期刊
CLINICAL BIOCHEMISTRY
卷 42, 期 7-8, 页码 736-738出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2008.11.006
关键词
Biomarkers; Tumour markers; Cell-free fetal DNA; Cell-free plasma DNA; DNA methylation; CpG
资金
- European Commission for the Special Noninvasive Advances in Fetal and Neonatal Evaluation (SAFE) Network of Excellence [LSHB-CT-2004-503243]
Objectives: To assess whether different genomic cell-free DNAs are equally abundant in the plasma of individual donors, and any relationship between DNA methylation and representation in plasma. Design and methods: The concentrations of DNA in plasma were determined by real-time PCR. Results: Different DNA sequences were not equally represented. The relative abundances were similar in different donors. Conclusions: Different DNA sequences are not equally abundant in plasma, with no relationship between DNA methylation and abundance. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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