3.9 Article

Septic Shock after Seasonal Influenza Vaccination in an HIV-Infected Patient during Treatment with Etanercept for Rheumatoid Arthritis: a Case Report

期刊

CLINICAL AND VACCINE IMMUNOLOGY
卷 20, 期 5, 页码 761-764

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00081-13

关键词

-

向作者/读者索取更多资源

Anti-tumor necrosis factor alpha (anti-TNF-alpha) is used in the treatment of rheumatic diseases not responsive to first-line regimens. Data on the safety of anti-TNF-alpha in HIV-infected patients are scarce and conflicting. We describe a case of septic shock and multiorgan failure that occurred after etanercept initiation and influenza vaccination in an HIV-infected woman with rheumatoid arthritis.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

3.9
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Public, Environmental & Occupational Health

Capabilities of global high-level isolation units: A pre-workshop survey

Jocelyn J. Herstein, Timo Wolf, Emanuele Nicastri, Yee Sin Leo, Poh Lian Lim, Michael Jacobs, Sharon Vanairsdale, Eric Toner, Matthew P. Shearer, Angela Vasa, Vikram Mukherjee, Andrea Echeverri, Erica S. Shenoy, John J. Lowe

Summary: The survey aimed to assess the experience, physical infrastructure, and capabilities of high-level isolation units planning to participate in a 2018 global workshop. Results showed variation in unit infrastructure, capabilities, and procedures, highlighting the diversity of HLIUs approaches. Collaboration among HLIUs is essential to define best practices for the design and development of such units.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2022)

Letter Pathology

Post-mortem differential diagnosis from COVID-19: A case of fulminant myocarditis HHV-6 related

Daniele Colombo, Camilla Cecannecchia, Marco Albore, Fabrizio Taglietti, Roberta Nardacci, Giorgio Bolino, Franca Del Nonno

PATHOLOGY INTERNATIONAL (2022)

Article Medicine, General & Internal

Aero-Medical Evacuation during SARS-CoV-2 Pandemic: Extraordinary Measure or Emerging Treatment Option?

Domenico Benvenuto, Tommaso Ascoli Bartoli, Ambrogio Curtolo, Claudia Palazzolo, Serena Vita, Andrea Mariano, Laura Scorzolini, Giuseppe Ippolito, Luisa Marchioni, Federico Cerini, Gianpiero D'Offizi, Francesco Vaia, Emanuele Nicastri

Summary: Aero-medical evacuation is a feasible and safe treatment option during the COVID-19 pandemic, especially for patients with complex cases and coinfections.

JOURNAL OF CLINICAL MEDICINE (2023)

Article Infectious Diseases

The possible effect of sociobehavioral factors and public health actions on the mpox epidemic slowdown

Francesco Vairo, Sara Leone, Valentina Mazzotta, Pierluca Piselli, Gabriella De Carli, Simone Lanini, Fabrizio Maggi, Emanuele Nicastri, Roberta Gagliardini, Serena Vita, Andrea Siddu, Giovanni Rezza, Alessandra Barca, Francesco Vaia, Andrea Antinori, Enrico Girardi

Summary: A pre-exposure vaccination campaign was initiated in Italy in August 2022 to prevent the spread of mpox virus. This study explores the factors affecting the trend of mpox cases in the Lazio region of Italy, which had a rapid roll-out of the vaccination campaign, through a Poisson segmented regression model.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2023)

Article Biochemistry & Molecular Biology

Comparison of SARS-CoV-2 Detection in Nasopharyngeal Swab and Saliva Samples from Patients Infected with Omicron Variant

Licia Bordi, Giuseppe Sberna, Eleonora Lalle, Lavinia Fabeni, Valentina Mazzotta, Simone Lanini, Angela Corpolongo, Anna Rosa Garbuglia, Emanuele Nicastri, Enrico Girardi, Francesco Vaia, Andrea Antinori, Fabrizio Maggi

Summary: The study compared the detection of the SARS-CoV-2 Omicron variant in nasopharyngeal-swab (NPS) and oral saliva samples. Results showed good agreement between the two types of samples, with a significant correlation among cycle threshold values. The study also found that saliva can be used as an alternative specimen for the detection and follow-up of Omicron-infected patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Biochemistry & Molecular Biology

Dynamic Evolution of Humoral and T-Cell Specific Immune Response to COVID-19 mRNA Vaccine in Patients with Multiple Sclerosis Followed until the Booster Dose

Serena Ruggieri, Alessandra Aiello, Carla Tortorella, Assunta Navarra, Valentina Vanini, Silvia Meschi, Daniele Lapa, Shalom Haggiag, Luca Prosperini, Gilda Cuzzi, Andrea Salmi, Maria Esmeralda Quartuccio, Anna Maria Gerarda Altera, Anna Rosa Garbuglia, Tommaso Ascoli Bartoli, Simonetta Galgani, Stefania Notari, Chiara Agrati, Vincenzo Puro, Emanuele Nicastri, Claudio Gasperini, Delia Goletti

Summary: This study investigated the antibody and T-cell immune responses in multiple sclerosis patients (PwMS) undergoing different disease-modifying treatments (DMTs) after receiving the two-dose schedule of a COVID-19 mRNA vaccine. The results showed a significant decrease in seroconversion rate and anti-receptor-binding domain (RBD)-IgG titers from the first dose to 24 weeks later, and a significant increase after the booster dose. The booster dose improved both humoral and cell-mediated immune responses, especially in PwMS, highlighting the need for tailored strategies for immunocompromised patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Infectious Diseases

A Cholera Case Imported from Bangladesh to Italy: Clinico-Epidemiological Management and Molecular Characterization in a Non-Endemic Country

Valeria Russini, Maria Letizia Giancola, Grazia Brunetti, Carmela Calbi, Elena Anzivino, Carla Nisii, Lucia Scaramella, Anna Maria Dionisi, Francesca Faraglia, Marina Selleri, Laura Villa, Sarah Lovari, Maria Laura De Marchis, Teresa Bossu, Francesco Vairo, Adolfo Pagnanelli, Emanuele Nicastri

Summary: Despite the global cholera outbreaks, returning European travelers have only reported few cases. The study presents a case of a 41-year-old male returning to Italy from Bangladesh with watery diarrhea. The patient's stools were tested positive for Vibrio cholerae and norovirus. Whole genome sequencing and bioinformatics analysis revealed the strain belonged to ST69 and was related to a 2018 outbreak in Dhaka, Bangladesh. The multidisciplinary approach adopted ensured rapid and accurate diagnosis, clinical management, and epidemiological investigation.

TROPICAL MEDICINE AND INFECTIOUS DISEASE (2023)

Letter Medicine, General & Internal

Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in Hospitalized Patients With COVID-19

Daniele Focosi, Emanuele Nicastri

ANNALS OF INTERNAL MEDICINE (2023)

Letter Immunology

Convalescent Plasma Versus Hyperimmune Immunoglobulins

Daniele Focosi, Massimo Franchini, Emanuele Nicastri, David J. Sullivan, Arturo Casadevall

CLINICAL INFECTIOUS DISEASES (2023)

Article Immunology

Older Age, a High Titre of Neutralising Antibodies and Therapy with Conventional DMARDs Are Associated with Protection from Breakthrough Infection in Rheumatoid Arthritis Patients after the Booster Dose of Anti-SARS-CoV-2 Vaccine

Andrea Picchianti-Diamanti, Assunta Navarra, Alessandra Aiello, Bruno Lagana, Gilda Cuzzi, Andrea Salmi, Valentina Vanini, Fabrizio Maggi, Silvia Meschi, Giulia Matusali, Stefania Notari, Chiara Agrati, Simonetta Salemi, Roberta Di Rosa, Damiano Passarini, Valeria Di Gioia, Giorgio Sesti, Fabrizio Conti, Francesca Romana Spinelli, Angela Corpolongo, Maria Sole Chimenti, Mario Ferraioli, Gian Domenico Sebastiani, Maurizio Benucci, Francesca Li Gobbi, Anna Paola Santoro, Andrea Capri, Vincenzo Puro, Emanuele Nicastri, Delia Goletti

Summary: Breakthrough infections (BIs) in rheumatoid arthritis (RA) patients after a COVID-19 vaccination booster dose were analyzed. Older age, receiving conventional synthetic disease modifying antirheumatic drugs (csDMARDs), and higher neutralising antibody titres were identified as protective factors, while anti-IL6R treatment and anti-CD20 therapy increased the risk. The incidence of hospitalization for BIs was significantly higher in RA patients compared to healthcare workers.

VACCINES (2023)

Article Immunology

Evaluation of Cross-Immunity to the Mpox Virus Due to Historic Smallpox Vaccination

Giulia Matusali, Elisa Petruccioli, Eleonora Cimini, Francesca Colavita, Aurora Bettini, Eleonora Tartaglia, Settimia Sbarra, Silvia Meschi, Daniele Lapa, Massimo Francalancia, Licia Bordi, Valentina Mazzotta, Sabrina Coen, Klizia Mizzoni, Alessia Beccacece, Emanuele Nicastri, Luca Pierelli, Andrea Antinori, Enrico Girardi, Francesco Vaia, Alessandro Sette, Alba Grifoni, Delia Goletti, Vincenzo Puro, Fabrizio Maggi

Summary: This study found that a high proportion of individuals who received the smallpox vaccine 40 to 60 years ago have humoral cross-immunity to MPXV, while a smaller group of vaccinated individuals showed a T-cell-specific response against MPXV.

VACCINES (2023)

Article Biochemistry & Molecular Biology

Treatment-Emergent Cilgavimab Resistance Was Uncommon in Vaccinated Omicron BA.4/5 Outpatients

Cesare Ernesto Maria Gruber, Fabio Giovanni Tucci, Martina Rueca, Valentina Mazzotta, Giulia Gramigna, Alessandra Vergori, Lavinia Fabeni, Giulia Berno, Emanuela Giombini, Ornella Butera, Daniele Focosi, Ingrid Guarnetti Prandi, Giovanni Chillemi, Emanuele Nicastri, Francesco Vaia, Enrico Girardi, Andrea Antinori, Fabrizio Maggi

Summary: Mutations in the SARS-CoV-2 Spike glycoprotein can affect monoclonal antibody efficacy. Recent findings report the occurrence of resistant mutations in immunocompromised patients after tixagevimab/cilgavimab treatment. Our study retrospectively reviewed 22 immunocompetent patients at high risk for disease progression who received intramuscular tixagevimab/cilgavimab as early COVID-19 treatment and presented a prolonged high viral load. The study highlights the importance of early virological investigation to prevent drug resistance or clinical failures in immunocompetent patients.

BIOMOLECULES (2023)

Article Microbiology

In Vitro and In Vivo Crosstalk between Type I IFN and IL-8 Responses in SARS-CoV-2 Infection

Mirella Biava, Stefania Notari, Germana Grassi, Licia Bordi, Eleonora Tartaglia, Chiara Agrati, Eleonora Cimini, Giuseppe Sberna, Emanuele Nicastri, Andrea Antinori, Enrico Girardi, Francesco Vaia, Fabrizio Maggi, Eleonora Lalle

Summary: COVID-19 patients show over-expression of cytokines, particularly IL-8, which may interfere with the activation of interferon and impair the immune response.

MICROORGANISMS (2023)

Review Infectious Diseases

Antiviral combination therapies for persistent COVID-19 in immunocompromised patients

Daniele Focosi, Fabrizio Maggi, Alessandra D'Abramo, Emanuele Nicastri, David J. Sullivan

Summary: After the third year of the COVID-19 pandemic, immunocompromised patients face persistent infection and ineffective treatment with standard antiviral monotherapy. Combined antiviral therapies can mitigate these consequences.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2023)

Article Medicine, General & Internal

Timing and Outcomes of Noninvasive Ventilation in 307 ARDS COVID-19 Patients: An Observational Study in an Italian Third Level COVID-19 Hospital

Nardi Tetaj, Pierluca Piselli, Sara Zito, Giada De Angelis, Maria Cristina Marini, Dorotea Rubino, Ilaria Gaviano, Maria Vittoria Antonica, Elisabetta Agostini, Candido Porcelli, Giulia Valeria Stazi, Gabriele Garotto, Donatella Busso, Silvana Scarcia, Assunta Navarra, Claudia Cimaglia, Simone Topino, Fabio Iacomi, Alessandra D'Abramo, Carmela Pinnetti, Gina Gualano, Alessandro Capone, Alberta Villanacci, Andrea Antinori, Fabrizio Palmieri, Gianpiero D'Offizi, Stefania Ianniello, Fabrizio Taglietti, Paolo Campioni, Francesco Vaia, Emanuele Nicastri, Enrico Girardi, Luisa Marchioni

Summary: This study found that NIV failure in COVID-19 ARDS patients is correlated with the severity of the disease. In COVID-19 patients, starting NIV treatment appears to increase its effectiveness and reduce the risk of intubation and/or death for patients with mild ARDS (P/F > 200 mmHg). Additionally, early NIV treatment seems to decrease the risk of ICU mortality at 28 days from ICU admission.

MEDICINA-LITHUANIA (2022)

暂无数据