Review
Biochemistry & Molecular Biology
Mieke Steenbeke, Reinhart Speeckaert, Stephanie Desmedt, Griet Glorieux, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Patients with chronic kidney disease (CKD) are more prone to oxidative stress and chronic inflammation, resulting in increased production and decreased clearance of advanced glycation end products (AGEs). AGEs may contribute to decreased kidney function and increased all-cause mortality in CKD patients. Interaction between AGEs and their cell-bound receptor RAGE activates nuclear factor kappa-B (NF-kappa B), leading to cell dysfunction and increased production of inflammatory cytokines. Alterations in the AGE-RAGE system are associated with the development of various chronic kidney diseases. Soluble RAGE (sRAGE) acts as a decoy receptor to inhibit membrane-bound RAGE activation and AGE-RAGE-related toxicity. The ratio of AGEs to sRAGE may be a useful tool for predicting the prognosis of kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Neda Emami, AliReza Alizadeh, Arezoo Maleki-Hajiagha, Alireza Dizavi, Samira Vesali, Ashraf Moini
Summary: This study found no significant differences in the levels of serum sRAGE and FF sRAGE between Iranian women with and without PCOS. However, BMI and dietary intake of AGEs had more significant effects on sRAGE concentration in Iranian women.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Shou-En Wu, Yi-Lin Chiu, Tung-Wei Kao, Wei-Liang Chen
Summary: The soluble receptor for advanced glycation end products (sRAGE) level is positively associated with sarcopenia, especially in female groups, possibly attributed to the loss of protection from estrogen in postmenopausal women. Using sRAGE level as a prospective marker for sarcopenia warrants further investigation in future studies.
Article
Clinical Neurology
Yasuhiro Aida, Tomoya Kamide, Hiroshi Ishii, Yasuko Kitao, Naoyuki Uchiyama, Mitsutoshi Nakada, Osamu Hori
Summary: Plasma sRAGE levels can serve as a potential biomarker for predicting SVS after SAH, showing significant correlation with SVS in both SAH patients and a rat model.
JOURNAL OF NEUROSURGERY
(2021)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mirko Luketin, Maja Mizdrak, Dijana Boric-Skaro, Dinko Martinovic, Daria Tokic, Marino Vilovic, Daniela Supe-Domic, Tina Ticinovic Kurir, Josko Bozic
Summary: The study revealed significantly higher plasma CST levels in HD patients compared to healthy controls, with a significant positive correlation between CST and AGEs. Additionally, there were positive correlations between plasma CST levels, Dialysis Malnutrition Score, and Malnutrition-Inflammation Score.
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Agnieszka Nowak, Brygida Przywara-Chowaniec, Aleksandra Damasiewicz-Bodzek, Dominika Blachut, Ewa Nowalany-Kozielska, Krystyna Tyrpien-Golder
Summary: Systemic lupus erythematosus (SLE) study found that SLE patients have higher concentrations of AGEs and lower concentrations of sRAGE in serum, which may pose a risk for exacerbating the disease course, but the compounds contributing to the increase of AGEs in blood are not clear at the moment.
Article
Biochemistry & Molecular Biology
Franziska Diekmann, Philippe Chouvarine, Hannes Sallmon, Louisa Meyer-Kobbe, Moritz Kieslich, Brian D. Plouffe, Shashi K. Murthy, Ralf Lichtinghagen, Ekaterina Legchenko, Georg Hansmann
Summary: In a study involving 120 PAH patients, plasma sRAGE was identified as a potential sensitive and accurate PAH biomarker, showing better performance compared to NTproBNP. The study suggests that sRAGE could be a valuable tool for distinguishing mild PAH from controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Oncology
Yu Peng, Fubin Liu, Yating Qiao, Peng Wang, Han Du, Changyu Si, Xixuan Wang, Kexin Chen, Fangfang Song
Summary: This study found that higher levels of plasma AGEs and AGEs/sRAGE-ratio were associated with an increased risk of breast cancer, but sRAGE levels were negatively associated with breast cancer risk. The study emphasized the potential of the AGE-RAGE axis as a new biomarker of breast cancer.
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Article
Biochemistry & Molecular Biology
Jorge D. Erusalimsky
Summary: sRAGE, as a potential biomarker, may reflect disease risk and adverse outcomes, with high levels possibly related to overstimulation of cell surface RAGE among other factors.