Article
Immunology
Stephanie S. Krieger, Sara R. Zwart, Satish Mehta, Honglu Wu, Richard J. Simpson, Scott M. Smith, Brian Crucian
Summary: Long-duration spaceflight can lead to immune dysregulation in astronauts, with changes in plasma and salivary cytokine concentrations observed before, during and after spaceflight. These biomarkers may be useful for monitoring the effectiveness of biomedical countermeasures for astronauts and potentially in terrestrial research and medicine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Seyong Kwon, Jieung Oh, Min Seok Lee, Eujin Um, Joonwoo Jeong, Joo H. Kang
Summary: A hemolysis-free and highly efficient plasma separation platform has been developed using enhanced diamagnetic repulsion of blood cells. By supplementing blood with superparamagnetic iron oxide nanoparticles, complete removal of blood cells from blood plasma is achieved, allowing for successful collection of plasma without losing plasma proteins, platelets, or exosomes.
Review
Nanoscience & Nanotechnology
Anamika Maurya, Janani Srree Murallidharan, Atul Sharma, Amit Agarwal
Summary: Significant advancements have been made in the field of diluted and whole blood plasma separation in the last two decades. Microfluidic devices with different geometries are used for this purpose, and a comparative analysis of these geometries is conducted to improve separation efficiency.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Anesthesiology
Lukas M. Mueller-Wirtz, Felix Maurer, Timo Brausch, Daniel Kiefer, Maximilian Floss, Jonas Doneit, Thomas Volk, Daniel I. Sessler, Tobias Fink, Thorsten Lehr, Sascha Kreuer
Summary: In rats, exhaled propofol concentrations correlate reasonably well with brain tissue and plasma concentrations, which may be useful in estimating the effect of anesthetic drugs. The elimination of propofol via the lungs is minimal, and exhaled quantities have negligible influence on plasma concentrations.
ANESTHESIA AND ANALGESIA
(2021)
Article
Cell Biology
Jerome Salignon, Omid R. Faridani, Tasso Miliotis, Georges E. Janssens, Ping Chen, Bader Zarrouki, Rickard Sandberg, Pia Davidsson, Christian G. Riedel
Summary: By analyzing proteins and small RNAs in human blood plasma samples, it was found that combining protein and miRNA data can result in more accurate age-predictive models, possibly capturing a broader range of age-related physiological changes.
Article
Chemistry, Multidisciplinary
Mario S. P. Correia, Bhawana Thapa, Miroslav Vujasinovic, J-Matthias Lohr, Daniel Globisch
Summary: The interaction between the metabolic microbiome and the human host is closely related to human physiology and disease development. Sulfated metabolites, as a readout for the co-metabolism of the microbiome and their host, play a key role in the identification of beneficial metabolites and disease modulators. The targeted analysis of sulfated metabolites in plasma and urine samples from the same individuals can help identify the core sulfatome and age effects on metabolites.
Article
Dermatology
Bibiana Trevisson, Ricardo Becerro-de-Bengoa-Vallejo, David Sevillano, Natalia Gonzalez, Marta Losa-Iglesias, Daniel Lopez-Lopez, Luis Alou
Summary: This study aimed to determine the inter-subject variability in PRP concentrates based on age and found age significantly affects the platelet and white blood cell concentrations in PRP.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biochemical Research Methods
Jens Martens-Lobenhoffer, Stefan Angermair, Stefanie M. Bode-Boeger
Summary: This study developed a method for the simultaneous quantification of ceftazidime and avibactam, and evaluated dried blood spots (DBS) as a matrix for improved stability of the drugs. The results showed that the stability of ceftazidime and avibactam was better in DBS compared to plasma, extending the maximal transport times to 24 hours for DBS samples.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Aruni Chathurya Pulukkody, Yeni P. Yung, Fabrizio Donnarumma, Kermit K. Murray, Ross P. Carlson, Luke Hanley
Summary: The study using LAST technology combined with proteomics revealed differential protein abundances between oxic and anoxic regions in Pseudomonas aeruginosa biofilms, showing a more active metabolism in the anoxic zone. Cellular adaptations to chemical gradients in the biofilm include glucose catabolizing proteins, high abundance of proteins from arginine and polyamine metabolism, and proteins that may support virulence and stress mediation in the anoxic region. The LAST methodology can identify hundreds of proteins using just a small area of biofilm.
Article
Medicine, General & Internal
Alan G. Palestine, Brandie D. Wagner, Jennifer L. Patnaik, Rebecca Baldermann, Marc T. Mathias, Naresh Mandava, Anne M. Lynch
Summary: The study aimed to investigate the relationship between C-C chemokines and intermediate age-related macular degeneration (iAMD) patients. The results showed that plasma concentrations of CCL2 were elevated, while CCL3 and CCL5 concentrations were decreased in iAMD patients compared with controls. This suggests a potential role for C-C chemokines in the systemic inflammatory processes associated with disease development.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Analytical
Yuchen Dai, Haotian Cha, Michael J. Simmonds, Hedieh Fallahi, Hongjie An, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang, Antony P. McNamee
Summary: This study investigates the effects of altering fluid viscoelasticity on blood plasma extraction. Poly (ethylene oxide) (PEO) was added to increase blood viscoelasticity, resulting in improved cell focusing performance. The optimal PEO concentration was found to be in the range of 100 to 200 ppm, and the optimal flow rate was determined to be between 1 and 15 mu L/min.
Article
Chemistry, Analytical
Han Zhang, Kanjirakat Anoop, Can Huang, Reza Sadr, Rohit Gupte, Jing Dai, Arum Han
Summary: This study introduces a continuous-flow blood plasma separation microfluidic device based on size exclusion cell separation. The device improves the efficiency, hemolysis resistance, and microchannel clogging compared to conventional designs, through the use of optimized crossflow microchannels and a circular geometry. The device achieves higher separation efficiency and produces high-quality blood plasma.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Jordan H. Machlin, Seth J. Barishansky, John Kelsh, Megan J. Larmore, Brian W. Johnson, Michele T. Pritchard, Mary Ellen Pavone, Francesca E. Duncan
Summary: The female reproductive system ages before other organs, leading to infertility, miscarriages, birth defects, and systemic deterioration. An increase in a unique fibroinflammatory cytokine signature in follicular fluid with age was identified, showing an inverse correlation with AMH levels and independence from BMI. This study highlights the importance of inflammaging in the female reproductive system and provides potential clinical targets in the ovary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Martin Valis, Alzbeta Dlabkova, Jakub Hort, Francesco Angelucci, Jaroslav Pejchal, Kamil Kuca, Zbysek Pavelek, Jana Zdarova Karasova, Michal Novotny
Summary: This study examined the differences in plasma and cerebrospinal fluid (CSF) levels of donepezil among Alzheimer's disease patients receiving a standard dose of 10 mg/day. The results showed that the CSF/plasma donepezil concentration ratio increased significantly in the 24 h group compared to the 6 h and 12 h groups. This finding suggests that measuring the CSF/plasma donepezil concentration ratio could help determine the optimal dose of donepezil.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Benjamin Deloison, Chloe Arthuis, Gabriel Benchimol, Daniel Balvay, Laurence Bussieres, Anne-Elodie Millischer, David Grevent, Cecile Butor, Gihad Chalouhi, Houman Mahallati, Olivier Helenon, Bertrand Tavitian, Olivier Clement, Yves Ville, Nathalie Siauve, Laurent Julien Salomon
Summary: The study evaluated the feasibility of using DCE MRI to measure placental perfusion in women, finding that fetuses affected by IUGR had significantly lower total placental blood flow values compared to AGA fetuses. Additionally, DCE perfusion parameters showed a linear correlation with gestational age.
Article
Surgery
James M. Clark, David T. Cooke, Habiba Hashimi, David Chin, Garth H. Utter, Lisa M. Brown, Miriam Nuno
Summary: The study examines the relationship between esophagectomy volume thresholds and patient characteristics, finding that the current Leapfrog Group guidelines may not accurately predict optimal outcomes for all patients.
Article
Surgery
Jacqueline C. Stocking, Garth H. Utter, Christiana Drake, J. Matthew Aldrich, Michael K. Ong, Alpesh Amin, Rebecca A. Marmor, Laura Godat, Maxime Cannesson, Michael A. Gropper, Patrick S. Romano
AMERICAN JOURNAL OF SURGERY
(2020)
Article
Gastroenterology & Hepatology
Jessica A. Bowman, Garth H. Utter
JOURNAL OF GASTROINTESTINAL SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
James M. Clark, David T. Cooke, David L. Chin, Garth H. Utter, Lisa M. Brown, Miriam Nuno
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Surgery
Jessica A. Bowman, Gregory J. Jurkovich, Daniel K. Nishijima, Garth H. Utter
JOURNAL OF SURGICAL RESEARCH
(2020)
Article
Critical Care Medicine
John W. Scott, Kristan Staudenmayer, Naveen Sangji, Zhaohui Fan, Mark Hemmila, Garth Utter
Summary: In this study, common EGS conditions were classified according to anatomic severity using ICD codes, with varying levels of severity identified for different conditions. Patients with more complex diseases generally had worse outcomes, although the relationship between increasing severity and outcomes was not consistent across all conditions.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)
Article
Medicine, General & Internal
Jessica A. Bowman, Miriam Nuno, Gregory J. Jurkovich, Garth H. Utter
Article
Surgery
Jacqueline C. Stocking, Christiana Drake, J. Matthew Aldrich, Michael K. Ong, Alpesh Amin, Rebecca A. Marmor, Laura Godat, Maxime Cannesson, Michael A. Gropper, Patrick S. Romano, Garth H. Utter
Summary: The study found that increased intraoperative ventilator volume and pressure, as well as greater 24-hour fluid balance, may be modifiable factors associated with early postoperative respiratory failure.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Surgery
Nikia R. McFadden, Debra R. Kahn, Garth H. Utter
Summary: Many injured prisoners have psychiatric illness, are involved in interpersonal violence, or harm themselves. Among hospitalized patients, abdominal stab/shank wounds sustained in prison are less likely to result in significant injuries or operative intervention than similar wounds in non-prisoners.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Critical Care Medicine
Angela Ingraham, Jessica Schumacher, Sara Fernandes-Taylor, Dou-Yan Yang, Laura Godat, Alan Smith, Ronald Barbosa, Chris Cribari, Ali Salim, Thomas Schroeppel, Kristan Staudenmayer, Marie Crandall, Garth Utter, Aast Committee On Patient Assessment
Summary: The current national burden and surgeon involvement in emergency general surgery (EGS) illnesses are not well understood. This study translated ICD-9-CM codes to ICD-10-CM codes and analyzed data to determine surgeon involvement across different EGS conditions. The results showed significant variability in surgeon involvement, highlighting the importance of multidisciplinary collaboration in EGS patient care.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Health Care Sciences & Services
Patricia A. Zrelak, Garth H. Utter, Kathryn M. McDonald, Robert L. Houchens, Sheryl M. Davies, Halcyon G. Skinner, Pamela L. Owens, Patrick S. Romano
Summary: This study successfully reweighted the Patient Safety Indicator Composite (PSI 90) by incorporating excess harm, resulting in a more clinically meaningful distribution of component weights. The reweighted PSI 90 showed satisfactory reliability and discrimination, demonstrating the feasibility of using harm-based weights in patient safety evaluations.
HEALTH SERVICES RESEARCH
(2022)
Article
Surgery
Nikia R. Mcfadden, Samantha K. Brown, Shannon M. Howard, Garth H. Utter
Summary: The AAST grading system for intestinal obstruction has predictive validity for some outcomes, but not all.
SURGERY IN PRACTICE AND SCIENCE
(2022)
Article
Critical Care Medicine
Nikia R. McFadden, Melissa M. Gosdin, Gregory J. Jurkovich, Garth H. Utter
Summary: This study investigated the challenges faced by trauma and acute care surgery patients during the discharge process and proposed recommendations for improving discharge care. Poor communication and education, as well as difficulties in coordinating outpatient care, were identified as major issues. Future interventions should focus on improving patient-clinician communication, actively engaging with primary care physicians, and providing appropriate support.
TRAUMA SURGERY & ACUTE CARE OPEN
(2022)
Article
Hematology
Kelsey Hazegh, Fang Fang, Marjorie D. Bravo, Johnson Q. Tran, Marcus O. Muench, Rachael P. Jackman, Nareg Roubinian, Lorenzo Bertolone, Angelo D'Alessandro, Larry Dumont, Grier P. Page, Tamir Kanias
Summary: Obesity is associated with significant changes in RBC metabolism and increased susceptibility to hemolysis under routine storage of RBC units. Further evaluation is needed to assess the impact on transfusion efficacy.
Article
Surgery
Timothy M. Guenther, Joshua D. Gustafson, Curtis J. Wozniak, Scott A. Zakaluzny, Garth H. Utter
JOURNAL OF SURGICAL CASE REPORTS
(2020)