Article
Immunology
Hortensia Alvarez, Alicia Gutierrez-Valencia, Ana Marino, Abraham Saborido-Alconchel, Beatriz Calderon-Cruz, Alexandre Perez-Gonzalez, Jacobo Alonso-Dominguez, Ines Martinez-Barros, Maria Gallego-Rodriguez, Santiago Moreno, Teresa Aldamiz, Marta Montero-Alonso, Enrique Bernal, Carlos Galera, Josep M. Llibre, Eva Poveda, CoRIS Study Grp
Summary: This study assessed the dynamics of IP-10 and MIG levels in HIV-1 patients after initiating antiretroviral treatment (ART). The results showed a significant decline in IP-10 and MIG plasma levels following ART initiation, with greater declines in MIG levels in INSTI-based regimens. These findings suggest that HIV-1 viremia has a strong impact on IP-10 and MIG levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Severine Carrere-Kremer, Pratt Kolia-Diafouka, Amandine Pisoni, Karine Bollore, Marianne Peries, Sylvain Godreuil, Arnaud Bourdin, Philippe Van de Perre, Edouard Tuaillon
Summary: This study analyzed the relationship between the results of the QuantiFERON Gold Plus assay (QFT) and cytokine patterns associated with active tuberculosis (ATB). The study found that higher levels of IFN-gamma secretion, preferential IFN-gamma response in tube 2, and lower secretion of IL-2, IP-10, and MIG were more likely to be observed in patients with ATB.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Johannes Thorman, Per Bjorkman, Gaetano Marrone, Taye Tolera Balcha, Fregenet Tesfaye, Tamene Abdissa, Denise Naniche, Patrik Medstrand, Anton Reepalu
Summary: IP-10 showed a biphasic pattern in dynamics during the initial year of ART in virological responders (VRs), with a more rapid decline in the first month. The prevalence of tuberculosis at ART initiation did not affect IP-10 kinetics, suggesting IP-10 as a potential surrogate marker for viral load monitoring in individuals starting ART.
MICROBIOLOGY SPECTRUM
(2021)
Article
Infectious Diseases
Maria Goretti Lopez-Ramos, Joan Vinent, Rob Aarnoutse, Angela Colbers, Eneritz Velasco-Arnaiz, Loreto Martorell, Lola Falcon-Neyra, Olaf Neth, Luis Prieto, Sara Guillen, Fernando Baquero-Artigao, Ana Mendez-Echevarria, David Gomez-Pastrana, Ana Belen Jimenez, Rebeca Lahoz, Jose Tomas Ramos-Amador, Antoni Soriano-Arandes, Begona Santiago, Rosa Farre, Claudia Fortuny, Dolors Soy, Antoni Noguera-Julian
Summary: In 2010, the WHO recommended increasing the daily doses of first-line anti-tuberculosis medicines in children. This study aimed to investigate the pharmacokinetics of a once-daily dose of isoniazid (INH) in infants under 6 months of age. The study found that the target adult levels were not reached in a few cases, but overall, the treatment was well tolerated and no major safety concerns were raised.
Article
Infectious Diseases
Nabila El-Sheikh, Nahla O. Mousa, Ahmed Osman, Amany M. Tawfeik, Bothiana A. Taha, Hazem Mahran, Alaa M. Saleh, Iman El-shiekh, Wagdy Amin, Mohamed Elrefaei
Summary: The study found that IP-10 and IFN-γ mRNA expression levels were significantly higher in pediatric household contacts with active TB or LTBI. IP-10 RT-qPCR showed high sensitivity and specificity in distinguishing active TB from LTBI.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Yang Tang, Yanhua Yu, Quan Wang, Zilu Wen, Ruixue Song, Yu Li, Yingquan Zhou, Ruiying Ma, Hongyan Jia, Shaoli Bai, Harimulati Abdulsalam, Boping Du, Qi Sun, Aiying Xing, Liping Pan, Jianyun Wang, Yanzheng Song
Summary: HIV-infected individuals are at high risk of developing active tuberculosis (TB) and the performance of interferon-gamma release assays (IGRAs) in this population is suboptimal. Interferon-inducible protein 10 (IP-10) mRNA may serve as a better biomarker for diagnosing TB in HIV-infected individuals.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Kimone L. Fisher, Denelle Moodley, Kerishka Rajkumar-Bhugeloo, Omolara O. Baiyegunhi, Farina Karim, Hlumani Ndlovu, Thumbi Ndung'u, Mohlopheni J. Marakalala
Summary: Accurate diagnostic tools are urgently needed to distinguish latent tuberculosis infection (LTBI) from active tuberculosis (TB). Recent studies have identified a group of cytokines that may serve as biomarkers of TB disease progression. This study found that IL-1RA, IL-6, and IP-10 were significantly more abundant in participants with active TB compared to those with LTBI, at both the protein and gene level.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Isabelle Suarez, Samuel Rohr, Melanie Stecher, Clara Lehmann, Sandra Winter, Norma Jung, Vanessa Priesner, Melanie Berger, Christoph Wyen, Max Augustin, Jakob J. Malin, Julia Fischer, Carola Horn, Florian Neuhann, Michael Puesken, Georg Plum, Gerd Faetkenheuer, Jan Rybniker
Summary: Our study found that IP-10 may be a valuable biomarker for estimating disease severity in EPTB and monitoring the disease course. However, IP-10 may be less suitable for diagnosis and monitoring of EPTB patients with limited disease. The QFT(R) Plus test does not appear to be a suitable marker for therapy monitoring.
Article
Medicine, Research & Experimental
Riham Abdel-Hamid Haroun, Waleed H. Osman, Asmaa M. Eessa
Summary: The study found that markers such as IP-10 and SAA were significantly elevated in severe to critically severe COVID-19 patients, while lymphocyte count was significantly decreased. ROC curve analysis showed that IP-10 had better predictive ability in discriminating between infection levels.
Article
Respiratory System
Merel Jacobs, Sven Verschraegen, Bihiyga Salhi, Jasper Anckaert, Pieter Mestdagh, Guy G. Brusselle, Ken R. Bracke
Summary: The presence and function of regulatory B cells in COPD were investigated in this study. The study found that the number and function of regulatory B cell subsets were decreased and impaired in patients with COPD and smokers, which may contribute to the initiation and progression of the disease.
RESPIRATORY RESEARCH
(2022)
Article
Medicine, General & Internal
Yuhpita Indah Efriyani, Ida Parwati, Nina Tristina, Anna Tjandrawati
Summary: The study showed a significant decline in IP-10 levels in active pulmonary TB patients after 2 months of TB treatment, indicating that serum IP-10 levels could be a reliable marker to monitor TB treatment progress.
MAJALAH KEDOKTERAN BANDUNG
(2021)
Article
Immunology
Javeed A. Shah, Alex J. Warr, Andrew D. Graustein, Aparajita Saha, Sarah J. Dunstan, Nguyen T. T. Thuong, Guy E. Thwaites, Maxine Caws, Phan V. K. Thai, Nguyen D. Bang, Tran T. H. Chau, Chiea Chuen Khor, Zheng Li, Martin Hibberd, Xuling Chang, Felicia K. Nguyen, Carlo A. Hernandez, Madison A. Jones, Christopher M. Sassetti, Katherine A. Fitzgerald, Munyaradzi Musvosvi, Anele Gela, Willem A. Hanekom, Mark Hatherill, Thomas J. Scriba, Thomas R. Hawn
Summary: This study identified genetic variations in REL and BHLHE40 that are associated with IL-12 and IL-10 cytokine responses and clinical outcomes of tuberculosis (TB). Understanding the common genetic regulation of intermediate cellular traits provides insights into the mechanisms underlying TB pathogenesis.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Respiratory System
Himanshu Saini, Parul Mrigpuri, Balakrishnan Menon, Sonal Sonal
Summary: Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, and there is a need for simple blood-based diagnostic tests. This study evaluated the role of IP-10 in the follow-up of PTB patients and found its diagnostic value to be limited. Further studies are needed to validate these findings.
MONALDI ARCHIVES FOR CHEST DISEASE
(2022)
Article
Immunology
S. Gowri Sankar, A. Alwin Prem Anand
Summary: The study revealed a higher incidence of severe symptoms in primary dengue infections, with children being more prone to severe symptoms in secondary infections. IP-10 and GM-CSF expression was significantly upregulated in serum samples from secondary infections, showing a strong correlation with disease severity indicators.
Article
Microbiology
Yuan Cao, Heta Parmar, Rajiv L. Gaur, Deanna Lieu, Shobana Raghunath, Nova Via, Simone Battaglia, Daniela M. Cirillo, Claudia Denkinger, Sophia Georghiou, Robert Kwiatkowski, David Persing, David Alland, Soumitesh Chakravorty
Summary: The study introduces a new 10-color Xpert MTB/XDR assay for detecting drug resistance in Mycobacterium tuberculosis, which shows high sensitivity and specificity with results available in under 90 minutes. The assay has the capacity to differentiate between low- and high-level resistance to specific drugs and has comparable performance to traditional drug-susceptibility testing methods.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Yi Cai, Youchao Dai, Yejun Wang, Qianqing Yang, Jiubiao Guo, Cailing Wei, Weixin Chen, Huanping Huang, Jialou Zhu, Chi Zhang, Weidong Zheng, Zhihua Wen, Haiying Liu, Mingxia Zhang, Shaojun Xing, Qi Jin, Carl G. Feng, Xinchun Chen
Article
Immunology
Qianting Yang, Mingxia Zhang, Qi Chen, Weixin Chen, Cailin Wei, Kun Qiao, Taosheng Ye, Guofang Deng, Jin Li, Jialou Zhu, Yi Cai, Xinchun Chen, Li Ma
JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Yuping Ning, Yi Cai, Youchao Dai, Fuxiang Li, Siwei Mo, Oliver Werz, Xinchun Chen
Summary: Mitochondrial dynamics play a critical role in macrophages' response to Mycobacterium tuberculosis infection, with MFN1-mediated fusion regulating ATP-dependent autophagy and mycobactericidal activity. Targeting the MFN1-mediated metabolism pathway could be a potential host-directed therapy strategy against tuberculosis.
INFECTION AND IMMUNITY
(2021)
Article
Cell Biology
Siwei Mo, Xiaoqian Liu, Kehong Zhang, Wenfei Wang, Yi Cai, Qi Ouyang, Chuanzhi Zhu, Dachuan Lin, Haoqiang Wan, Dechang Li, Zhihua Wen, Xinchun Chen
Summary: Flunarizine enhances the bactericidal ability of macrophages against Mycobacterium tuberculosis by increasing the phosphorylated levels of calcium/calmodulin-dependent protein kinase II. The expression of CaM is decreased in Mtb-infected macrophages, but restored following flunarizine treatment, leading to phagolysosome maturation and acidification. Silencing CaM or inhibiting CAMKII activity reduces the ability of macrophages to fight against TB infection.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Chuanzhi Zhu, Yi Cai, Siwei Mo, Jialou Zhu, Wenfei Wang, Bin Peng, Jiubiao Guo, Zongde Zhang, Xinchun Chen
Summary: Mtb infection increases 5hmC levels in the TNF promoter and promotes TET2 demethylase expression, leading to TNF over-expression. NF-kappa B binds to TET2 and mediates TNF demethylation on the TNF promoter.
Article
Microbiology
Yi Cai, Eleni Jaecklein, Jared Mackenzie, Kadamba Papavinasasundaram, Andrew J. Olive, Xinchun Chen, Adrie J. C. Steyn, Christopher M. Sassetti
Summary: Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a major global health problem resulting in over one million deaths annually. Mtb's ability to adapt to various immunological and environmental pressures, including through flexible respiratory capacity, is crucial for its pathogenic success. This study highlights the importance of cytochrome bd oxidase in Mtb's resistance to the adaptive immune response, particularly in acidic conditions induced by IFN gamma, and shows its impact on the efficacy of a potential new tuberculosis therapy.
Article
Infectious Diseases
Liang Fu, Taoping Weng, Feng Sun, Peize Zhang, Hui Li, Yang Li, Qianting Yang, Yi Cai, Xilin Zhang, Hancheng Liang, Xinchun Chen, Zhaoqin Wang, Lei Liu, Wenhong Zhang, Guofang Deng
Summary: This study evaluated two optimized all-oral short-course regimens for MDR-TB patients in China and found satisfactory efficacy and safety in the early treatment stage. Further research is needed to confirm these results.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Yi Cai, Yejun Wang, Chenyan Shi, Youchao Dai, Fuxiang Li, Yuzhong Xu, Peize Zhang, Fanhui Kong, Guofang Deng, Zhihua Wen, Qi Zhou, Boxi Chris Kang, Amit Singhal, Qianting Yang, Carl G. Feng, Xinchun Chen
Summary: The study reveals the landscape of local T cell immunity in tuberculosis and provides insights into the involvement of specific T cell populations in the pathogenesis of tuberculous pleural effusion (TPE). The findings suggest a link between clonal expansion of Granzyme K-expressing CD8 T cells and TPE.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Wenfei Wang, Yuping Ning, Yejun Wang, Guofang Deng, Simona Pace, Stefanie A. Barth, Christian Menge, Kehong Zhang, Youchao Dai, Yi Cai, Xinchun Chen, Oliver Werz
Summary: This study found that infection of human macrophages by M.tb significantly increases the expression of COX-2 and mPGES-1, leading to the formation of a large amount of PGE(2). However, the anti-inflammatory drug SASP can reduce the expression of COX-2 and the release of PGE(2).
FRONTIERS IN IMMUNOLOGY
(2022)
Correction
Medicine, General & Internal
Yi Cai, Youchao Dai, Yejun Wang, Qianting Yang, Jiubiao Guo, Cailing Wei, Weixin Chen, Huanping Huang, Jialou Zhu, Chi Zhang, Weidong Zheng, Zhihua Wen, Haiying Liu, Mingxia Zhang, Shaojun Xing, Qi Jin, Carl G. Feng, Xinchun Chen
Editorial Material
Cell Biology
Youchao Dai, Chuanzhi Zhu, Wei Xiao, Xinchun Chen, Yi Cai
Summary: In order to survive in the host despite ongoing immune responses, Mycobacterium tuberculosis (Mtb) exploits the autophagic degradation of ferritin mediated by a selective autophagy receptor, NCOA4, in macrophages to enhance iron bioavailability and bacterial growth. The degradation of ferritin in macrophages is also involved in the progression of human tuberculosis disease. The study identifies modulation of host ferritin metabolism as a novel strategy for Mtb's intracellular growth and suggests it as a potential target for host-directed therapy against tuberculosis.
Article
Immunology
Yuping Ning, Wenfei Wang, Paul M. Jordan, Stefanie A. Barth, Robert Klaus Hofstetter, Jinjin Xu, Ximeng Zhang, Yi Cai, Christian Menge, Xinchun Chen, Oliver Werz
Summary: Tuberculosis caused by Mycobacterium tuberculosis is a global health concern. In this study, it is shown that M. tuberculosis induces COX-2 expression in human macrophages and promotes the formation of anti-inflammatory J2-PGs. These J2-PGs have anti-inflammatory effects in M1-MDMs, downregulating proinflammatory cytokines and upregulating anti-inflammatory cytokines and M2 markers.
JOURNAL OF IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Ruiyao Xu, Wei Xiao, Guanggui Ding, Jiang Zeng, Hui Liu, Yi Cai, Xinchun Chen
Summary: Traditional pathological techniques have limitations in revealing the heterogeneity of tuberculosis granulomas. Multiplex tissue imaging tools combined with spatial analysis have enabled the detection of various cell phenotypes and visualization of the granuloma complex. This updated understanding of tuberculous granuloma heterogeneity provides vital insights for uncovering immunoregulatory mechanisms and identifying biological targets for host-directed therapies.
WIRES MECHANISMS OF DISEASE
(2023)
Article
Medicine, Research & Experimental
Lina Daniel, Nayan D. Bhattacharyya, Claudio Counoupas, Yi Cai, Xinchun Chen, James A. Triccas, Warwick J. Britton, Carl G. Feng
Summary: During chronic tissue inflammation, Mycobacterium tuberculosis infection remodels the structure of lymph nodes by increasing the number of B cells. The presence of B cells limits the T cell response to persistent intracellular infection.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Microbiology
Jiubiao Guo, Ximeng Zhang, Xinchun Chen, Yi Cai
Summary: Researchers are utilizing proteomics technology to discover new biomarkers for tuberculosis diagnosis, and while some progress has been made, challenges and uncertainties still remain.
FRONTIERS IN MICROBIOLOGY
(2022)