Article
Immunology
Chihiro Ishiwatari-Ogata, Masanao Kyuuma, Hitoshi Ogata, Machi Yamakawa, Katsuya Iwata, Motoki Ochi, Miyuki Hori, Noriyuki Miyata, Yasuyuki Fujii
Summary: In this study, we found that ozoralizumab is a promising treatment for rheumatoid arthritis, with low immunogenicity and superior efficacy in secondary failure.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Shuilian Fu, Zhiting Cao, Baolian Huang, Te Yin, Chujun Huang, Zhiqian Bi, Yingying Yao, Xiaoyao Chang, Hongqin Zhuang, Zi-Chun Hua
Summary: The dysfunction of tight junctions in the nasal epithelial barrier leads to increased allergen penetration and cytokine release, causing allergic rhinitis. TNF-a inhibitors have been used for treating autoimmune diseases, but their role in AR is unclear. In this study, an anti-TNF-a nanobody (V) assembled with tannic acid (V/TA) effectively inhibited cytokine release in an AR murine model. V/TA treatment restored infiltration of inflammatory cells, mucus-secreting cells, and mast cells to normal levels. The therapeutic effect was associated with reduced levels of TJ molecules and enhanced by tannic acid, without observed toxicity. This study offers a promising delivery strategy for treating complicated allergic rhinitis with superior epithelial barrier restoration compared to the commercial drug Infliximab.
Review
Biochemistry & Molecular Biology
Katarzyna Romanowska-Prochnicka, Anna Felis-Giemza, Marzena Olesinska, Piotr Wojdasiewicz, Agnieszka Paradowska-Gorycka, Dariusz Szukiewicz
Summary: TNF-alpha plays a crucial role in influencing hormone synthesis, placental architecture, and embryonic development during pregnancy. Increased levels of TNF-alpha are associated with pregnancy loss and preeclampsia, and may also impact trophoblast biology and maternal immune cells. Additionally, the release of cytokines and chemokines in syncytiotrophoblasts may be affected by chronic inflammatory diseases in pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Fang-fang Dai, Min Hu, Yu-wei Zhang, Rong-hui Zhu, Li-ping Chen, Zhi-dian Li, Yan-jie Huang, Wei Hu, Yan-xiang Cheng
Summary: This study reviewed the effects of TNF-alpha disorder on pathological conditions during pregnancy and summarized the impact of anti-TNF-alpha drugs on adverse pregnancy outcomes. Intrauterine growth restriction, spontaneous abortion, and preterm birth were found to be the most common adverse pregnancy outcomes associated with anti-TNF-alpha drugs.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ya-Chu Tsai, Hsun-Hao Chang, Sheng-Chieh Chou, Thomas W. Chu, Yu-Jou Hsu, Chien-Yu Hsiao, Yuan-Hsin Lo, Nan-Lin Wu, Der-Chen Chang, Chi-Feng Hung
Summary: Alpha-boswellic acid has shown efficacy in reducing inflammation, improving skin hydration, and reducing cytokine expression, suggesting its potential as a component in the development of anti-atopic dermatitis drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fujun Miao, Chunlan Shan, Syed Aftab Hussain Shah, Rana Waseem Akhtar, Xuanjun Wang, Delu Ning
Summary: The study found that walnut oil has antioxidant, anti-inflammatory, immune-enhancing, and gut microbiota regulation effects in mice, reducing oxidative stress, inflammation, and promoting beneficial gut bacteria.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Fisheries
Mingmin Lu, Youngsub Lee, Charles Li, Hyun S. Lillehoj
Summary: In this study, chTNF-alpha was functionally characterized and its immunomodulatory properties were explored using novel anti-chTNF-alpha mouse monoclonal antibodies. The tissue expression of chTNF-alpha was determined, and a specific antigen-capture sandwich ELISA was developed to measure its levels. The intracellular expression of chTNF-alpha in chicken immune cells was validated, and the antibodies were found to neutralize chTNF-alpha-induced nitric oxide production. These findings enhance our understanding of chTNF-alpha and provide valuable immune reagents for studying inflammatory responses and disease pathogenesis in avian species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Virology
Efi Makdasi, Yinon Levy, Ron Alcalay, Tal Noy-Porat, Eran Zahavy, Adva Mechaly, Eyal Epstein, Eldar Peretz, Hila Cohen, Liat Bar-On, Theodor Chitlaru, Ofer Cohen, Itai Glinert, Hagit Achdout, Tomer Israely, Ronit Rosenfeld, Ohad Mazor
Summary: Monoclonal antibodies play a significant role in COVID-19 therapy and diagnosis of SARS-CoV-2 infection. Research has shown that a diverse repertoire of antibodies targeting multiple epitopes of the virus can be generated through specific immunization methods, which can enhance the efficacy of immunotherapy.
Article
Multidisciplinary Sciences
Ruei-Min Lu, Kang-Hao Liang, Hsiao-Ling Chiang, Fu-Fei Hsu, Hsiu-Ting Lin, Wan-Yu Chen, Feng-Yi Ke, Monika Kumari, Yu-Chi Chou, Mi-Hua Tao, Yi-Ling Lin, Han-Chung Wu
Summary: The COVID-19 pandemic continues to pose a threat to human health globally with the emergence of new SARS-CoV-2 variants. This study developed a set of monoclonal antibodies targeting the Omicron variants using the mRNA-lipid nanoparticle immunization method. These antibodies demonstrated strong binding and neutralizing activities against all SARS-CoV-2 variants, including Omicron, suggesting their potential as universal neutralizing antibodies against SARS-CoV-2.
Review
Biochemistry & Molecular Biology
Sarit Uzzan, Abed N. Azab
Summary: Millions of people worldwide suffer from psychiatric illnesses, causing a heavy burden on patients and their families. Research suggests that increased levels of TNF-α in patients with mood disorders could lead to potential therapeutic strategies using anti-TNF-α drugs.
Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jian Gao, Jinlin Miao, Haoyang Sun, Xianghui Fu, Peiyan Zhang, Zhinan Chen, Ping Zhu
Summary: This study successfully established a humanized mouse model of immune-related adverse effects and discovered that immune checkpoint inhibitors may lead to arthritis and pneumonitis. Additionally, TNF-alpha(+) T cells were identified as potential therapeutic targets for intervention in immune-related arthritis and pneumonitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
M. Orozco-Uribe, R. Maqueda-Alfaro, F. Hernandez-Cazares, A. D. Saucedo-Campos, L. Donis-Maturano, J. Calderon-Amador, L. Flores-Romo, V. Ortiz-Navarrete, J. M. Hernandez-Hernandez
Summary: Plasma cells (PCs) are antibody-secreting cells derived from activated B-lymphocytes. Neonates receive antibodies from breastmilk to compensate for their immature immune system. However, this protection is limited to antigens the mother encountered, making neonates potentially susceptible to new antigens.
IMMUNOLOGY LETTERS
(2023)
Article
Biochemical Research Methods
Etienne Laborie, Victor Le-Minh, Thanh Duc Mai, Mehdi Ammar, Myriam Taverna, Claire Smadja
Summary: This study presents a new analytical approach to assess antibody orientation and density on magnetic beads. Results showed that different functionalized beads have varying capture efficiency towards human TNF-alpha immunocapture, with Protein G beads providing the highest efficiency.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Gian Marco Leone, Katia Mangano, Maria Cristina Petralia, Ferdinando Nicoletti, Paolo Fagone
Summary: Due to the important role of TNF-alpha in immunoinflammatory diseases, TNF-alpha inhibitors have been successfully developed and used in the treatment of autoimmune disorders. Currently, there are five approved anti-TNF-alpha drugs and biosimilars available. This review discusses the historical development, current and potential future applications, as well as the search for biomarkers to predict responsiveness to these therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Francois Santinon, Maxime Batignes, Majda Lyna Mebrek, Jerome Biton, Gaelle Clavel, Roxane Herve, Delphine Lemeiter, Magali Breckler, Florence Busato, Jorg Tost, Marianne Ziol, Marie-Christophe Boissier, Patrice Decker, Luca Semerano, Natacha Bessis
ARTHRITIS & RHEUMATOLOGY
(2020)
Review
Rheumatology
Marie-Christophe Boissier, Jerome Biton, Luca Semerano, Patrice Decker, Natacha Bessis
Article
Rheumatology
Agathe Leblond, Sonia Pezet, Anne Cauvet, Claudine Casas, Julie Pires Da Silva, Roxane Herve, Gaelle Clavel, Sebastien Dumas, Sylvia Cohen-Kaminsky, Natacha Bessis, Luca Semerano, Christophe Lemaire, Yannick Allanore, Jerome Avouac
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Editorial Material
Rheumatology
Luca Quartuccio, Luca Semerano, Maurizio Benucci, Marie-Christophe Boissier, Salvatore De Vita
Article
Respiratory System
Pierre-Antoine Juge, Joyce S. Lee, Jessica Lau, Leticia Kawano-Dourado, Jorge Rojas Serrano, Marco Sebastiani, Gouri Koduri, Eric Matteson, Karina Bonfiglioli, Marcio Sawamura, Ronaldo Kairalla, Lorenzo Cavagna, Emanuele Bozzalla Cassione, Andreina Manfredi, Mayra Mejia, Pedro Rodriguez-Henriquez, Montserrat I. Gonzalez-Perez, Ramces Falfan-Valencia, Ivette Buendia-Roldan, Gloria Perez-Rubio, Esther Ebstein, Steven Gazal, Raphael Borie, Sebastien Ottaviani, Caroline Kannengiesser, Benoit Wallaert, Yurdagul Uzunhan, Hilario Nunes, Dominique Valeyre, Nathalie Saidenberg-Kermanac, Marie-Christophe Boissier, Lidwine Wemeau-Stervinou, Rene-Marc Flipo, Sylvain Marchand-Adam, Pascal Richette, Yannick Allanore, Claire Dromer, Marie-Elise Truchetet, Christophe Richez, Thierry Schaeverbeke, Huguette Liote, Gabriel Thabut, Kevin D. Deane, Joshua J. Solomon, Tracy Doyle, Jay H. Ryu, Ivan Rosas, V. Michael Holers, Catherine Boileau, Marie-Pierre Debray, Raphael Porcher, David A. Schwartz, Robert Vassallo, Bruno Crestani, Philippe Dieude
Summary: The study found that there is no increased risk of RA-ILD associated with MTX use in patients with RA, and that ILD was detected later in MTX-treated patients.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Immunology
Guillaume Harle, Camille Kowalski, Juan Dubrot, Dale Brighouse, Gaelle Clavel, Robert Pick, Natacha Bessis, Jennifer Niven, Christoph Scheiermann, Monique Gannage, Stephanie Hugues
Summary: The study reveals that autophagy in LECs plays a crucial role in modulating T cell activation in arthritis, potentially affecting T reg cell populations and S1P production to influence the migration of pathogenic T cells and inflammation development.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Rheumatology
Caroline Ngoufack, Luca Semerano, Isabelle Podglajen, Patrick Bruneval, Christophe Meune, Dominique Valeyre, Robin Dhote, Marie-Christophe Boissier, Nathalie Saidenberg-Kermanac'h
Summary: This case report describes a 26-year-old Caucasian male with rheumatoid arthritis who developed a granulomatous cardiac valve complication while receiving etanercept treatment. The diagnosis of a paradoxical reaction to etanercept was made after ruling out other potential causes. The patient achieved remission after switching to tocilizumab monotherapy.
Editorial Material
Rheumatology
Imen Abdelkefi, Nathalie Saidenberg-Kermanac'h, Marie-Christophe Boissier, Luca Semerano, Johanna Sigaux
Article
Rheumatology
Pierre-Antoine Juge, Joshua J. Solomon, Coline H. M. van Moorsel, Romain Garofoli, Joyce S. Lee, Fabienne Louis-Sydney, Jorge Rojas-Serrano, Montserrat Gonzalez-Perez, Mayra Mejia, Ivette Buendia-Roldan, Ramces Falfan-Valencia, Enrique Ambrocio-Ortiz, Effrosyni Manali, Spyros A. Papiris, Theofanis Karageorgas, Dimitrios Boumpas, Katarina M. Antoniou, Prodromos Sidiropoulos, Athina Trachalaki, Joanne J. Van der Vis, Anna Jamnitski, Jan C. Grutters, Caroline Kannengiesser, Raphael Borie, Leticia Kawano-Dourado, Lidwine Wemeau-Stervinou, Rene-Marc Flipo, Hilario Nunes, Yurdagul Uzunhan, Dominique Valeyre, Nathalie Saidenberg-Kermanac'h, Marie-Christophe Boissier, Christophe Richez, Thierry Schaeverbeke, Tracy Doyle, Paul J. Wolters, Marie-Pierre Debray, Catherine Boileau, Raphael Porcher, David A. Schwartz, Bruno Crestani, Philippe Dieude
Summary: The study found that the MUC5B rs35705950 variant does not impact lung transplant-free survival or decline in pulmonary function in patients with RA-ILD, regardless of the HRCT pattern.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Review
Rheumatology
Jerome Biton, Nathalie Saidenberg-Kermanac, Patrice Decker, Marie-Christophe Boissiera, Luca Semeranoa, Johanna Sigauxa
Summary: The exposome refers to the integration of various external and internal exposures an individual experiences from conception to death, and can be a valuable tool in understanding the role of these factors in the pathophysiology of rheumatoid arthritis (RA). Measuring the exposome requires specific tools, approaches, and a global perspective.
Article
Nutrition & Dietetics
Johanna Sigaux, Alice Bellicha, Camille Buscail, Chantal Julia, Rene-Marc Flipo, Alain Cantagrel, Francois Laporte, Caroline Beal, Marie-Christophe Boissier, Luca Semerano
Summary: This study aimed to investigate the relationship between serum lipid profiles and disease activity in patients with early rheumatoid arthritis (RA). The study found that a serum lipid profile rich in n-3 fatty acids was independently associated with persistently reduced disease activity, while a profile rich in n-6 fatty acids was associated with lower disease activity.
Article
Rheumatology
Catherine Cavalin, Alain Lescoat, Johanna Sigaux, Odile Macchi, Alice Ballerie, Mickael Catinon, Michel Vincent, Luca Semerano, Marie-Christophe Boissier, Paul-Andre Rosental
Summary: This study developed and validated a thorough exposure questionnaire to investigate crystalline silica (SiO2) exposure in the general population and patients with autoimmune diseases. The results showed that the exposure gap between rheumatoid arthritis (RA) and systemic sclerosis (SSc) patients and controls was mainly due to occupational exposure.
Article
Rheumatology
F. Rodrigues, S. Abad, G. Elourimi, S. Le Jeune, J. -J. Mourad, U. Warzocha, C. Larroche, M. C. Boissier, A. Bourgarit-Durand, P. Y. Brillet, A. Mekinian, M. Soussan, R. Dhote
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2020)
