期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 20, 期 8, 页码 1333-1337出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00339-13
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Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity, or opsonization of viral antigen for improved antigen presentation to CD8(+) T cells by dendritic cells.
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