期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 17, 期 10, 页码 1584-1588出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00152-10
关键词
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资金
- Doris Duke Foundation
- Howard Hughes Medical Institute
- Packard Foundation
- National Institutes of Health, NIDDK [F32 DK083867-01]
- Burroughs Wellcome Fund
- [P30 DK52574]
Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an age-banded serological cohort from two St. Louis hospitals indicated a seroprevalence of 6.8%.
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