a valuable source of bioactive compounds for various industries.
Article
Sport Sciences
Yiannis Michailidis, Panagiotis Venegas, Thomas Metaxas
Summary: The aim of this study was to investigate the effects of combined training on anaerobic performance in youth U17 soccer players. The intervention group, which performed additional plyometric and change of direction exercises, showed significant improvements in the 505 test and Illinois agility test. However, there was no significant improvement in sprint and jump performance. These results suggest that a short-term combined program of plyometric and change of direction exercises can enhance change of direction ability in youth soccer players.
Article
Behavioral Sciences
D. Parker Kelley, Lucas Albrechet-Souza, Shealan Cruise, Rajani Maiya, Aspasia Destouni, Siva S. V. P. Sakamuri, Alexander Duplooy, Meghan Hibicke, Charles Nichols, Prasad V. G. Katakam, Nicholas W. Gilpin, Joseph Francis
Summary: Stress is associated with contextual memory deficits, which may lead to avoidance of trauma-associated contexts in posttraumatic stress disorder. These deficits may result from impaired pattern separation in the brain, which affects the ability to distinguish similar experiences. The production of reactive oxygen species in the hippocampus has been found to be related to pattern separation and may play a role in the effects of stress on memory.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Fotios Tekos, Zoi Skaperda, Periklis Vardakas, Despina Kyriazi, Georgios C. C. Maravelis, Konstantinos Poulas, Ioannis A. A. Taitzoglou, Charitini Nepka, Demetrios Kouretas
Summary: Wine and its by-products, such as grape stems, contain bioactive polyphenolic compounds that can potentially benefit animal and human health. However, there are limited studies on the safety and toxicological risks of these compounds in vivo. This study examined the effects of oral administration of grape stem and wine extracts on redox biomarkers in mice and rats. The results showed that grape stem extract improved redox homeostasis in mice, while wine extract had both beneficial and harmful effects on rat redox status, indicating the complexity of biological systems.
Article
Chemistry, Multidisciplinary
Lazaros Vardakis, Yiannis Michailidis, Panagiotis Topalidis, Charalambos Zelenitsas, Athanasios Mandroukas, Ioannis Gissis, Kosmas Christoulas, George Mavrommatis, Thomas Metaxas
Summary: The aim of this study was to apply a training plan to microcycles of different lengths in soccer and analyze the load within the training weeks and its short-term effect on the matches. The study found that the training load differed between microcycles, with lower load in short microcycles and higher load in long microcycles. However, the length of the microcycle did not have an impact on game performance.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Michail Christaras, Yiannis Michailidis, Athanasios Mandroukas, Lazaros Vardakis, Kosmas Christoulas, Thomas Metaxas
Summary: The aim of this study was to investigate the effect of a half-time short re-warm-up (RW) strategy on the performance of young soccer players. Twenty-three under 17 players participated in the study. The results showed that the short RW program can limit the decrement in performance in power tests such as sprints and jumps.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Emmanouil Karampinis, Athina-Maria Aloizou, Efterpi Zafiriou, Alexandra Bargiota, Zoi Skaperda, Demetrios Kouretas, Angeliki-Viktoria Roussaki-Schulze
Summary: UV radiation has both harmful and beneficial effects on skin health. It can cause oxidative stress, leading to skin cancer and photoaging. However, it is also necessary for the production of vitamin D, which has important antioxidant and anticancer properties. This study found that skin cancer patients have lower levels of vitamin D and increased oxidative stress.
Article
Sport Sciences
Athanasios Mandroukas, Yiannis Michailidis, Thomas Metaxas
Summary: The aim of this study was to compare the strength and ratio of knee flexors and extensors muscles in young soccer players. The results showed that the H:Q strength ratio varied across different age groups, with younger players having a smaller ratio and older players having a larger ratio. It was found that hamstring muscle training is still inadequate for young athletes.
JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Evangelia Papaevangelou, Zacharoula Papadopoulou, Yiannis Michailidis, Athanasios Mandroukas, Pantelis T. Nikolaidis, Nikolaos V. Margaritelis, Thomas Metaxas
Summary: The study aimed to examine the changes in cardiorespiratory fitness of female soccer, basketball, and handball players during an annual training cycle. The results showed that there was a significant improvement in cardiorespiratory fitness in the middle of the competitive season, but a decrease at the end.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Chariton Papadopoulos, Yiannis Michailidis, Thomas I. Metaxas, Athanasios Mandroukas, Eleni G. Fotiadou, Paraskevi Giagazoglou, Kosmas Christoulas, Vasilios Tsimaras
Summary: The study aimed to investigate the relationship between aerobic capacity and running performance in soccer players with visual impairment, as well as to describe the physiological parameters and running distances during matches. The findings showed that relative VO2max was not related to running performance, indicating that tactics, playing style, and player position may have a greater impact on the distances covered.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Yiannis Michailidis
Summary: This study aimed to evaluate lower limb asymmetries in U16 youth male soccer players and examine their effects on fitness. The results showed that different asymmetry tests could detect asymmetries in different limbs. Only the asymmetry observed in single-leg countermovement jump (SLCMJ) was correlated with squat jump performance. Asymmetries did not significantly affect performance on most fitness tests. Individualized training programs should be implemented to eliminate observed asymmetries and protect athletes from injuries and negative impacts on performance. Additionally, detecting asymmetries during the developmental age provides a longer time period for elimination before entering professional sports.
MEDICINA-LITHUANIA
(2023)
