Article
Hospitality, Leisure, Sport & Tourism
Oya Yigitturk, Faruk Turgay, Servet Kizildag, Dua Ozsoylu, Gorkem Aybars Balci
Summary: This study aimed to investigate the effects of hypoxic underwater rugby training on PON1 enzyme activity and oxLDL levels, as well as the role of PON1-Q192R and PON1-L55M polymorphisms. The results showed that hypoxic training led to significant oxidative stress and antioxidant response, resulting in increased PON1 and PON3 activity. The activity of PON1 and ARE was affected by PON1-Q192R and PON1-L55M polymorphisms, and improvements in PON1 activity were observed in QQ and LL genotype groups. However, hypoxic training had a detrimental effect on ARE activity in LL and Rc groups.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Multidisciplinary Sciences
Joelma Figueiredo Menezes, Magda Oliveira Seixas Carvalho, Larissa Carneiro Rocha, Felipe Miranda dos Santos, Elisangela Vitoria Adorno, Cyntia Cajado de Souza, Rayra Pereira Santiago, Caroline Conceicao da Guarda, Rodrigo Mota de Oliveira, Camylla Vilas Boas Figueiredo, Suellen Pinheiro Carvalho, Setondji Cocou Modeste Alexandre Yahouedehou, Luciana Magalhaes Fiuza, Corynne Stephanie Ahouefa Adanho, Thassila Nogueira Pitanga, Isa Menezes Lyra, Valma Maria Lopes Nascimento, Alberto Augusto Noronha-Dutra, Marilda Souza Goncalves
Summary: Sickle cell disease (SCD) patients often exhibit dyslipidemia. This study investigated the influence of PON1c.192Q > R and PON1c.55L > M polymorphisms on PON1 activity and laboratory parameters in SCD patients. Results showed increased PON1 activity in SCD individuals compared to the control group, and carriers of the variant genotype of each polymorphism had lower PON1 activity. Association between PON1 activity and clinical manifestations, such as stroke and splenectomy, were observed.
SCIENTIFIC REPORTS
(2023)
Article
Anthropology
Igrid Garcia-Gonzalez, Gerardo Perez-Mendoza, Alberto Solis-Cardenas, Jorge Flores-Ocampo, Luis Fernando Herrera-Sanchez, Renan Mendoza-Alcocer, Lizbeth Gonzalez-Herrera
Summary: The null allele/genotype of GSTT1 is associated with an increased risk of developing premature CAD, and there is a significant interaction between GSTT1 and LL55 genotype. Other SNPs did not independently show significant associations with premature CAD. Additionally, GSTT1 interacts with BMI and smoking in their effects on CAD risk in the population studied in Yucatan.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ali Khattib, Sanaa Musa, Majdi Halabi, Tony Hayek, Soliman Khatib
Summary: This study examined the effects of lipids on PON1 enzyme activity and LDL oxidation using structure-activity relationship methods. The results showed that certain lipids significantly increased PON1 activity and inhibited LDL oxidation.
Article
Biotechnology & Applied Microbiology
Tugrul Demirel, Ilhan Yaylim, Hayriye Arzu Ergen, Mustafa Kayihan Gunay, Yaman Tekant, Turgay Isbir
Summary: The study of Paraoxonase 1 (PON1) polymorphism and enzyme activity in colorectal cancer patients revealed that the AA genotype was the most common in this group, with decreased enzyme activity possibly contributing to cancerous DNA damage. Further research with more patients considering the location and stage of colorectal tumors is warranted to gain a broader understanding of the role of this polymorphism and enzyme activity in cancer formation.
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
(2021)
Article
Biochemistry & Molecular Biology
Geetika Aggarwal, Linda S. May-Zhang, Valery Yermalitsky, Sergey Dikalov, Maxim A. Voynov, Venkataraman Amarnath, Valentina Kon, MacRae F. Linton, Kasey C. Vickers, Sean S. Davies
Summary: Research has shown that the association of MPO with HDL can lead to reduced PON1 activity through IsoLG-mediated modifications, increasing the risk of atherosclerosis. Blocking this modification could potentially reduce the development of atherosclerosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Rheumatology
Sangmee Sharon Bae, Ani Shahbazian, Jennifer Wang, Ilana Golub, Buzand Oganesian, Tyler Dowd, Beata Vayngortin, Ryan Wang, David Elashoff, Srinivasa T. Reddy, Christina Charles-Schoeman
Summary: This study found that the activity of PON1 is significantly reduced in patients with IIM compared to healthy controls, and it is inversely associated with disease activity and the presence of severe ILD. The PON1 Q192R polymorphism is strongly linked to the paraoxonase activity of PON1 in IIM, and patients with the PON1 QQ genotype may have better disease outcomes in IIM.
Article
Biochemistry & Molecular Biology
Ayla Solmaz Avcikurt, Nahit Gencer, Hasmet Yazici
Summary: The study indicates that the Q192R polymorphism of the PON1 gene is associated with nasal-polyp disease, with the QQ genotype showing a higher risk and the QR genotype showing a lower risk.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingyan Huang, Siyun Huang, Jinhong Li, Minhua Li, Lin Gong, Tongshun Li, Lian Gu
Summary: CALM1 gene rs3179089 polymorphism is associated with the development of coronary artery disease (CAD), especially in male patients, affecting CAD risk as well as blood pressure, blood glucose, blood coagulation, and serum lipid levels.
Review
Genetics & Heredity
Jiangang Jiang, Xinmin Chen, Chengwei Li, Xiaoma Du, Huadong Zhou
Summary: This study systematically reviewed the literature on TRIB1 gene polymorphisms and susceptibility to coronary atherosclerotic heart disease (CAD) and stroke. It found that the rs2954029 genetic polymorphism significantly increased the risk of CAD and stroke, while the rs17321515 polymorphism was not associated with the risk of CAD and stroke.
Article
Cardiac & Cardiovascular Systems
Jing-Lu Jin, Hui-Wen Zhang, Hui-Hui Liu, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Jian-Jun Li
Summary: Among patients with angiography-proven stable CAD, Lp(a) has a more significant prognostic value in both MUO and MUN individuals regardless of obesity, suggesting the importance of screening for cardiovascular risk with Lp(a) in metabolically unhealthy patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Chenyu Jiang, Meng Chen, Yujie Wu, Huai Bai, Xinghui Liu, Ping Fan
Summary: This study examined the changes of oxidative stress and PON1 lactonase activity in older women undergoing ART. The results showed that ART women had higher total antioxidant capacity and PON1 lactonase activity compared to control women, indicating an increased compensatory antioxidant capacity in ART women, but also a higher susceptibility to oxidative stress-related injury and diseases.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Sonu Kumar, Nalin Maniya, Ceming Wang, Satyajyoti Senapati, Hsueh-Chia Chang
Summary: This study proposes using a highly atheroprotective subset of HDL (PON1-HDL) as a biomarker for cardiovascular risk assessment. To overcome the complexity caused by interference from HDL-associated substances in existing methods, the researchers developed a new sensor platform (NGEMS) to quantitate PON1-HDL in plasma quickly and accurately within 60 minutes. Experimental results demonstrate the high accuracy of PON1-HDL in diagnosing cardiovascular diseases.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Ting Zhang, Chunlei Zhou, Jiejie Guo, Jiamin Chang, Haiyan Wu, Jing He
Summary: Our study indicates that the rs3848672 CC and rs2297441 AA genotypes of the RTEL1 gene are significantly associated with an increased risk of neuroblastoma in Chinese children in a gender- and site-specific manner.
Article
Critical Care Medicine
Richard J. Allen, Justin M. Oldham, David A. Jenkins, Olivia C. Leavy, Beatriz Guillen-Guio, Carl A. Melbourne, Shwu-Fan Ma, Jonathan Jou, John S. Kim, William A. Fahy, Eunice Oballa, Richard B. Hubbard, Vidya Navaratnam, Rebecca Braybrooke, Gauri Saini, Katy M. Roach, Martin D. Tobin, Nik Hirani, Moira K. B. Whyte, Naftali Kaminski, Yingze Zhang, Fernando J. Martinez, Angela L. Linderholm, Ayodeji Adegunsoye, Mary E. Strek, Toby M. Maher, Philip L. Molyneaux, Carlos Flores, Imre Noth, R. Gisli Jenkins, Louise Wain
Summary: In this study, a genetic variant associated with disease progression in idiopathic pulmonary fibrosis (IPF) was identified, and the PKN2 gene was proposed as a potential target for novel therapeutic approaches. This finding provides insights into the biological mechanisms underlying IPF and offers potential implications for its treatment.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Anatomy & Morphology
Mona G. Amer, Rehab A. Karam
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2018)
Article
Genetics & Heredity
Mona G. Amer, Azza S. Embaby, Rehab A. Karam, Marwa G. Amer
Article
Genetics & Heredity
Rehab A. Karam, Noha A. Rezk, Tamer M. Abdel Rahman, Mohamed Al Saeed
Article
Nutrition & Dietetics
Atef G. Hussein, Randa H. Mohamed, Sally M. Shalaby, Dalia M. Abd El Motteleb
Article
Oncology
Haidy E. Zidan, Rehab A. Karam, Omnia S. Ei-Seifi, Tamer M. Abd Elrahman
Article
Endocrinology & Metabolism
Ashgan Abdalla Alghobashy, Usama M. Alkholy, Mohamed A. Talat, Nermin Abdalmonem, Ahmed Zaki, Ihab A. Ahmed, Randa H. Mohamed
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2018)
Article
Oncology
Heba F. Pasha, Randa H. Mohamed, Mohamed Radwan
Article
Biochemistry & Molecular Biology
Rehab A. Karam, Haidy E. Zidan, Tamer M. Abd Elrahman, Samir A. Badr, Samar A. Amer
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Medical Laboratory Technology
Rehab A. Karam, Doaa M. Abd Elrahman
CLINICAL BIOCHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
Heba F. Pasha, Randa H. Mohamed, Mostafa M. Toam, Ahmed M. Yehia
JOURNAL OF GENE MEDICINE
(2019)
Article
Biotechnology & Applied Microbiology
Rehab A. Karam, Haidy E. Zidan, Nehad A. Karam, Doaa M. Abdel Rahman, Omnia S. El-Seifi
JOURNAL OF GENE MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Amani Ahmed Alrehaili, Amal Fathi Gharib, Rehab Ahmed Karam, Reem Ali Alhakami, Wael Hassan El Sawy, Tamer Mohamed Abd Elrahman
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Pharmacology & Pharmacy
Tarek A. Abdelaziz, Randa H. Mohamed, Gehan F. Balata, Omar Y. El-Azzazy
Summary: The study found that carriers of allele D of ACE gene were more likely to experience in-stent restenosis (ISR), while carriers of allele I of ACE gene were also more prone to ISR after ACEI administration. There was a negative interaction between the DD genotype of ACE gene and ACEI use, while a positive interaction was observed between the II and ID genotypes of ACE gene and ACEI use.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rehab A. Karam, Mona M. Amer, Haidy E. Zidan
Summary: This study found that the high expression of NEAT1 is associated with an increased risk of acute ischemic stroke (AIS) in diabetic patients, as well as the severity of stroke, inflammation, and prognosis. NEAT1 expression levels could be used as a diagnostic marker of stroke in diabetic patients.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Article
Oncology
Amal F. Ghareib, Randa H. Mohamed, Ahmed R. Abd El-Fatah, Sara F. Saadawy
JOURNAL OF GASTROINTESTINAL CANCER
(2020)
