Article
Agriculture, Multidisciplinary
Leila M. Carvalho, Josue Delgado, Marta S. Madruga, Mario Estevez
Summary: This study identified oxidative stress and protein oxidation as key factors in the onset of white striping myopathy, leading to severe loss of meat quality. The analysis showed that muscles affected by the myopathy exhibited chronic impairment of physiological and metabolic processes, indicating a disruption in protein turnover possibly mediated by oxidative stress.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Richard Kehm, Tim Baldensperger, Jana Raupbach, Annika Hoehn
Summary: Generation of reactive oxygen species and related oxidants during life processes can lead to irreversible modifications of proteins, potentially contributing to pathological conditions and diseases.
Article
Agriculture, Dairy & Animal Science
Carl A. Frame, Elisabeth Huff-Lonergan, Brian J. Kerr, Mariana Rossoni Serao
Summary: The study aimed to investigate the effects of feedstuff containing oxidized protein and lipid on diet digestibility, growth performance, and oxidative stress in nursery pigs. Results showed that feeding pigs with oxidized proteins and lipids reduced feed intake and growth performance, but did not induce oxidative stress.
JOURNAL OF ANIMAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Wolnicka-Glubisz, Anna Wisniewska-Becker
Summary: Curcumin, a natural polyphenol with antioxidant properties, can have therapeutic effects on different disorders. However, it can also be toxic under certain conditions, such as exposure to blue light or excessive use.
Article
Biochemistry & Molecular Biology
Vy Ngo, Nadun C. Karunatilleke, Anne Brickenden, Wing-Yiu Choy, Martin L. Duennwald
Summary: Cells respond to oxidative stress by inducing antioxidant proteins through the activation of Nrf2. Both Nrf2 and Keap1 are susceptible to protein misfolding under oxidative stress, potentially due to their intrinsic characteristics. This study provides new insights into the regulation of Nrf2 and Keap1 by oxidation-induced protein misfolding.
Review
Genetics & Heredity
Kaixian Wang, Yuanyuan Gao, Chen Wang, Meng Liang, Yaping Liao, Ke Hu
Summary: According to WHO statistics, millions of couples and individuals suffer from infertility, with varicocele identified as a leading cause of male infertility. This review examines the role of oxidative stress and reactive oxygen species (ROS) in the pathophysiology of varicocele and its impact on fertility. High levels of ROS can lead to infertility by damaging DNA, affecting lipid peroxidation, and inactivating enzymes and proteins involved in spermatogenesis.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Ang Lu, Shi-meng Yuan, Huai Xiao, Da-song Yang, Zhi-qiong Ai, Qi-Yan Li, Yu Zhao, Zhuang-zhi Chen, Xiu-mei Wu
Summary: This study used QSAR to investigate the relationship between molecular descriptors, physicochemical properties, and antioxidant activity of polyphenol analogues, providing guidance for the design and discovery of highly-potent antioxidants.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Bo Wang, Peipei Zhang, Qianqian Wang, Shuaijun Zou, Juxingsi Song, Fuhai Zhang, Guoyan Liu, Liming Zhang
Summary: This study confirms that the fusion protein PTD-CcTrx1 obtained from the jellyfish Cyanea capillata has antioxidant abilities and can protect skin cells from oxidative damage. The findings provide critical evidence for the future application of PTD-CcTrx1 as a treatment for skin oxidative damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Pengyu Tao, Wenxin Xu, Simeng Gu, Haiyan Shi, Qian Wang, Yuzhen Xu
Summary: Dementia is a syndrome that impairs learning and memory, and there is currently no effective therapy. Traditional Chinese medicine has shown potential in treating dementia, with the ability to improve memory and cognitive dysfunctions. It has fewer adverse effects and lower costs compared to prescription drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vy Ngo, Martin L. L. Duennwald
Summary: Oxidative stress is associated with major human diseases, and the transcription factor Nrf2 plays a key role in the antioxidant defense system and has been extensively studied in disease contexts.
Review
Nutrition & Dietetics
Beata Olas
Summary: English Summary: Graviola, a plant found in tropical regions, has various ethnomedicinal uses such as treating insomnia, diabetes, cystitis, and headaches. It contains active components called annonaceous acetogenins, with over 100 compounds isolated from it. Graviola is also a source of phenolic compounds, essential oils, alkaloids, flavonol triglycosides, and megastigmanes, as well as several minerals. This paper provides an overview of the antioxidant properties of graviola and its major constituents, based on a review of electronic databases, but more research is needed to determine its antioxidant potential and safety.
Article
Biochemistry & Molecular Biology
Emilie Rugemalira, Irmeli Roine, Julia Kuligowski, Angel Sanchez-Illana, Jose David Pineiro-Ramos, Sture Andersson, Manuel Leite Cruzeiro, Maximo Vento, Tuula Pelkonen
Summary: We investigated the association between cerebrospinal fluid (CSF) biomarkers indicating oxidative damage to proteins and the course of illness and outcome in childhood bacterial meningitis (BM) in Angola. We found that children with a lower o-Tyr/Phe ratio in their CSF upon admission were more likely to experience focal convulsions and secondary fever during recovery and have a suboptimal outcome at Day 7 and one month after discharge. The most common sequelae observed in these children were ataxia. This suggests that a higher admission CSF o-Tyr/Phe ratio is associated with a better course and outcome in pediatric BM.
Article
Biochemistry & Molecular Biology
Noralyn Manucat-Tan, Rafaa Zeineddine Abdallah, Harsimran Kaur, Daniel Saviane, Mark R. Wilson, Amy R. Wyatt
Summary: Fibrinogen in blood plasma may have a role in antioxidant defense, as it reacts with the biological oxidant hypochlorite to form high molecular weight assemblies with potential antioxidant properties. Unlike hypochlorite-modified albumin, hypochlorite-modified fibrinogen does not induce reactive oxygen species production or cell death in immune cells. The interaction of hypochlorite with fibrinogen in plasma may reduce the accumulation of other hypochlorite-modified species, indicating a novel role for fibrinogen in blood plasma antioxidant defense.
Article
Immunology
Hui-Yi Lin, Qiufan Fu, Yu-Hsiang Kao, Tung-Sung Tseng, Krzysztof Reiss, Jennifer E. Cameron, Martin J. Ronis, Joseph Su, Navya Nair, Hsiao-Man Chang, Michael E. Hagensee
Summary: This study identified serum albumin and 4 dietary antioxidants (vitamin A, B2, E, and folate) inversely associated with high-risk HPV infection in women. Low serum albumin level and inadequate intake of antioxidants may increase the risk of HPV infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Shasha Chen, Na Hu, Honglun Wang, Yongning Wu, Guoliang Li
Summary: Pn3G5G, derived from LRF, exhibited strong antioxidant capacity and protective effects on CML-treated cells. In aging mice, Pn3G5G improved cognitive impairment, neuroinflammation, and neuronal apoptosis. These findings suggest the potential development of Pn3G5G as a healthcare product or potent dietary supplement with antioxidant and neuroprotective effects.
Review
Cell Biology
Patrizia Mecocci, Virginia Boccardi
Summary: This passage challenges the traditional view that amyloid is the leading cause of AD, proposing instead that the progressive decline in brain energy levels during aging is the main risk factor for dementia in older individuals. It suggests that optimizing brain energetics should be a key component in future strategies for preventing and treating dementia.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Joel Simren, Antoine Leuzy, Thomas K. Karikari, Abdul Hye, Andrea Lessa Benedet, Juan Lantero-Rodriguez, Niklas Mattsson-Carlgren, Michael Scholl, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Simon Lovestone, Dag Aarsland, Oskar Hansson, Pedro Rosa-Neto, Eric Westman, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton
Summary: P-tau181 shows potential as an effective diagnostic and prognostic biomarker in AD, detecting the disease at MCI and dementia stages and being strongly associated with cognitive decline and gray matter loss.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Luke Whiley, Katie E. Chappell, Ellie D'Hondt, Matthew R. Lewis, Beatriz Jimenez, Stuart G. Snowden, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Jonathan R. Swann, Abdul Hye, Simon Lovestone, Cristina Legido-Quigley, Elaine Holmes
Summary: The study found significantly lower concentrations of tryptophan pathway metabolites in the AD group, while higher concentrations of indoleamine pathway metabolites were observed. Concentrations of various metabolites showed a decreasing trend with clinical diagnosis: control > MCI > AD. There were no significant differences between the two MCI subgroups, and the use of SSRI medication influenced serum observations but not urine results.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Marina Boccardi, Andreas U. Monsch, Clarissa Ferrari, Daniele Altomare, Manfred Berres, Isabelle Bos, Andreas Buchmann, Chiara Cerami, Mira Didic, Cristina Festari, Valentina Nicolosi, Leonardo Sacco, Liesbeth Aerts, Emiliano Albanese, Jean-Marie Annoni, Nicola Ballhausen, Christian Chicherio, Jean-Francois Demonet, Virginie Descloux, Suzie Diener, Daniel Ferreira, Jean Georges, Anton Gietl, Nicola Girtler, Ingo Kilimann, Stefan Kloppel, Nicole Kustyniuk, Patrizia Mecocci, Nathalie Mella, Martina Pigliautile, Katrin Seeher, Steven D. Shirk, Alessio Toraldo, Andrea Brioschi-Guevara, Kwun C. G. Chan, Paul K. Crane, Alessandra Dodich, Alice Grazia, Nicole A. Kochan, Fabricio Ferreira de Oliveira, Flavio Nobili, Walter Kukull, Oliver Peters, Inez Ramakers, Perminder S. Sachdev, Stefan Teipel, Pieter Jelle Visser, Michael Wagner, Sandra Weintraub, Eric Westman, Lutz Froelich, Henry Brodaty, Bruno Dubois, Stefano F. Cappa, David Salmon, Bengt Winblad, Giovanni B. Frisoni, Matthias Kliegel
Summary: An expert consensus has been reached on harmonizing the diagnosis of neurocognitive disorders across European countries and potentially beyond, by defining a standardized assessment battery and methodology for obtaining consistent normative data.
ALZHEIMERS & DEMENTIA
(2022)
Correction
Neurosciences
Eleni Poptsi, Magda Tsolaki, Sverre Bergh, Bruno Mario Cesana, Alfonso Ciceone, Andrea Fabbo, Giovanni B. Frisoni, Lutz Froelich, Anna Giulia Guazzarini, Jacques Hugon, Sara Fascendini, Sara Lavolpe, Patrizia Mecocci, Oliver Peters, Carlo Alberto Defanti
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
Virginia Boccardi, Patrizia Mecocci
Summary: This review summarizes the current knowledge on targeting senescent cells to reduce the risk of age-related diseases, including the use of senotherapeutic strategies and drugs. Research suggests that senotherapeutic approach may be translatable to humans, but caution is needed due to a lack of evidence of potential side-effects of senolytic agents.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Mary Ann A. DeMichele-Sweet, Lambertus Klei, Byron Creese, Janet C. Harwood, Elise A. Weamer, Lora McClain, Rebecca Sims, Isabel Hernandez, Sonia Moreno-Grau, Lluis Tarraga, Merce Boada, Emilio Alarcon-Martin, Sergi Valero, Yushi Liu, Basavaraj Hooli, Dag Aarsland, Geir Selbaek, Sverre Bergh, Arvid Rongve, Ingvild Saltvedt, Havard K. Skjellegrind, Bo Engdahl, Eystein Stordal, Ole A. Andreassen, Srdjan Djurovic, Lavinia Athanasiu, Davide Seripa, Barbara Borroni, Diego Albani, Gianluigi Forloni, Patrizia Mecocci, Alessandro Serretti, Diana De Ronchi, Antonis Politis, Julie Williams, Richard Mayeux, Tatiana Foroud, Agustin Ruiz, Clive Ballard, Peter Holmans, Oscar L. Lopez, M. Ilyas Kamboh, Bernie Devlin, Robert A. Sweet
Summary: Psychotic symptoms in Alzheimer's disease are common and have genetic components, with significant associations found in two loci - ENPP6 and SUMF1. AD + P shows negative genetic correlations with cognitive and educational attainment, and positive genetic correlations with depressive symptoms. This study provides insights into the genetic architecture of psychosis in Alzheimer's disease.
MOLECULAR PSYCHIATRY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Giorgio Fano-Illic, Stefania Fulle, Patrizia Mecocci
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Cristina Polidori, Patrizia Mecocci
Summary: This review explores the role of oxidative stress in aging and frailty, highlighting the need for effective management strategies to prevent and address frailty.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Virginia Boccardi, Francesca Mancinetti, Marta Baroni, Roberta Cecchetti, Patrizia Bastiani, Carmelinda Ruggiero, Patrizia Mecocci
Summary: The study found that plasma levels of EGF, Eotaxin, and MCP-1 are closely associated with insulin resistance in women, with BMI being a significant mediator. This suggests that the association between cytokines and insulin resistance is gender-specific.
Article
Nutrition & Dietetics
Virginia Boccardi, Giulia Poli, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Marta Febo, Emanuela Mazzon, Stefano Bruscoli, Stefano Brancorsini, Patrizia Mecocci
Summary: Alzheimer's disease (AD) is the leading cause of dementia globally and is a major contributor to disability in older individuals. Vitamin E levels are lower in AD patients, and inflammation and microRNAs also play significant roles in the development of AD. MiR-122 may be a modulating factor, correlating with alpha-tocopherol and inflammation molecules.
Editorial Material
Geriatrics & Gerontology
Virginia Boccardi, Patrizia Mecocci
Summary: The concept of intermediate care is increasingly recognized in Italy as a critical strategy to improve healthcare quality and integration across different settings. Person-tailored care is a key challenge, requiring a shift towards a holistic approach that prioritizes individual preferences and values. This necessitates greater collaboration, communication, and innovation in care delivery, including the use of technology for remote monitoring. Despite challenges, intermediate care offers significant opportunities to enhance care quality, reduce costs, and promote social cohesion and community engagement.
Article
Engineering, Electrical & Electronic
Sten Hanke, Francesca Mangialasche, Markus Bodenler, Bernhard Neumayer, Tiia Ngandu, Patrizia Mecocci, Helena Untersteiner, Elisabeth Stogmann
Summary: Dementia prevention is a global public health priority. The FINGER study in Finland has shown that dementia risk can be reduced through non-pharmacological interventions. The LETHE project aims to provide a digital-enabled intervention model for delaying or preventing cognitive decline.
Article
Geriatrics & Gerontology
Theresa Koenig, Martina Pigliautile, Oscar Aguila, Jon Arambarri, Christophoros Christophorou, Matteo Colombo, Argyris Constantinides, Rosario Curia, Kathrina Dankl, Sten Hanke, Christopher Clemens Mayer, Stefan Moritsch, Markus Muellner-Rieder, Fritz Pernkopf, Christian Schueler, Maria Stillo, Patrizia Mecocci, Elisabeth Stoegmann
Summary: The study evaluated an assistive system prototype for dementia patients, showing that a positive attitude towards technology is crucial for successful implementation regardless of age. Frequent use was correlated with a positive attitude towards technology, and participants showed great interest in digital solutions, believing that technological systems will help maintain independence for individuals with cognitive dysfunction in the future.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Virginia Boccardi, Valentina Bubba, Ilenia Murasecco, Martina Pigliautile, Roberto Monastero, Roberta Cecchetti, Michela Scamosci, Patrizia Bastiani, Patrizia Mecocci
Summary: The study found that serum alkaline phosphatase (ALP) levels were significantly higher in the Subjective Cognitive Decline (SCD) group compared to the healthy control group, and were inversely correlated with cognitive functions, especially with attentional matrices and letter fluency tests.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
