Article
Environmental Sciences
Megha Murali, T. Shivanandappa
Summary: Endosulfan exposure causes high levels of oxidative stress in the liver and brain, leading to reduced antioxidant enzyme activity and increased ROS and lipid peroxidation. The brain is more susceptible to oxidative stress than the liver, likely due to its lower antioxidant defenses and higher oxygen consumption.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Ines Guerreiro, Carolina Castro, Claudia R. Serra, Filipe Coutinho, Ana Couto, Helena Peres, Pedro Pousao-Ferreira, Genevieve Corraze, Aires Oliva-Teles, Paula Enes
Summary: This study aimed to investigate the effects of including yellow worm meal in the diet of meagre fish on their fatty acid profile and oxidative status of the liver and intestine. The results showed that increasing levels of yellow worm meal in the diet led to an increase in certain fatty acids and a decrease in others in the whole body of the fish. The activity of certain enzymes involved in antioxidant defense increased in the liver and intestine, while others decreased. However, there was no significant effect on oxidative stress or lipid peroxidation. In conclusion, it is recommended to limit the inclusion of yellow worm meal to 10% in meagre fish diets to avoid major changes in fatty acid composition and oxidative imbalance.
Article
Agriculture, Dairy & Animal Science
Ines Guerreiro, Carolina Castro, Claudia R. Serra, Filipe Coutinho, Ana Couto, Helena Peres, Pedro Pousao-Ferreira, Laura Gasco, Francesco Gai, Aires Oliva-Teles, Paula Enes
Summary: Insect meal is being considered as a sustainable alternative to fishmeal in fish diets. However, chitin, a component of insect meal, has been identified as a potential limitation for the inclusion of high levels of insect meal in aquafeeds. This study evaluated the effects of Hermetia illucens meal dietary inclusion on meagre liver and intestine oxidative status and found that chitin or insect lipid composition did not greatly affect meagre antioxidant status. Overall, Hermetia illucens meal can be included as up to 30% of the diet without compromising meagre antioxidant status.
Article
Multidisciplinary Sciences
Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-Ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, Andre Santos Dias Mourao, Andreas Linkermann, Edward K. Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, Bettina Proneth, Derek A. Pratt, Marcus Conrad
Summary: A study identifies the anti-ferroptotic function of vitamin K and reveals FSP1 as the enzyme mediating warfarin-resistant vitamin K reduction, highlighting the importance of FSP1 in protecting cells against lipid peroxidation and ferroptosis.
Article
Biochemistry & Molecular Biology
Hanna Lesiewska, Alina Wozniak, Pawel Reisner, Krzysztof Czosnyka, Joanna Stachura, Grazyna Malukiewicz
Summary: Oxidative stress and depletion of antioxidant defenses may contribute to cataract incidence in patients under 60 years. This study measured antioxidant enzyme activity, vitamin concentrations, and oxidative stress markers in cataract patients and controls. The results showed lower activity of antioxidant enzymes and lower concentrations of vitamins A and E in cataract patients. Additionally, higher levels of lipid peroxidation and protein oxidation were observed, indicating increased oxidative stress in cataract patients. Supplementation with antioxidants could be beneficial for this group of patients.
Article
Biochemistry & Molecular Biology
Antonio Currais, Devin Kepchia, Zhibin Liang, Pamela Maher
Summary: This article provides an overview of the research progress on the oxytosis/ferroptosis regulated cell death pathway, with a focus on the role of the AMPK pathway. However, further research is needed to understand the conditions under which AMPK signaling has a protective effect in oxytosis/ferroptosis, as well as its role in the brain, especially the aging brain.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Environmental Sciences
Yin Jia, Xiancai Yin, Jian Zhao, Yuanzhi Pan, Beibei Jiang, Qinglin Liu, Yifeng Li, Zhuolin Li
Summary: This study investigated the interaction between 24-epibrassinolide (EBR) and melatonin (MT) and their effects on cadmium (Cd)-stressed Primula forbesii seedlings. The results showed that 24-EBR effectively alleviated Cd stress and promoted plant growth and development by increasing the activities of antioxidant enzymes and removing reactive oxygen species produced by stress. Thus, 24-EBR can effectively enhance the tolerance of P. forbesii to Cd stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Physiology
Li Long, Hongmei Guo, Xixi Chen, Yan Liu, Ruyi Wang, Xiaomei Zheng, Xiaobo Huang, Qiao Zhou, Yi Wang
Summary: Rheumatoid arthritis (RA) is a chronic disease characterized by inflammatory synovitis, and ferroptosis may play a role in the pathogenesis and progression of RA. Targeting ferroptosis could be a potential therapeutic approach for treating RA.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Anabella Aguilera, Federico Berdun, Carlos Bartoli, Charlotte Steelheart, Matias Alegre, Hulya Bayir, Yulia Y. Tyurina, Valerian E. Kagan, Graciela Salerno, Gabriela Pagnussat, Maria Victoria Martin
Summary: Ferroptosis, an oxidative and iron-dependent form of regulated cell death, has been found to occur in the photosynthetic prokaryote Synechocystis sp. PCC 6803 in response to heat stress. This cell death pathway in Synechocystis sp. PCC 6803 shares similar characteristics with eukaryotic ferroptosis, including depletion of antioxidants and lipid peroxidation. These findings suggest that ferroptosis might be a conserved ancient cell death program.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Environmental Sciences
Francesca Provenza, Paolo Pastorino, Serena Anselmi, Marco Leporatti Persiano, Tommaso Scirocco, Gianluca De Rinaldis, Maria Cristina Fossi, Cristina Panti, Monia Renzi, Antonietta Specchiulli
Summary: This study assessed microplastics, trace elements, polycyclic aromatic hydrocarbon (PHA) levels, and the oxidative stress response in Mytilus galloprovincialis from two Italian lagoon ecosystems. They also determined the ecotoxicological effects of high-density polyethylene (HDPE) microplastics on the mussels. Trace element levels were comparable among sites, while microplastics were only found in mussels from one site. Polycyclic aromatic hydrocarbon levels were always below the limit of quantification. The mussels from a different site had higher levels of oxidative stress biomarkers. The exposure test showed significant effects on mortality and biochemical biomarkers, and similar effects were observed based on color and nourishment conditions.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Plant Sciences
Ragia M. Mazrou, Sabry Hassan, Mei Yang, Fahmy A. S. Hassan
Summary: Exogenous melatonin (MT) treatment was found to extend the vase life of cut roses by maintaining relative water content and reducing stomatal aperture. In addition, MT treatment increased phenol content, enzyme activities, and radical scavenging capacity, while reducing H2O2 production and lipid peroxidation. This overall contributed to membrane stability maintenance and preservation of postharvest quality in cut flowers.
Article
Biology
Paula Mariela Gonzalez, Oaquin Cabrera, Susana Puntarulo
Summary: The purpose of this review is to summarize the role of iron (Fe) in cellular oxidative/protective balance with a focus on ferroptosis-dependent disruption in aquatic organisms. Increased intracellular Fe level and treatment with Fe chelators have been found to be related to ferroptosis. Algae assimilate Fe through various mechanisms, while aquatic animals acquire dissolved Fe and Fe bound to particles or organic matter. Both low and high Fe concentrations can induce oxidative stress and cell death in some algae, while aquatic animals with high levels of polyunsaturated fatty acids are also susceptible to Fe effects on lipidic fraction and ferroptosis. The ferroptosis reaction can be regulated through antioxidant defense system, protein degradation, metabolism, and gene transcription. Depletion of non-enzymatic antioxidants like reduced glutathione (GSH) in animals and reduction of both GSH and ascorbate in photosynthetic organisms are characteristic features of ferroptosis. Fe chelators, specific antioxidants, and gene regulation can prevent ferroptosis. Further research is needed to understand the complex role of Fe as a toxic component in biological systems and to protect aquatic organisms from adverse conditions.
Review
Biochemistry & Molecular Biology
Kamari Weaver, Rachid Skouta
Summary: This review provides a comprehensive overview of the research on GPX4, highlighting its role as a potential therapeutic target.
Article
Oncology
Marine Delvaux, Perrine Hague, Ligia Craciun, Agnieszka Wozniak, Pieter Demetter, Patrick Schoffski, Christophe Erneux, Jean-Marie Vanderwinden
Summary: This study reveals that GIST cell lines are highly sensitive to the ferroptosis inducer RSL3 and inhibition of YAP can promote ferroptosis in GIST cells. The highly expressed transferrin receptor protein 1 (TFRC) is positively correlated with high-risk GISTs, elevated mitotic count, and YAP expression/activation. These findings suggest that induction of ferroptosis and modulation of YAP activity have promising potential for GIST treatment.
Article
Biochemistry & Molecular Biology
Gabriela Perez-Barron, Sergio Montes, Yoshajandith Aguirre-Vidal, Marti Santiago, Elena Gallardo, Jose Luis Espartero, Camilo Rios, Antonio Monroy-Noyola
Summary: The study evaluated the antioxidant effects of hydroxytyrosol and its derivatives in a rat model of oxidative stress, finding that these compounds significantly reduced ipsilateral turns induced by MPP+ and preserved striatal dopamine levels while decreasing oxidative stress markers. These results demonstrate an antioxidant effect of hydroxytyrosol, hydroxytyrosol acetate, and nitrohydroxytyrosol in a rat model of Parkinson's disease using MPP+.
NEUROCHEMICAL RESEARCH
(2021)
Article
Oncology
Adam R. Brentnall, Natasa Vasiljevic, Dorota Scibior-Bentkowska, Louise Cadman, Janet Austin, Jack Cuzick, Attila T. Lorincz
Article
Oncology
Attila T. Lorincz, Adam R. Brentnall, Dorota Scibior-Bentkowska, Caroline Reuter, Rawinder Banwait, Louise Cadman, Janet Austin, Jack Cuzick, Natasa Vasiljevic
INTERNATIONAL JOURNAL OF CANCER
(2016)
Article
Biochemistry & Molecular Biology
Michal Skrzycki, Hanna Czeczot, Magdalena Mielczarek-Puta, Dagmara Otto-Slusarczyk, Wojciech Grabon
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
(2017)
Review
Food Science & Technology
Cichosz Grazyna, Czeczot Hanna, Ambroziak Adam, Bielecka Marika Magdalena
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Michal Skrzycki, Hanna Czeczot
CURRENT PROTEIN & PEPTIDE SCIENCE
(2014)
Article
Oncology
Natasa Vasiljevic, Dorota Scibior-Bentkowska, Adam R. Brentnall, Jack Cuzick, Attila T. Lorincz
GYNECOLOGIC ONCOLOGY
(2014)
Article
Oncology
Karolina Louvanto, Eduardo L. Franco, Agnihotram V. Ramanakumar, Natasa Vasiljevic, Dorota Scibior-Bentkowska, Anita Koushik, Jack Cuzick, Francois Coutlee, Attila T. Lorincz
INTERNATIONAL JOURNAL OF CANCER
(2015)
Article
Oncology
Adam R. Brentnall, Natasa Vasiljevic, Dorota Scibior-Bentkowska, Louise Cadman, Janet Austin, Anne Szarewski, Jack Cuzick, Attila T. Lorincz
INTERNATIONAL JOURNAL OF CANCER
(2014)
Article
Virology
Natasa Vasiljevic, Dorota Scibior-Bentkowska, Adam Brentnall, Jack Cuzick, Attila Lorincz
JOURNAL OF CLINICAL VIROLOGY
(2014)
Article
Biochemistry & Molecular Biology
Giuseppina Sanna, Silvia Madeddu, Gabriele Giliberti, Sandra Piras, Marta Struga, Malgorzata Wrzosek, Grazyna Kubiak-Tomaszewska, Anna E. Koziol, Oleksandra Savchenko, Tadeusz Lis, Joanna Stefanska, Piotr Tomaszewski, Michal Skrzycki, Daniel Szulczyk
Article
Oncology
Rubi Hernandez-Lopez, Attila T. Lorincz, Leticia Torres-Ibarra, Caroline Reuter, Dorota Scibior-Bentkowska, Rhian Warman, Belinda Nedjai, Indira Mendiola-Pastrana, Leith Leon-Maldonado, Berenice Rivera-Paredez, Paula Ramirez-Palacios, Eduardo Lazcano-Ponce, Jack Cuzick, Jorge Salmeron, Attila Lorincz, Cosette Wheeler, Patti Gravitt, Eduardo Lazcano, Leticia Torres, Leith Leon, Paula Ramirez, Berenice Rivera, Eduardo L. Franco, Jack Cuzick, Pablo Mendez, Jorge Salmeron, Mauricio Hernandez, Anna Barbara Moscicki, Yvonne Flores, Enrique Carmona, Kathleen M. Schmeler, David Bishai, Pilar Hernandez, Rubi Hernandez, Indira Mendiola
CLINICAL EPIGENETICS
(2019)
Review
Environmental Sciences
Grazyna Cichosz, Hanna Czeczot, Marika Bielecka
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2020)
Article
Oncology
Cristiana Banila, Attila T. Lorincz, Dorota Scibior-Bentkowska, Gary M. Clifford, Birhanu Kumbi, Dereje Beyene, Cosette M. Wheeler, Kate Cuschieri, Jack Cuzick, Belinda Nedjai
Summary: The study evaluated the performance of a DNA methylation test for detecting CIN3 and cancer, demonstrating that the S5 test had high sensitivity and specificity in diverse geographic settings. Compared to HPV16/18 genotyping, S5 showed higher accuracy in distinguishing between women with negative histology and those with CIN3 or cancer. Adjusting the S5 cut-off could potentially improve the balance between sensitivity and specificity.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Rachael Adcock, Belinda Nedjai, Attila T. Lorincz, Dorota Scibior-Bentkowska, Rawinder Banwait, Norah Torrez-Martinez, Michael Robertson, Jack Cuzick, Cosette M. Wheeler
Summary: Methylation of host and viral genes shows promise in stratifying women with high-risk human papillomavirus infections. The study compared the clinical value of the S5 methylation classifier, HPV genotyping, and cytology as potential triage tests, and found that the S5 classifier performed well in discriminating CIN3+.
INTERNATIONAL JOURNAL OF CANCER
(2022)
